cullin 4B (CUL4B) - coding DNA reference sequence

(used for variant description)

(last modified June 8, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_003588.3 in the CUL4B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000023.10, covering CUL4B transcript NM_003588.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5017
                                            actacccaattgtgaag       c.-421

 .         .         .         .         .         .                g.5077
 acacaatccctccccagcagttcagtttagaaactgccagtcttggtatagaacaaccta       c.-361

 .         .         .         .         .         .                g.5137
 ggcttatctgtttaagtcccataggtagtattattagagaataacccaggctttgggaac       c.-301

 .         .         .         .         .         .                g.5197
 tgtataactctgagatcgtttgaaattttcgttttgtttttcttttggctccaaccaggc       c.-241

 .         .         .         .         .         .                g.5257
 ctctgttgttagactaatggggtttcccctgcagagattggtcagccctgcagtctatca       c.-181

 .         .         .         .         .         .                g.5317
 tcccggaaggtgttaaatacacatgaaagccagcctcggcgggcagaacctagcccgccg       c.-121

 .         .         .         .         .         .                g.5377
 aaagggcgggcattgctaaagtgttttcaaaaggtcttcccaatcctctgctttagacag       c.-61

 .         .         .         .         .       | 02 .             g.6212
 ctcggaccttagatagaagaacacaacggatcctccagtgactgacg | acccaaaggacgg    c.-1

          .         .         .         .         .         .       g.6272
 ATGATGTCACAGTCATCTGGATCAGGAGATGGGAATGATGATGAGGCTACTACCTCTAAA       c.60
 M  M  S  Q  S  S  G  S  G  D  G  N  D  D  E  A  T  T  S  K         p.20

         | 03.         .         .         .         .         .    g.20257
 GACGGTG | GTTTTTCTTCCCCCAGTCCCTCAGCTGCTGCTGCTGCTCAGGAGGTCAGATCT    c.120
 D  G  G |   F  S  S  P  S  P  S  A  A  A  A  A  Q  E  V  R  S      p.40

          .         .         .         .         .         .       g.20317
 GCCACTGATGGTAATACCAGCACCACTCCGCCCACCTCTGCCAAGAAGAGAAAGTTAAAC       c.180
 A  T  D  G  N  T  S  T  T  P  P  T  S  A  K  K  R  K  L  N         p.60

          .         .         .         .         .         .       g.20377
 AGCAGCAGCAGTAGCAGCAGTAACAGTAGTAACGAGAGAGAAGACTTTGATTCCACCTCT       c.240
 S  S  S  S  S  S  S  N  S  S  N  E  R  E  D  F  D  S  T  S         p.80

          .         .         .         .         .         .       g.20437
 TCCTCCTCTTCCACTCCTCCTTTACAACCCAGGGATTCGGCATCCCCTTCAACCTCGTCC       c.300
 S  S  S  S  T  P  P  L  Q  P  R  D  S  A  S  P  S  T  S  S         p.100

          .         .         .         .         .         .       g.20497
 TTCTGCCTGGGGGTTTCAGTGGCTGCTTCCAGCCACGTACCGATACAGAAGAAGCTGCGT       c.360
 F  C  L  G  V  S  V  A  A  S  S  H  V  P  I  Q  K  K  L  R         p.120

          .         .         .         .         .         .       g.20557
 TTTGAAGACACCCTGGAGTTTGTAGGGTTTGATGCGAAGATGGCTGAGGAATCCTCCTCC       c.420
 F  E  D  T  L  E  F  V  G  F  D  A  K  M  A  E  E  S  S  S         p.140

          .         .         .         .         .         .       g.20617
 TCCTCCTCCTCATCTTCACCAACTGCTGCAACATCTCAGCAGCAGCAACTTAAAAATAAG       c.480
 S  S  S  S  S  S  P  T  A  A  T  S  Q  Q  Q  Q  L  K  N  K         p.160

          .         .         .         .         .         .       g.20677
 AGTATATTAATCTCTTCTGTGGCTTCGGTGCATCATGCAAACGGCCTAGCCAAATCTTCT       c.540
 S  I  L  I  S  S  V  A  S  V  H  H  A  N  G  L  A  K  S  S         p.180

          .         .         .         .         .         .       g.20737
 ACCACCGTCTCTAGCTTTGCTAACAGCAAACCTGGCTCTGCTAAGAAGTTAGTGATCAAG       c.600
 T  T  V  S  S  F  A  N  S  K  P  G  S  A  K  K  L  V  I  K         p.200

