cartilage associated protein (CRTAP) - coding DNA reference sequence

(used for variant description)

(last modified February 23, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_006371.4 in the CRTAP gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008122.1, covering CRTAP transcript NM_006371.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
 .         .         .         .         .         .                g.5060
 aggctggcgtccccgccccgaaagcactgggcccgccgcgtcgcaccgtcctctttcctt       c.-61

 .         .         .         .         .         .                g.5120
 tccttctccctccccttttcccttccttcgtcccttccttccttcctttcgccgggcgcg       c.-1

          .         .         .         .         .         .       g.5180
 ATGGAGCCGGGGCGCCGGGGGGCCGCGGCGCTGCTAGCGCTGCTGTGCGTGGCCTGCGCG       c.60
 M  E  P  G  R  R  G  A  A  A  L  L  A  L  L  C  V  A  C  A         p.20

          .         .         .         .         .         .       g.5240
 CTGCGCGCCGGGCGCGCCCAATACGAACGCTACAGCTTCCGCAGCTTCCCACGGGACGAG       c.120
 L  R  A  G  R  A  Q  Y  E  R  Y  S  F  R  S  F  P  R  D  E         p.40

          .         .         .         .         .         .       g.5300
 CTGATGCCGCTCGAGTCGGCCTACCGGCACGCGCTGGACAAGTACAGCGGCGAGCACTGG       c.180
 L  M  P  L  E  S  A  Y  R  H  A  L  D  K  Y  S  G  E  H  W         p.60

          .         .         .         .         .         .       g.5360
 GCCGAGAGCGTGGGCTACCTGGAGATCAGCCTGCGGCTGCACCGCTTGCTGCGCGACAGC       c.240
 A  E  S  V  G  Y  L  E  I  S  L  R  L  H  R  L  L  R  D  S         p.80

          .         .         .         .         .         .       g.5420
 GAGGCCTTCTGCCACCGCAACTGCAGCGCCGCGCCGCAGCCCGAGCCCGCCGCCGGCCTC       c.300
 E  A  F  C  H  R  N  C  S  A  A  P  Q  P  E  P  A  A  G  L         p.100

          .         .         .         .         .         .       g.5480
 GCCAGCTATCCCGAGCTGCGCCTCTTCGGGGGCCTGCTGCGCCGCGCGCACTGCCTCAAG       c.360
 A  S  Y  P  E  L  R  L  F  G  G  L  L  R  R  A  H  C  L  K         p.120

          .         .         .         .         .         .       g.5540
 CGCTGCAAGCAGGGCCTGCCAGCCTTCCGCCAGTCCCAGCCCAGCCGCGAGGTGCTGGCG       c.420
 R  C  K  Q  G  L  P  A  F  R  Q  S  Q  P  S  R  E  V  L  A         p.140

          .         .         .         .         .  | 02      .    g.11395
 GACTTCCAGCGCCGCGAGCCCTACAAGTTCCTGCAGTTCGCTTACTTCAAG | GCAAATAAT    c.480
 D  F  Q  R  R  E  P  Y  K  F  L  Q  F  A  Y  F  K   | A  N  N      p.160

          .         .         .         .         .         .       g.11455
 CTCCCCAAAGCCATCGCCGCTGCTCACACCTTTCTACTGAAGCATCCTGATGACGAAATG       c.540
 L  P  K  A  I  A  A  A  H  T  F  L  L  K  H  P  D  D  E  M         p.180

          .         .         .         .         .         .       g.11515
 ATGAAGAGGAACATGGCATATTATAAGAGCCTGCCTGGTGCCGAGGACTACATTAAAGAC       c.600
 M  K  R  N  M  A  Y  Y  K  S  L  P  G  A  E  D  Y  I  K  D         p.200

          .         .  | 03      .         .         .         .    g.15489
 CTGGAAACCAAGTCATATGAA | AGCCTGTTCATCCGAGCAGTGCGGGCATACAACGGTGAG    c.660
 L  E  T  K  S  Y  E   | S  L  F  I  R  A  V  R  A  Y  N  G  E      p.220

          .         .         .         .         .         .       g.15549
 AACTGGAGAACATCCATCACAGACATGGAGCTGGCCCTTCCCGACTTCTTCAAAGCCTTT       c.720
 N  W  R  T  S  I  T  D  M  E  L  A  L  P  D  F  F  K  A  F         p.240

