cytochrome P450, family 2, subfamily B, polypeptide 6 (CYP2B6) - coding DNA reference sequence

(used for variant description)

(last modified February 2, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_000767.4 in the CYP2B6 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007929.1, covering CYP2B6 transcript NM_000767.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5007
                                                      caggacc       c.-1

          .         .         .         .         .         .       g.5067
 ATGGAACTCAGCGTCCTCCTCTTCCTTGCACTCCTCACAGGACTCTTGCTACTCCTGGTT       c.60
 M  E  L  S  V  L  L  F  L  A  L  L  T  G  L  L  L  L  L  V         p.20

          .         .         .         .         .         .       g.5127
 CAGCGCCACCCTAACACCCATGACCGCCTCCCACCAGGGCCCCGCCCTCTGCCCCTTTTG       c.120
 Q  R  H  P  N  T  H  D  R  L  P  P  G  P  R  P  L  P  L  L         p.40

          .         .         .         .         .  | 02      .    g.17711
 GGAAACCTTCTGCAGATGGATAGAAGAGGCCTACTCAAATCCTTTCTGAGG | TTCCGAGAG    c.180
 G  N  L  L  Q  M  D  R  R  G  L  L  K  S  F  L  R   | F  R  E      p.60

          .         .         .         .         .         .       g.17771
 AAATATGGGGACGTCTTCACGGTACACCTGGGACCGAGGCCCGTGGTCATGCTGTGTGGA       c.240
 K  Y  G  D  V  F  T  V  H  L  G  P  R  P  V  V  M  L  C  G         p.80

          .         .         .         .         .         .       g.17831
 GTAGAGGCCATACGGGAGGCCCTTGTGGACAAGGCTGAGGCCTTCTCTGGCCGGGGAAAA       c.300
 V  E  A  I  R  E  A  L  V  D  K  A  E  A  F  S  G  R  G  K         p.100

          .         .         .     | 03   .         .         .    g.18024
 ATCGCCATGGTCGACCCATTCTTCCGGGGATATG | GTGTGATCTTTGCCAATGGAAACCGC    c.360
 I  A  M  V  D  P  F  F  R  G  Y  G |   V  I  F  A  N  G  N  R      p.120

          .         .         .         .         .         .       g.18084
 TGGAAGGTGCTTCGGCGATTCTCTGTGACCACTATGAGGGACTTCGGGATGGGAAAGCGG       c.420
 W  K  V  L  R  R  F  S  V  T  T  M  R  D  F  G  M  G  K  R         p.140

          .         .         .         .         .         .       g.18144
 AGTGTGGAGGAGCGGATTCAGGAGGAGGCTCAGTGTCTGATAGAGGAGCTTCGGAAATCC       c.480
 S  V  E  E  R  I  Q  E  E  A  Q  C  L  I  E  E  L  R  K  S         p.160

      | 04   .         .         .         .         .         .    g.20662
 AAGG | GGGCCCTCATGGACCCCACCTTCCTCTTCCAGTCCATTACCGCCAACATCATCTGC    c.540
 K  G |   A  L  M  D  P  T  F  L  F  Q  S  I  T  A  N  I  I  C      p.180

          .         .         .         .         .         .       g.20722
 TCCATCGTCTTTGGAAAACGATTCCACTACCAAGATCAAGAGTTCCTGAAGATGCTGAAC       c.600
 S  I  V  F  G  K  R  F  H  Y  Q  D  Q  E  F  L  K  M  L  N         p.200

          .         .         .         .      | 05  .         .    g.22935
 TTGTTCTACCAGACTTTTTCACTCATCAGCTCTGTATTCGGCCAG | CTGTTTGAGCTCTTC    c.660
 L  F  Y  Q  T  F  S  L  I  S  S  V  F  G  Q   | L  F  E  L  F      p.220

          .         .         .         .         .         .       g.22995
 TCTGGCTTCTTGAAATACTTTCCTGGGGCACACAGGCAAGTTTACAAAAACCTGCAGGAA       c.720
 S  G  F  L  K  Y  F  P  G  A  H  R  Q  V  Y  K  N  L  Q  E         p.240

