cytochrome P450, family 11, subfamily B, polypeptide 1 (CYP11B1) - coding DNA reference sequence

(used for variant description)

(last modified July 20, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_000497.3 in the CYP11B1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007954.1, covering CYP11B1 transcript NM_000497.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5007
                                                      cattgga       c.-1

          .         .         .         .         .         .       g.5067
 ATGGCACTCAGGGCAAAGGCAGAGGTGTGCATGGCAGTGCCCTGGCTGTCCCTGCAAAGG       c.60
 M  A  L  R  A  K  A  E  V  C  M  A  V  P  W  L  S  L  Q  R         p.20

          .         .         .         .         .         .       g.5127
 GCACAGGCACTGGGCACGAGAGCCGCCCGGGTCCCCAGGACAGTGCTGCCCTTTGAAGCC       c.120
 A  Q  A  L  G  T  R  A  A  R  V  P  R  T  V  L  P  F  E  A         p.40

          .         .         .         .         .         .       g.5187
 ATGCCCCGGCGTCCAGGCAACAGGTGGCTGAGGCTGCTGCAGATCTGGAGGGAGCAGGGT       c.180
 M  P  R  R  P  G  N  R  W  L  R  L  L  Q  I  W  R  E  Q  G         p.60

          .         .         .         .         .          | 02    g.5634
 TATGAGGACCTGCACCTGGAAGTACACCAGACCTTCCAGGAACTAGGGCCCATTTTCAG | G    c.240
 Y  E  D  L  H  L  E  V  H  Q  T  F  Q  E  L  G  P  I  F  R  |      p.80

          .         .         .         .         .         .       g.5694
 TACGACTTGGGAGGAGCAGGCATGGTGTGTGTGATGCTGCCGGAGGACGTGGAGAAGCTG       c.300
 Y  D  L  G  G  A  G  M  V  C  V  M  L  P  E  D  V  E  K  L         p.100

          .         .         .         .         .         .       g.5754
 CAACAGGTGGACAGCCTGCATCCCCACAGGATGAGCCTGGAGCCCTGGGTGGCCTACAGA       c.360
 Q  Q  V  D  S  L  H  P  H  R  M  S  L  E  P  W  V  A  Y  R         p.120

          .         .         .      | 03  .         .         .    g.7623
 CAACATCGTGGGCACAAATGTGGCGTGTTCTTGCT | GAATGGGCCTGAATGGCGCTTCAAC    c.420
 Q  H  R  G  H  K  C  G  V  F  L  L  |  N  G  P  E  W  R  F  N      p.140

          .         .         .         .         .         .       g.7683
 CGATTGCGGCTGAATCCAGAAGTGCTGTCGCCCAACGCTGTGCAGAGGTTCCTCCCGATG       c.480
 R  L  R  L  N  P  E  V  L  S  P  N  A  V  Q  R  F  L  P  M         p.160

          .         .         .         .         .         .       g.7743
 GTGGATGCAGTGGCCAGGGACTTCTCCCAGGCCCTGAAGAAGAAGGTGCTGCAGAACGCC       c.540
 V  D  A  V  A  R  D  F  S  Q  A  L  K  K  K  V  L  Q  N  A         p.180

          .         .         .         .         .      | 04  .    g.7940
 CGGGGGAGCCTGACCCTGGACGTCCAGCCCAGCATCTTCCACTACACCATAGAAG | CCAGC    c.600
 R  G  S  L  T  L  D  V  Q  P  S  I  F  H  Y  T  I  E  A |   S      p.200

          .         .         .         .         .         .       g.8000
 AACTTGGCTCTTTTTGGAGAGCGGCTGGGCCTGGTTGGCCACAGCCCCAGTTCTGCCAGC       c.660
 N  L  A  L  F  G  E  R  L  G  L  V  G  H  S  P  S  S  A  S         p.220

          .         .         .         .         .         .       g.8060
 CTGAACTTCCTCCATGCCCTGGAGGTCATGTTCAAATCCACCGTCCAGCTCATGTTCATG       c.720
 L  N  F  L  H  A  L  E  V  M  F  K  S  T  V  Q  L  M  F  M         p.240

          .         .         .         .         .         .       g.8120
 CCCAGGAGCCTGTCTCGCTGGACCAGCCCCAAGGTGTGGAAGGAGCACTTTGAGGCCTGG       c.780
 P  R  S  L  S  R  W  T  S  P  K  V  W  K  E  H  F  E  A  W         p.260

          .          | 05        .         .         .         .    g.8466
 GACTGCATCTTCCAGTACG | GCGACAACTGTATCCAGAAAATCTATCAGGAACTGGCCTTC    c.840
 D  C  I  F  Q  Y  G |   D  N  C  I  Q  K  I  Y  Q  E  L  A  F      p.280

