cytokine receptor-like factor 1 (CRLF1) - coding DNA reference sequence

(used for variant description)

(last modified June 27, 2014)

This file was created to facilitate the description of sequence variants on transcript NM_004750.4 in the CRLF1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_013370.1, covering CRLF1 transcript NM_004750.4.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                                   .                g.5014
                                               ggggccgggcgggg       c.-181

 .         .         .         .         .         .                g.5074
 ccagcggcgcattagcgccttgtcaattcggctgctcagacttgctccggcctccgcgtc       c.-121

 .         .         .         .         .         .                g.5134
 cgcgcccagcgacgtgcgggcggcctggcccgcgccctcccgcgcccggcctgcgtcccg       c.-61

 .         .         .         .         .         .                g.5194
 cgccctgcgccaccgccgccgagccgcagcccgccgcgcgcccccggcagcgccggcccc       c.-1

          .         .         .         .         .         .       g.5254
 ATGCCCGCCGGCCGCCGGGGCCCCGCCGCCCAATCCGCGCGGCGGCCGCCGCCGTTGCTG       c.60
 M  P  A  G  R  R  G  P  A  A  Q  S  A  R  R  P  P  P  L  L         p.20

          .         .         .         .         .      | 02  .    g.12009
 CCCCTGCTGCTGCTGCTCTGCGTCCTCGGGGCGCCGCGAGCCGGATCAGGAGCCC | ACACA    c.120
 P  L  L  L  L  L  C  V  L  G  A  P  R  A  G  S  G  A  H |   T      p.40

          .         .         .         .         .         .       g.12069
 GCTGTGATCAGTCCCCAGGATCCCACGCTTCTCATCGGCTCCTCCCTGCTGGCCACCTGC       c.180
 A  V  I  S  P  Q  D  P  T  L  L  I  G  S  S  L  L  A  T  C         p.60

          .         .         .         .         .         .       g.12129
 TCAGTGCACGGAGACCCACCAGGAGCCACCGCCGAGGGCCTCTACTGGACCCTCAACGGG       c.240
 S  V  H  G  D  P  P  G  A  T  A  E  G  L  Y  W  T  L  N  G         p.80

          .         .         .         .         .         .       g.12189
 CGCCGCCTGCCCCCTGAGCTCTCCCGTGTACTCAACGCCTCCACCTTGGCTCTGGCCCTG       c.300
 R  R  L  P  P  E  L  S  R  V  L  N  A  S  T  L  A  L  A  L         p.100

          .         .         .         .         .         .       g.12249
 GCCAACCTCAATGGGTCCAGGCAGCGGTCGGGGGACAACCTCGTGTGCCACGCCCGTGAC       c.360
 A  N  L  N  G  S  R  Q  R  S  G  D  N  L  V  C  H  A  R  D         p.120

          .         .         .        | 03.         .         .    g.12972
 GGCAGCATCCTGGCTGGCTCCTGCCTCTATGTTGGCC | TGCCCCCAGAGAAACCCGTCAAC    c.420
 G  S  I  L  A  G  S  C  L  Y  V  G  L |   P  P  E  K  P  V  N      p.140

          .         .         .         .         .         .       g.13032
 ATCAGCTGCTGGTCCAAGAACATGAAGGACTTGACCTGCCGCTGGACGCCAGGGGCCCAC       c.480
 I  S  C  W  S  K  N  M  K  D  L  T  C  R  W  T  P  G  A  H         p.160

          .         .         .         .        | 04.         .    g.13262
 GGGGAGACCTTCCTCCACACCAACTACTCCCTCAAGTACAAGCTTAG | GTGGTATGGCCAG    c.540
 G  E  T  F  L  H  T  N  Y  S  L  K  Y  K  L  R  |  W  Y  G  Q      p.180

          .         .         .         .         .         .       g.13322
 GACAACACATGTGAGGAGTACCACACAGTGGGGCCCCACTCCTGCCACATCCCCAAGGAC       c.600
 D  N  T  C  E  E  Y  H  T  V  G  P  H  S  C  H  I  P  K  D         p.200

          .         .         .         .         .         .       g.13382
 CTGGCTCTCTTTACGCCCTATGAGATCTGGGTGGAGGCCACCAACCGCCTGGGCTCTGCC       c.660
 L  A  L  F  T  P  Y  E  I  W  V  E  A  T  N  R  L  G  S  A         p.220

