cytochrome P450, family 1, subfamily A, polypeptide 2 (CYP1A2) - coding DNA reference sequence

(used for variant description)

(last modified December 16, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_000761.3 in the CYP1A2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008431.1, covering CYP1A2 transcript NM_000761.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.31305
                                                         gaag       c.-61

 .         .         .         .         .         . | 02           g.32197
 ctccacaccagccattacaaccctgccaatctcaagcacctgcctctacag | ttggtacag    c.-1

          .         .         .         .         .         .       g.32257
 ATGGCATTGTCCCAGTCTGTTCCCTTCTCGGCCACAGAGCTTCTCCTGGCCTCTGCCATC       c.60
 M  A  L  S  Q  S  V  P  F  S  A  T  E  L  L  L  A  S  A  I         p.20

          .         .         .         .         .         .       g.32317
 TTCTGCCTGGTATTCTGGGTGCTCAAGGGTTTGAGGCCTCGGGTCCCCAAAGGCCTGAAA       c.120
 F  C  L  V  F  W  V  L  K  G  L  R  P  R  V  P  K  G  L  K         p.40

          .         .         .         .         .         .       g.32377
 AGTCCACCAGAGCCATGGGGCTGGCCCTTGCTCGGGCATGTGCTGACCCTGGGGAAGAAC       c.180
 S  P  P  E  P  W  G  W  P  L  L  G  H  V  L  T  L  G  K  N         p.60

          .         .         .         .         .         .       g.32437
 CCGCACCTGGCACTGTCAAGGATGAGCCAGCGCTACGGGGACGTCCTGCAGATCCGCATT       c.240
 P  H  L  A  L  S  R  M  S  Q  R  Y  G  D  V  L  Q  I  R  I         p.80

          .         .         .         .         .         .       g.32497
 GGCTCCACGCCCGTGCTGGTGCTGAGCCGCCTGGACACCATCCGGCAGGCCCTGGTGCGG       c.300
 G  S  T  P  V  L  V  L  S  R  L  D  T  I  R  Q  A  L  V  R         p.100

          .         .         .         .         .         .       g.32557
 CAGGGCGACGATTTCAAGGGCCGGCCTGACCTCTACACCTCCACCCTCATCACTGATGGC       c.360
 Q  G  D  D  F  K  G  R  P  D  L  Y  T  S  T  L  I  T  D  G         p.120

          .         .         .         .         .         .       g.32617
 CAGAGCTTGACCTTCAGCACAGACTCTGGACCGGTGTGGGCTGCCCGCCGGCGCCTGGCC       c.420
 Q  S  L  T  F  S  T  D  S  G  P  V  W  A  A  R  R  R  L  A         p.140

          .         .         .         .         .         .       g.32677
 CAGAATGCCCTCAACACCTTCTCCATCGCCTCTGACCCAGCTTCCTCATCCTCCTGCTAC       c.480
 Q  N  A  L  N  T  F  S  I  A  S  D  P  A  S  S  S  S  C  Y         p.160

          .         .         .         .         .         .       g.32737
 CTGGAGGAGCATGTGAGCAAGGAGGCTAAGGCCCTGATCAGCAGGTTGCAGGAGCTGATG       c.540
 L  E  E  H  V  S  K  E  A  K  A  L  I  S  R  L  Q  E  L  M         p.180

          .         .         .         .         .         .       g.32797
 GCAGGGCCTGGGCACTTCGACCCTTACAATCAGGTGGTGGTGTCAGTGGCCAACGTCATT       c.600
 A  G  P  G  H  F  D  P  Y  N  Q  V  V  V  S  V  A  N  V  I         p.200

          .         .         .         .         .         .       g.32857
 GGTGCCATGTGCTTCGGACAGCACTTCCCTGAGAGTAGCGATGAGATGCTCAGCCTCGTG       c.660
 G  A  M  C  F  G  Q  H  F  P  E  S  S  D  E  M  L  S  L  V         p.220

          .         .         .         .         .         .       g.32917
 AAGAACACTCATGAGTTCGTGGAGACTGCCTCCTCCGGGAACCCCCTGGACTTCTTCCCC       c.720
 K  N  T  H  E  F  V  E  T  A  S  S  G  N  P  L  D  F  F  P         p.240

