cytochrome c, somatic (CYCS) - coding DNA reference sequence

(used for variant description)

(last modified October 11, 2013)
This file was created to facilitate the description of sequence variants on transcript NM_018947.5 in the CYCS gene based on a coding DNA reference sequence following the HGVS recommendations.
The sequence was taken from NG_023438.1, covering CYCS transcript NM_018947.5.
Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5050
           gtagccgccagctcggccgcacgtcagggcgcgggagcgcggagcgagtt       c.-121

 .         .         .         .         .         .                g.5110
 tggttgcacttacaccggtacttaagcgcggaccggcgtgtccttggacttagagagtgg       c.-61

 .         .         .         .         .         .  | 02          g.6242
 ggacgtccggcttcggagcgggagtgttcgttgtgccagcgactaaaaagag | aattaaat    c.-1

          .         .         .         .         .         .       g.6302
 ATGGGTGATGTTGAGAAAGGCAAGAAGATTTTTATTATGAAGTGTTCCCAGTGCCACACC       c.60
 M  G  D  V  E  K  G  K  K  I  F  I  M  K  C  S  Q  C  H  T         p.20

          .         .         .         .         .         .       g.6362
 GTTGAAAAGGGAGGCAAGCACAAGACTGGGCCAAATCTCCATGGTCTCTTTGGGCGGAAG       c.120
 V  E  K  G  G  K  H  K  T  G  P  N  L  H  G  L  F  G  R  K         p.40

          .         .         .         .          | 03        .    g.6523
 ACAGGTCAGGCCCCTGGATACTCTTACACAGCCGCCAATAAGAACAAAG | GCATCATCTGG    c.180
 T  G  Q  A  P  G  Y  S  Y  T  A  A  N  K  N  K  G |   I  I  W      p.60

          .         .         .         .         .         .       g.6583
 GGAGAGGATACACTGATGGAGTATTTGGAGAATCCCAAGAAGTACATCCCTGGAACAAAA       c.240
 G  E  D  T  L  M  E  Y  L  E  N  P  K  K  Y  I  P  G  T  K         p.80

          .         .         .         .         .         .       g.6643
 ATGATCTTTGTCGGCATTAAGAAGAAGGAAGAAAGGGCAGACTTAATAGCTTATCTCAAA       c.300
 M  I  F  V  G  I  K  K  K  E  E  R  A  D  L  I  A  Y  L  K         p.100

          .                                                         g.6661
 AAAGCTACTAATGAGTAA                                                 c.318
 K  A  T  N  E  X                                                   p.105

          .         .         .         .         .         .       g.6721
 taattggccactgccttatttattacaaaacagaaatgtctcatgacttttttatgtgta       c.*60

          .         .         .         .         .         .       g.6781
 ccatcctttaatagatctcatacaccagaattcagatcatgaatgactgacagaatattt       c.*120

          .         .         .         .         .         .       g.6841
 tgttgggcagtcctgatttaaaactaagactggcttgtggttaaatgaatatgttcagtt       c.*180

          .         .         .         .         .         .       g.6901
 tttgaattttaatagtaactccaattcagtaaatggtatcactgtttaccccttttaaag       c.*240

          .         .         .         .         .         .       g.6961
 atatgattagacttcgttagtaatgttcaacttttcacaaagatggtgagtgccatctta       c.*300

          .         .         .         .         .         .       g.7021
 aaacttactggagattggttttatatttagatttatataactggttatgtgaatatattt       c.*360

          .         .         .         .         .         .       g.7081
 aaatactggggaaattgcttcactgtcttagaaccaagcaagattcacctgtgttttgtg       c.*420

          .         .         .         .         .         .       g.7141
 ttcatgttcatttgcctcttaaaggcaagggttgaagataaataaggtagcaatgtctat       c.*480

          .         .         .         .         .         .       g.7201
 agttttggccttaactatgccaatctaattataattccctgtatttaaaatggtttcttt       c.*540

          .         .         .         .         .         .       g.7261
 tacttattgaaaggcattttagtgtggtttatgtgtaatattaaagattattcaacacct       c.*600