          .         .         .         .         .         .       g.15609
 TACGAGTGTCTCGCAGCCTGCGAGGGTTCCAGGGAGATCAAGGACTTCAAGGATTTCTAC       c.780
 Y  E  C  L  A  A  C  E  G  S  R  E  I  K  D  F  K  D  F  Y         p.260

          .    | 04    .         .         .         .         .    g.21028
 CTTTCCATAGCAG | ATCATTATGTAGAAGTTCTGGAATGCAAAATACAGTGTGAAGAGAAC    c.840
 L  S  I  A  D |   H  Y  V  E  V  L  E  C  K  I  Q  C  E  E  N      p.280

          .         .         .         .         .         .       g.21088
 CTCACCCCAGTTATAGGAGGCTATCCGGTTGAGAAATTTGTGGCTACCATGTATCATTAC       c.900
 L  T  P  V  I  G  G  Y  P  V  E  K  F  V  A  T  M  Y  H  Y         p.300

          .         .   | 05     .         .         .         .    g.23635
 TTGCAGTTTGCCTATTATAAGT | TGAACGACCTGAAGAATGCAGCCCCCTGTGCAGTCAGC    c.960
 L  Q  F  A  Y  Y  K  L |   N  D  L  K  N  A  A  P  C  A  V  S      p.320

          .         .         .         .         .         .       g.23695
 TATCTGCTCTTTGATCAGAATGACAAGGTCATGCAGCAGAACCTGGTGTATTACCAGTAC       c.1020
 Y  L  L  F  D  Q  N  D  K  V  M  Q  Q  N  L  V  Y  Y  Q  Y         p.340

          .         .         .         .         | 06         .    g.25236
 CACAGGGACACTTGGGGCCTCTCGGATGAGCACTTCCAGCCCAGACCT | GAAGCAGTTCAG    c.1080
 H  R  D  T  W  G  L  S  D  E  H  F  Q  P  R  P   | E  A  V  Q      p.360

          .         .         .         .         .         .       g.25296
 TTCTTTAATGTGACCACACTCCAGAAGGAGCTGTATGACTTTGCTAAGGAAAATATAATG       c.1140
 F  F  N  V  T  T  L  Q  K  E  L  Y  D  F  A  K  E  N  I  M         p.380

          .   | 07     .         .         .         .         .    g.33485
 GATGATGATGAG | GGAGAAGTTGTGGAATATGTGGATGACCTCTTGGAACTGGAGGAGACC    c.1200
 D  D  D  E   | G  E  V  V  E  Y  V  D  D  L  L  E  L  E  E  T      p.400

                                                                    g.33491
 AGCTAG                                                             c.1206
 S  X                                                               p.401

          .         .         .         .         .         .       g.33551
 cccacagcaaccaaagagacttcctcttggcgttcaggaaacacagattctttgtccttt       c.*60

          .         .         .         .         .         .       g.33611
 tcccaacagcccaggctgttgatacctcagagccttctctttactctccaaagtgaaagg       c.*120

          .         .         .         .         .         .       g.33671
 gaagcccccgtctctctaactgcatgtcatcaggggtgagcctgcctttcctatcttcac       c.*180

          .         .         .         .         .         .       g.33731
 acctgccacctcatgttcacacctatctttctcaccttttttttgagatggagtctcgct       c.*240

          .         .         .         .         .         .       g.33791
 ctcttgcccaggctggagtgcaatggcacgttctcagctcactgcaacctccgcctcttg       c.*300

          .         .         .         .         .         .       g.33851
 ggttcaagcaattctgctgcatcagcctcccgagtacctgggattacaggcatgtgccac       c.*360

          .         .         .         .         .         .       g.33911
 cacgcccggctaattttgtatttttagtagagacggggttttgccatgttggccaggctg       c.*420

          .         .         .         .         .         .       g.33971
 gtctcgaactcttgacttcagatgatccatctgccttggcctcccacagtgctgggatta       c.*480

          .         .         .         .         .         .       g.34031
 caggcgtgagccaccatgcccggcctctttctcacctttacacctgtcttcttatcctca       c.*540

          .         .         .         .         .         .       g.34091
 catctgttttcacaccttcatccctgtcttcctcatgttcacacttgtcttccccatgtt       c.*600

