cytochrome P450, family 4, subfamily V, polypeptide 2 (CYP4V2) - coding DNA reference sequence

(used for variant description)

(last modified November 13, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_207352.3 in the CYP4V2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007965.1, covering CYP4V2 transcript NM_207352.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5004
                                                         gggc       c.-301

 .         .         .         .         .         .                g.5064
 ctccagtgcaatcactacgccctggggcccggaaaccgttttccggtctttcgctttcgg       c.-241

 .         .         .         .         .         .                g.5124
 ctggggcgtggaggccgcggtgctgcgtaggccgggccgggcgcaggaacagccccgtgg       c.-181

 .         .         .         .         .         .                g.5184
 cgccctctctggccgccgcccgggcgggaaacgtcgttccggggaccgggcgaccccgca       c.-121

 .         .         .         .         .         .                g.5244
 gcggggagcgcgccaggtccgcgcggggaagtgggcggtgtgcggccggcaccgcctcgc       c.-61

 .         .         .         .         .         .                g.5304
 accacgcccccgcgggcccgcactttcccggagtgcaccccgcggccgccagccggggcg       c.-1

          .         .         .         .         .         .       g.5364
 ATGGCGGGGCTCTGGCTGGGGCTCGTGTGGCAGAAGCTGCTGCTGTGGGGCGCGGCGAGT       c.60
 M  A  G  L  W  L  G  L  V  W  Q  K  L  L  L  W  G  A  A  S         p.20

          .         .         .         .         .         .       g.5424
 GCCCTTTCCCTGGCCGGCGCCAGTCTGGTCCTGAGCCTGCTGCAGAGGGTGGCGAGCTAC       c.120
 A  L  S  L  A  G  A  S  L  V  L  S  L  L  Q  R  V  A  S  Y         p.40

          .         .         .         .         .         .       g.5484
 GCGCGGAAATGGCAGCAGATGCGGCCCATCCCCACGGTGGCCCGCGCCTACCCACTGGTG       c.180
 A  R  K  W  Q  Q  M  R  P  I  P  T  V  A  R  A  Y  P  L  V         p.60

          .         .         .     | 02   .         .         .    g.8006
 GGCCACGCGCTGCTGATGAAGCCGGACGGGCGAG | AATTTTTTCAGCAGATCATTGAGTAC    c.240
 G  H  A  L  L  M  K  P  D  G  R  E |   F  F  Q  Q  I  I  E  Y      p.80

          .         .         .         .         .         .       g.8066
 ACAGAGGAATACCGCCACATGCCGCTGCTGAAGCTCTGGGTCGGGCCAGTGCCCATGGTG       c.300
 T  E  E  Y  R  H  M  P  L  L  K  L  W  V  G  P  V  P  M  V         p.100

          .         .        | 03.         .         .         .    g.9516
 GCCCTTTATAATGCAGAAAATGTGGAG | GTAATTTTAACTAGTTCAAAGCAAATTGACAAA    c.360
 A  L  Y  N  A  E  N  V  E   | V  I  L  T  S  S  K  Q  I  D  K      p.120

          .         .         .         .         .    | 04    .    g.10427
 TCCTCTATGTACAAGTTTTTAGAACCATGGCTTGGCCTAGGACTTCTTACAAG | TACTGGA    c.420
 S  S  M  Y  K  F  L  E  P  W  L  G  L  G  L  L  T  S  |  T  G      p.140

          .         .         .         .         .         .       g.10487
 AACAAATGGCGCTCCAGGAGAAAGATGTTAACACCCACTTTCCATTTTACCATTCTGGAA       c.480
 N  K  W  R  S  R  R  K  M  L  T  P  T  F  H  F  T  I  L  E         p.160

          .         .         .         .         .         .       g.10547
 GATTTCTTAGATATCATGAATGAACAAGCAAATATATTGGTTAAGAAACTTGAAAAACAC       c.540
 D  F  L  D  I  M  N  E  Q  A  N  I  L  V  K  K  L  E  K  H         p.180

          .         .         .         .         .         .       g.10607
 ATTAACCAAGAAGCATTTAACTGCTTTTTTTACATCACTCTTTGTGCCTTAGATATCATC       c.600
 I  N  Q  E  A  F  N  C  F  F  Y  I  T  L  C  A  L  D  I  I         p.200

      | 05   .         .         .         .         .         .    g.11069
 TGTG | AAACAGCTATGGGGAAGAATATTGGTGCTCAAAGTAATGATGATTCCGAGTATGTC    c.660
 C  E |   T  A  M  G  K  N  I  G  A  Q  S  N  D  D  S  E  Y  V      p.220

