cytochrome P450, family 11, subfamily B, polypeptide 2 (CYP11B2) - coding DNA reference sequence

(used for variant description)

(last modified June 15, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_000498.3 in the CYP11B2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008374.1, covering CYP11B2 transcript NM_000498.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5003
                                                          gga       c.-1

          .         .         .         .         .         .       g.5063
 ATGGCACTCAGGGCAAAGGCAGAGGTGTGCGTGGCAGCGCCCTGGCTGTCCCTGCAAAGG       c.60
 M  A  L  R  A  K  A  E  V  C  V  A  A  P  W  L  S  L  Q  R         p.20

          .         .         .         .         .         .       g.5123
 GCACGGGCACTGGGCACTAGAGCCGCTCGGGCCCCTAGGACGGTGCTGCCGTTTGAAGCC       c.120
 A  R  A  L  G  T  R  A  A  R  A  P  R  T  V  L  P  F  E  A         p.40

          .         .         .         .         .         .       g.5183
 ATGCCCCAGCATCCAGGCAACAGGTGGCTGAGGCTGCTGCAGATCTGGAGGGAGCAGGGT       c.180
 M  P  Q  H  P  G  N  R  W  L  R  L  L  Q  I  W  R  E  Q  G         p.60

          .         .         .         .         .          | 02    g.5630
 TATGAGCACCTGCACCTGGAGATGCACCAGACCTTCCAGGAGCTGGGGCCCATTTTCAG | G    c.240
 Y  E  H  L  H  L  E  M  H  Q  T  F  Q  E  L  G  P  I  F  R  |      p.80

          .         .         .         .         .         .       g.5690
 TACAACTTGGGAGGACCACGCATGGTGTGTGTGATGCTGCCGGAGGATGTGGAGAAGCTG       c.300
 Y  N  L  G  G  P  R  M  V  C  V  M  L  P  E  D  V  E  K  L         p.100

          .         .         .         .         .         .       g.5750
 CAACAGGTGGACAGCCTGCATCCCTGCAGGATGATCCTGGAGCCCTGGGTGGCCTACAGA       c.360
 Q  Q  V  D  S  L  H  P  C  R  M  I  L  E  P  W  V  A  Y  R         p.120

          .         .         .      | 03  .         .         .    g.7623
 CAACATCGTGGGCACAAATGTGGCGTGTTCTTGTT | GAATGGGCCTGAATGGCGCTTCAAC    c.420
 Q  H  R  G  H  K  C  G  V  F  L  L  |  N  G  P  E  W  R  F  N      p.140

          .         .         .         .         .         .       g.7683
 CGATTGCGGCTGAACCCAGATGTGCTGTCGCCCAAGGCCGTGCAGAGGTTCCTCCCGATG       c.480
 R  L  R  L  N  P  D  V  L  S  P  K  A  V  Q  R  F  L  P  M         p.160

          .         .         .         .         .         .       g.7743
 GTGGATGCAGTGGCCAGGGACTTCTCCCAGGCCCTGAAGAAGAAGGTGCTGCAGAACGCC       c.540
 V  D  A  V  A  R  D  F  S  Q  A  L  K  K  K  V  L  Q  N  A         p.180

          .         .         .         .         .      | 04  .    g.7940
 CGGGGGAGCCTGACCCTGGACGTCCAGCCCAGCATCTTCCACTACACCATAGAAG | CCAGC    c.600
 R  G  S  L  T  L  D  V  Q  P  S  I  F  H  Y  T  I  E  A |   S      p.200

          .         .         .         .         .         .       g.8000
 AACTTAGCTCTTTTTGGAGAGCGGCTGGGCCTGGTTGGCCACAGCCCCAGTTCTGCCAGC       c.660
 N  L  A  L  F  G  E  R  L  G  L  V  G  H  S  P  S  S  A  S         p.220

          .         .         .         .         .         .       g.8060
 CTGAACTTCCTCCATGCCCTGGAGGTCATGTTCAAATCCACCGTCCAGCTCATGTTCATG       c.720
 L  N  F  L  H  A  L  E  V  M  F  K  S  T  V  Q  L  M  F  M         p.240