          . | 04       .         .         .         .         .    g.22840
 AACTTTAAAG | ATAAGCCTAAATTACCAGAAAACTACACAGATGAAACCTGGCAAAAACTG    c.660
 N  F  K  D |   K  P  K  L  P  E  N  Y  T  D  E  T  W  Q  K  L      p.220

          .         .         .         .         .         .       g.22900
 AAAGAAGCAGTGGAAGCTATTCAGAATAGTACTTCAATTAAGTACAATTTAGAAGAACTC       c.720
 K  E  A  V  E  A  I  Q  N  S  T  S  I  K  Y  N  L  E  E  L         p.240

        | 05 .         .         .         .         .         .    g.33644
 TACCAG | GCTGTAGAAAATCTCTGTTCTTACAAGATTTCTGCAAACTTGTACAAACAGCTG    c.780
 Y  Q   | A  V  E  N  L  C  S  Y  K  I  S  A  N  L  Y  K  Q  L      p.260

          .         .         .         .         . | 06       .    g.34223
 AGACAGATCTGCGAAGATCACATCAAAGCACAGATTCATCAATTCAGAGA | GGATTCATTG    c.840
 R  Q  I  C  E  D  H  I  K  A  Q  I  H  Q  F  R  E  |  D  S  L      p.280

          .         .         .         .         .         .       g.34283
 GATAGCGTTCTTTTTTTAAAGAAGATTGATAGATGCTGGCAAAACCATTGCAGACAAATG       c.900
 D  S  V  L  F  L  K  K  I  D  R  C  W  Q  N  H  C  R  Q  M         p.300

  | 07       .         .         .         .         .         .    g.35372
  | ATCATGATCAGGAGCATTTTTTTGTTTCTGGATAGAACTTACGTTCTTCAGAATTCAATG    c.960
  | I  M  I  R  S  I  F  L  F  L  D  R  T  Y  V  L  Q  N  S  M      p.320

          .     | 08   .         .         .         .         .    g.36232
 CTACCCTCCATTTG | GGACATGGGACTGGAGTTATTTAGGGCTCATATTATAAGTGATCAG    c.1020
 L  P  S  I  W  |  D  M  G  L  E  L  F  R  A  H  I  I  S  D  Q      p.340

          .         .         .         .         .         .       g.36292
 AAAGTGCAGAATAAGACAATTGATGGCATTCTTCTCTTGATTGAGAGGGAAAGGAATGGT       c.1080
 K  V  Q  N  K  T  I  D  G  I  L  L  L  I  E  R  E  R  N  G         p.360

          .         .         .         .         .        | 09.    g.36629
 GAAGCAATTGATAGAAGTTTACTTCGAAGCCTTTTAAGCATGCTGTCTGATTTGCAA | ATT    c.1140
 E  A  I  D  R  S  L  L  R  S  L  L  S  M  L  S  D  L  Q   | I      p.380

          .         .         .         .         .         .       g.36689
 TATCAAGATTCTTTTGAACAACGATTTTTGGAAGAAACTAACCGGCTCTATGCAGCTGAA       c.1200
 Y  Q  D  S  F  E  Q  R  F  L  E  E  T  N  R  L  Y  A  A  E         p.400

          .         .        | 10.         .         .         .    g.37053
 GGCCAAAAATTAATGCAAGAAAGAGAG | GTTCCTGAATATCTACATCATGTTAACAAACGT    c.1260
 G  Q  K  L  M  Q  E  R  E   | V  P  E  Y  L  H  H  V  N  K  R      p.420

          .         .         .         .         . | 11       .    g.37806
 CTAGAAGAAGAAGCAGACAGACTTATTACTTACTTAGATCAGACCACCCA | GAAGTCATTA    c.1320
 L  E  E  E  A  D  R  L  I  T  Y  L  D  Q  T  T  Q  |  K  S  L      p.440

          .         .         .         .         .         | 12    g.39111
 ATTGCTACTGTAGAAAAACAACTTCTAGGTGAACACTTAACAGCAATTCTTCAGAAAG | GT    c.1380
 I  A  T  V  E  K  Q  L  L  G  E  H  L  T  A  I  L  Q  K  G |       p.460

