cytochrome P450, family 2, subfamily U, polypeptide 1 (CYP2U1) - coding DNA reference sequence

(used for variant description)

(last modified October 7, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_183075.2 in the CYP2U1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007961.1, covering CYP2U1 transcript NM_183075.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5023
                                      gacactggcgccgcgggtcaggc       c.-61

 .         .         .         .         .         .                g.5083
 agctgcgtgcgcgtctcctccaggcagcaaggggaacccgaggccgccggcgcccggacc       c.-1

          .         .         .         .         .         .       g.5143
 ATGTCGTCTCCGGGGCCGTCGCAGCCGCCGGCCGAGGACCCGCCCTGGCCCGCGCGCCTC       c.60
 M  S  S  P  G  P  S  Q  P  P  A  E  D  P  P  W  P  A  R  L         p.20

          .         .         .         .         .         .       g.5203
 CTGCGTGCGCCTCTGGGGCTGCTGCGGCTGGACCCCAGCGGGGGCGCGCTGCTGCTATGC       c.120
 L  R  A  P  L  G  L  L  R  L  D  P  S  G  G  A  L  L  L  C         p.40

          .         .         .         .         .         .       g.5263
 GGCCTCGTAGCGCTGCTGGGCTGGAGCTGGCTGCGGAGGCGCCGGGCGCGGGGCATCCCG       c.180
 G  L  V  A  L  L  G  W  S  W  L  R  R  R  R  A  R  G  I  P         p.60

          .         .         .         .         .         .       g.5323
 CCCGGGCCCACGCCCTGGCCTCTGGTGGGCAACTTCGGTCACGTGCTGCTGCCTCCCTTC       c.240
 P  G  P  T  P  W  P  L  V  G  N  F  G  H  V  L  L  P  P  F         p.80

          .         .         .         .         .         .       g.5383
 CTCCGGCGGCGGAGCTGGCTGAGCAGCAGGACCAGGGCCGCAGGGATTGATCCCTCGGTC       c.300
 L  R  R  R  S  W  L  S  S  R  T  R  A  A  G  I  D  P  S  V         p.100

          .         .         .         .         .         .       g.5443
 ATAGGCCCGCAGGTGCTCCTGGCTCACCTAGCCCGCGTGTACGGCAGCATCTTCAGCTTC       c.360
 I  G  P  Q  V  L  L  A  H  L  A  R  V  Y  G  S  I  F  S  F         p.120

          .         .         .         .         .         .       g.5503
 TTTATCGGCCACTACCTGGTGGTGGTCCTCAGCGACTTCCACAGCGTGCGCGAGGCGCTG       c.420
 F  I  G  H  Y  L  V  V  V  L  S  D  F  H  S  V  R  E  A  L         p.140

          .         .         .         .         .         .       g.5563
 GTGCAGCAGGCCGAGGTCTTCAGCGACCGCCCGCGGGTGCCGCTCATCTCCATCGTGACC       c.480
 V  Q  Q  A  E  V  F  S  D  R  P  R  V  P  L  I  S  I  V  T         p.160

          . | 02       .         .         .         .         .    g.18459
 AAGGAGAAGG | GGGTTGTGTTTGCACATTATGGTCCCGTCTGGAGACAACAAAGGAAGTTC    c.540
 K  E  K  G |   V  V  F  A  H  Y  G  P  V  W  R  Q  Q  R  K  F      p.180

          .         .         .         .         .         .       g.18519
 TCTCATTCAACTCTTCGTCATTTTGGGTTGGGAAAACTTAGCTTGGAGCCCAAGATTATT       c.600
 S  H  S  T  L  R  H  F  G  L  G  K  L  S  L  E  P  K  I  I         p.200

          .         .         .         .         .         .       g.18579
 GAGGAGTTCAAATATGTGAAAGCAGAAATGCAAAAGCACGGAGAAGACCCCTTCTGCCCT       c.660
 E  E  F  K  Y  V  K  A  E  M  Q  K  H  G  E  D  P  F  C  P         p.220

          .         .         .         .         .         .       g.18639
 TTCTCCATCATCAGCAATGCCGTCTCTAACATCATTTGCTCCTTGTGCTTTGGCCAGCGC       c.720
 F  S  I  I  S  N  A  V  S  N  I  I  C  S  L  C  F  G  Q  R         p.240

