cytochrome P450, family 24, subfamily A, polypeptide 1 (CYP24A1) - coding DNA reference sequence

(used for variant description)

(last modified May 27, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_000782.4 in the CYP24A1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008334.1, covering CYP24A1 transcript NM_000782.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5038
                       gacaggaggaaacgcagcgccagcagcatctcatctac       c.-361

 .         .         .         .         .         .                g.5098
 cctccttgacacctccccgtggctccagccagaccctagaggtcagccttgcggaccaac       c.-301

 .         .         .         .         .         .                g.5158
 aggaggactcccagctttcccttttcaagaggtccccagacaccggccaccctcttccag       c.-241

 .         .         .         .         .         .                g.5218
 cccctgcggccagtgcaaggaggcaccaatgctctgaggctgtcgcgtggtgcagcgtcg       c.-181

 .         .         .         .         .         .                g.5278
 agcatcctcgccgaggtcctttctgctgcctgtcccgcctcaccccgctccatcacacca       c.-121

 .         .         .         .         .         .                g.5338
 gctggccctctttgcttccttttcccagaatcgttaagccccgactcccactagcacctc       c.-61

 .         .         .         .         .         .                g.5398
 gtaccaacctcgccccaccccatcctcctgccttcccgcgctccggtgtcccccgctgcc       c.-1

          .         .         .         .         .         .       g.5458
 ATGAGCTCCCCCATCAGCAAGAGCCGCTCGCTTGCCGCCTTCCTGCAGCAGCTGCGCAGT       c.60
 M  S  S  P  I  S  K  S  R  S  L  A  A  F  L  Q  Q  L  R  S         p.20

          .         .         .         .         .         .       g.5518
 CCGAGGCAGCCCCCGAGACTGGTGACATCTACGGCGTACACGTCCCCTCAGCCGCGAGAG       c.120
 P  R  Q  P  P  R  L  V  T  S  T  A  Y  T  S  P  Q  P  R  E         p.40

          .         .         .         .         .         .       g.5578
 GTGCCAGTCTGCCCGCTGACAGCTGGTGGCGAGACTCAGAACGCGGCCGCCCTGCCGGGC       c.180
 V  P  V  C  P  L  T  A  G  G  E  T  Q  N  A  A  A  L  P  G         p.60

          .         .         .         .         .         .       g.5638
 CCCACCAGCTGGCCACTGCTGGGCAGCCTGCTGCAGATTCTCTGGAAAGGGGGTCTCAAG       c.240
 P  T  S  W  P  L  L  G  S  L  L  Q  I  L  W  K  G  G  L  K         p.80

          .         | 02         .         .         .         .    g.5920
 AAACAGCACGACACCCTG | GTGGAGTACCACAAGAAGTATGGCAAGATTTTCCGCATGAAG    c.300
 K  Q  H  D  T  L   | V  E  Y  H  K  K  Y  G  K  I  F  R  M  K      p.100

          .         .         .         .         .         .       g.5980
 TTGGGTTCCTTTGAGTCGGTGCACCTGGGCTCGCCATGCCTGCTGGAAGCGCTGTACCGC       c.360
 L  G  S  F  E  S  V  H  L  G  S  P  C  L  L  E  A  L  Y  R         p.120

          .         .         .         .         .         .       g.6040
 ACCGAGAGCGCGTACCCGCAGCGGCTGGAGATCAAACCGTGGAAGGCCTATCGCGACTAC       c.420
 T  E  S  A  Y  P  Q  R  L  E  I  K  P  W  K  A  Y  R  D  Y         p.140

          .         .          | 03        .         .         .    g.7338
 CGCAAAGAAGGCTACGGGCTGCTGATCCT | GGAAGGGGAAGACTGGCAGCGGGTCCGGAGT    c.480
 R  K  E  G  Y  G  L  L  I  L  |  E  G  E  D  W  Q  R  V  R  S      p.160

          .         .         .         .         .         .       g.7398
 GCCTTTCAAAAGAAACTAATGAAACCAGGGGAAGTGATGAAGCTGGACAACAAAATCAAT       c.540
 A  F  Q  K  K  L  M  K  P  G  E  V  M  K  L  D  N  K  I  N         p.180

     | 04    .         .         .         .         .         .    g.9346
 GAG | GTCTTGGCCGATTTTATGGGCAGAATAGATGAGCTCTGTGATGAAAGAGGCCACGTT    c.600
 E   | V  L  A  D  F  M  G  R  I  D  E  L  C  D  E  R  G  H  V      p.200