          .         .         .         .         .         .       g.8120
 CCCAGGAGCCTGTCTCGCTGGATCAGCCCCAAGGTGTGGAAGGAGCACTTTGAGGCCTGG       c.780
 P  R  S  L  S  R  W  I  S  P  K  V  W  K  E  H  F  E  A  W         p.260

          .          | 05        .         .         .         .    g.8466
 GACTGCATCTTCCAGTACG | GTGACAACTGTATCCAGAAAATCTACCAGGAACTGGCCTTC    c.840
 D  C  I  F  Q  Y  G |   D  N  C  I  Q  K  I  Y  Q  E  L  A  F      p.280

          .         .         .         .         .         .       g.8526
 AACCGCCCTCAACACTACACAGGCATCGTGGCGGAGCTCCTGTTGAAGGCGGAACTGTCA       c.900
 N  R  P  Q  H  Y  T  G  I  V  A  E  L  L  L  K  A  E  L  S         p.300

          .         .         .         .         .     | 06   .    g.9398
 CTAGAAGCCATCAAGGCCAACTCTATGGAACTCACTGCAGGGAGCGTGGACACG | ACAGCG    c.960
 L  E  A  I  K  A  N  S  M  E  L  T  A  G  S  V  D  T   | T  A      p.320

          .         .         .         .         .         .       g.9458
 TTTCCCTTGCTGATGACGCTCTTTGAGCTGGCTCGGAACCCCGACGTGCAGCAGATCCTG       c.1020
 F  P  L  L  M  T  L  F  E  L  A  R  N  P  D  V  Q  Q  I  L         p.340

          .         .         .         .         .         .       g.9518
 CGCCAGGAGAGCCTGGCCGCCGCAGCCAGCATCAGTGAACATCCCCAGAAGGCAACCACC       c.1080
 R  Q  E  S  L  A  A  A  A  S  I  S  E  H  P  Q  K  A  T  T         p.360

          .         .         .         .  | 07      .         .    g.9977
 GAGCTGCCCTTGCTGCGGGCGGCCCTCAAGGAGACCTTGCG | GCTCTACCCTGTGGGTCTG    c.1140
 E  L  P  L  L  R  A  A  L  K  E  T  L  R  |  L  Y  P  V  G  L      p.380

          .         .         .         .         .         .       g.10037
 TTTTTGGAGCGAGTGGTGAGCTCAGACTTGGTGCTTCAGAACTACCACATCCCAGCTGGG       c.1200
 F  L  E  R  V  V  S  S  D  L  V  L  Q  N  Y  H  I  P  A  G         p.400

  | 08       .         .         .         .         .         .    g.10176
  | ACATTGGTACAGGTTTTCCTCTACTCGCTGGGTCGCAATGCCGCCTTGTTCCCGAGGCCT    c.1260
  | T  L  V  Q  V  F  L  Y  S  L  G  R  N  A  A  L  F  P  R  P      p.420

          .         .         .         .         .         .       g.10236
 GAGCGGTATAATCCCCAGCGCTGGCTAGACATCAGGGGCTCCGGCAGGAACTTCCACCAC       c.1320
 E  R  Y  N  P  Q  R  W  L  D  I  R  G  S  G  R  N  F  H  H         p.440

          .         .         .         .         .         .       g.10296
 GTGCCCTTTGGCTTTGGCATGCGCCAGTGCCTCGGGCGGCGCCTGGCAGAGGCAGAGATG       c.1380
 V  P  F  G  F  G  M  R  Q  C  L  G  R  R  L  A  E  A  E  M         p.460

          .         | 09         .         .         .         .    g.10792
 CTGCTGCTGCTGCACCAC | GTGCTGAAGCACTTCCTGGTGGAGACACTAACTCAAGAGGAC    c.1440
 L  L  L  L  H  H   | V  L  K  H  F  L  V  E  T  L  T  Q  E  D      p.480

          .         .         .         .         .         .       g.10852
 ATAAAGATGGTCTACAGCTTCATATTGAGGCCTGGCACGTCCCCCCTCCTCACTTTCAGA       c.1500
 I  K  M  V  Y  S  F  I  L  R  P  G  T  S  P  L  L  T  F  R         p.500