          .         .         .         .         .         .       g.18699
 TTTGATTACACTAATAGTGAGTTCAAGAAAATGCTTGGTTTTATGTCACGAGGCCTAGAA       c.780
 F  D  Y  T  N  S  E  F  K  K  M  L  G  F  M  S  R  G  L  E         p.260

          .         .         .         .         .         .       g.18759
 ATCTGTCTGAACAGTCAAGTCCTCCTGGTCAACATATGCCCTTGGCTTTATTACCTTCCC       c.840
 I  C  L  N  S  Q  V  L  L  V  N  I  C  P  W  L  Y  Y  L  P         p.280

          .         .         .         .         .         .       g.18819
 TTTGGACCATTTAAGGAATTAAGACAAATTGAAAAGGATATAACCAGTTTCCTTAAAAAA       c.900
 F  G  P  F  K  E  L  R  Q  I  E  K  D  I  T  S  F  L  K  K         p.300

          .         .         .         .         .         .       g.18879
 ATCATCAAAGACCATCAAGAGTCTCTGGATAGAGAGAACCCTCAGGACTTCATAGACATG       c.960
 I  I  K  D  H  Q  E  S  L  D  R  E  N  P  Q  D  F  I  D  M         p.320

          .         .         .         .         .         .       g.18939
 TACCTTCTCCACATGGAAGAGGAGAGGAAAAATAATAGTAACAGCAGTTTTGATGAAGAG       c.1020
 Y  L  L  H  M  E  E  E  R  K  N  N  S  N  S  S  F  D  E  E         p.340

          .         .         .         .         .         .       g.18999
 TACTTATTTTATATCATTGGGGATCTCTTTATTGCTGGGACTGATACCACAACTAACTCT       c.1080
 Y  L  F  Y  I  I  G  D  L  F  I  A  G  T  D  T  T  T  N  S         p.360

          .         .         .         .       | 03 .         .    g.20829
 TTGCTCTGGTGCCTGCTGTATATGTCGCTGAACCCCGATGTACAAG | AAAAGGTTCATGAA    c.1140
 L  L  W  C  L  L  Y  M  S  L  N  P  D  V  Q  E |   K  V  H  E      p.380

          .         .         .         .         .         .       g.20889
 GAAATTGAAAGAGTCATTGGCGCCAACCGAGCTCCTTCCCTCACAGACAAGGCCCAGATG       c.1200
 E  I  E  R  V  I  G  A  N  R  A  P  S  L  T  D  K  A  Q  M         p.400

          .         .         .         .         .         .       g.20949
 CCCTACACAGAAGCCACCATCATGGAAGTGCAGAGGCTAACTGTGGTGGTGCCGCTTGCC       c.1260
 P  Y  T  E  A  T  I  M  E  V  Q  R  L  T  V  V  V  P  L  A         p.420

          .         .         | 04         .         .         .    g.22821
 ATTCCTCATATGACCTCAGAGAACACAG | TGCTCCAAGGGTATACCATTCCTAAAGGCACA    c.1320
 I  P  H  M  T  S  E  N  T  V |   L  Q  G  Y  T  I  P  K  G  T      p.440

          .         .         .         .         .         .       g.22881
 TTGATCTTACCCAACCTGTGGTCAGTACATAGAGACCCAGCCATTTGGGAGAAACCGGAG       c.1380
 L  I  L  P  N  L  W  S  V  H  R  D  P  A  I  W  E  K  P  E         p.460

          .         .         .         .         .         .       g.22941
 GATTTCTACCCTAATCGATTTCTGGATGACCAAGGACAACTAATTAAAAAAGAAACCTTT       c.1440
 D  F  Y  P  N  R  F  L  D  D  Q  G  Q  L  I  K  K  E  T  F         p.480

          .       | 05 .         .         .         .         .    g.23728
 ATTCCTTTTGGGATAG | GGAAGCGGGTGTGTATGGGAGAACAACTGGCAAAGATGGAATTA    c.1500
 I  P  F  G  I  G |   K  R  V  C  M  G  E  Q  L  A  K  M  E  L      p.500

          .         .         .         .         .         .       g.23788
 TTCCTAATGTTTGTGAGCCTAATGCAGAGTTTCGCATTTGCTTTACCTGAGGATTCTAAG       c.1560
 F  L  M  F  V  S  L  M  Q  S  F  A  F  A  L  P  E  D  S  K         p.520