          .         .         .         . | 05       .         .    g.13164
 GAAGACTTGTACAGCGAACTGAACAAATGGTCGTTTGAAA | GTATCTGCCTCGTGTTGTAT    c.660
 E  D  L  Y  S  E  L  N  K  W  S  F  E  S |   I  C  L  V  L  Y      p.220

          .         .         .         .         .         .       g.13224
 GAGAAGAGATTTGGGCTTCTCCAGAAGAATGCAGGGGATGAAGCTGTGAACTTCATCATG       c.720
 E  K  R  F  G  L  L  Q  K  N  A  G  D  E  A  V  N  F  I  M         p.240

          .   | 06     .         .         .         .         .    g.14462
 GCCATCAAAACA | ATGATGAGCACGTTTGGGAGGATGATGGTCACTCCAGTCGAGCTGCAC    c.780
 A  I  K  T   | M  M  S  T  F  G  R  M  M  V  T  P  V  E  L  H      p.260

          .         .         .         .         .         .       g.14522
 AAGAGCCTCAACACCAAGGTCTGGCAGGACCACACTCTGGCCTGGGACACCATTTTCAAA       c.840
 K  S  L  N  T  K  V  W  Q  D  H  T  L  A  W  D  T  I  F  K         p.280

      | 07   .         .         .         .         .         .    g.16171
 TCAG | TCAAAGCTTGTATCGACAACCGGTTAGAGAAGTATTCTCAGCAGCCTAGTGCAGAT    c.900
 S  V |   K  A  C  I  D  N  R  L  E  K  Y  S  Q  Q  P  S  A  D      p.300

          .         .         .         .         .         .       g.16231
 TTCCTTTGTGACATTTATCACCAGAATCGGCTTTCAAAGAAAGAATTGTATGCTGCTGTC       c.960
 F  L  C  D  I  Y  H  Q  N  R  L  S  K  K  E  L  Y  A  A  V         p.320

          .         .         . | 08       .         .         .    g.19884
 ACAGAGCTCCAGCTGGCTGCGGTGGAAACG | ACAGCAAACAGTCTAATGTGGATTCTCTAC    c.1020
 T  E  L  Q  L  A  A  V  E  T   | T  A  N  S  L  M  W  I  L  Y      p.340

          .         .         .         .         .         .       g.19944
 AATTTATCCCGTAATCCCCAAGTGCAACAAAAGCTTCTTAAGGAAATTCAAAGTGTATTA       c.1080
 N  L  S  R  N  P  Q  V  Q  Q  K  L  L  K  E  I  Q  S  V  L         p.360

          .         .         .         .         .         .       g.20004
 CCTGAGAATCAGGTGCCACGGGCAGAAGATTTGAGGAATATGCCGTATTTAAAAGCCTGT       c.1140
 P  E  N  Q  V  P  R  A  E  D  L  R  N  M  P  Y  L  K  A  C         p.380

          .        | 09.         .         .         .         .    g.20856
 CTGAAAGAATCTATGAG | GCTTACGCCGAGTGTACCATTTACAACTCGGACTCTTGACAAG    c.1200
 L  K  E  S  M  R  |  L  T  P  S  V  P  F  T  T  R  T  L  D  K      p.400

          .         .         .       | 10 .         .         .    g.21416
 GCAACAGTTCTGGGTGAATATGCTTTACCCAAAGGA | ACAGTGCTCATGCTAAATACCCAG    c.1260
 A  T  V  L  G  E  Y  A  L  P  K  G   | T  V  L  M  L  N  T  Q      p.420

          .         .         .         .         .         .       g.21476
 GTGTTGGGATCCAGTGAAGACAATTTTGAAGATTCAAGTCAGTTTAGACCTGAACGTTGG       c.1320
 V  L  G  S  S  E  D  N  F  E  D  S  S  Q  F  R  P  E  R  W         p.440

          .         .         .         .         .         .       g.21536
 CTTCAGGAGAAGGAAAAAATTAATCCTTTTGCGCATCTTCCATTTGGCGTTGGAAAAAGA       c.1380
 L  Q  E  K  E  K  I  N  P  F  A  H  L  P  F  G  V  G  K  R         p.460