          .         .         .         .         .         .       g.23055
 ATCAATGCTTACATTGGCCACAGTGTGGAGAAGCACCGTGAAACCCTGGACCCCAGCGCC       c.780
 I  N  A  Y  I  G  H  S  V  E  K  H  R  E  T  L  D  P  S  A         p.260

          .         .         .         .   | 06     .         .    g.23713
 CCCAAGGACCTCATCGACACCTACCTGCTCCACATGGAAAAA | GAGAAATCCAACGCACAC    c.840
 P  K  D  L  I  D  T  Y  L  L  H  M  E  K   | E  K  S  N  A  H      p.280

          .         .         .         .         .         .       g.23773
 AGTGAATTCAGCCACCAGAACCTCAACCTCAACACGCTCTCGCTCTTCTTTGCTGGCACT       c.900
 S  E  F  S  H  Q  N  L  N  L  N  T  L  S  L  F  F  A  G  T         p.300

          .         .         .         .         .         .       g.23833
 GAGACCACCAGCACCACTCTCCGCTACGGCTTCCTGCTCATGCTCAAATACCCTCATGTT       c.960
 E  T  T  S  T  T  L  R  Y  G  F  L  L  M  L  K  Y  P  H  V         p.320

      | 07   .         .         .         .         .         .    g.26055
 GCAG | AGAGAGTCTACAGGGAGATTGAACAGGTGATTGGCCCACATCGCCCTCCAGAGCTT    c.1020
 A  E |   R  V  Y  R  E  I  E  Q  V  I  G  P  H  R  P  P  E  L      p.340

          .         .         .         .         .         .       g.26115
 CATGACCGAGCCAAAATGCCATACACAGAGGCAGTCATCTATGAGATTCAGAGATTTTCC       c.1080
 H  D  R  A  K  M  P  Y  T  E  A  V  I  Y  E  I  Q  R  F  S         p.360

          .         .         .         .         .         .       g.26175
 GACCTTCTCCCCATGGGTGTGCCCCACATTGTCACCCAACACACCAGCTTCCGAGGGTAC       c.1140
 D  L  L  P  M  G  V  P  H  I  V  T  Q  H  T  S  F  R  G  Y         p.380

          .   | 08     .         .         .         .         .    g.26423
 ATCATCCCCAAG | GACACAGAAGTATTTCTCATCCTGAGCACTGCTCTCCATGACCCACAC    c.1200
 I  I  P  K   | D  T  E  V  F  L  I  L  S  T  A  L  H  D  P  H      p.400

          .         .         .         .         .         .       g.26483
 TACTTTGAAAAACCAGACGCCTTCAATCCTGACCACTTTCTGGATGCCAATGGGGCACTG       c.1260
 Y  F  E  K  P  D  A  F  N  P  D  H  F  L  D  A  N  G  A  L         p.420

          .         .         .     | 09   .         .         .    g.30373
 AAAAAGACTGAAGCTTTTATCCCCTTCTCCTTAG | GGAAGCGGATTTGTCTTGGTGAAGGC    c.1320
 K  K  T  E  A  F  I  P  F  S  L  G |   K  R  I  C  L  G  E  G      p.440

          .         .         .         .         .         .       g.30433
 ATCGCCCGTGCGGAATTGTTCCTCTTCTTCACCACCATCCTCCAGAACTTCTCCATGGCC       c.1380
 I  A  R  A  E  L  F  L  F  F  T  T  I  L  Q  N  F  S  M  A         p.460

          .         .         .         .         .         .       g.30493
 AGCCCCGTGGCCCCAGAAGACATCGATCTGACACCCCAGGAGTGTGGTGTGGGCAAAATA       c.1440
 S  P  V  A  P  E  D  I  D  L  T  P  Q  E  C  G  V  G  K  I         p.480

          .         .         .                                     g.30529
 CCCCCAACATACCAGATCCGCTTCCTGCCCCGCTGA                               c.1476
 P  P  T  Y  Q  I  R  F  L  P  R  X                                 p.491

          .         .         .         .         .         .       g.30589
 aggggctgagggaagggggtcaaaggattccagggtcattcagtgtccccgcctctgtag       c.*60