          .         .         .         .         .         .       g.7321
 ctcacatcttacagatctataaggtcacatgcttttaaaatagtagcaagttaaacttca       c.*660

          .         .         .         .         .         .       g.7381
 ctcttgaattctttacaatctaagtcaaactaagttataatttaggattgtctttaaaca       c.*720

          .         .         .         .         .         .       g.7441
 gccattcagaaacaaaactgtagaactgtgtatttgattgggaatggtgcttttgccaac       c.*780

          .         .         .         .         .         .       g.7501
 ttaaaaggattaaagtaacggagatatacacaaattttaaaattatgtgtgatcacaaga       c.*840

          .         .         .         .         .         .       g.7561
 ctaaagataattaaaaagaaaaccacagatcatgactttttgactgtgcttgatttcatg       c.*900

          .         .         .         .         .         .       g.7621
 actgatgcacaaattttaatgattaaaaagtgcaggagccctaaatgtcagtgcagcagc       c.*960

          .         .         .         .         .         .       g.7681
 cctaaatgtcagtgcagcagtgttaaccagtcatggtgctagattgtttacttggttttc       c.*1020

          .         .         .         .         .         .       g.7741
 taggactgcctcaactagaataacacttcactaattgactcttagtttctttgctcagat       c.*1080

          .         .         .         .         .         .       g.7801
 tgagaactgcagcatttatgccagacatggacagaggaatgcctgtggtcatagttttgt       c.*1140

          .         .         .         .         .         .       g.7861
 gatgtgtaacagtgtataattacatactgaattatttcatgcatagtctgtgccatacac       c.*1200

          .         .         .         .         .         .       g.7921
 atttagagtagtccttggagattttatggagatggtgagcacaaggtaagtcataaagaa       c.*1260

          .         .         .         .         .         .       g.7981
 taatgagaaaataaatctatgctggtgcagctgagaactgtatctttgtgggacagtgag       c.*1320

          .         .         .         .         .         .       g.8041
 aagactgagaagatgtgaatccatggtctcaaaggtgatagggacgattagataggtgtt       c.*1380

          .         .         .         .         .         .       g.8101
 ttaaggcctgaaagcaatttataacatatgagtcttatttttatttatagaaatgtggaa       c.*1440

          .         .         .         .         .         .       g.8161
 agcttgctgtaattcatatttgaagtcctagtctgagttctggtggggaatttaaaaatg       c.*1500

          .         .         .         .         .         .       g.8221
 catcctggaaatcctttaaagatttcagactttgaaaggccttgtagcagaggacttggt       c.*1560

          .         .         .         .         .         .       g.8281
 gactgtataaagttagtggtattcagggacagtgtagcaagtagcttacaaggggacaat       c.*1620

          .         .         .         .         .         .       g.8341
 tctggactaatgagaaagacctgaagtgaaggctagagagttgattttttttttttttgg       c.*1680

          .         .         .         .         .         .       g.8401
 catcctggaaatgatacaggaaacatattaagatagatacagaaatgtgttcaaccttcc       c.*1740

          .         .         .         .         .         .       g.8461
 atcttggctagttgtggcgtttagtttgttttttgagacatggtcacgctgtgtcgccaa       c.*1800

          .         .         .         .         .         .       g.8521
 ggctggagtgcagtggtgcgatctcggctggctgcaacctctatttcccaggctcaagcg       c.*1860

          .         .         .         .         .         .       g.8581
 attctctcacttcagcttcccaagtagctgggactacaggtgttcgccaccatgcccagc       c.*1920

          .         .         .         .         .         .       g.8641
 taatttttttgtagagatggagttttgccatgtggtcccaggctggtctcaaactcctga       c.*1980

          .         .         .         .         .         .       g.8701
 gctcaagcaatccgtccacttgccttggctccccaaagtgctgggattacaggcgtgagc       c.*2040

          .         .         .         .         .         .       g.8761
 caccaggccctgcctggttttcaaattcagaaatcttattatttaacccagaagtaatca       c.*2100

