casein kinase 2, beta polypeptide (CSNK2B) - coding DNA reference sequence

(used for variant description)

(last modified May 16, 2017)

This file was created to facilitate the description of sequence variants on transcript NM_001320.5 in the CSNK2B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering CSNK2B transcript NM_001320.5.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                     .         .         .         .                g.5040
                     gcttctcgttgtgccccgcccgcaagcgccctcctccggg       c.-301

 .         .         .         .         .         .                g.5100
 ccttcgtgacagccaggtcgtgcgcgggtcatcctgggattggtagttcgctttctctca       c.-241

 .         .         .         .         .         .                g.5160
 tttagccagtttctttctctaccggggactccgtgtcccggcatccaccgcggcacctga       c.-181

 .         .         .         .         .         .                g.5220
 cccttggcgcttgcgtgttgccctcttccccaccctccctaatttccactccccccaccc       c.-121

 .         .         .         .         .         .                g.5280
 cacttcgcctgccgcggtcgggtccgcggcctgcgctgtagcggtcgccgccgttccctg       c.-61

 .         .         .         .         .         | 02             g.5952
 gaagtagcaacttccctaccccaccccagtcctggtccccgtccagccg | ctgacgtgaag    c.-1

          .         .         .         .         .         .       g.6012
 ATGAGCAGCTCAGAGGAGGTGTCCTGGATTTCCTGGTTCTGTGGGCTCCGTGGCAATGAA       c.60
 M  S  S  S  E  E  V  S  W  I  S  W  F  C  G  L  R  G  N  E         p.20

          .   | 03     .         .         .         .         .    g.7036
 TTCTTCTGTGAA | GTGGATGAAGACTACATCCAGGACAAATTTAATCTTACTGGACTCAAT    c.120
 F  F  C  E   | V  D  E  D  Y  I  Q  D  K  F  N  L  T  G  L  N      p.40

          .         .         .         .         .      | 04  .    g.7664
 GAGCAGGTCCCTCACTATCGACAAGCTCTAGACATGATCTTGGACCTGGAGCCTG | ATGAA    c.180
 E  Q  V  P  H  Y  R  Q  A  L  D  M  I  L  D  L  E  P  D |   E      p.60

          .         .         .         .         .         .       g.7724
 GAACTGGAAGACAACCCCAACCAGAGTGACCTGATTGAGCAGGCAGCCGAGATGCTTTAT       c.240
 E  L  E  D  N  P  N  Q  S  D  L  I  E  Q  A  A  E  M  L  Y         p.80

          .         .         .         .         .  | 05      .    g.8226
 GGATTGATCCACGCCCGCTACATCCTTACCAACCGTGGCATCGCCCAGATG | TTGGAAAAG    c.300
 G  L  I  H  A  R  Y  I  L  T  N  R  G  I  A  Q  M   | L  E  K      p.100

          .         .         .         .         .         .       g.8286
 TACCAGCAAGGAGACTTTGGTTACTGTCCTCGTGTGTACTGTGAGAACCAGCCAATGCTT       c.360
 Y  Q  Q  G  D  F  G  Y  C  P  R  V  Y  C  E  N  Q  P  M  L         p.120

         | 06.         .         .         .         .         .    g.8492
 CCCATTG | GCCTTTCAGACATCCCAGGTGAAGCCATGGTGAAGCTCTACTGCCCCAAGTGC    c.420
 P  I  G |   L  S  D  I  P  G  E  A  M  V  K  L  Y  C  P  K  C      p.140

          .         .         .         .         .         .       g.8552
 ATGGATGTGTACACACCCAAGTCATCAAGACACCATCACACGGATGGCGCCTACTTCGGC       c.480
 M  D  V  Y  T  P  K  S  S  R  H  H  H  T  D  G  A  Y  F  G         p.160

          .         .         .         .         .         .       g.8612
 ACTGGTTTCCCTCACATGCTCTTCATGGTGCATCCCGAGTACCGGCCCAAGAGACCTGCC       c.540
 T  G  F  P  H  M  L  F  M  V  H  P  E  Y  R  P  K  R  P  A         p.180

          .        | 07.         .         .         .         .    g.8999
 AACCAGTTTGTGCCCAG | GCTCTACGGTTTCAAGATCCATCCGATGGCCTACCAGCTGCAG    c.600
 N  Q  F  V  P  R  |  L  Y  G  F  K  I  H  P  M  A  Y  Q  L  Q      p.200

          .         .         .         .                           g.9047
 CTCCAAGCCGCCAGCAACTTCAAGAGCCCAGTCAAGACGATTCGCTGA                   c.648
 L  Q  A  A  S  N  F  K  S  P  V  K  T  I  R  X                     p.215

          .         .         .         .         .         .       g.9107
 ttccctcccccacctgtcctgcagtctttgacttttcctttcttttttgccaccctttca       c.*60

          .         .         .         .         .         .       g.9167
 ggaaccctgtatggtttttagtttaaattaaaggagtcgttatcgtggtgggaatatgaa       c.*120

          .         .                                               g.9187
 ataaagtagaagaaaaggcc                                               c.*140

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Casein kinase 2, beta polypeptide protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.