cytochrome P450, family 2, subfamily R, polypeptide 1 (CYP2R1) - coding DNA reference sequence

(used for variant description)

(last modified December 8, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_024514.4 in the CYP2R1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007936.1, covering CYP2R1 transcript NM_024514.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
          .         .         .         .         .         .       g.60
 ATGTGGAAGCTTTGGAGAGCTGAAGAGGGCGCGGCGGCGCTCGGCGGCGCGCTCTTCCTG       c.60
 M  W  K  L  W  R  A  E  E  G  A  A  A  L  G  G  A  L  F  L         p.20

          .         .         .         .         .         .       g.120
 CTGCTCTTCGCGCTAGGGGTCCGCCAGCTGCTGAAGCAGAGGCGGCCGATGGGCTTCCCC       c.120
 L  L  F  A  L  G  V  R  Q  L  L  K  Q  R  R  P  M  G  F  P         p.40

          .         .         .         .         .         .       g.180
 CCGGGGCCGCCGGGGCTGCCATTTATCGGCAACATCTATTCCCTGGCAGCCTCATCCGAG       c.180
 P  G  P  P  G  L  P  F  I  G  N  I  Y  S  L  A  A  S  S  E         p.60

          .         .         .         .      | 02  .         .    g.6303
 CTTCCCCATGTCTACATGAGAAAGCAGAGCCAGGTGTACGGAGAG | ATCTTCAGTTTAGAT    c.240
 L  P  H  V  Y  M  R  K  Q  S  Q  V  Y  G  E   | I  F  S  L  D      p.80

          .         .         .         .         .         .       g.6363
 CTTGGAGGCATATCAACTGTGGTTCTAAATGGCTATGATGTAGTAAAGGAATGCCTTGTT       c.300
 L  G  G  I  S  T  V  V  L  N  G  Y  D  V  V  K  E  C  L  V         p.100

          .         .         .         .         .         .       g.6423
 CATCAAAGCGAAATTTTTGCAGACAGACCATGCCTTCCTTTATTCATGAAGATGACAAAA       c.360
 H  Q  S  E  I  F  A  D  R  P  C  L  P  L  F  M  K  M  T  K         p.120

         | 03.         .         .         .         .         .    g.11490
 ATGGGAG | GCTTACTCAATTCCAGATATGGCCGAGGATGGGTTGATCACAGACGATTAGCT    c.420
 M  G  G |   L  L  N  S  R  Y  G  R  G  W  V  D  H  R  R  L  A      p.140

          .         .         .         .         .         .       g.11550
 GTAAACAGTTTTCGATATTTTGGATATGGCCAAAAGTCTTTTGAATCTAAAATCTTGGAA       c.480
 V  N  S  F  R  Y  F  G  Y  G  Q  K  S  F  E  S  K  I  L  E         p.160

          .         .         .         .         .         .       g.11610
 GAAACCAAATTTTTCAATGATGCTATTGAAACATACAAAGGTAGACCTTTTGACTTTAAA       c.540
 E  T  K  F  F  N  D  A  I  E  T  Y  K  G  R  P  F  D  F  K         p.180

          .         .         .         .         .         .       g.11670
 CAGTTAATAACGAATGCTGTTTCAAACATAACCAATCTGATCATTTTTGGAGAACGATTC       c.600
 Q  L  I  T  N  A  V  S  N  I  T  N  L  I  I  F  G  E  R  F         p.200

          .         .         .         .         .         .       g.11730
 ACTTATGAAGACACCGATTTTCAGCACATGATTGAGTTATTTAGTGAAAATGTGGAACTA       c.660
 T  Y  E  D  T  D  F  Q  H  M  I  E  L  F  S  E  N  V  E  L         p.220

          .         .         .         .         .         .       g.11790
 GCTGCCAGTGCCTCAGTCTTCTTGTATAATGCCTTTCCATGGATTGGCATCCTGCCTTTT       c.720
 A  A  S  A  S  V  F  L  Y  N  A  F  P  W  I  G  I  L  P  F         p.240

          .         .         .         .         .         .       g.11850
 GGAAAACATCAACAGCTGTTTAGAAATGCAGCTGTAGTCTATGATTTTCTCTCCAGACTC       c.780
 G  K  H  Q  Q  L  F  R  N  A  A  V  V  Y  D  F  L  S  R  L         p.260