          .         .         .         .         .         .       g.32977
 ATCCTTCGCTACCTGCCTAACCCTGCCCTGCAGAGGTTCAAGGCCTTCAACCAGAGGTTC       c.780
 I  L  R  Y  L  P  N  P  A  L  Q  R  F  K  A  F  N  Q  R  F         p.260

          .         .         .         .         .  | 03      .    g.33656
 CTGTGGTTCCTGCAGAAAACAGTCCAGGAGCACTATCAGGACTTTGACAAG | AACAGTGTC    c.840
 L  W  F  L  Q  K  T  V  Q  E  H  Y  Q  D  F  D  K   | N  S  V      p.280

          .         .         .         .         .         .       g.33716
 CGGGACATCACGGGTGCCCTGTTCAAGCACAGCAAGAAGGGGCCTAGAGCCAGCGGCAAC       c.900
 R  D  I  T  G  A  L  F  K  H  S  K  K  G  P  R  A  S  G  N         p.300

          .         .         .         .         .   | 04     .    g.34231
 CTCATCCCACAGGAGAAGATTGTCAACCTTGTCAATGACATCTTTGGAGCAG | GATTTGAC    c.960
 L  I  P  Q  E  K  I  V  N  L  V  N  D  I  F  G  A  G |   F  D      p.320

          .         .         .         .         .         .       g.34291
 ACAGTCACCACAGCCATCTCCTGGAGCCTCATGTACCTTGTGACCAAGCCTGAGATACAG       c.1020
 T  V  T  T  A  I  S  W  S  L  M  Y  L  V  T  K  P  E  I  Q         p.340

          .         .   | 05     .         .         .         .    g.34620
 AGGAAGATCCAGAAGGAGCTGG | ACACTGTGATTGGCAGGGAGCGGCGGCCCCGGCTCTCT    c.1080
 R  K  I  Q  K  E  L  D |   T  V  I  G  R  E  R  R  P  R  L  S      p.360

          .         .         .         .         .         .       g.34680
 GACAGACCCCAGCTGCCCTACTTGGAGGCCTTCATCCTGGAGACCTTCCGACACTCCTCC       c.1140
 D  R  P  Q  L  P  Y  L  E  A  F  I  L  E  T  F  R  H  S  S         p.380

          .         .       | 06 .         .         .         .    g.35676
 TTCTTGCCCTTCACCATCCCCCACAG | CACAACAAGGGACACAACGCTGAATGGCTTCTAC    c.1200
 F  L  P  F  T  I  P  H  S  |  T  T  R  D  T  T  L  N  G  F  Y      p.400

          .         .         .         .         .    | 07    .    g.37256
 ATCCCCAAGAAATGCTGTGTCTTCGTAAACCAGTGGCAGGTCAACCATGACCC | AGAGCTG    c.1260
 I  P  K  K  C  C  V  F  V  N  Q  W  Q  V  N  H  D  P  |  E  L      p.420

          .         .         .         .         .         .       g.37316
 TGGGAGGACCCCTCTGAGTTCCGGCCTGAGCGGTTCCTCACCGCCGATGGCACTGCCATT       c.1320
 W  E  D  P  S  E  F  R  P  E  R  F  L  T  A  D  G  T  A  I         p.440

          .         .         .         .         .         .       g.37376
 AACAAGCCCTTGAGTGAGAAGATGATGCTGTTTGGCATGGGCAAGCGCCGGTGTATCGGG       c.1380
 N  K  P  L  S  E  K  M  M  L  F  G  M  G  K  R  R  C  I  G         p.460

          .         .         .         .         .         .       g.37436
 GAAGTCCTGGCCAAGTGGGAGATCTTCCTCTTCCTGGCCATCCTGCTACAGCAACTGGAG       c.1440
 E  V  L  A  K  W  E  I  F  L  F  L  A  I  L  L  Q  Q  L  E         p.480

          .         .         .         .         .         .       g.37496
 TTCAGCGTGCCGCCGGGCGTGAAAGTCGACCTGACCCCCATCTACGGGCTGACCATGAAG       c.1500
 F  S  V  P  P  G  V  K  V  D  L  T  P  I  Y  G  L  T  M  K         p.500