          .         .         .         .         .         .       g.30649
 acaatggctctgactccccgcaacttcctgcctctgagagacctgctacaagccagcttc       c.*120

          .         .         .         .         .         .       g.30709
 cttcccctccatggcaccagttgtctgaggtcacattgcaagtgagtgcaggagtgagat       c.*180

          .         .         .         .         .         .       g.30769
 tatcgaaaattataatatacaaaatcatatatatatatatgttcttgttttttgagacag       c.*240

          .         .         .         .         .         .       g.30829
 agtctcacactgttgcccaggctggagtgcagtggcgtgatctcggctcactgcaacctc       c.*300

          .         .         .         .         .         .       g.30889
 cacccccggggatcaagcaactctcctgcctcagcctccctagtagctgggattacaggc       c.*360

          .         .         .         .         .         .       g.30949
 atgcactaccacgcttggctaatttttgtatttttagtagagatggggtttcactgtgta       c.*420

          .         .         .         .         .         .       g.31009
 ggccaggctggtctcgaactcctgaactcaagtgattcacccaccttagcctcccaaagt       c.*480

          .         .         .         .         .         .       g.31069
 gctgggattacaggcgtgagtcaccgtgcccagccatgtatatatataattttaaaaatt       c.*540

          .         .         .         .         .         .       g.31129
 aagctgaaattcacataacataaaattagctgttttaaagtgtaaaatttagtggcgtgt       c.*600

          .         .         .         .         .         .       g.31189
 ggttcattcacaaagctgtacaaccaccaccatctagttccaaacattttctttttttct       c.*660

          .         .         .         .         .         .       g.31249
 gagatggagtctcactctgtcacccaggttcgagttcagtggtgccatctctgtccactg       c.*720

          .         .         .         .         .         .       g.31309
 caacctccacatcctgggttcaagtgattctcctgcctcagcctctggaggagctggtat       c.*780

          .         .         .         .         .         .       g.31369
 cacaggcgtcccccaccacgcctggctaaattttgtatttttaggtggtcttgaactcct       c.*840

          .         .         .         .         .         .       g.31429
 gatgtcaggtgattctcctagctccaaatgttttcattatctctcccccaacaaaaccca       c.*900

          .         .         .         .         .         .       g.31489
 tacctatcaagctgtcactccccataccccattctctttttcatctcggcccctgtcaat       c.*960

          .         .         .         .         .         .       g.31549
 ctggtttttgtcactatggacttaccaattctgaatatttcccataaacagaatcataca       c.*1020

          .         .         .         .         .         .       g.31609
 atatttgattttttttttttttttgaaactaagccttgctctgtctcccaggctggagtg       c.*1080

          .         .         .         .         .         .       g.31669
 ctatggtgcaatttttgttcactgcaacctctgccttccaagatcaagagattctccagt       c.*1140

          .         .         .         .         .         .       g.31729
 ctcagctcccaagtagctgggattacaggcatgtactaccatgcctggctaattttcttg       c.*1200

          .         .         .         .         .         .       g.31789
 tagttttagtagggacatgttggccaggctggtggtgagctcctggcctcaggtgatcca       c.*1260

          .         .         .         .         .         .       g.31849
 cccacctcagtgttccaaagtgctgatattacaggcataatatgtgatcttttgtgtctg       c.*1320

          .         .         .         .         .         .       g.31909
 gttgctttcatgttgaatgctatttttgaggttcatgcctgttgtagaccacagtcacac       c.*1380

          .         .         .         .         .         .       g.31969
 actgctgtagtcttccccagtcctcattcccagctgcctcttcctactgcttccgtctat       c.*1440

          .         .         .         .         .         .       g.32029
 caaaaagcccccttggcccaggttccctgagctgtgggattctgcactggtgctttggat       c.*1500

          .         .         .         .         .         .       g.32089
 tccctgatatgttccttcaaatctgctgagaattaaataaacatctctaaagcctgacct       c.*1560

                                                                    g.32098
 ccccacgtc                                                          c.*1569

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Cytochrome P450, family 2, subfamily B, polypeptide 6 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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