cytochrome P450, family 17, subfamily A, polypeptide 1 (CYP17A1) - coding DNA reference sequence

(used for variant description)

(last modified August 25, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_000102.3 in the CYP17A1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007955.1, covering CYP17A1 transcript NM_000102.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5052
         atatgagctcaggcctggctgggctccaggagaatctttccacaaggcaaga       c.-121

 .         .         .         .         .         .                g.5112
 gataacacaaagtcaaggtgaagatcagggtagccctttaaaaggcctccttgtgcccta       c.-61

 .         .         .         .         .         .                g.5172
 gagttgccacagctcttctactccactgctgtctatcttgcctgccggcacccagccacc       c.-1

          .         .         .         .         .         .       g.5232
 ATGTGGGAGCTCGTGGCTCTCTTGCTGCTTACCCTAGCTTATTTGTTTTGGCCCAAGAGA       c.60
 M  W  E  L  V  A  L  L  L  L  T  L  A  Y  L  F  W  P  K  R         p.20

          .         .         .         .         .         .       g.5292
 AGGTGCCCTGGTGCCAAGTACCCCAAGAGCCTCCTGTCCCTGCCCCTGGTGGGCAGCCTG       c.120
 R  C  P  G  A  K  Y  P  K  S  L  L  S  L  P  L  V  G  S  L         p.40

          .         .         .         .         .         .       g.5352
 CCATTCCTCCCCAGACACGGCCATATGCATAACAACTTCTTCAAGCTGCAGAAAAAATAT       c.180
 P  F  L  P  R  H  G  H  M  H  N  N  F  F  K  L  Q  K  K  Y         p.60

          .         .         .         .         .         .       g.5412
 GGCCCCATCTATTCGGTTCGTATGGGCACCAAGACTACAGTGATTGTCGGCCACCACCAG       c.240
 G  P  I  Y  S  V  R  M  G  T  K  T  T  V  I  V  G  H  H  Q         p.80

          .         .         .         .         .        | 02.    g.7144
 CTGGCCAAGGAGGTGCTTATTAAGAAGGGCAAGGACTTCTCTGGGCGGCCTCAAATG | GCA    c.300
 L  A  K  E  V  L  I  K  K  G  K  D  F  S  G  R  P  Q  M   | A      p.100

          .         .         .         .         .         .       g.7204
 ACTCTAGACATCGCGTCCAACAACCGTAAGGGTATCGCCTTCGCTGACTCTGGCGCACAC       c.360
 T  L  D  I  A  S  N  N  R  K  G  I  A  F  A  D  S  G  A  H         p.120

          .         .         .         .         .         .       g.7264
 TGGCAGCTGCATCGAAGGCTGGCGATGGCCACCTTTGCCCTGTTCAAGGATGGCGATCAG       c.420
 W  Q  L  H  R  R  L  A  M  A  T  F  A  L  F  K  D  G  D  Q         p.140

          .       | 03 .         .         .         .         .    g.7563
 AAGCTGGAGAAGATCA | TTTGTCAGGAAATCAGTACATTGTGTGATATGCTGGCCACCCAC    c.480
 K  L  E  K  I  I |   C  Q  E  I  S  T  L  C  D  M  L  A  T  H      p.160

          .         .         .         .         .         .       g.7623
 AACGGACAGTCCATAGACATCTCCTTTCCTGTCTTCGTGGCGGTAACCAATGTCATCTCC       c.540
 N  G  Q  S  I  D  I  S  F  P  V  F  V  A  V  T  N  V  I  S         p.180

          .         .         .         .         .         .       g.7683
 TTGATCTGCTTCAATACCTCCTACAAGAATGGGGACCCTGAGTTGAATGTCATACAGAAT       c.600
 L  I  C  F  N  T  S  Y  K  N  G  D  P  E  L  N  V  I  Q  N         p.200

          .         .         .         .         .         .       g.7743
 TACAATGAAGGCATCATAGACAACCTGAGCAAAGACAGCCTGGTGGACCTAGTCCCCTGG       c.660
 Y  N  E  G  I  I  D  N  L  S  K  D  S  L  V  D  L  V  P  W         p.220

        | 04 .         .         .         .         .         .    g.8465
 TTGAAG | ATTTTCCCCAACAAAACCCTGGAAAAATTAAAGAGCCATGTTAAAATACGAAAT    c.720
 L  K   | I  F  P  N  K  T  L  E  K  L  K  S  H  V  K  I  R  N      p.240

          .         .         .    | 05    .         .         .    g.9352
 GATCTGCTGAATAAAATACTTGAAAATTACAAG | GAGAAATTCCGGAGTGACTCTATCACC    c.780
 D  L  L  N  K  I  L  E  N  Y  K   | E  K  F  R  S  D  S  I  T      p.260