          .         .         .         .         .         .       g.39171
 TTAAATAACCTCCTTGATGAAAACCGAATTCAAGATTTGTCTCTTCTGTATCAGCTCTTC       c.1440
 L  N  N  L  L  D  E  N  R  I  Q  D  L  S  L  L  Y  Q  L  F         p.480

          .         .         .         .         .        | 13.    g.40270
 AGTAGAGTTCGAGGTGGAGTTCAGGTTCTTTTGCAGCAGTGGATCGAATATATCAAG | GCA    c.1500
 S  R  V  R  G  G  V  Q  V  L  L  Q  Q  W  I  E  Y  I  K   | A      p.500

          .         .         .         .         .         .       g.40330
 TTTGGCAGCACTATTGTAATTAATCCTGAAAAAGATAAAACCATGGTTCAAGAATTGCTG       c.1560
 F  G  S  T  I  V  I  N  P  E  K  D  K  T  M  V  Q  E  L  L         p.520

          .         .         .         .         .         .       g.40390
 GATTTTAAAGATAAGGTTGACCATATAATTGATATCTGCTTTCTGAAGAATGAGAAATTT       c.1620
 D  F  K  D  K  V  D  H  I  I  D  I  C  F  L  K  N  E  K  F         p.540

          .         .         .         .         .         .       g.40450
 ATCAATGCCATGAAAGAAGCATTTGAAACGTTCATTAACAAAAGACCAAATAAACCAGCT       c.1680
 I  N  A  M  K  E  A  F  E  T  F  I  N  K  R  P  N  K  P  A         p.560

          . | 14       .         .         .         .         .    g.41507
 GAACTTATAG | CTAAGTATGTAGATTCAAAACTTCGTGCAGGCAACAAAGAAGCTACAGAT    c.1740
 E  L  I  A |   K  Y  V  D  S  K  L  R  A  G  N  K  E  A  T  D      p.580

          .         .         .         .         .      | 15  .    g.42064
 GAAGAACTTGAGAAAATGTTGGATAAAATTATGATCATATTTAGATTTATCTATG | GCAAG    c.1800
 E  E  L  E  K  M  L  D  K  I  M  I  I  F  R  F  I  Y  G |   K      p.600

          .         .         .         .         .         .       g.42124
 GATGTTTTTGAGGCCTTCTATAAGAAAGATTTAGCCAAGCGCCTGTTAGTCGGAAAGAGT       c.1860
 D  V  F  E  A  F  Y  K  K  D  L  A  K  R  L  L  V  G  K  S         p.620

          .         .         .         .       | 16 .         .    g.42634
 GCATCTGTAGATGCTGAAAAATCAATGCTGTCCAAACTTAAACATG | AATGCGGAGCTGCT    c.1920
 A  S  V  D  A  E  K  S  M  L  S  K  L  K  H  E |   C  G  A  A      p.640

          .         .         .         .         .         .       g.42694
 TTCACCAGCAAACTTGAAGGAATGTTTAAAGACATGGAACTTTCTAAAGACATCATGATT       c.1980
 F  T  S  K  L  E  G  M  F  K  D  M  E  L  S  K  D  I  M  I         p.660

          .   | 17     .         .         .         .         .    g.43843
 CAGTTCAAACAG | TATATGCAGAATCAGAATGTTCCGGGAAATATTGAGTTAACTGTGAAT    c.2040
 Q  F  K  Q   | Y  M  Q  N  Q  N  V  P  G  N  I  E  L  T  V  N      p.680

          .         .         .         .         .         .       g.43903
 ATCCTGACAATGGGCTATTGGCCGACATATGTGCCTATGGAAGTTCATTTACCACCAGAG       c.2100
 I  L  T  M  G  Y  W  P  T  Y  V  P  M  E  V  H  L  P  P  E         p.700

  | 18       .         .         .         .         .         .    g.44946
  | ATGGTAAAACTTCAGGAGATTTTCAAGACATTTTACCTAGGCAAACATAGTGGCAGGAAA    c.2160
  | M  V  K  L  Q  E  I  F  K  T  F  Y  L  G  K  H  S  G  R  K      p.720

          .         .         .         .         .     | 19   .    g.46249
 CTTCAGTGGCAGTCAACCCTAGGACACTGTGTGTTAAAAGCAGAATTTAAAGAG | GGTAAA    c.2220
 L  Q  W  Q  S  T  L  G  H  C  V  L  K  A  E  F  K  E   | G  K      p.740

