cytochrome P450, family 27, subfamily B, polypeptide 1 (CYP27B1) - coding DNA reference sequence

(used for variant description)

(last modified August 25, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_000785.3 in the CYP27B1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007076.1, covering CYP27B1 transcript NM_000785.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5032
                             gggtgctaatccccagcacagaccactcagga       c.-121

 .         .         .         .         .         .                g.5092
 ggagggattggctgaggagcttggagagggggcgtcatcacctcacccaaaggttaaata       c.-61

 .         .         .         .         .         .                g.5152
 ggggttgagatatgatgctcaggagaagcgctttctttcgcgagcaccctgaaccagacc       c.-1

          .         .         .         .         .         .       g.5212
 ATGACCCAGACCCTCAAGTACGCCTCCAGAGTGTTCCATCGCGTCCGCTGGGCGCCCGAG       c.60
 M  T  Q  T  L  K  Y  A  S  R  V  F  H  R  V  R  W  A  P  E         p.20

          .         .         .         .         .         .       g.5272
 TTGGGCGCCTCCCTAGGCTACCGAGAGTACCACTCAGCACGCCGGAGCTTGGCAGACATC       c.120
 L  G  A  S  L  G  Y  R  E  Y  H  S  A  R  R  S  L  A  D  I         p.40

          .         .         .         .         .         .       g.5332
 CCAGGCCCCTCTACGCCCAGCTTTCTGGCCGAACTTTTCTGCAAGGGGGGGCTGTCGAGG       c.180
 P  G  P  S  T  P  S  F  L  A  E  L  F  C  K  G  G  L  S  R         p.60

          .      | 02  .         .         .         .         .    g.6041
 CTACACGAGCTGCAG | GTGCAGGGCGCCGCGCACTTCGGGCCGGTGTGGCTAGCCAGCTTT    c.240
 L  H  E  L  Q   | V  Q  G  A  A  H  F  G  P  V  W  L  A  S  F      p.80

          .         .         .         .         .         .       g.6101
 GGGACAGTGCGCACCGTGTACGTGGCTGCCCCTGCACTCGTCGAGGAGCTGCTGCGACAG       c.300
 G  T  V  R  T  V  Y  V  A  A  P  A  L  V  E  E  L  L  R  Q         p.100

          .         .         .         .         .         .       g.6161
 GAGGGACCCCGGCCCGAGCGCTGCAGCTTCTCGCCCTGGACGGAGCACCGCCGCTGCCGC       c.360
 E  G  P  R  P  E  R  C  S  F  S  P  W  T  E  H  R  R  C  R         p.120

          .         .       | 03 .         .         .         .    g.6728
 CAGCGGGCTTGCGGACTGCTCACTGC | GGAAGGCGAAGAATGGCAAAGGCTCCGCAGTCTC    c.420
 Q  R  A  C  G  L  L  T  A  |  E  G  E  E  W  Q  R  L  R  S  L      p.140

          .         .         .         .         .         .       g.6788
 CTGGCCCCGCTCCTCCTCCGGCCTCAAGCGGCCGCCCGCTACGCCGGAACCCTGAACAAC       c.480
 L  A  P  L  L  L  R  P  Q  A  A  A  R  Y  A  G  T  L  N  N         p.160

          .         .         .         .         .         .       g.6848
 GTAGTCTGCGACCTTGTGCGGCGTCTGAGGCGCCAGCGGGGACGTGGCACGGGGCCGCCC       c.540
 V  V  C  D  L  V  R  R  L  R  R  Q  R  G  R  G  T  G  P  P         p.180

          .         .         .         .          | 04        .    g.6993
 GCCCTGGTTCGGGACGTGGCGGGGGAATTTTACAAGTTCGGACTGGAAG | GCATCGCCGCG    c.600
 A  L  V  R  D  V  A  G  E  F  Y  K  F  G  L  E  G |   I  A  A      p.200

          .         .         .         .         .         .       g.7053
 GTTCTGCTCGGCTCGCGCTTGGGCTGCCTGGAGGCTCAAGTGCCACCCGACACGGAGACC       c.660
 V  L  L  G  S  R  L  G  C  L  E  A  Q  V  P  P  D  T  E  T         p.220

          .         .         .         .         .         .       g.7113
 TTCATCCGCGCTGTGGGCTCGGTGTTTGTGTCCACGCTGTTGACCATGGCGATGCCCCAC       c.720
 F  I  R  A  V  G  S  V  F  V  S  T  L  L  T  M  A  M  P  H         p.240

          .         .         .         .         .         .       g.7173
 TGGCTGCGCCACCTTGTGCCTGGGCCCTGGGGCCGCCTCTGCCGAGACTGGGACCAGATG       c.780
 W  L  R  H  L  V  P  G  P  W  G  R  L  C  R  D  W  D  Q  M         p.260

          . | 05       .         .         .         .         .    g.7317
 TTTGCATTTG | CTCAGAGGCACGTGGAGCGGCGAGAGGCAGAGGCAGCCATGAGGAACGGA    c.840
 F  A  F  A |   Q  R  H  V  E  R  R  E  A  E  A  A  M  R  N  G      p.280

          .         .         .         .         .         .       g.7377
 GGACAGCCCGAGAAGGACCTGGAGTCTGGGGCGCACCTGACCCACTTCCTGTTCCGGGAA       c.900
 G  Q  P  E  K  D  L  E  S  G  A  H  L  T  H  F  L  F  R  E         p.300