          .         .         .         .         .         .       g.23848
 AAGCCCCTCCTGACTGGAAGATTTGGTCTAACTTTAGCCCCACATCCATTTAATATAACT       c.1620
 K  P  L  L  T  G  R  F  G  L  T  L  A  P  H  P  F  N  I  T         p.540

          .                                                         g.23863
 ATTTCAAGGAGATGA                                                    c.1635
 I  S  R  R  X                                                      p.544

          .         .         .         .         .         .       g.23923
 agagcatctccaagaagagatggtaaaaagatatataaatacatatccttctaagcagat       c.*60

          .         .         .         .         .         .       g.23983
 tcttcctactgcaaaggacagtgaatccagcaactcagtggatccaagctgggctcagag       c.*120

          .         .         .         .         .         .       g.24043
 gtcggaaggagggtagagcacactgggaggtttcatcttggaggattcctcagcaggata       c.*180

          .         .         .         .         .         .       g.24103
 cttcagccattttagtaatgcaggtctgtgatttgggggatagaaaacaaagtacctatg       c.*240

          .         .         .         .         .         .       g.24163
 aaacgggatatctggattttacttgcagtggcttccaccgatgggccaatcttctcattt       c.*300

          .         .         .         .         .         .       g.24223
 cttagtgcctcagacatcccatatgtaaaatgagagtaataaaacttggcttctctctac       c.*360

          .         .         .         .         .         .       g.24283
 ctctcagcactaatgatggtcaaatgccttacatcttttctgatatctctaaaatgctgt       c.*420

          .         .         .         .         .         .       g.24343
 taagttctggagaagaacttcaggagaagaagatctatcagctggcttttaaagacctat       c.*480

          .         .         .         .         .         .       g.24403
 gacaacatgaaagtggtgttcagcctggaatgctttgtcagagatgggtgtggatttagg       c.*540

          .         .         .         .         .         .       g.24463
 ttatactgggggagaacttttctcagcacagattctatgccagcttctttgggcttgttc       c.*600

          .         .         .         .         .         .       g.24523
 tgtcactatctttttgtttatgattttagtttttactttttgtagatgtgggatgaagtg       c.*660

          .         .         .         .         .         .       g.24583
 gactctgtcgtgtatattgaggaaaaaagaaattataattttaaaaaatcccttgtagga       c.*720

          .         .         .         .         .         .       g.24643
 ttattatctaaatttatatgtctaacttctactacaactacaggaacagtgagccttgct       c.*780

          .         .         .         .         .         .       g.24703
 acttctttagtagcttcttggcagaattcctttctactgagttatttgcaaagatgcagc       c.*840

          .         .         .         .         .         .       g.24763
 tctacctttttacttaaggcctgaatggtgagcatggggattttgatactgggactcatc       c.*900

          .         .         .         .         .         .       g.24823
 aggaaaggattctgctttcaaactatactgaacattcctgtcctagcgtccctgccacca       c.*960

          .         .         .         .         .         .       g.24883
 ggcccaatgcatctgatccttgaatatactctcaaagaattcactctctttttattaaga       c.*1020

          .         .         .         .         .         .       g.24943
 gaactaaattgtttctaaatgtagatggtccctctggaaaagcagttttcagcaggggtg       c.*1080

          .         .         .         .         .         .       g.25003
 gtaaccccttcagagggagtttggaaatgtgtgggtatgattcttggttatcataatgat       c.*1140

          .         .         .         .         .         .       g.25063
 gggggtgctactggccttctgctgccatgggaccaggatgctaaatgtcaaggtagtcct       c.*1200

          .         .         .         .         .         .       g.25123
 atacagtgaagaattgtcctgctcaagatgccaggatttcccccagtgagaacatgctct       c.*1260

          .         .         .         .         .         .       g.25183
 aaggaatgaccacccctttcttttattctcccacagtgctccatgtacagaagtaagcat       c.*1320

          .         .         .         .         .         .       g.25243
 agcagtcatatgagcaaccacattcctgaacctttcctcatgctggctctacacttaatc       c.*1380

          .         .         .         .         .         .       g.25303
 ctttacttgtatgtttctgtaattcttacataaattctattaagagggtggcatactgta       c.*1440