          .         .         .         .         .         .       g.46309
 AAGGAACTCCAGGTCTCTCTTTTTCAAACACTGGTGCTGCTAATGTTTAATGAGGGAGAG       c.2280
 K  E  L  Q  V  S  L  F  Q  T  L  V  L  L  M  F  N  E  G  E         p.760

          .         .         .         . | 20       .         .    g.48255
 GAGTTCAGTTTAGAAGAGATCAAGCAGGCAACTGGAATAG | AGGATGGAGAGTTAAGGAGA    c.2340
 E  F  S  L  E  E  I  K  Q  A  T  G  I  E |   D  G  E  L  R  R      p.780

          .         .         .         .         .         .       g.48315
 ACACTGCAGTCATTAGCCTGTGGCAAAGCTAGAGTTCTGGCGAAAAATCCAAAGGGCAAA       c.2400
 T  L  Q  S  L  A  C  G  K  A  R  V  L  A  K  N  P  K  G  K         p.800

          .         .         .         .         .         .       g.48375
 GACATTGAAGATGGTGACAAGTTCATTTGTAATGATGATTTCAAACATAAACTTTTCAGG       c.2460
 D  I  E  D  G  D  K  F  I  C  N  D  D  F  K  H  K  L  F  R         p.820

          .         .         .    | 21    .         .         .    g.50602
 ATAAAGATCAATCAAATCCAGATGAAAGAAACG | GTTGAAGAACAAGCAAGCACTACAGAA    c.2520
 I  K  I  N  Q  I  Q  M  K  E  T   | V  E  E  Q  A  S  T  T  E      p.840

          .         .         .         .         .         .       g.50662
 AGAGTATTTCAAGACAGACAGTATCAAATTGATGCTGCAATTGTTCGAATTATGAAGATG       c.2580
 R  V  F  Q  D  R  Q  Y  Q  I  D  A  A  I  V  R  I  M  K  M         p.860

          .         .         .         .         .         .       g.50722
 AGAAAGACACTTAGCCACAATCTCCTTGTTTCAGAAGTGTACAACCAGTTGAAATTTCCA       c.2640
 R  K  T  L  S  H  N  L  L  V  S  E  V  Y  N  Q  L  K  F  P         p.880

        | 22 .         .         .         .         .         .    g.54027
 GTAAAG | CCTGCTGATCTTAAGAAGAGAATAGAATCTTTAATTGACCGGGACTACATGGAA    c.2700
 V  K   | P  A  D  L  K  K  R  I  E  S  L  I  D  R  D  Y  M  E      p.900

          .         .         .         .                           g.54069
 AGAGATAAAGAAAATCCAAACCAGTACAACTATATTGCATAG                         c.2742
 R  D  K  E  N  P  N  Q  Y  N  Y  I  A  X                           p.913

          .         .         .         .         .         .       g.54129
 aatgttggccttgcagcatttggtgtcatatgcagtagccagtggataaactaacctgtt       c.*60

          .         .         .         .         .         .       g.54189
 gattcaatattatttgactccttttttactaccgatgaccaaatgaagcagtgtaattaa       c.*120

          .         .         .         .         .         .       g.54249
 tggaaatagttgagtggactttttctcagtggttaacatgcccattttaaagagtaatac       c.*180

          .         .         .         .         .         .       g.54309
 ttacctttaagaagaatgttgttgaactctttgcatgttatttagtatgatgtgcagaaa       c.*240

          .         .         .         .         .         .       g.54369
 acacttaagaacgtacctggtcttcatgaattcctctttggaactgggaaagagatccct       c.*300

          .         .         .         .         .         .       g.54429
 gtggctattaaaaaggggggagggttcttacacaccattaattatgaagcaaaaggttta       c.*360

          .         .         .         .         .         .       g.54489
 tttgcttaaaatgtcatttaaagatacttaaactgcatgcaaactttatttactgtacag       c.*420

          .         .         .         .         .         .       g.54549
 agttctggatgtatttatcaaatagaaaaaccacccttgacttggttgttcacccgtttt       c.*480

          .         .         .         .         .         .       g.54609
 gtgatttcccttgaaaagagaaatgaattgtcatagctattgatattttactaggtgatg       c.*540

