cullin 1 (CUL1) - coding DNA reference sequence

(used for variant description)

(last modified April 6, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_003592.2 in the CUL1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_065171.1, covering CUL1 transcript NM_003592.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5050
           aggaggagggccgggcgggcaggggaggaggaggaggcgggcgccgtgtc       c.-301

 .         .         .         .         .         .                g.5110
 gcacgcagctccaggcggggcagccccggtagctgagggacgcagctagaccttggcggg       c.-241

 .         .         .         .         .         .                g.5170
 acggggctttcgccggggcccaggcccagggaccaggcggaggcgtcgcgggagcctttg       c.-181

 .         .         | 02         .         .         .             g.36162
 gggcaccacagagatgcgg | gtttgcctgcaatgagatttcattctctacatttaaaggac    c.-121

 .         .         .         .         .         .                g.36222
 atcctttctgagctgctgtgaataaatttggaatggtactgtatattttcatctaatgga       c.-61

 .         .         .         .         .         .                g.36282
 gaactagctgtactttgaataaggattgctgcactggacgactttagaacatccctcaca       c.-1

          .         .         .         .         .         .       g.36342
 ATGTCGTCAACCCGGAGCCAGAACCCCCACGGCCTGAAGCAGATTGGCCTGGACCAGATC       c.60
 M  S  S  T  R  S  Q  N  P  H  G  L  K  Q  I  G  L  D  Q  I         p.20

          .         .         .         .         .         .       g.36402
 TGGGACGACCTCAGAGCCGGCATCCAGCAGGTGTACACACGGCAGAGCATGGCCAAGTCC       c.120
 W  D  D  L  R  A  G  I  Q  Q  V  Y  T  R  Q  S  M  A  K  S         p.40

          .         . | 03       .         .         .         .    g.60175
 AGATATATGGAGCTCTACAC | TCATGTTTATAACTACTGTACTAGTGTTCACCAGTCAAAC    c.180
 R  Y  M  E  L  Y  T  |  H  V  Y  N  Y  C  T  S  V  H  Q  S  N      p.60

          .         .         .         .         .         .       g.60235
 CAAGCACGAGGAGCTGGAGTTCCTCCTTCTAAGTCGAAAAAGGGGCAGACACCTGGAGGA       c.240
 Q  A  R  G  A  G  V  P  P  S  K  S  K  K  G  Q  T  P  G  G         p.80

          .         .         .         .         .         .       g.60295
 GCTCAGTTTGTTGGCCTGGAATTATATAAACGACTTAAGGAATTTTTGAAGAATTACTTG       c.300
 A  Q  F  V  G  L  E  L  Y  K  R  L  K  E  F  L  K  N  Y  L         p.100

          .      | 04  .         .         .         .         .    g.63187
 ACAAATCTTCTTAAG | GATGGAGAAGATTTGATGGATGAGAGTGTACTGAAATTCTACACT    c.360
 T  N  L  L  K   | D  G  E  D  L  M  D  E  S  V  L  K  F  Y  T      p.120

          .         .         .         .         .         .       g.63247
 CAACAATGGGAAGATTATCGATTTTCAAGCAAAGTGCTGAATGGAATTTGTGCCTACCTC       c.420
 Q  Q  W  E  D  Y  R  F  S  S  K  V  L  N  G  I  C  A  Y  L         p.140

          .         .         .         .         .         .       g.63307
 AATAGACATTGGGTTCGCCGTGAATGTGACGAAGGACGAAAAGGAATATATGAAATCTAT       c.480
 N  R  H  W  V  R  R  E  C  D  E  G  R  K  G  I  Y  E  I  Y         p.160

     | 05    .         .         .         .         .     | 06   . g.65713
 TCG | CTTGCATTGGTGACTTGGAGAGACTGTCTGTTCAGGCCACTGAATAAACAG | GTAACA c.540
 S   | L  A  L  V  T  W  R  D  C  L  F  R  P  L  N  K  Q   | V  T   p.180

          .         .         .         .         .         .       g.65773
 AATGCTGTTTTAAAGCTGATTGAAAAGGAAAGGAATGGTGAAACCATCAATACAAGATTG       c.600
 N  A  V  L  K  L  I  E  K  E  R  N  G  E  T  I  N  T  R  L         p.200

          .         .      | 07  .         .         .         .    g.66527
 ATTAGTGGAGTTGTACAGTCTTACG | TGGAATTGGGGCTGAATGAAGATGATGCATTTGCA    c.660
 I  S  G  V  V  Q  S  Y  V |   E  L  G  L  N  E  D  D  A  F  A      p.220

          .         .         .         .         .         .       g.66587
 AAGGGCCCTACGTTAACAGTGTATAAAGAATCCTTTGAATCTCAATTTTTGGCTGACACA       c.720
 K  G  P  T  L  T  V  Y  K  E  S  F  E  S  Q  F  L  A  D  T         p.240