          .         .         .         .         .         .       g.25363
 gtggatgaagctgaggcttatagtaggtaaggcacaaagttaaaaagtaacatcactggg       c.*1500

          .         .         .         .         .         .       g.25423
 tttcaaacctactggtctctgtgactaaagaacactttcagaaccacttcttgattctgc       c.*1560

          .         .         .         .         .         .       g.25483
 caccacttgatcccataacaggctaccccttggcctcatgctggagttgtgtgtgtctgt       c.*1620

          .         .         .         .         .         .       g.25543
 cttcatcccaggctgagctccttgaggtgaggatgttgtgctgtttgcctccctcacagt       c.*1680

          .         .         .         .         .         .       g.25603
 gccttggtcttagtggatgcccagttgtcttgtgaatgacttttaagaagtgtacttaag       c.*1740

          .         .         .         .         .         .       g.25663
 agaaaaatcctaccttatttgaataattacaagtcatgtttttgttgcttaaaggtgata       c.*1800

          .         .         .         .         .         .       g.25723
 aatcagtgtatattatttgttaatgtccattaaagccagtttttaaaaaaatcactggac       c.*1860

          .         .         .         .         .         .       g.25783
 ttttgtgtttaccatttaaaacaaccattttaaacaaacttagaacgatgccttagctgt       c.*1920

          .         .         .         .         .         .       g.25843
 ttataggtaacagaatgtaaactcccaccacctggagactaggccatatccagggacctc       c.*1980

          .         .         .         .         .         .       g.25903
 acactgactttcctaaaggagagaagcagctacgctgttcatactgatagagaagagggc       c.*2040

          .         .         .         .         .         .       g.25963
 aagaaaagatccagagtggctgttactttgaaaattaaacgaaagatgaaattctgaact       c.*2100

          .         .         .         .         .         .       g.26023
 taaaacacttctgtttggccttctataactgatcacccttctttgctctgttttccagat       c.*2160

          .         .         .         .         .         .       g.26083
 aaatggagacaccagatctccctaacctctgacttctgccgttagccatactctgtgtag       c.*2220

          .         .         .         .         .         .       g.26143
 ttagatctcagtctgggaatggcattccagggcaattgtgaacatgaggctagatttttc       c.*2280

          .         .         .         .         .         .       g.26203
 ctttgatttagcacattcctaggcagacttttgcaagctcaaaaaatgaaaataatatct       c.*2340

          .         .         .         .         .         .       g.26263
 gcttaaccaaaacataatcataggaagaagaaaaattttaaaatgattgatttttgactc       c.*2400

          .         .         .         .         .         .       g.26323
 tacattctttatctaccatactgctcttttcctttttagaaatattactaagcactttcc       c.*2460

          .         .         .         .         .         .       g.26383
 gtatagataaatgaaatacaggctaatctttaggtgtcttaggaatttttgctttttgaa       c.*2520

          .         .         .         .         .         .       g.26443
 aaagaaaagctaatagcctaactgcagaggaactgagtggatggggtagctgctgtatag       c.*2580

          .         .         .         .         .         .       g.26503
 atttttagatgagatgatacagtgtggattacactgtaccttgggcgggagagtttgttc       c.*2640

          .         .         .         .         .         .       g.26563
 ttgatatggaattcatatgcttttgaattgcactaataactcagcattaacaagtatatt       c.*2700

          .         .         .         .         .         .       g.26623
 actccttaaattatacatgcattttcaatattcctaaccaaatagtttatagcttattga       c.*2760

          .         .         .         .         .         .       g.26683
 gaagaagtctgttcttggagagatgttgaaattagatgtttattaaactttaaaatataa       c.*2820

          .         .         .         .         .         .       g.26743
 tgccttaagctgtggcactttaaaaacatctttatatataaattgctaaaaggactgtta       c.*2880

          .         .         .         .         .         .       g.26803
 atgcttttctcagacacattggcattttacaattttgcacatggtttatttgaaatcaaa       c.*2940

          .         .         .         .         .         .       g.26863
 aaataactatactttgttttataagtctacctaatatctcatttttgattctcatcgtta       c.*3000

          .         .         .                                     g.26897
 gcacagttttgttgcttttattaaactattttaa                                 c.*3034

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Cytochrome P450, family 2, subfamily U, polypeptide 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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