casein kinase 2, alpha 1 polypeptide (CSNK2A1) - coding DNA reference sequence

(used for variant description)

(last modified February 14, 2025)


This file was created to facilitate the description of sequence variants on transcript NM_177559.2 in the CSNK2A1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000020.10, covering CSNK2A1 transcript NM_177559.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5033
                            cccgcctcctggtaggagggggtttccgcttcc       c.-361

 .         .         .         .         .         .                g.5093
 ggcagcagcggctgcagcctcgctctggtccctgcggctggcggccgagccgtgtgtctc       c.-301

 .         .         .         .         .         .                g.5153
 ctcctccatcgccgccatattgtctgtgtgagcagaggggagagcggccgccgccgctgc       c.-241

 .         .    | 02    .         .         .         .             g.20835
 cgcttccaccacag | ctctatcaaggcttgtcaagcagtgtgctcatcacatggtaaatca    c.-181

 .         .         .         .         .         .                g.20895
 tgcagcgtggaacctcataaaatctccaagaaacatcattcacccatactgactagtttc       c.-121

 .         . | 03       .         .         .         .             g.40227
 acatctctttg | tttgaagaaaacaggtctgaaacaaggtcttacccccagctgcttctga    c.-61

 .         .         .         .         .         .                g.40287
 acacagtgactgccagatctccaaacatcaagtccagctttgtccgccaacctgtctgac       c.-1

          .         .         .         .         .         .       g.40347
 ATGTCGGGACCCGTGCCAAGCAGGGCCAGAGTTTACACAGATGTTAATACACACAGACCT       c.60
 M  S  G  P  V  P  S  R  A  R  V  Y  T  D  V  N  T  H  R  P         p.20

          .         .         .         .  | 04      .         .    g.43628
 CGAGAATACTGGGATTACGAGTCACATGTGGTGGAATGGGG | AAATCAAGATGACTACCAG    c.120
 R  E  Y  W  D  Y  E  S  H  V  V  E  W  G  |  N  Q  D  D  Y  Q      p.40

          .         .         .         .         .         .       g.43688
 CTGGTTCGAAAATTAGGCCGAGGTAAATACAGTGAAGTATTTGAAGCCATCAACATCACA       c.180
 L  V  R  K  L  G  R  G  K  Y  S  E  V  F  E  A  I  N  I  T         p.60

          .         .         .    | 05    .         .         .    g.48931
 AATAATGAAAAAGTTGTTGTTAAAATTCTCAAG | CCAGTAAAAAAGAAGAAAATTAAGCGT    c.240
 N  N  E  K  V  V  V  K  I  L  K   | P  V  K  K  K  K  I  K  R      p.80

          .         .         .         .         .         .       g.48991
 GAAATAAAGATTTTGGAGAATTTGAGAGGAGGTCCCAACATCATCACACTGGCAGACATT       c.300
 E  I  K  I  L  E  N  L  R  G  G  P  N  I  I  T  L  A  D  I         p.100

          .      | 06  .         .         .         .         .    g.49578
 GTAAAAGACCCTGTG | TCACGAACCCCCGCCTTGGTTTTTGAACACGTAAACAACACAGAC    c.360
 V  K  D  P  V   | S  R  T  P  A  L  V  F  E  H  V  N  N  T  D      p.120

        | 07 .         .         .         .         .         .    g.51112
 TTCAAG | CAATTGTACCAGACGTTAACAGACTATGATATTCGATTTTACATGTATGAGATT    c.420
 F  K   | Q  L  Y  Q  T  L  T  D  Y  D  I  R  F  Y  M  Y  E  I      p.140

        | 08 .         .         .         .         .         .    g.53090
 CTGAAG | GCCCTGGATTATTGTCACAGCATGGGAATTATGCACAGAGATGTCAAGCCCCAT    c.480
 L  K   | A  L  D  Y  C  H  S  M  G  I  M  H  R  D  V  K  P  H      p.160

          .         .         . | 09       .         .         .    g.56504
 AATGTCATGATTGATCATGAGCACAGAAAG | CTACGACTAATAGACTGGGGTTTGGCTGAG    c.540
 N  V  M  I  D  H  E  H  R  K   | L  R  L  I  D  W  G  L  A  E      p.180

          .         .         .         .         .         .       g.56564
 TTTTATCATCCTGGCCAAGAATATAATGTCCGAGTTGCTTCCCGATACTTCAAAGGTCCT       c.600
 F  Y  H  P  G  Q  E  Y  N  V  R  V  A  S  R  Y  F  K  G  P         p.200

          .         .  | 10      .         .         .         .    g.58996
 GAGCTACTTGTAGACTATCAG | ATGTACGATTATAGTTTGGATATGTGGAGTTTGGGTTGT    c.660
 E  L  L  V  D  Y  Q   | M  Y  D  Y  S  L  D  M  W  S  L  G  C      p.220

          .         .         .         .         .         .       g.59056
 ATGCTGGCAAGTATGATCTTTCGGAAGGAGCCATTTTTCCATGGACATGACAATTATGAT       c.720
 M  L  A  S  M  I  F  R  K  E  P  F  F  H  G  H  D  N  Y  D         p.240

     | 11    .         .         .         .         .         .    g.60117
 CAG | TTGGTGAGGATAGCCAAGGTTCTGGGGACAGAAGATTTATATGACTATATTGACAAA    c.780
 Q   | L  V  R  I  A  K  V  L  G  T  E  D  L  Y  D  Y  I  D  K      p.260