          .                                                         g.10864
 GCGATTAACTAG                                                       c.1512
 A  I  N  X                                                         p.503

          .         .         .         .         .         .       g.10924
 tcttgcatctgcacccagggtcccagcctggccaccagcttccctctgcctgaccccagg       c.*60

          .         .         .         .         .         .       g.10984
 ccacctgtcttctctcccacgtgcacagcttcctgagtcacccctctgtccagccagctc       c.*120

          .         .         .         .         .         .       g.11044
 ctgcacaaatggaactccccagggcctccaggactggggcttgccaggcttgtcaaatag       c.*180

          .         .         .         .         .         .       g.11104
 caaggccagggcacagctggagacgatcttgctggcagggcctggccttgtccccagctc       c.*240

          .         .         .         .         .         .       g.11164
 cacctggccccttctccagcaagcagtgccctctggacagcttgactctactcccagcgc       c.*300

          .         .         .         .         .         .       g.11224
 tggctccaggctcctcatgaggccatgcaagggtgctgtgattttgtcccttgccttcct       c.*360

          .         .         .         .         .         .       g.11284
 gcctagtctcacatgtccctgtccctctcgccctggccagggcctctgtgcagacagtgt       c.*420

          .         .         .         .         .         .       g.11344
 cagagtcattaagcgggatcccagcatctcagagtccagtcaagttccctcctgcagcct       c.*480

          .         .         .         .         .         .       g.11404
 gaccccaggcagctcgagcatgccctgagctctctgaaagttgtcaccctggaatacgat       c.*540

          .         .         .         .         .         .       g.11464
 cctgcagggtagactaaaaaggcccctgtggtcacttatcctgacacattttcaagtgat       c.*600

          .         .         .         .         .         .       g.11524
 acaactgagtctcgaggggcgtgtgttccccagctgatcatgtcagcctcatgccccagg       c.*660

          .         .         .         .         .         .       g.11584
 cctcgtctttcatggaccaggtcttgttcaagcagcgagtgttgggtcctctgcttcctg       c.*720

          .         .         .         .         .         .       g.11644
 agctgtcccctggagaaggtcccgaggatgctgtcaggagatggaagagtcatgtggggt       c.*780

          .         .         .         .         .         .       g.11704
 gggaacctggggtgtggttccagaaatgtttttggcaacaggagagacaggattgggcca       c.*840

          .         .         .         .         .         .       g.11764
 acaaggactcagatgagttttattgactcattcctctggttgatacggagccatgtcatg       c.*900

          .         .         .         .         .         .       g.11824
 tgccacgacctggggtgggcacagggaggctgcagttccctacgtgaacctgccttgggc       c.*960

          .         .         .         .         .         .       g.11884
 ctcatctgctcctagcccagcagagagagttgacccctcctgaactggccactccccagt       c.*1020

          .         .         .         .         .         .       g.11944
 gctcctgtgcagggataggaagtgccccagggtgagaacgtgcccagccacatcatcttt       c.*1080

          .         .         .         .         .         .       g.12004
 atctcctgggattttcattagggcaaagatctcagcagccagctcctggtagctgatgag       c.*1140

          .         .         .         .         .         .       g.12064
 gatcagagcgtttgttcccccatgaaaggggaaatacttaggtaatcattccaggtgtgt       c.*1200

          .         .         .         .         .         .       g.12124
 tcagtagttccaggactcagggactcaggccagtcaccctgtgaccgcaggttgctttcc       c.*1260

          .         .         .         .         .         .       g.12184
 caccctgggcaatgcagtgcagcatgggaaaggaataagggggcaacaaggtgcacagac       c.*1320

          .         .         .         .         .         .       g.12244
 ctcagagatggcttccttgtttatggggctctcacagatacccatccaactcctctagtc       c.*1380

          .         .         .         .                           g.12285
 agcactagatcatgggatcctaaaataaaccttggaaaaat                          c.*1421

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Cytochrome P450, family 11, subfamily B, polypeptide 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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