cathepsin F (CTSF) - coding DNA reference sequence

(used for variant description)

(last modified April 3, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_003793.3 in the CTSF gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_032973.1, covering CTSF transcript NM_003793.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5030
                               ggaggactcaggccccgctggccgcgggct       c.-61

 .         .         .         .         .         .                g.5090
 cggtacccggtgggtcggtggagcgtctgttgggtccgggccgccggcttcgccctcgcc       c.-1

          .         .         .         .         .         .       g.5150
 ATGGCGCCCTGGCTGCAGCTCCTGTCGCTGCTGGGGCTGCTCCCGGGCGCAGTGGCCGCC       c.60
 M  A  P  W  L  Q  L  L  S  L  L  G  L  L  P  G  A  V  A  A         p.20

          .         .         .         .         .         .       g.5210
 CCCGCCCAGCCCCGAGCCGCCAGCTTTCAGGCCTGGGGGCCGCCGTCCCCGGAGCTGCTG       c.120
 P  A  Q  P  R  A  A  S  F  Q  A  W  G  P  P  S  P  E  L  L         p.40

          .         .         .         .         .         .       g.5270
 GCGCCCACCCGCTTCGCGCTGGAGATGTTCAACCGCGGCCGGGCTGCGGGGACGCGGGCC       c.180
 A  P  T  R  F  A  L  E  M  F  N  R  G  R  A  A  G  T  R  A         p.60

          .         .         .    | 02    .         .         .    g.5521
 GTGCTGGGCCTTGTGCGCGGCCGCGTCCGCCGG | GCGGGTCAGGGGTCGCTGTACTCCCTG    c.240
 V  L  G  L  V  R  G  R  V  R  R   | A  G  Q  G  S  L  Y  S  L      p.80

          .         .         .         .         .         .       g.5581
 GAGGCCACCCTGGAGGAGCCACCCTGCAACGACCCCATGGTGTGCCGGCTCCCCGTGTCC       c.300
 E  A  T  L  E  E  P  P  C  N  D  P  M  V  C  R  L  P  V  S         p.100

          .   | 03     .         .         .         .         .    g.5962
 AAGAAAACCCTG | CTCTGCAGCTTCCAAGTCCTGGATGAGCTCGGAAGACACGTGCTGCTG    c.360
 K  K  T  L   | L  C  S  F  Q  V  L  D  E  L  G  R  H  V  L  L      p.120

          .         .         .         .         .         .       g.6022
 CGGAAGGACTGTGGCCCAGTGGACACCAAGGTTCCAGGTGCTGGGGAGCCCAAGTCAGCC       c.420
 R  K  D  C  G  P  V  D  T  K  V  P  G  A  G  E  P  K  S  A         p.140

          .         .         .         .         .         .       g.6082
 TTCACTCAGGGCTCAGCCATGATTTCTTCTCTGTCCCAAAACCATCCAGACAACAGAAAC       c.480
 F  T  Q  G  S  A  M  I  S  S  L  S  Q  N  H  P  D  N  R  N         p.160

          .         .         .         .         .  | 04      .    g.6264
 GAGACTTTCAGCTCAGTCATTTCCCTGTTGAATGAGGATCCCCTGTCCCAG | GACTTGCCT    c.540
 E  T  F  S  S  V  I  S  L  L  N  E  D  P  L  S  Q   | D  L  P      p.180

          .         .         .         .         .         .       g.6324
 GTGAAGATGGCTTCAATCTTCAAGAACTTTGTCATTACCTATAACCGGACATATGAGTCA       c.600
 V  K  M  A  S  I  F  K  N  F  V  I  T  Y  N  R  T  Y  E  S         p.200

         | 05.         .         .         .         .         .    g.7225
 AAGGAAG | AAGCCCGGTGGCGCCTGTCCGTCTTTGTCAATAACATGGTGCGAGCACAGAAG    c.660
 K  E  E |   A  R  W  R  L  S  V  F  V  N  N  M  V  R  A  Q  K      p.220

          .         .         .         .         .         .       g.7285
 ATCCAGGCCCTGGACCGTGGCACAGCTCAGTATGGAGTCACCAAGTTCAGTGATCTCACA       c.720
 I  Q  A  L  D  R  G  T  A  Q  Y  G  V  T  K  F  S  D  L  T         p.240

   | 06      .         .         .         .         .         .    g.7468
 G | AGGAGGAGTTCCGCACTATCTACCTGAATACTCTCCTGAGGAAAGAGCCTGGCAACAAG    c.780
 E |   E  E  F  R  T  I  Y  L  N  T  L  L  R  K  E  P  G  N  K      p.260

          .         .         .         .         .         .       g.7528
 ATGAAGCAAGCCAAGTCTGTGGGTGACCTCGCCCCACCTGAATGGGACTGGAGGAGTAAG       c.840
 M  K  Q  A  K  S  V  G  D  L  A  P  P  E  W  D  W  R  S  K         p.280