          .         .         .         .         .         .       g.34151
 catagctgcctttcttaccattttggtttgaagggcagtcttctctggcttgtttttttg       c.*660

          .         .         .         .         .         .       g.34211
 tttttcccagaaaatcagtattattttttaaataagaaaaacattcctagaagatgataa       c.*720

          .         .         .         .         .         .       g.34271
 ttgtgaaaacctcctttggcttatttgcttttccagattttagtctcctttctccccatc       c.*780

          .         .         .         .         .         .       g.34331
 cgggaaagatggtggaagacataggctaaatttctccagcctcacaatggtcttcacttg       c.*840

          .         .         .         .         .         .       g.34391
 gtctgacttgtaccaattctagcacccactgaaaaacaagttgagtagagagtgtagagt       c.*900

          .         .         .         .         .         .       g.34451
 gcagaaatgtggcttttgccccactttgcatctccaaaattacaacggttggccgatccc       c.*960

          .         .         .         .         .         .       g.34511
 atttgaggacaatgcttagttataagtctccgagttggaaaaggaagaaagccagagctg       c.*1020

          .         .         .         .         .         .       g.34571
 tctagtttcattcattctttcagtaaatatttattgagtacctactgtgtgctaggcatt       c.*1080

          .         .         .         .         .         .       g.34631
 gacctgggaactagagatacttcacagaataacagggaaagttccctgtgctcatggagc       c.*1140

          .         .         .         .         .         .       g.34691
 ttacattctacagggagaaagagatagccaatacataggaataaatatatacaaggtatc       c.*1200

          .         .         .         .         .         .       g.34751
 atgtagtgataattgctgtggagaaaaataaagcaggggagggagtaagaaatcctggag       c.*1260

          .         .         .         .         .         .       g.34811
 atgaggctgcagttttaaatggggcctcactgggaatgtgacgttgagcagagacgttag       c.*1320

          .         .         .         .         .         .       g.34871
 ggaagtggatcctggacaaggcattccaggcagaggaacaggatgtgcactgccccaaag       c.*1380

          .         .         .         .         .         .       g.34931
 tgagaacttgctctacgtggtcaggaaagagcagggagaccaagcagagtcgtgggcagg       c.*1440

          .         .         .         .         .         .       g.34991
 ggtagaatggaaggagaggcggctggggaggacaggtggtggagggccttggcttctgct       c.*1500

          .         .         .         .         .         .       g.35051
 aagtgagatgggaaccactggagggtttgaacagaggagtgccttgattgatttatattt       c.*1560

          .         .         .         .         .         .       g.35111
 tgcaagggtcattctagctgccatattgtgaaaaactttagtggacaagggcagaaggaa       c.*1620

          .         .         .         .         .         .       g.35171
 gagggaagacctgttaggaagctactgcaaggttccaggcttgggcctgggccacagcaa       c.*1680

          .         .         .         .         .         .       g.35231
 cagcagtggtcaaatatctagatttattttgaaaagagccaataggatttgctgagagtt       c.*1740

          .         .         .         .         .         .       g.35291
 tgaatgtggagtgtaagagaaggaagagttaatgatgacattaaggtttttggcctgaat       c.*1800

          .         .         .         .         .         .       g.35351
 agcaggaaagatggagttaccagttactgaaatagggaaggatgggctgggtaagtatgg       c.*1860

          .         .         .         .         .         .       g.35411
 aatttggtgcaaagcaggctgtctgtggttggaatgggaggttctggctgcaaatcaaag       c.*1920

          .         .         .         .         .         .       g.35471
 tggagagttctctcaggtcaggtctgcagcagagctcgagacagggatctgaatgcactt       c.*1980

          .         .         .         .         .         .       g.35531
 ggtttattgttgggggtgctctcagaaggaacctgtgaaagcctttatcagtcatttatt       c.*2040

          .         .         .         .         .         .       g.35591
 ggctgtgagaagttctctgggagtgtgggtacatttgaaggcaagtgacttcagttgagg       c.*2100

          .         .         .         .         .         .       g.35651
 gcaagtctctggaaaagaggctgtaggcatctggcagctaccatgcatggtagtgtgttg       c.*2160