          .         .         .         .         .                 g.37547
 CACGCCCGCTGTGAACATGTCCAGGCGCGGCTGCGCTTCTCCATCAACTGA                c.1551
 H  A  R  C  E  H  V  Q  A  R  L  R  F  S  I  N  X                  p.516

          .         .         .         .         .         .       g.37607
 agaagacaccaccattctgaggccagggagcgagtgggggccagccacggggactcagcc       c.*60

          .         .         .         .         .         .       g.37667
 cttgtttctcttcctttctttttttaaaaaatagcagctttagccaagtgcagggcctgt       c.*120

          .         .         .         .         .         .       g.37727
 aatcccagcattttaggaggccaaggttggaggatcatttgagcccaggaattggaaagc       c.*180

          .         .         .         .         .         .       g.37787
 agcctggccaacatagtgggaccctgtctctacaaaaaaaaaatttgccaagagcctgag       c.*240

          .         .         .         .         .         .       g.37847
 tgacagagcaagaccccatctcaaaaaaaaaaacaaacaaacaaaaaaaaaaccatatat       c.*300

          .         .         .         .         .         .       g.37907
 atacatatatatatagcagctttatggagatataattcttatgccatataattcaccttc       c.*360

          .         .         .         .         .         .       g.37967
 tttttttttttttgtctgagacagaatctcagtctgtcacccaggttggagtgcagtggc       c.*420

          .         .         .         .         .         .       g.38027
 gtgatctcagctcactgcaacctccacctcgcaggttcaagcaatcctcccacttcagcc       c.*480

          .         .         .         .         .         .       g.38087
 tcccaagcacctgggattacaagcatgagtcactacgcctggctgatttttgtagtttta       c.*540

          .         .         .         .         .         .       g.38147
 gtggagatggggtttcaccatgttggccaggcttgtctcgaactcctgaccccaagttat       c.*600

          .         .         .         .         .         .       g.38207
 ccacctgccttggcttcccaaagtcctgggattacaggtgtgagccaccacatccagcct       c.*660

          .         .         .         .         .         .       g.38267
 aacttacattcttaaagtgtcgaatgacttctagtgtagaattgtgcaaccatcaccaga       c.*720

          .         .         .         .         .         .       g.38327
 attaattttattattcttattatttttgagacagagtcttactctgttgccaggctggag       c.*780

          .         .         .         .         .         .       g.38387
 tgcagtggcgcgatctcagctcactacaacctccgcctcccatgttcaagcgattctcct       c.*840

          .         .         .         .         .         .       g.38447
 gcctcagcctcccgagtagctgggactataggcatgcgccaccatggccagctaattttt       c.*900

          .         .         .         .         .         .       g.38507
 gtatttttagtagagacgaggtttcactgtgttggccaggatggtctccatctcttgacc       c.*960

          .         .         .         .         .         .       g.38567
 tcgtgatccacccgcctcagcctcccaaagtgctgggattaacaggtatgaaccaccgcg       c.*1020

          .         .         .         .         .         .       g.38627
 cccagcctttttgttttttttttttttgagacagagtcttcctctgtctcctaagctgga       c.*1080

          .         .         .         .         .         .       g.38687
 gtgcagtggcatcatctcagctcactgcaacctctgcctcccaggttcaagtgcttctcc       c.*1140

          .         .         .         .         .         .       g.38747
 agcctcagcctcccaagtagctgagactacaggcacacaccaccacgcctggctaatttt       c.*1200

          .         .         .         .         .         .       g.38807
 tgtatttttagtagagacgggtttcaccatgttggctagactagtctcaaactcctgacc       c.*1260

          .         .         .         .         .         .       g.38867
 tcaagtgatctgcccgcctcgacctctctcaaagtgctggcattacaggtgtgagccacg       c.*1320

          .         .         .         .         .         .       g.38927
 gtgcccggcccacaattaattttagaacattttcatcacccctaaaagaaaccctgcacc       c.*1380

          .         .         .         .         .         .       g.38987
 cattagcagtccctccacatttccccctagcctgcctcccctgcctcaccagccctggca       c.*1440

          .         .         .         .         .         .       g.39047
 actgctaatctactttctgtgtctatggatttgccttctctaaacatttcatataaatgg       c.*1500

          .                                                         g.39059
 aattacacaatg                                                       c.*1512

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Cytochrome P450, family 1, subfamily A, polypeptide 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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