cathepsin D (CTSD) - coding DNA reference sequence

(used for variant description)

(last modified April 3, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_001909.4 in the CTSD gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008655.1, covering CTSD transcript NM_001909.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5013
                                                gcgcacgccggcc       c.-121

 .         .         .         .         .         .                g.5073
 gcgcccacgtgaccggtccgggtgcaaacacgcgggtcagctgatccggcccaactgcgg       c.-61

 .         .         .         .         .         .                g.5133
 cgtcatcccggctataagcgcacggcctcggcgaccctctccgacccggccgccgccgcc       c.-1

          .         .         .         .         .         .       g.5193
 ATGCAGCCCTCCAGCCTTCTGCCGCTCGCCCTCTGCCTGCTGGCTGCACCCGCCTCCGCG       c.60
 M  Q  P  S  S  L  L  P  L  A  L  C  L  L  A  A  P  A  S  A         p.20

          | 02         .         .         .         .         .    g.7576
 CTCGTCAG | GATCCCGCTGCACAAGTTCACGTCCATCCGCCGGACCATGTCGGAGGTTGGG    c.120
 L  V  R  |  I  P  L  H  K  F  T  S  I  R  R  T  M  S  E  V  G      p.40

          .         .         .         .         .         .       g.7636
 GGCTCTGTGGAGGACCTGATTGCCAAAGGCCCCGTCTCAAAGTACTCCCAGGCGGTGCCA       c.180
 G  S  V  E  D  L  I  A  K  G  P  V  S  K  Y  S  Q  A  V  P         p.60

          .         .         .         .         | 03         .    g.9365
 GCCGTGACCGAGGGGCCCATTCCCGAGGTGCTCAAGAACTACATGGAC | GCCCAGTACTAC    c.240
 A  V  T  E  G  P  I  P  E  V  L  K  N  Y  M  D   | A  Q  Y  Y      p.80

          .         .         .         .         .         .       g.9425
 GGGGAGATTGGCATCGGGACGCCCCCCCAGTGCTTCACAGTCGTCTTCGACACGGGCTCC       c.300
 G  E  I  G  I  G  T  P  P  Q  C  F  T  V  V  F  D  T  G  S         p.100

          .         .         .         .         .   | 04     .    g.9913
 TCCAACCTGTGGGTCCCCTCCATCCACTGCAAACTGCTGGACATCGCTTGCT | GGATCCAC    c.360
 S  N  L  W  V  P  S  I  H  C  K  L  L  D  I  A  C  W |   I  H      p.120

          .         .         .         .         .         .       g.9973
 CACAAGTACAACAGCGACAAGTCCAGCACCTACGTGAAGAATGGTACCTCGTTTGACATC       c.420
 H  K  Y  N  S  D  K  S  S  T  Y  V  K  N  G  T  S  F  D  I         p.140

          .         .         .         .         .  | 05      .    g.11445
 CACTATGGCTCGGGCAGCCTCTCCGGGTACCTGAGCCAGGACACTGTGTCG | GTGCCCTGC    c.480
 H  Y  G  S  G  S  L  S  G  Y  L  S  Q  D  T  V  S   | V  P  C      p.160

          .         .         .         .         .         .       g.11505
 CAGTCAGCGTCGTCAGCCTCTGCCCTGGGCGGTGTCAAAGTGGAGAGGCAGGTCTTTGGG       c.540
 Q  S  A  S  S  A  S  A  L  G  G  V  K  V  E  R  Q  V  F  G         p.180

          .         .         .         .         .         .       g.11565
 GAGGCCACCAAGCAGCCAGGCATCACCTTCATCGCAGCCAAGTTCGATGGCATCCTGGGC       c.600
 E  A  T  K  Q  P  G  I  T  F  I  A  A  K  F  D  G  I  L  G         p.200

          .         .         .         .         .         .       g.11625
 ATGGCCTACCCCCGCATCTCCGTCAACAACGTGCTGCCCGTCTTCGACAACCTGATGCAG       c.660
 M  A  Y  P  R  I  S  V  N  N  V  L  P  V  F  D  N  L  M  Q         p.220

          .         .         .         .     | 06   .         .    g.13980
 CAGAAGCTGGTGGACCAGAACATCTTCTCCTTCTACCTGAGCAG | GGACCCAGATGCGCAG    c.720
 Q  K  L  V  D  Q  N  I  F  S  F  Y  L  S  R  |  D  P  D  A  Q      p.240

          .         .         .         .         .         .       g.14040
 CCTGGGGGTGAGCTGATGCTGGGTGGCACAGACTCCAAGTATTACAAGGGTTCTCTGTCC       c.780
 P  G  G  E  L  M  L  G  G  T  D  S  K  Y  Y  K  G  S  L  S         p.260