          .         .         .         .         .         .       g.7437
 GAGTTGCCTGCCCAGTCCATCCTGGGAAATGTGACAGAGTTGCTATTGGCGGGAGTGGAC       c.960
 E  L  P  A  Q  S  I  L  G  N  V  T  E  L  L  L  A  G  V  D         p.320

     | 06    .         .         .         .         .         .    g.7700
 ACG | GTGTCCAACACGCTCTCTTGGGCTCTGTATGAGCTCTCCCGGCACCCCGAAGTCCAG    c.1020
 T   | V  S  N  T  L  S  W  A  L  Y  E  L  S  R  H  P  E  V  Q      p.340

          .         .         .         .         .         .       g.7760
 ACAGCACTCCACTCAGAGATCACAGCTGCCCTGAGCCCTGGCTCCAGTGCCTACCCCTCA       c.1080
 T  A  L  H  S  E  I  T  A  A  L  S  P  G  S  S  A  Y  P  S         p.360

          .         .         .         .         .       | 07 .    g.8021
 GCCACTGTTCTGTCCCAGCTGCCCCTGCTGAAGGCGGTGGTCAAGGAAGTGCTAAG | ACTG    c.1140
 A  T  V  L  S  Q  L  P  L  L  K  A  V  V  K  E  V  L  R  |  L      p.380

          .         .         .         .         .         .       g.8081
 TACCCTGTGGTACCTGGAAATTCTCGTGTCCCAGACAAAGACATTCATGTGGGTGACTAT       c.1200
 Y  P  V  V  P  G  N  S  R  V  P  D  K  D  I  H  V  G  D  Y         p.400

          .      | 08  .         .         .         .         .    g.8430
 ATTATCCCCAAAAAT | ACGCTGGTCACTCTGTGTCACTATGCCACTTCAAGGGACCCTGCC    c.1260
 I  I  P  K  N   | T  L  V  T  L  C  H  Y  A  T  S  R  D  P  A      p.420

          .         .         .         .         .         .       g.8490
 CAGTTCCCAGAGCCAAATTCTTTTCGTCCAGCTCGCTGGCTGGGGGAGGGTCCCACCCCC       c.1320
 Q  F  P  E  P  N  S  F  R  P  A  R  W  L  G  E  G  P  T  P         p.440

          .         .         .         .         .         .       g.8550
 CACCCATTTGCATCTCTTCCCTTTGGCTTTGGCAAGCGCAGCTGTATGGGGAGACGCCTG       c.1380
 H  P  F  A  S  L  P  F  G  F  G  K  R  S  C  M  G  R  R  L         p.460

          .         .         .    | 09    .         .         .    g.8965
 GCAGAGCTTGAATTGCAAATGGCTTTGGCCCAG | ATCCTAACACATTTTGAGGTGCAGCCT    c.1440
 A  E  L  E  L  Q  M  A  L  A  Q   | I  L  T  H  F  E  V  Q  P      p.480

          .         .         .         .         .         .       g.9025
 GAGCCAGGTGCGGCCCCAGTTAGACCCAAGACCCGGACTGTCCTGGTACCTGAAAGGAGC       c.1500
 E  P  G  A  A  P  V  R  P  K  T  R  T  V  L  V  P  E  R  S         p.500

          .         .                                               g.9052
 ATCAACCTACAGTTTTTGGACAGATAG                                        c.1527
 I  N  L  Q  F  L  D  R  X                                          p.508

          .         .         .         .         .         .       g.9112
 tcccatggaaagagactgtcatcatcaccctttcattcatcatagggataagattttttg       c.*60

          .         .         .         .         .         .       g.9172
 taggcacaagaccaaggtatacatcttcccctaatgcctatctgaccaaactggatagaa       c.*120

          .         .         .         .         .         .       g.9232
 ccaccatagtgaagtgtgaggcggccctgaccaatgtgtgaagtatgcacttggcctgac       c.*180

          .         .         .         .         .         .       g.9292
 tcaggaagccaggtgagaaaaccatggtctctctgcttgcttggcccttctgatcatgta       c.*240

          .         .         .         .         .         .       g.9352
 tgcatcccccaaggatgaaatcagattttaactaataatgctggatggcctgaggaaaga       c.*300

          .         .         .         .         .         .       g.9412
 ttcaactgcctctctttttgggctttcatagtgttcattgatgctgctggctaagcattt       c.*360

          .         .         .         .         .         .       g.9472
 atcaaagcataagctcagtaactgtgcatctggtctgtacctggttggtccttcgtcttt       c.*420

          .         .         .         .         .         .       g.9532
 gcatgtaagctctttgagaggaagggtgaagccttatttgttttttatgtcccctgccag       c.*480

          .         .         .         .         .         .       g.9592
 ggcctgtctctgactaggtgtcaccatacacattcttagattgaatctgaaccatgtggc       c.*540

          .         .         .         .         .         .       g.9652
 agaagggataagcagcttacttagtaggctctgtctacccccttccttctttgtcttgcc       c.*600

          .         .         .         .         .         .       g.9712
 cctaggaaggtgaatctgccctagcctggtttacggtttcttataactctcctttgctct       c.*660

          .         .         .         .         .         .       g.9772
 ctggccactattaagtgggtttgccccatcacttagttctcaggcagagacatctttggg       c.*720

          .         .         .         .         .         .       g.9832
 cctgtccctgcccaggcctctggctttttatattgaaaatttttaaatattcacaaattt       c.*780

          .         .                                               g.9860
 tagaataaatcaaatattccattcttga                                       c.*808

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Cytochrome P450, family 27, subfamily B, polypeptide 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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