          .         .         .         .         .         .       g.8821
 gcccagtagtaacttaggtttaattttttttcaggtttaaaatttttctcatttattttt       c.*2160

          .         .         .         .         .         .       g.8881
 tctgagacggagtttcgcccttttcgcccaggctgagtacagtggtgcaatctcactgca       c.*2220

          .         .         .         .         .         .       g.8941
 acctccgccttccagttgcaagtgattctcctgcctcagcctcctgagtagctgggatta       c.*2280

          .         .         .         .         .         .       g.9001
 caggcacccgccaccacgcctggctaatttttgtatttttagtggagatggtgtttcacc       c.*2340

          .         .         .         .         .         .       g.9061
 atgttggccagactggtcttggactcctgacctcgtgatccacccaccttggcctcccaa       c.*2400

          .         .         .         .         .         .       g.9121
 agttctaggattacaggtgtgagccaccacgtccggccaatttttctcatttctatgcct       c.*2460

          .         .         .         .         .         .       g.9181
 cctatattaaggtctgtgttggcacagatgagtaactgccatgttctaggtcagttatac       c.*2520

          .         .         .         .         .         .       g.9241
 ccaagcacttctggtggtttaaaatgtgattctgtaacttttttatttttatttttttga       c.*2580

          .         .         .         .         .         .       g.9301
 gataatttcactcttgttgcccaggctggagtgcaatggcgtgatcgctgctcaccgcaa       c.*2640

          .         .         .         .         .         .       g.9361
 cctccgccttccaggttcaagcgattctcctgactcagcctctcaagtagctgggattac       c.*2700

          .         .         .         .         .         .       g.9421
 aagcatgcgccaccatgcccagcttattttgtgtttttagtagagacagggtttctccat       c.*2760

          .         .         .         .         .         .       g.9481
 gctggacaggctggtcttgaactcccgacgtcaggtgatctacctgcctcggcctcccaa       c.*2820

          .         .         .         .         .         .       g.9541
 agtgctgggattacaggcgtgagccaccacgcctggccaattatgtaattttttaaaaag       c.*2880

          .         .         .         .         .         .       g.9601
 gacatttctatcagggatatataccttcagaaataaggaaataggggaaaaaaagagcac       c.*2940

          .         .         .         .         .         .       g.9661
 tataaaccacatgttttcatttctagtgcttcgctgtaagtggctaggttggtagaatca       c.*3000

          .         .         .         .         .         .       g.9721
 aaaacaagggccagatgtatttaaggggtattcagatgccacctacatgcttattttgtc       c.*3060

          .         .         .         .         .         .       g.9781
 tagaacagtgctgtctaatagaactttctgtgacgatggatattttgtagacttttgctg       c.*3120

          .         .         .         .         .         .       g.9841
 tccagtgtggtagccactaaccacatgtggctgttaagcccttgaaatatagctagtgtg       c.*3180

          .         .         .         .         .         .       g.9901
 actagaaagtattttattttaaatttacataggcacaagtggctagtggctactgtattg       c.*3240

          .         .         .         .         .         .       g.9961
 acattctgggtctaggactagaaccagtggtctgtaacaaaagtactttctctttactct       c.*3300

          .         .         .         .         .         .       g.10021
 attaaatctagaattagccgggcatggtcgctcatgcctgtaatcccagcactttgggag       c.*3360

          .         .         .         .         .         .       g.10081
 gccaaggcaggcagatcacttgaggtcaggcgtttgagaccagcctggtcaacatggcga       c.*3420

          .         .         .         .         .         .       g.10141
 aaccctgtctctacaaaaaacataaaaattagccaggtgtggtggtgggcacctgtaatc       c.*3480

          .         .         .         .         .         .       g.10201
 tcagctacttgggaggctgaggcacaagaatcacttgaacttgggaggtggaggttgcag       c.*3540

          .         .         .         .         .         .       g.10261
 tgagccaagattgtgccactgcactcaagcctgggtgacgagtgaaactgtctccaaaaa       c.*3600