          .         .         .         .        | 07.         .    g.14867
 TACCTGAATGTCACCCGCAAGGCCTACTGGCAGGTCCACCTGGACCA | GGTGGAGGTGGCC    c.840
 Y  L  N  V  T  R  K  A  Y  W  Q  V  H  L  D  Q  |  V  E  V  A      p.280

          .         .         .         .         .         .       g.14927
 AGCGGGCTGACCCTGTGCAAGGAGGGCTGTGAGGCCATTGTGGACACAGGCACTTCCCTC       c.900
 S  G  L  T  L  C  K  E  G  C  E  A  I  V  D  T  G  T  S  L         p.300

          .         .         .         .         .         .       g.14987
 ATGGTGGGCCCGGTGGATGAGGTGCGCGAGCTGCAGAAGGCCATCGGGGCCGTGCCGCTG       c.960
 M  V  G  P  V  D  E  V  R  E  L  Q  K  A  I  G  A  V  P  L         p.320

          .   | 08     .         .         .         .         .    g.15139
 ATTCAGGGCGAG | TACATGATCCCCTGTGAGAAGGTGTCCACCCTGCCCGCGATCACACTG    c.1020
 I  Q  G  E   | Y  M  I  P  C  E  K  V  S  T  L  P  A  I  T  L      p.340

          .         .         .         .         .  | 09      .    g.15331
 AAGCTGGGAGGCAAAGGCTACAAGCTGTCCCCAGAGGACTACACGCTCAAG | GTGTCGCAG    c.1080
 K  L  G  G  K  G  Y  K  L  S  P  E  D  Y  T  L  K   | V  S  Q      p.360

          .         .         .         .         .         .       g.15391
 GCCGGGAAGACCCTCTGCCTGAGCGGCTTCATGGGCATGGACATCCCGCCACCCAGCGGG       c.1140
 A  G  K  T  L  C  L  S  G  F  M  G  M  D  I  P  P  P  S  G         p.380

          .         .         .         .         .         .       g.15451
 CCACTCTGGATCCTGGGCGACGTCTTCATCGGCCGCTACTACACTGTGTTTGACCGTGAC       c.1200
 P  L  W  I  L  G  D  V  F  I  G  R  Y  Y  T  V  F  D  R  D         p.400

          .         .         .                                     g.15490
 AACAACAGGGTGGGCTTCGCCGAGGCTGCCCGCCTCTAG                            c.1239
 N  N  R  V  G  F  A  E  A  A  R  L  X                              p.412

          .         .         .         .         .         .       g.15550
 ttcccaaggcgtccgcgcgccagcacagaaacagaggagagtcccagagcaggaggcccc       c.*60

          .         .         .         .         .         .       g.15610
 tggcccagcggcccctcccacacacacccacacactcgcccgcccactgtcctgggcgcc       c.*120

          .         .         .         .         .         .       g.15670
 ctggaagccggcggcccaagcccgacttgctgttttgttctgtggttttcccctccctgg       c.*180

          .         .         .         .         .         .       g.15730
 gttcagaaatgctgcctgcctgtctgtctctccatctgtttggtgggggtagagctgatc       c.*240

          .         .         .         .         .         .       g.15790
 cagagcacagatctgtttcgtgcattggaagaccccacccaagcttggcagccgagctcg       c.*300

          .         .         .         .         .         .       g.15850
 tgtatcctggggctcccttcatctccagggagtcccctccccggccctaccagcgcccgc       c.*360

          .         .         .         .         .         .       g.15910
 tgggctgagcccctaccccacaccaggccgtcctcccgggccctcccttggaaacctgcc       c.*420

          .         .         .         .         .         .       g.15970
 ctgcctgagggcccctctgcccagcttgggcccagctgggctctgccaccctacctgttc       c.*480

          .         .         .         .         .         .       g.16030
 agtgtcccgggcccgttgaggatgaggccgctagaggcctgaggatgagctggaaggagt       c.*540

          .         .         .         .         .         .       g.16090
 gagaggggacaaaacccaccttgttggagcctgcagggtggtgctgggactgagccagtc       c.*600

          .         .         .         .         .         .       g.16150
 ccaggggcatgtattggcctggaggtggggttgggattgggggctggtgccagccttcct       c.*660

          .         .         .         .         .         .       g.16210
 ctgcagctgacctctgttgtcctccccttgggcggctgagagccccagctgacatggaaa       c.*720

          .         .         .                                     g.16241
 tacagttgttggcctccggcctcccctctgt                                    c.*751

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Cathepsin D protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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