          .         .         .         .     | 12   .         .    g.61279
 TACAACATTGAATTAGATCCACGTTTCAATGATATCTTGGGCAG | ACACTCTCGAAAGCGA    c.840
 Y  N  I  E  L  D  P  R  F  N  D  I  L  G  R  |  H  S  R  K  R      p.280

          .         .         .         .         .         .       g.61339
 TGGGAACGCTTTGTCCACAGTGAAAATCAGCACCTTGTCAGCCCTGAGGCCTTGGATTTC       c.900
 W  E  R  F  V  H  S  E  N  Q  H  L  V  S  P  E  A  L  D  F         p.300

          .         .         .         .         .         .       g.61399
 CTGGACAAACTGCTGCGATATGACCACCAGTCACGGCTTACTGCAAGAGAGGCAATGGAG       c.960
 L  D  K  L  L  R  Y  D  H  Q  S  R  L  T  A  R  E  A  M  E         p.320

          .    | 13    .         .         .         .         .    g.62423
 CACCCCTATTTCT | ACACTGTTGTGAAGGACCAGGCTCGAATGGGTTCATCTAGCATGCCA    c.1020
 H  P  Y  F  Y |   T  V  V  K  D  Q  A  R  M  G  S  S  S  M  P      p.340

          .         .         .         . | 14       .         .    g.64782
 GGGGGCAGTACGCCCGTCAGCAGCGCCAATATGATGTCAG | GGATTTCTTCAGTGCCAACC    c.1080
 G  G  S  T  P  V  S  S  A  N  M  M  S  G |   I  S  S  V  P  T      p.360

          .         .         .         .         .         .       g.64842
 CCTTCACCCCTTGGACCTCTGGCAGGCTCACCAGTGATTGCTGCTGCCAACCCCCTTGGG       c.1140
 P  S  P  L  G  P  L  A  G  S  P  V  I  A  A  A  N  P  L  G         p.380

          .         .         .                                     g.64878
 ATGCCTGTTCCAGCTGCCGCTGGCGCTCAGCAGTAA                               c.1176
 M  P  V  P  A  A  A  G  A  Q  Q  X                                 p.391

          .         .         .         .         .         .       g.64938
 cggccctatctgtctcctgatgcctgagcagaggtgggggagtccaccctctccttgatg       c.*60

          .         .         .         .         .         .       g.64998
 cagcttgcgcctggcggggaggggtgaaacacttcagaagcaccgtgtctgaaccgttgc       c.*120

          .         .         .         .         .         .       g.65058
 ttgtggatttatagtagttcagtcataaaaaaaaaattataataggctgattttcttttt       c.*180

          .         .         .         .         .         .       g.65118
 tctttttttttttaactcgaacttttcataactcaggggattccctgaaaaattacctgc       c.*240

          .         .         .         .         .         .       g.65178
 aggtggaatatttcatggacaaatttttttttctcccctcccaaatttagttcctcatca       c.*300

          .         .         .         .         .         .       g.65238
 caaaagaacaaagataaaccagcctcaatcccggctgctgcatttaggtggagacttctt       c.*360

          .         .         .         .         .         .       g.65298
 cccattcccaccattgttcctccaccgtcccacactttagggggttggtatctcgtgctc       c.*420

          .         .         .         .         .         .       g.65358
 ttctccagagattacaaaaatgtagcttctcaggggaggcaggaagaaaggaaggaagga       c.*480

          .         .         .         .         .         .       g.65418
 aagaaggaagggaggacccaatctataggagcagtggactgcttgctggtcgcttacatc       c.*540

          .         .         .         .         .         .       g.65478
 actttactccataagcgcttcagtggggttatcctagtggctcttgtggaagtgtgtctt       c.*600

          .         .         .         .         .         .       g.65538
 agttacatcaagatgttgaaaatctacccaaaatgcagacagatactaaaaacttctgtt       c.*660

          .         .         .         .         .         .       g.65598
 cagtaagaatcatgtcttactgatctaaccctaaatccaactcatttatacttttatttt       c.*720

          .         .         .         .         .         .       g.65658
 tagttcagtttaaaatgttgataccttccctcccaggctccttaccttggtcttttccct       c.*780

          .         .         .         .         .         .       g.65718
 gttcatctcccaacatgctgtgctccatagctggtaggagagggaaggcaaaatctttct       c.*840

          .         .         .         .         .         .       g.65778
 tagttttctttgtcttggccattttgaattcatttagttactgggcataacttactgctt       c.*900

          .         .         .         .         .         .       g.65838
 tttacaaaagaaacaaacattgtctgtacaggtttcatgctagagctaatgggagatgtg       c.*960

          .         .         .         .         .         .       g.65898
 gccacactgacttccattttaagctttctaccttcttttcctccgaccgtccccttccct       c.*1020

          .         .         .         .         .         .       g.65958
 cacatgccatccagtgagaagacctgctcctcagtcttgtaaatgtatcttgagaggtag       c.*1080

          .         .         .         .         .         .       g.66018
 gagcagagccactatctccattgaagctgaaatggtagacctgtaattgtgggaaaacta       c.*1140

          .         .         .         .         .         .       g.66078
 taaactctcttgttacagccccgccaccccttgctgtgtgtatatatataatactttgtc       c.*1200

          .         .         .         .         .         .       g.66138
 cttcatatgtgaaagatccagtgttggaattctttggtgtaaataaacgtttggttttat       c.*1260

                                                                    g.66145
 ttatcaa                                                            c.*1267

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Casein kinase 2, alpha 1 polypeptide protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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