          .         .         .        | 05.         .         .    g.14824
 CGCTCCGATGTACTCACGCTGGATATCCTGGATGTGG | TGACCACGGACCCCCCGCCCGAC    c.720
 R  S  D  V  L  T  L  D  I  L  D  V  V |   T  T  D  P  P  P  D      p.240

          .         .         .         .         .         .       g.14884
 GTGCACGTGAGCCGCGTCGGGGGCCTGGAGGACCAGCTGAGCGTGCGCTGGGTGTCGCCA       c.780
 V  H  V  S  R  V  G  G  L  E  D  Q  L  S  V  R  W  V  S  P         p.260

          .         .         .         .         .         .       g.14944
 CCCGCCCTCAAGGATTTCCTCTTTCAAGCCAAATACCAGATCCGCTACCGAGTGGAGGAC       c.840
 P  A  L  K  D  F  L  F  Q  A  K  Y  Q  I  R  Y  R  V  E  D         p.280

          .      | 06  .         .         .         .         .    g.15105
 AGTGTGGACTGGAAG | GTGGTGGACGATGTGAGCAACCAGACCTCCTGCCGCCTGGCCGGC    c.900
 S  V  D  W  K   | V  V  D  D  V  S  N  Q  T  S  C  R  L  A  G      p.300

          .         .         .         .         .         .       g.15165
 CTGAAACCCGGCACCGTGTACTTCGTGCAAGTGCGCTGCAACCCCTTTGGCATCTATGGC       c.960
 L  K  P  G  T  V  Y  F  V  Q  V  R  C  N  P  F  G  I  Y  G         p.320

          .         .         .         .         .         .       g.15225
 TCCAAGAAAGCCGGGATCTGGAGTGAGTGGAGCCACCCCACAGCCGCCTCCACTCCCCGC       c.1020
 S  K  K  A  G  I  W  S  E  W  S  H  P  T  A  A  S  T  P  R         p.340

      | 07   .         .         .         .         .         .    g.17472
 AGTG | AGCGCCCGGGCCCGGGCGGCGGGGCGTGCGAACCGCGGGGCGGAGAGCCGAGCTCG    c.1080
 S  E |   R  P  G  P  G  G  G  A  C  E  P  R  G  G  E  P  S  S      p.360

          .         .         .         .         .         .       g.17532
 GGGCCGGTGCGGCGCGAGCTCAAGCAGTTCCTGGGCTGGCTCAAGAAGCACGCGTACTGC       c.1140
 G  P  V  R  R  E  L  K  Q  F  L  G  W  L  K  K  H  A  Y  C         p.380

          .         .         .         .         .         .       g.17592
 TCCAACCTCAGCTTCCGCCTCTACGACCAGTGGCGAGCCTGGATGCAGAAGTCGCACAAG       c.1200
 S  N  L  S  F  R  L  Y  D  Q  W  R  A  W  M  Q  K  S  H  K         p.400

          .   | 08     .         .         .         .      | 09  . g.18276
 ACCCGCAACCAG | GACGAGGGGATCCTGCCCTCGGGCAGACGGGGCACGGCGAGAG | GTCCT c.1260
 T  R  N  Q   | D  E  G  I  L  P  S  G  R  R  G  T  A  R  G |   P   p.420

                                                                    g.18285
 GCCAGATAA                                                          c.1269
 A  R  X                                                            p.422

          .         .         .         .         .         .       g.18345
 gctgtaggggctcaggccaccctccctgccacgtggagacgcagaggccgaacccaaact       c.*60

          .         .         .         .         .         .       g.18405
 ggggccacctctgtaccctcacttcagggcacctgagccaccctcagcaggagctggggt       c.*120

          .         .         .         .         .         .       g.18465
 ggcccctgagctccaacggccataacagctctgactcccacgtgaggccacctttgggtg       c.*180

          .         .         .         .         .         .       g.18525
 caccccagtgggtgtgtgtgtgtgtgtgagggttggttgagttgcctagaacccctgcca       c.*240

          .         .         .         .         .         .       g.18585
 gggctgggggtgagaaggggagtcattactccccattacctagggcccctccaaaagagt       c.*300

          .         .         .         .                           g.18626
 ccttttaaataaatgagctatttaggtgctgtgattgtgaa                          c.*341

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Cytokine receptor-like factor 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.