          .         .         .         .         .         .       g.11910
 ATTGAAAAAGCTTCAGTCAACAGAAAGCCTCAGCTACCTCAGCATTTTGTTGATGCTTAT       c.840
 I  E  K  A  S  V  N  R  K  P  Q  L  P  Q  H  F  V  D  A  Y         p.280

          .         .         .         .         .         .       g.11970
 TTAGATGAGATGGATCAAGGTAAAAATGACCCATCATCTACTTTCTCCAAAGAAAACCTA       c.900
 L  D  E  M  D  Q  G  K  N  D  P  S  S  T  F  S  K  E  N  L         p.300

          .         .         .         .         .         .       g.12030
 ATTTTCTCAGTGGGTGAACTCATCATTGCTGGAACTGAAACTACAACCAATGTGCTACGG       c.960
 I  F  S  V  G  E  L  I  I  A  G  T  E  T  T  T  N  V  L  R         p.320

          .         .         .         . | 04       .         .    g.12782
 TGGGCGATTCTTTTCATGGCCCTTTATCCTAATATTCAAG | GACAAGTTCAGAAAGAGATT    c.1020
 W  A  I  L  F  M  A  L  Y  P  N  I  Q  G |   Q  V  Q  K  E  I      p.340

          .         .         .         .         .         .       g.12842
 GATTTAATTATGGGCCCTAATGGGAAGCCTTCTTGGGACGACAAATGCAAAATGCCTTAT       c.1080
 D  L  I  M  G  P  N  G  K  P  S  W  D  D  K  C  K  M  P  Y         p.360

          .         .         .         .         .         .       g.12902
 ACTGAGGCAGTTTTGCATGAAGTTTTAAGATTCTGTAATATAGTTCCATTAGGGATTTTC       c.1140
 T  E  A  V  L  H  E  V  L  R  F  C  N  I  V  P  L  G  I  F         p.380

          .         .         .         .         .         .       g.12962
 CATGCAACCTCTGAAGATGCAGTTGTACGTGGTTATTCCATTCCTAAAGGCACAACAGTA       c.1200
 H  A  T  S  E  D  A  V  V  R  G  Y  S  I  P  K  G  T  T  V         p.400

          .         .         .         .         .         .       g.13022
 ATTACAAATCTTTATTCTGTACACTTTGATGAAAAGTACTGGAGAGACCCAGAAGTGTTC       c.1260
 I  T  N  L  Y  S  V  H  F  D  E  K  Y  W  R  D  P  E  V  F         p.420

          .         .         .         .         .         .       g.13082
 CATCCTGAGCGATTTCTGGACAGCAGTGGATATTTTGCCAAGAAGGAAGCTTTGGTTCCT       c.1320
 H  P  E  R  F  L  D  S  S  G  Y  F  A  K  K  E  A  L  V  P         p.440

          . | 05       .         .         .         .         .    g.13958
 TTTTCCCTAG | GAAGAAGACATTGTCTTGGAGAACACTTGGCTCGGATGGAAATGTTCTTG    c.1380
 F  S  L  G |   R  R  H  C  L  G  E  H  L  A  R  M  E  M  F  L      p.460

          .         .         .         .         .         .       g.14018
 TTTTTTACAGCATTGCTTCAGAGGTTTCATTTGCATTTTCCACATGAACTAGTTCCAGAT       c.1440
 F  F  T  A  L  L  Q  R  F  H  L  H  F  P  H  E  L  V  P  D         p.480

          .         .         .         .         .         .       g.14078
 CTGAAGCCCAGGTTAGGCATGACATTGCAGCCCCAACCCTACCTCATCTGTGCTGAAAGA       c.1500
 L  K  P  R  L  G  M  T  L  Q  P  Q  P  Y  L  I  C  A  E  R         p.500

                                                                    g.14084
 CGCTGA                                                             c.1506
 R  X                                                               p.501

          .         .         .         .         .         .       g.14144
 aactgcctgggatgttttcgggaacaagaatgtatatttgccttatccctgaacttggtt       c.*60

          .         .         .         .         .                 g.14197
 taatcaaatcaatgtgtgtattagaataaaagtcacagcatcaaaaagccaaa              c.*113

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Cytochrome P450, family 2, subfamily R, polypeptide 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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