          .         .         .         .         .     | 11   .    g.21694
 ATGTGCATTGGTCGCCGATTAGCAGAGCTTCAACTGCATTTGGCTCTTTGTTGG | ATTGTC    c.1440
 M  C  I  G  R  R  L  A  E  L  Q  L  H  L  A  L  C  W   | I  V      p.480

          .         .         .         .         .         .       g.21754
 CGCAAATACGACATCCAGGCCACAGACAATGAGCCTGTTGAGATGCTACACTCAGGCACC       c.1500
 R  K  Y  D  I  Q  A  T  D  N  E  P  V  E  M  L  H  S  G  T         p.500

          .         .         .         .                       g.21799
 CTGGTGCCCAGCCGGGAACTCCCCATCGCGTTTTGCCAGCGATAA |                   c.1546
 L  V  P  S  R  E  L  P  I  A  F  C  Q  R  X                     p.514

          . | 12       .         .         .         .         .    g.24266
 tacgcctcag | atggtggtatttgctaacatcatatccaactcagggaagcggactgagtg    c.*60

          .         .         .         .         .         .       g.24326
 ctgggatccaaggcattctacagggttcactgctggtttacacttcacctgtgtcagcac       c.*120

          .         .         .         .         .         .       g.24386
 catcttcaggtgcttagaatggcctgggagcctgttctgtcttgcatcttccatgacatg       c.*180

          .         .         .         .         .         .       g.24446
 aaagggaggctggcacttgtcagtcaggtagaggttacaaaccgtttcaggccctgccta       c.*240

          .         .         .         .         .         .       g.24506
 ccacattcactgtttgaatctttaattcccaagaataagtttacatttcacaatgaatga       c.*300

          .         .         .         .         .         .       g.24566
 cctacaacagctaaattttctggggctgggagtaatactgacaatccatttactgtagct       c.*360

          .         .         .         .         .         .       g.24626
 ctgcttaatgtactacttaggaaaatgtccctgcttaataatgtaagccaagctaaatga       c.*420

          .         .         .         .         .         .       g.24686
 tggttaaagttatcaggcctcccatgaaattgcgttcttcctgcattgaaataaaaacat       c.*480

          .         .         .         .         .         .       g.24746
 tattgggaaactagagaacacctctatttttaaaaggactttaacgaagtcaaacaactt       c.*540

          .         .         .         .         .         .       g.24806
 ataagactagtgattcactggggcattattttgttagaggaccttaaaattgtttatttt       c.*600

          .         .         .         .         .         .       g.24866
 ttaaatgtgattcctttatggcattagggtaaagatgaagcaataatttttaaattgtgt       c.*660

          .         .         .         .         .         .       g.24926
 atgtgcatatgaagcacagacatgcatgtgtgtgtgtgtctgtgtgtgtgtgtccgtgta       c.*720

          .         .         .         .         .         .       g.24986
 tgtgtgtgtgggttctaatggtaatttgcctcagtcatttttttaatatttgcagtactt       c.*780

          .         .         .         .         .         .       g.25046
 gatttaggatctgtggtgcagggcaatgtttcaaagtttagtcacagcttaaaaacattc       c.*840

          .         .         .         .         .         .       g.25106
 agtgtgactttaatattataaaatgatttcccatgccataatttttctgtctattaaatg       c.*900

          .         .         .         .         .         .       g.25166
 ggacaagtgtaaagcatgcaaaagttagagatctgttatataacatttgttttgtgattt       c.*960

          .         .         .         .         .         .       g.25226
 gaactcctaggaaaaatatgatttcataaatgtaaaatgcacagaaatgcatgcaatact       c.*1020

          .         .         .         .         .         .       g.25286
 tataagacttaaaaattgtgtttacagatggtttatttgtgcatatttttactactgctt       c.*1080

          .         .         .         .         .         .       g.25346
 ttcctaaatgcatactgtatataattctgtgtatttgataaatatttcttcctacattat       c.*1140

          .         .         .         .         .         .       g.25406
 atttttagaatatttcagaaatatacatttatgtctttatattgtaataaatatgtacat       c.*1200

          .         .         .         .         .         .       g.25466
 atctaggtatatgctttctctctgctgtgaaattatttttagaattataaattcacgtct       c.*1260

          .         .         .         .         .         .       g.25526
 tgtcagatttcatctgtataccttcaaattctctgaaagtaaaaataaaagtttttaaat       c.*1320

                                                                    g.25529
 att                                                                c.*1323

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Cytochrome P450, family 24, subfamily A, polypeptide 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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