          .         .         .         .         .         .       g.35711
 ggggtgggggtcctgggcactggctgtgtgaagggatctggcagggcaccacagcgcccc       c.*2220

          .         .         .         .         .         .       g.35771
 ctactgaaccatcagcatgtcagtggcatttaaagccatgcagctggaggggccactgag       c.*2280

          .         .         .         .         .         .       g.35831
 attgtctctgagtattactgagaagcaacagaaaagagccatggatggagcccttgggct       c.*2340

          .         .         .         .         .         .       g.35891
 ctctgggaaatgggaaatcagccaaaggactgagaaggagttaccttaaggtcagagaaa       c.*2400

          .         .         .         .         .         .       g.35951
 accaagagagtgtggtgttctggaagctgagctttctttattcaacctcattcccttctc       c.*2460

          .         .         .         .         .         .       g.36011
 caaataagccacttgtgtagttgggcccctccagggttgaaggcaagaggagaaaggcac       c.*2520

          .         .         .         .         .         .       g.36071
 agcgtttgggaaacaagacttttcctgcaatagcctgggaaggaataaaaggatagagtg       c.*2580

          .         .         .         .         .         .       g.36131
 tttgggtttttgtgtaatggtggttaattggggtggaacactcacacgttgtgctttttc       c.*2640

          .         .         .         .         .         .       g.36191
 tgggcttcccttatcccccagaacactctaccaacctcggggaactcgggcacatccttc       c.*2700

          .         .         .         .         .         .       g.36251
 tgtttctccttcagctctatcctgctttcctcatcccttctgacaccacgtcctcactca       c.*2760

          .         .         .         .         .         .       g.36311
 cctgcacaagaatccctgcatcaggttctcctttgagggtacccacccaggacagtcccc       c.*2820

          .         .         .         .         .         .       g.36371
 taccacttctgtcttgggctgaagttgcccacgtccacaaaatctgtactcccagcgggg       c.*2880

          .         .         .         .         .         .       g.36431
 gtgtttggcccgaggagtcagtgttattactggtggatgcaccgtgtccacagcagcccc       c.*2940

          .         .         .         .         .         .       g.36491
 caatcccagcgatgcgtcagatcttacgtggcttcctgctgggggagatggccttcaccc       c.*3000

          .         .         .         .         .         .       g.36551
 acgggatgccgggttctcctttctttcctcaccccaacctttactccaccagagaaactt       c.*3060

          .         .         .         .         .         .       g.36611
 ccttttgaactcagtggggaagagggtgatgagacaggactagaaagtagtgggggaccc       c.*3120

          .         .         .         .         .         .       g.36671
 agcgagtggacgccctgctccgggattcctgagtctgtaaatagtgtgcccagcagctgt       c.*3180

          .         .         .         .         .         .       g.36731
 gaactccccttatagcctcaggctgcagtgtccttcccagctgtgtgagaaaatgaaagc       c.*3240

          .         .         .         .         .         .       g.36791
 cgacgtccacagggacccaggcagggttgggtgttgtgactcactccacctctgtgccct       c.*3300

          .         .         .         .         .         .       g.36851
 gcagaggtactgttgggtccttgtcttgtgagcctggggtgagctctctgtacatgttgt       c.*3360

          .         .         .         .         .         .       g.36911
 tgttccacgtatgggttgacttggcatgctggggggtcctcgttcactctctgaagttgg       c.*3420

          .         .         .         .         .         .       g.36971
 cctcctttcactggggattgaaaagcacctccacccctaccctagtgatgtcccctgagg       c.*3480

          .         .         .         .         .         .       g.37031
 acccgggtgatagtacagtcaatattgtcagtactttgctttgattgaaggctgtagagc       c.*3540

          .         .         .         .         .         .       g.37091
 tgagttaccaaaatttctatttcaaaggaaaccaaaccttaaaaaaaaaaaacaaaaact       c.*3600

          .         .         .         .         .         .       g.37151
 gggctgggtcttccaaacctaccatgaaaccctggtgtgcaggctgcactcaatgacctc       c.*3660

          .         .         .         .         .         .       g.37211
 aacccaacacctccctgagtgtgcttcttggaagagcctagaagattcctggatggagac       c.*3720