          .         .        | 07.         .         .         .    g.7682
 GGGGCTGTCACAAAAGTCAAAGACCAG | GGCATGTGTGGCTCCTGCTGGGCCTTCTCAGTC    c.900
 G  A  V  T  K  V  K  D  Q   | G  M  C  G  S  C  W  A  F  S  V      p.300

          .         .         .         .         .         .       g.7742
 ACAGGCAATGTGGAGGGCCAGTGGTTTCTCAACCAGGGGACCCTGCTCTCCCTCTCTGAA       c.960
 T  G  N  V  E  G  Q  W  F  L  N  Q  G  T  L  L  S  L  S  E         p.320

      | 08   .         .         .         .         .         .    g.7881
 CAGG | AGCTCTTGGACTGTGACAAGATGGACAAGGCCTGCATGGGCGGCTTGCCCTCCAAT    c.1020
 Q  E |   L  L  D  C  D  K  M  D  K  A  C  M  G  G  L  P  S  N      p.340

          .         .      | 09  .         .         .         .    g.8605
 GCCTACTCGGCCATAAAGAATTTGG | GAGGGCTGGAGACAGAGGATGACTACAGCTACCAG    c.1080
 A  Y  S  A  I  K  N  L  G |   G  L  E  T  E  D  D  Y  S  Y  Q      p.360

          .         .         .         .         .         .       g.8665
 GGTCACATGCAGTCCTGCAACTTCTCAGCAGAGAAGGCCAAGGTCTACATCAATGACTCC       c.1140
 G  H  M  Q  S  C  N  F  S  A  E  K  A  K  V  Y  I  N  D  S         p.380

          .         .      | 10  .         .         .         .    g.8805
 GTGGAGCTGAGCCAGAACGAGCAGA | AGCTGGCAGCCTGGCTGGCCAAGAGAGGCCCAATC    c.1200
 V  E  L  S  Q  N  E  Q  K |   L  A  A  W  L  A  K  R  G  P  I      p.400

          .         .         . | 11       .         .         .    g.8958
 TCCGTGGCCATCAATGCCTTTGGCATGCAG | TTTTACCGCCACGGGATCTCCCGCCCTCTC    c.1260
 S  V  A  I  N  A  F  G  M  Q   | F  Y  R  H  G  I  S  R  P  L      p.420

          .         .         .         .         .         .       g.9018
 CGGCCCCTCTGCAGCCCTTGGCTCATTGACCATGCGGTGTTGCTTGTGGGCTACGGCAAC       c.1320
 R  P  L  C  S  P  W  L  I  D  H  A  V  L  L  V  G  Y  G  N         p.440

   | 12      .         .         .         .         .         .    g.9489
 C | GCTCTGACGTTCCCTTTTGGGCCATCAAGAACAGCTGGGGCACTGACTGGGGTGAGAAG    c.1380
 R |   S  D  V  P  F  W  A  I  K  N  S  W  G  T  D  W  G  E  K      p.460

  | 13       .         .         .         .         .         .    g.9629
  | GGTTACTACTACTTGCATCGTGGGTCCGGGGCCTGTGGCGTGAACACCATGGCCAGCTCG    c.1440
  | G  Y  Y  Y  L  H  R  G  S  G  A  C  G  V  N  T  M  A  S  S      p.480

          .                                                         g.9644
 GCGGTGGTGGACTGA                                                    c.1455
 A  V  V  D  X                                                      p.484

          .         .         .         .         .         .       g.9704
 agaggggcccccagctcgggacctggtgctgatcagagtggctgctgccccagcctgaca       c.*60

          .         .         .         .         .         .       g.9764
 tgtgtccaggcccctccccgggaggtacagctggcagagggaaaggcactgggtacctca       c.*120

          .         .         .         .         .         .       g.9824
 gggtgagcagagggcactgggctggggcacagcccctgcttccctgcaccccattcccac       c.*180

          .         .         .         .         .         .       g.9884
 cctgaagttctgcacctgcacctttgttgaattgtggtagcttaggaggatgtcggggtg       c.*240

          .         .         .         .         .         .       g.9944
 aagggtggtatcttggcagttgaagctggggcaagaactctgggcttgggtaatgagcag       c.*300

          .         .         .         .         .         .       g.10004
 gaagaaaattttctgatcttaagcccagctctgttctgcccccgctttcctctgtttgat       c.*360

          .         .         .         .         .         .       g.10064
 actataaattttctggttcccttggatttagggatagtgtccctctccatgtccaggaaa       c.*420

          .         .         .         .                           g.10113
 cttgtaaccacccttttctaacagcaataaagaggtgtccttgtcccga                  c.*469

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Cathepsin F protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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