          .         .         .         .         .         .       g.66647
 GAGAGATTTTATACCAGAGAGAGTACTGAATTCTTGCAGCAGAACCCAGTTACTGAATAT       c.780
 E  R  F  Y  T  R  E  S  T  E  F  L  Q  Q  N  P  V  T  E  Y         p.260

           | 08        .         .         .         .         .    g.72771
 ATGAAAAAG | GCAGAGGCTCGTCTGCTTGAGGAACAACGAAGAGTTCAGGTTTACCTTCAT    c.840
 M  K  K   | A  E  A  R  L  L  E  E  Q  R  R  V  Q  V  Y  L  H      p.280

          .         .         .         .         .         .       g.72831
 GAAAGCACACAAGATGAATTAGCAAGGAAATGTGAACAAGTCCTCATTGAAAAACACTTG       c.900
 E  S  T  Q  D  E  L  A  R  K  C  E  Q  V  L  I  E  K  H  L         p.300

          .         .         .         .         .   | 09     .    g.73786
 GAAATTTTCCACACAGAATTTCAGAATTTATTGGATGCTGACAAAAATGAAG | ATTTGGGA    c.960
 E  I  F  H  T  E  F  Q  N  L  L  D  A  D  K  N  E  D |   L  G      p.320

          .         .         .         .         .         .       g.73846
 CGCATGTATAATCTTGTATCTAGAATCCAGGATGGCCTAGGAGAATTGAAAAAACTGTTG       c.1020
 R  M  Y  N  L  V  S  R  I  Q  D  G  L  G  E  L  K  K  L  L         p.340

          .         .         .         .         .         .       g.73906
 GAGACACACATTCATAATCAGGGTCTTGCAGCCATTGAAAAGTGTGGAGAAGCTGCTTTA       c.1080
 E  T  H  I  H  N  Q  G  L  A  A  I  E  K  C  G  E  A  A  L         p.360

     | 10    .         .         .         .         .         .    g.89999
 AAT | GACCCCAAAATGTATGTACAGACAGTGCTTGATGTTCATAAAAAATACAATGCCCTG    c.1140
 N   | D  P  K  M  Y  V  Q  T  V  L  D  V  H  K  K  Y  N  A  L      p.380

          .         .         .         .         .  | 11      .    g.90139
 GTAATGTCTGCATTCAACAATGACGCTGGCTTTGTGGCTGCTCTTGATAAG | GCTTGTGGT    c.1200
 V  M  S  A  F  N  N  D  A  G  F  V  A  A  L  D  K   | A  C  G      p.400

          .         .         .         .         .         .       g.90199
 CGCTTCATAAACAACAACGCGGTTACCAAGATGGCCCAATCATCCAGTAAATCCCCTGAG       c.1260
 R  F  I  N  N  N  A  V  T  K  M  A  Q  S  S  S  K  S  P  E         p.420

          .         .         .         | 12         .         .    g.92732
 TTGCTGGCTCGATACTGTGACTCCTTGTTGAAGAAAAG | TTCCAAGAACCCAGAGGAGGCA    c.1320
 L  L  A  R  Y  C  D  S  L  L  K  K  S  |  S  K  N  P  E  E  A      p.440

          .         .        | 13.         .         .         .    g.93181
 GAACTAGAAGACACACTCAATCAAGTG | ATGGTTGTCTTCAAGTACATAGAAGACAAAGAC    c.1380
 E  L  E  D  T  L  N  Q  V   | M  V  V  F  K  Y  I  E  D  K  D      p.460

          .         .         .         .         .         .       g.93241
 GTATTTCAGAAGTTCTATGCGAAGATGCTCGCCAAGAGGCTCGTCCACCAGAACAGTGCA       c.1440
 V  F  Q  K  F  Y  A  K  M  L  A  K  R  L  V  H  Q  N  S  A         p.480

          .         .         .          | 14        .         .    g.94737
 AGTGACGATGCCGAAGCCAGCATGATCTCCAAGTTAAAG | CAAGCTTGCGGGTTCGAGTAC    c.1500
 S  D  D  A  E  A  S  M  I  S  K  L  K   | Q  A  C  G  F  E  Y      p.500

          .         .         .         .         .         .       g.94797
 ACCTCTAAACTTCAGCGCATGTTTCAAGACATTGGCGTGAGCAAAGATCTGAACGAGCAA       c.1560
 T  S  K  L  Q  R  M  F  Q  D  I  G  V  S  K  D  L  N  E  Q         p.520

          .         .         .        | 15.         .         .    g.95932
 TTCAAAAAGCACTTGACAAACTCAGAACCCCTAGACT | TGGATTTCAGCATTCAAGTGCTG    c.1620
 F  K  K  H  L  T  N  S  E  P  L  D  L |   D  F  S  I  Q  V  L      p.540

          .         .         .         .         .     | 16   .    g.96475
 AGCTCCGGGTCCTGGCCCTTCCAGCAGTCTTGTACATTTGCCTTGCCGTCAGAG | TTGGAA    c.1680
 S  S  G  S  W  P  F  Q  Q  S  C  T  F  A  L  P  S  E   | L  E      p.560