          .         .         .         .         .         .       g.8526
 AGCCGCCCTCAACAGTACACCAGCATCGTGGCGGAGCTCCTGTTGAATGCGGAACTGTCG       c.900
 S  R  P  Q  Q  Y  T  S  I  V  A  E  L  L  L  N  A  E  L  S         p.300

          .         .         .         .         .     | 06   .    g.8948
 CCAGATGCCATCAAGGCCAACTCTATGGAACTCACTGCAGGGAGCGTGGACACG | ACGGTG    c.960
 P  D  A  I  K  A  N  S  M  E  L  T  A  G  S  V  D  T   | T  V      p.320

          .         .         .         .         .         .       g.9008
 TTTCCCTTGCTGATGACGCTCTTTGAGCTGGCTCGGAACCCCAACGTGCAGCAGGCCCTG       c.1020
 F  P  L  L  M  T  L  F  E  L  A  R  N  P  N  V  Q  Q  A  L         p.340

          .         .         .         .         .         .       g.9068
 CGCCAGGAGAGCCTGGCCGCCGCAGCCAGCATCAGTGAACATCCCCAGAAGGCAACCACC       c.1080
 R  Q  E  S  L  A  A  A  A  S  I  S  E  H  P  Q  K  A  T  T         p.360

          .         .         .         .  | 07      .         .    g.9527
 GAGCTGCCCTTGCTGCGTGCGGCCCTCAAGGAGACCTTGCG | GCTCTACCCTGTGGGTCTG    c.1140
 E  L  P  L  L  R  A  A  L  K  E  T  L  R  |  L  Y  P  V  G  L      p.380

          .         .         .         .         .         .       g.9587
 TTTCTGGAGCGAGTGGCGAGCTCAGACTTGGTGCTTCAGAACTACCACATCCCAGCTGGG       c.1200
 F  L  E  R  V  A  S  S  D  L  V  L  Q  N  Y  H  I  P  A  G         p.400

  | 08       .         .         .         .         .         .    g.9726
  | ACATTGGTGCGCGTGTTCCTCTACTCTCTGGGTCGCAACCCCGCCTTGTTCCCGAGGCCT    c.1260
  | T  L  V  R  V  F  L  Y  S  L  G  R  N  P  A  L  F  P  R  P      p.420

          .         .         .         .         .         .       g.9786
 GAGCGCTATAACCCCCAGCGCTGGCTAGACATCAGGGGCTCCGGCAGGAACTTCTACCAC       c.1320
 E  R  Y  N  P  Q  R  W  L  D  I  R  G  S  G  R  N  F  Y  H         p.440

          .         .         .         .         .         .       g.9846
 GTGCCCTTTGGCTTTGGCATGCGCCAGTGCCTTGGGCGGCGCCTGGCAGAGGCAGAGATG       c.1380
 V  P  F  G  F  G  M  R  Q  C  L  G  R  R  L  A  E  A  E  M         p.460

          .         | 09         .         .         .         .    g.10376
 CTGCTGCTGCTGCACCAT | GTGCTGAAACACCTCCAGGTGGAGACACTAACCCAAGAGGAC    c.1440
 L  L  L  L  H  H   | V  L  K  H  L  Q  V  E  T  L  T  Q  E  D      p.480

          .         .         .         .         .         .       g.10436
 ATAAAGATGGTCTACAGCTTCATATTGAGGCCCAGCATGTTCCCCCTCCTCACCTTCAGA       c.1500
 I  K  M  V  Y  S  F  I  L  R  P  S  M  F  P  L  L  T  F  R         p.500

          .                                                         g.10448
 GCCATCAACTAA                                                       c.1512
 A  I  N  X                                                         p.503

          .         .         .         .         .         .       g.10508
 tcacgtctctgcacccagggtcccagcctggccaccagcctccctttctgcctgacccca       c.*60

          .         .         .         .         .         .       g.10568
 ggccacccctcttctctcccacatgcacagcttcctgagtcacccctctgtctaaccagc       c.*120

          .         .         .         .         .         .       g.10628
 cccagcacaaatggaactcccgagggcctctaggaccagggtttgccaggctaagcagca       c.*180

          .         .         .         .         .         .       g.10688
 atgccagggcacagctggggaagatcttgctgaccttgtccccagccccacctggccctt       c.*240

          .         .         .         .         .         .       g.10748
 tctccagcaagcactgtcctctgggcagtttgcccccatccctcccagtgctggctccag       c.*300