          .         .         .         .         .         .       g.37271
 cccattggttcagcctcaagtctggcccgtcttcgaaaaaacaaacacatttgtaagctt       c.*3780

          .         .         .         .         .         .       g.37331
 tgtgggagcttccaggcctgctctaagatgccttgcttgtcctttgacccatcagcatgg       c.*3840

          .         .         .         .         .         .       g.37391
 agctcagtggttgctgtttggttctgcaggctggtggggaggccgcccatcgtggtgggg       c.*3900

          .         .         .         .         .         .       g.37451
 catctgtccagccccattgccactcagggcatccaaacaggaggcacccgctgggaaggg       c.*3960

          .         .         .         .         .         .       g.37511
 tctaaagatactccttgtggccactgctactgttcacacttgacttgtggagaagcgaag       c.*4020

          .         .         .         .         .         .       g.37571
 ggctgaggggaggtttgtgtacacccatgtatttaaaagtgactgactgactgaaatgag       c.*4080

          .         .         .         .         .         .       g.37631
 cacataccgacatatgcaacatactaataccttcctgattttcgagactttctaattact       c.*4140

          .         .         .         .         .         .       g.37691
 acaactaacctgttgtgctcacctctggaattcagaaagagagccactgcgagcactgac       c.*4200

          .         .         .         .         .         .       g.37751
 cacaagggctgccttaggaaggaaatgtgtgctttcaggagttcttattaggggaatttt       c.*4260

          .         .         .         .         .         .       g.37811
 aagagcacaaaaattttattgaacccaccttagtgacaaacagaaaatgatttgttagat       c.*4320

          .         .         .         .         .         .       g.37871
 tgtcagttggaaggggtttattatgactgctggtgaaataaacagtgaccagtttctgcc       c.*4380

          .         .         .         .         .         .       g.37931
 aacatttatggaaataacgtttctaggttttaaatgtgagccgtaaactgaagctacttc       c.*4440

          .         .         .         .         .         .       g.37991
 agttaaaaaaaaaaaaatcaatacttaaactgtagggaaaaggtggattggtgccagaga       c.*4500

          .         .         .         .         .         .       g.38051
 aaacattatttaatagtgtcagaacatggaactgcaacacagtttgtagcaaggcactga       c.*4560

          .         .         .         .         .         .       g.38111
 gaaaaacccacaactaatccttcatcgcagctgtctgaactcttgatcatctgccatccc       c.*4620

          .         .         .         .         .         .       g.38171
 ccaaacagtgacttctttttttctggtgactccaggcctgaatgacctagtgtggagagt       c.*4680

          .         .         .         .         .         .       g.38231
 ttaaactatgtacaagggaggaaagaaaaaaaggaaaggaaccttaagtaagcctcagcc       c.*4740

          .         .         .         .         .         .       g.38291
 aaaggttttatgcattggacttcctgtgcctgcccccaggggcaagactgatccccatgc       c.*4800

          .         .         .         .         .         .       g.38351
 ctgtgcccatgacatctccctgaaagaggacaccatgacagcccggctttgccttgactg       c.*4860

          .         .         .         .         .         .       g.38411
 acccactgctaccccagaaataagaatcaagagcagctattgttatccttagagtgtttt       c.*4920

          .         .         .         .         .         .       g.38471
 ccgtctagggccggctcgtgaacagccacatatccttgcacctgacactgtccccacaca       c.*4980

          .         .         .         .         .         .       g.38531
 aatagctggctttcgttgcttgttgaatgaatgagtgagttggctctatatccccttgga       c.*5040

          .         .         .         .         .         .       g.38591
 gctggccggtaagatattagtgcctcattttacaagaagagaataggaaggaattaagca       c.*5100

          .         .         .         .         .         .       g.38651
 atttggccaacagatacaagatagattccagagttttatctcccactttagggtggcagc       c.*5160

          .         .         .         .         .         .       g.38711
 cagtaggccaaactccaaagaccgttgctgatgtctttttctgcctcccctctttgggtt       c.*5220

          .         .         .         .         .         .       g.38771
 agtgtggtatgtacaagctcactcttgttgaaaattagaaaatagttgaaaacaaaaggt       c.*5280

          .         .         .         .                           g.38816
 ttttgtttttctttttaaatcacattaaatgttttacattgctta                      c.*5325

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Cartilage associated protein protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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