          .         .         .         .         .         .       g.54669
 ttctgttacactgaaagggatgttttttaaaaaaaattatttggaaacaagttttcaagt       c.*600

          .         .         .         .         .         .       g.54729
 agggggacagttgcttacataatatcttgtatattcacatcctaaaaattttcatttatg       c.*660

          .         .         .         .         .         .       g.54789
 agtatgggatgtgtgtatatggcttagccccaagttaactgtgctgattaacaagtactt       c.*720

          .         .         .         .         .         .       g.54849
 ataaaaatagctaaagtagaaaattaatgatcagttgtactagaggaacatcatagaaga       c.*780

          .         .         .         .         .         .       g.54909
 gaaaaatccaactctttatattaaaaatgaatacaataagaaaattgcaaaagagaccaa       c.*840

          .         .         .         .         .         .       g.54969
 aatgaacgtgttttgtaaattgttacaggagcaaaaactttgcaactagttttcaacata       c.*900

          .         .         .         .         .         .       g.55029
 ctttagactttaaatgttgtttggacagttttgtcttcaacttggaccaattgtagattg       c.*960

          .         .         .         .         .         .       g.55089
 ttacaggcttcctaggatttagcattcctattttctctaccaaagttttttttagaagca       c.*1020

          .         .         .         .         .         .       g.55149
 tcccaactcttctctttgttgataaataagcctttcctgtcatcttcattttaacttgct       c.*1080

          .         .         .         .         .         .       g.55209
 aaaaccctagatacaaaggtcctccctcatttttcccacagagcccctgtttgggaattt       c.*1140

          .         .         .         .         .         .       g.55269
 gagattctgtgtcatgctggttttcctttcagaattgcttgaaatcgagttctcttagcc       c.*1200

          .         .         .         .         .         .       g.55329
 actggacacctagttttcaggagaatgtcccaagattgtttatatatacaaaatggcaaa       c.*1260

          .         .         .         .         .         .       g.55389
 agtactgtttttcgaattgataattcaagcaaaggcttctctttactgtcactgattttt       c.*1320

          .         .         .         .         .         .       g.55449
 ttttgtttttattttgtttccttgtttctatttccttgaagctttgaagggaggagaagc       c.*1380

          .         .         .         .         .         .       g.55509
 agaaaattttgtttatgtttgttaaaaatcagaactacttaatgctttttgccacagcat       c.*1440

          .         .         .         .         .         .       g.55569
 atttccttgcctgttggagccgttaggaagattacctatgtcctaatcttcaacctgaga       c.*1500

          .         .         .         .         .         .       g.55629
 agatttttgactcttgtgtctactgttgattgtttgcttgagttctcaaagacctgtggc       c.*1560

          .         .         .         .         .         .       g.55689
 caggtattttaaaaagtcgtctatttctttctagttgcatcaacttgcacactggtgtct       c.*1620

          .         .         .         .         .         .       g.55749
 aactatatgtggtattcggaacttgtaattcttattgagcagccattgcctatattttct       c.*1680

          .         .         .         .         .         .       g.55809
 cagctcctcactgatttctttatatgagctcagctgacaagcaaatgcagctattttgtt       c.*1740

          .         .         .         .         .         .       g.55869
 taccctctcttcataccggaccatcaacaacagtgttctaactcatccctgatggtctgt       c.*1800

          .         .         .         .         .         .       g.55929
 gagatgtagactattacacaagattcaagttactcgtaagcaacttttagatagagttgg       c.*1860

          .         .         .         .         .         .       g.55989
 tcctgttaggaggagactcttgatgtcaccttcagtatcttgaaagcgggtcccctcccc       c.*1920

          .         .         .         .         .         .       g.56049
 gaggctcttaattctttgaaaacttgatgctgtttcagctgaaaaattagcaagactgtt       c.*1980

          .         .         .         .         .         .       g.56109
 aaaaaaaaaaagttgaggggagctgtttaagaaactgaaaagtaattgcaaactacattg       c.*2040

          .         .         .         .         .         .       g.56169
 gataattgtgactttcagttgttgttctgtatcagttgaatttttgtgctcttttccctg       c.*2100

          .         .         .         .         .         .       g.56229
 tgtacgtggtggttctatttttctccaataaaacttttatttaaaaaaagtttctagaga       c.*2160

          .                                                         g.56241
 agatctttaaaa                                                       c.*2172

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Cullin 4B protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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