          .         .         .         .         .         .       g.10808
 gctcctcgtgtggccatacaagggtgctgtggttttgtcccttgccttcctgcctagtct       c.*360

          .         .         .         .         .         .       g.10868
 cacatgtccctgttcctcttcccctggccagggcccctgcgcagactgtcagagtcatta       c.*420

          .         .         .         .         .         .       g.10928
 agcgggatcccagcatctcagagtccagtcaagttccctcctgcagcctgacccctaggc       c.*480

          .         .         .         .         .         .       g.10988
 agctcgagcatgccctgagctctctgaaagttgtcaccctggaatagggtcctgcagggt       c.*540

          .         .         .         .         .         .       g.11048
 agaataaaaaggcccctgtggtcacttgtcctgacatccccattttcaagtgatacaact       c.*600

          .         .         .         .         .         .       g.11108
 gagtctcgagggacgtgtgttccccagctgatcgtgtcagcctcatgccccaggcctcat       c.*660

          .         .         .         .         .         .       g.11168
 ctttcatggaccaggccttgttccaggagtgggtgttgggtcctctgcttcctgtgctgt       c.*720

          .         .         .         .         .         .       g.11228
 cccctggggaaggtcccgaggatgctgtcaggagatggaagagtcatgtggggtgggaac       c.*780

          .         .         .         .         .         .       g.11288
 ctggggtgtggttccagaaatgtttttggcaacaggagagacaggattgggccaacaagg       c.*840

          .         .         .         .         .         .       g.11348
 actcagacgagttttattgactcatttctctggttgatacggagccatgtcatgtgccac       c.*900

          .         .         .         .         .         .       g.11408
 gacctggggtgggcacagggaggctgcagtttcctgcgtgaacctgccttgggcctcatc       c.*960

          .         .         .         .         .         .       g.11468
 tgctcctagcccagcagagagagttgacccctcctgaactggccactccccagtgctccc       c.*1020

          .         .         .         .         .         .       g.11528
 gtgcagggagaggaagcacccagtttgagagtgtacccagccagactgtctttatctcca       c.*1080

          .         .         .         .         .         .       g.11588
 tggattttcatcagggcaaagatcacagcagccagctcctggtggctgatgaggatcaga       c.*1140

          .         .         .         .         .         .       g.11648
 gcatttgttcccccatgaaaggggaaatccctatggcatcattccagtggtggtcagtag       c.*1200

          .         .         .         .         .         .       g.11708
 atccaggacgccctgcaggactcagcctgtacagggagatgaagtgccccaggttgggag       c.*1260

          .         .         .         .         .         .       g.11768
 cacacctagctagagttatttgtgttaatctattcaggatgctctaagaaaacgccatag       c.*1320

          .         .         .         .         .         .       g.11828
 actgggttgctgacaaacatcagaattctatttctcatggttctgaaggcttagaaggct       c.*1380

          .         .         .         .         .         .       g.11888
 aagatcaaggtgtcagcaggttctgtgtctggtgaggacccacctcttgtttcatagata       c.*1440

          .         .         .         .         .         .       g.11948
 aaaccttcttgctgtgtcctcacatggtggaaaagggcaagacagctcacagagacctct       c.*1500

          .         .         .         .         .         .       g.12008
 tttataaggacgccagttccattcaagagggcactgcctgcattcccttcccccctcaaa       c.*1560

          .         .         .         .         .         .       g.12068
 ggcccggccctgctattatcgtcaccttggtgactagatttcagcctatgaattctggag       c.*1620

          .         .         .         .         .         .       g.12128
 gcggacacaaaaattcagattaaactactctgcttctgtttctctaaaatctacatcctt       c.*1680

          .         .         .         .         .         .       g.12188
 ctcatatacaaaatacatgcatttctccccagtagccccaaatatcaactcattttagca       c.*1740

          .         .         .         .         .         .       g.12248
 tcaactttaaaattgtagtccaaagtgtgatttaaatgttatctgagtcaaacatgggta       c.*1800

          .         .         .         .         .         .       g.12308
 agactcaaggtacaatttatcctgagtccaactgttcttgctgcgaacctatgaaatcaa       c.*1860

          .         .         .         .         .         .       g.12368
 acatgttatgtgcttccaaaatacagtggttggagaggcataggataaacattcccattc       c.*1920

          .         .         .         .         .         .       g.12428
 cagaaaggagaaacaggaaagaagaaaggagtaacaagtttcaagcaactccaaaattga       c.*1980

          .         .         .                                     g.12464
 atgtgacaaacagtattaaaccttaagcctcaagaa                               c.*2016

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Cytochrome P450, family 11, subfamily B, polypeptide 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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