          .         .         .         .         .         .       g.9412
 AACATGCTGGACACACTGATGCAAGCCAAGATGAACTCAGATAATGGCAATGCTGGCCCA       c.840
 N  M  L  D  T  L  M  Q  A  K  M  N  S  D  N  G  N  A  G  P         p.280

          .         .         .         .         .         .       g.9472
 GATCAAGACTCAGAGCTGCTTTCAGATAACCACATTCTCACCACCATAGGGGACATCTTT       c.900
 D  Q  D  S  E  L  L  S  D  N  H  I  L  T  T  I  G  D  I  F         p.300

          .         .         .         .         .         .       g.9532
 GGGGCTGGCGTGGAGACCACCACCTCTGTGGTTAAATGGACCCTGGCCTTCCTGCTGCAC       c.960
 G  A  G  V  E  T  T  T  S  V  V  K  W  T  L  A  F  L  L  H         p.320

           | 06        .         .         .         .         .    g.9904
 AATCCTCAG | GTGAAGAAGAAGCTCTACGAGGAGATTGACCAGAATGTGGGTTTCAGCCGC    c.1020
 N  P  Q   | V  K  K  K  L  Y  E  E  I  D  Q  N  V  G  F  S  R      p.340

          .         .         .         .         .         .       g.9964
 ACACCAACTATCAGTGACCGTAACCGTCTCCTCCTGCTGGAGGCCACCATCCGAGAGGTG       c.1080
 T  P  T  I  S  D  R  N  R  L  L  L  L  E  A  T  I  R  E  V         p.360

          .         .         .         .         .          | 07    g.10923
 CTTCGCCTCAGGCCCGTGGCCCCTATGCTCATCCCCCACAAGGCCAACGTTGACTCCAG | C    c.1140
 L  R  L  R  P  V  A  P  M  L  I  P  H  K  A  N  V  D  S  S  |      p.380

          .         .         .         .         .         .       g.10983
 ATCGGTGAGTTTGCTGTGGACAAGGGCACAGAAGTTATCATCAATCTGTGGGCGCTGCAT       c.1200
 I  G  E  F  A  V  D  K  G  T  E  V  I  I  N  L  W  A  L  H         p.400

          .         .         .         .    | 08    .         .    g.11565
 CACAATGAGAAGGAGTGGCACCAGCCGGATCAGTTCATGCCTG | AGCGTTTCTTGAATCCA    c.1260
 H  N  E  K  E  W  H  Q  P  D  Q  F  M  P  E |   R  F  L  N  P      p.420

          .         .         .         .         .         .       g.11625
 GCGGGGACCCAGCTCATCTCACCGTCAGTAAGCTATTTGCCCTTCGGAGCAGGACCTCGC       c.1320
 A  G  T  Q  L  I  S  P  S  V  S  Y  L  P  F  G  A  G  P  R         p.440

          .         .         .         .         .         .       g.11685
 TCCTGTATAGGTGAGATCCTGGCCCGCCAGGAGCTCTTCCTCATCATGGCCTGGCTGCTG       c.1380
 S  C  I  G  E  I  L  A  R  Q  E  L  F  L  I  M  A  W  L  L         p.460

          .         .         .         .         .         .       g.11745
 CAGAGGTTCGACCTGGAGGTGCCAGATGATGGGCAGCTGCCCTCCCTGGAAGGCATCCCC       c.1440
 Q  R  F  D  L  E  V  P  D  D  G  Q  L  P  S  L  E  G  I  P         p.480

          .         .         .         .         .         .       g.11805
 AAGGTGGTCTTTCTGATCGACTCTTTCAAAGTGAAGATCAAGGTGCGCCAGGCCTGGAGG       c.1500
 K  V  V  F  L  I  D  S  F  K  V  K  I  K  V  R  Q  A  W  R         p.500

          .         .                                               g.11832
 GAAGCCCAGGCTGAGGGTAGCACCTAA                                        c.1527
 E  A  Q  A  E  G  S  T  X                                          p.508

          .         .         .         .         .         .       g.11892
 aggctgtaactcacagcccctgtccaccctatgtggccccacaacacagatttagagata       c.*60

          .         .         .         .         .         .       g.11952
 caaccccccacccttctccgccattcttccctactcccaacccactctgccttctttttc       c.*120

          .         .         .         .         .                 g.12003
 agcttgtggcaatgccagtgatgtgcataaacagtttttttttttccataa                c.*171

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Cytochrome P450, family 17, subfamily A, polypeptide 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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