          .         .         .         .         .         .       g.96535
 CGTAGTTATCAGCGATTCACAGCTTTCTACGCCAGCCGCCACAGTGGCCGAAAATTGACG       c.1740
 R  S  Y  Q  R  F  T  A  F  Y  A  S  R  H  S  G  R  K  L  T         p.580

          .         .         .         .         .         .       g.96595
 TGGTTATATCAGTTGTCTAAAGGAGAATTGGTAACTAACTGCTTCAAAAACAGATATACT       c.1800
 W  L  Y  Q  L  S  K  G  E  L  V  T  N  C  F  K  N  R  Y  T         p.600

        | 17 .         .         .         .         .         .    g.98939
 TTGCAG | GCGTCGACATTCCAGATGGCTATCCTGCTTCAGTACAACACGGAAGATGCCTAC    c.1860
 L  Q   | A  S  T  F  Q  M  A  I  L  L  Q  Y  N  T  E  D  A  Y      p.620

          .         .         .          | 18        .         .    g.103992
 ACTGTGCAGCAGCTGACCGACAGCACTCAAATTAAAATG | GACATTTTGGCGCAAGTTTTA    c.1920
 T  V  Q  Q  L  T  D  S  T  Q  I  K  M   | D  I  L  A  Q  V  L      p.640

          .         .        | 19.         .         .         .    g.104129
 CAGATTTTATTAAAGTCGAAGCTATTG | GTCTTGGAAGATGAAAATGCAAATGTTGATGAG    c.1980
 Q  I  L  L  K  S  K  L  L   | V  L  E  D  E  N  A  N  V  D  E      p.660

          .         .         .         .         . | 20       .    g.104741
 GTGGAATTGAAGCCAGATACCTTAATAAAATTATATCTTGGTTATAAAAA | TAAGAAATTA    c.2040
 V  E  L  K  P  D  T  L  I  K  L  Y  L  G  Y  K  N  |  K  K  L      p.680

          .         .         .         .         .         .       g.104801
 AGGGTTAACATCAATGTGCCAATGAAAACCGAACAGAAGCAGGAACAAGAAACCACACAC       c.2100
 R  V  N  I  N  V  P  M  K  T  E  Q  K  Q  E  Q  E  T  T  H         p.700

          .         .         .       | 21 .         .         .    g.105458
 AAAAACATCGAGGAAGACCGCAAACTACTGATTCAG | GCGGCCATCGTGAGAATCATGAAG    c.2160
 K  N  I  E  E  D  R  K  L  L  I  Q   | A  A  I  V  R  I  M  K      p.720

          .         .         .         .         .         .       g.105518
 ATGAGGAAGGTTCTGAAACACCAGCAGTTACTTGGCGAGGTCCTCACTCAGCTGTCCTCC       c.2220
 M  R  K  V  L  K  H  Q  Q  L  L  G  E  V  L  T  Q  L  S  S         p.740

          .         .         . | 22       .         .         .    g.106691
 AGGTTCAAACCTCGAGTCCCTGTGATCAAG | AAATGCATTGACATTCTAATTGAGAAAGAA    c.2280
 R  F  K  P  R  V  P  V  I  K   | K  C  I  D  I  L  I  E  K  E      p.760

          .         .         .         .         .                 g.106742
 TATTTGGAGCGAGTGGATGGTGAAAAGGACACCTACAGTTACTTGGCTTAA                c.2331
 Y  L  E  R  V  D  G  E  K  D  T  Y  S  Y  L  A  X                  p.776

          .         .         .         .         .         .       g.106802
 cccttctggaagggtctgactgtgtgacccgcagcaaatagttcatgttggaaagaatga       c.*60

          .         .         .         .         .         .       g.106862
 aaacaactcaagttcatagcagccagcctgccgccattggacctcccttttaaaaactga       c.*120

          .         .         .         .         .         .       g.106922
 gaccaagactcccatcagctggtctcggatttacatcggaactgctcaggattgatacat       c.*180

          .         .         .         .         .         .       g.106982
 ttcaagtctgtaaatacggacaccaacgccatttaccctaatttaagaacagcggggact       c.*240

          .         .         .         .         .         .       g.107042
 gaccctccgtgccgagggctgcatgctaccgcactaagtcaatacatgggctccccgatt       c.*300

          .         .         .         .         .         .       g.107102
 cgcagctgtcgtcttggcagcacttgtcacgttggcagcactttgagagcaagtctgagt       c.*360

          .         .         .         .         .         .       g.107162
 ggacccacatgtaacctgctatgaaaaccatttgtatagtgtgtttcattttttaatgtg       c.*420

          .         .         .         .         .         .       g.107222
 tgaaaataaagaaaattaaaggatttctgtacaagtcgcattgggttttgttttaagttt       c.*480

          .         .         .         .                           g.107270
 tactaatttctatatgtaaataaaagatataatgattgtgcaaattta                   c.*528

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Cullin 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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