          .         .         .         .         .         .       g.10321
 aaaaaaaaaatctagaattcttggaagtacattatattgcccttcagaatagattccagt       c.*3660

          .         .         .         .         .         .       g.10381
 tcctgttgtgctcacctttataattttaccataagttttacctattcgtaagttggcagt       c.*3720

          .         .         .         .         .         .       g.10441
 tttagatagataacattctggtggtagctagggatttaccttttgtcatccttttcctgc       c.*3780

          .         .         .         .         .         .       g.10501
 acttctcttgaattcctttatagatgtacagttttgctttaaccactgaagattgctgta       c.*3840

          .         .         .         .         .         .       g.10561
 aattataaagggtgtgatagaatccacatggctgtcaagaaggagatcttaccaaggaca       c.*3900

          .         .         .         .         .         .       g.10621
 gttgactgactagtctcagattgtttcatatcatttatacttgggtaagagtaaactaga       c.*3960

          .         .         .         .         .         .       g.10681
 taactgggcgtcgtggtgcacacctgtagtcccagccactctgaggcaggaggactgctt       c.*4020

          .         .         .         .         .         .       g.10741
 gtgcccagaagttcgaggctgcagtgtagctgtgattgtgctactgcactccagcctggg       c.*4080

          .         .         .         .         .         .       g.10801
 caacagataaaggaaactccatctcttttaaaaaaaaaaaaagtggtctgggtgcagtag       c.*4140

          .         .         .         .         .         .       g.10861
 gtcatgcctgcaatcccagcactttgggaggccaaggcaggcagatcacctgaggtcagg       c.*4200

          .         .         .         .         .         .       g.10921
 agcttgagaccagcctggccaacatggtgaaaccccatctctaccaaaaatataaaaact       c.*4260

          .         .         .         .         .         .       g.10981
 agctgggcgtggtggcggcacctgtaattgcagctatttgagaggctgaggcaggagaat       c.*4320

          .         .         .         .         .         .       g.11041
 cgcttgaacctgggagatgggggttgcagtgagccaagaccgccccatcgcactccagcc       c.*4380

          .         .         .         .         .         .       g.11101
 tgggcaacaatagtgaaactccgtctcaaaaagaaaaaaagtttccttagaatggaaaat       c.*4440

          .         .         .         .         .         .       g.11161
 attcattcatgagctcttttggcaatccgtcatcagtatattctgaaaaccaataagatg       c.*4500

          .         .         .         .         .         .       g.11221
 ttgccaagttgggggcgagagctatgtaatgcaaggcatatgcctgatgaagtatacaaa       c.*4560

          .         .         .         .         .         .       g.11281
 tacacctgaccagaaactttgtctcccacataagtctcttctaggcactgtcggggtaca       c.*4620

          .         .         .         .         .         .       g.11341
 tactgagctgctgctttggctgtattttctgtgcctcagaataaccattgtcctggtgtt       c.*4680

          .         .         .         .         .         .       g.11401
 catatccttagagttcagtacaaaatgttggatatccatttaataggttccaggttatct       c.*4740

          .         .         .         .         .         .       g.11461
 tagttggagtttggggtatttgaaaacgtcatgccttcaggctatcatttccctcagaaa       c.*4800

          .         .         .         .         .         .       g.11521
 gctaagtaaatttactgcattcatttctcaaagagtaaaagtgcaggttgtatgtgtcta       c.*4860

          .         .         .         .         .         .       g.11581
 tgaacatttaaacatgttaaaatgttaaatttaacattttaaatttaaacatttaaatat       c.*4920

          .         .         .         .         .         .       g.11641
 gtctgtaacttgaacagtgtagtttcagaaaggaccactgggctagtgtaatgcagaaaa       c.*4980

          .         .         .         .         .         .       g.11701
 tgctgggtctaggattaggagaaaattgtgtttagtgtgtatcaataaacagcccgtgga       c.*5040

          .                                                         g.11711
 cccaatctga                                                         c.*5050

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Cytochrome c, somatic protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.