          .     | 06   .         .         .         .         .    g.12483
 CGTGCAGTTTATAG | AATGAGTGAGATGATATTTCGAAGAATAAAGATGCCCTGGCTTTGG    c.720
 R  A  V  Y  R  |  M  S  E  M  I  F  R  R  I  K  M  P  W  L  W      p.240

          .         .         .         .         .         .       g.12543
 CTTGATCTCTGGTACCTTATGTTTAAAGAAGGATGGGAACACAAAAAGAGCCTTCAGATC       c.780
 L  D  L  W  Y  L  M  F  K  E  G  W  E  H  K  K  S  L  Q  I         p.260

          .         .  | 07      .         .         .         .    g.14676
 CTACATACTTTTACCAACAGT | GTCATCGCTGAACGGGCCAATGAAATGAACGCCAATGAA    c.840
 L  H  T  F  T  N  S   | V  I  A  E  R  A  N  E  M  N  A  N  E      p.280

          .         .         .         .         .         .       g.14736
 GACTGTAGAGGTGATGGCAGGGGCTCTGCCCCCTCCAAAAATAAACGCAGGGCCTTTCTT       c.900
 D  C  R  G  D  G  R  G  S  A  P  S  K  N  K  R  R  A  F  L         p.300

          .         .         .         .         .         .       g.14796
 GACTTGCTTTTAAGTGTGACTGATGACGAAGGGAACAGGCTAAGTCATGAAGATATTCGA       c.960
 D  L  L  L  S  V  T  D  D  E  G  N  R  L  S  H  E  D  I  R         p.320

          .         .        | 08.         .         .         .    g.18713
 GAAGAAGTTGACACCTTCATGTTTGAG | GGGCACGATACAACTGCAGCTGCAATAAACTGG    c.1020
 E  E  V  D  T  F  M  F  E   | G  H  D  T  T  A  A  A  I  N  W      p.340

          .         .         .         .         .         .       g.18773
 TCCTTATACCTGTTGGGTTCTAACCCAGAAGTCCAGAAAAAAGTGGATCATGAATTGGAT       c.1080
 S  L  Y  L  L  G  S  N  P  E  V  Q  K  K  V  D  H  E  L  D         p.360

          . | 09       .         .         .         .         .    g.22395
 GACGTGTTTG | GGAAGTCTGACCGTCCCGCTACAGTAGAAGACCTGAAGAAACTTCGGTAT    c.1140
 D  V  F  G |   K  S  D  R  P  A  T  V  E  D  L  K  K  L  R  Y      p.380

          .         .         .         .         .         .       g.22455
 CTGGAATGTGTTATTAAGGAGACCCTTCGCCTTTTTCCTTCTGTTCCTTTATTTGCCCGT       c.1200
 L  E  C  V  I  K  E  T  L  R  L  F  P  S  V  P  L  F  A  R         p.400

          .         .      | 10  .         .         .         .    g.22608
 AGTGTTAGTGAAGATTGTGAAGTGG | CAGGTTACAGAGTTCTAAAAGGCACTGAAGCCGTC    c.1260
 S  V  S  E  D  C  E  V  A |   G  Y  R  V  L  K  G  T  E  A  V      p.420

          .         .         .         .         .         .       g.22668
 ATCATTCCCTATGCATTGCACAGAGATCCGAGATACTTCCCCAACCCCGAGGAGTTCCAG       c.1320
 I  I  P  Y  A  L  H  R  D  P  R  Y  F  P  N  P  E  E  F  Q         p.440

          .         .         .         .         .         .       g.22728
 CCTGAGCGGTTCTTCCCCGAGAATGCACAAGGGCGCCATCCATATGCCTACGTGCCCTTC       c.1380
 P  E  R  F  F  P  E  N  A  Q  G  R  H  P  Y  A  Y  V  P  F         p.460

          .         .      | 11  .         .         .         .    g.23984
 TCTGCTGGCCCCAGGAACTGTATAG | GTCAAAAGTTTGCTGTGATGGAAGAAAAGACCATT    c.1440
 S  A  G  P  R  N  C  I  G |   Q  K  F  A  V  M  E  E  K  T  I      p.480

          .         .         .         .         .         .       g.24044
 CTTTCGTGCATCCTGAGGCACTTTTGGATAGAATCCAACCAGAAAAGAGAAGAGCTTGGT       c.1500
 L  S  C  I  L  R  H  F  W  I  E  S  N  Q  K  R  E  E  L  G         p.500

          .         .         .         .         .         .       g.24104
 CTAGAAGGACAGTTGATTCTTCGTCCAAGTAATGGCATCTGGATCAAGTTGAAGAGGAGA       c.1560
 L  E  G  Q  L  I  L  R  P  S  N  G  I  W  I  K  L  K  R  R         p.520

          .                                                         g.24122
 AATGCAGATGAACGCTAA                                                 c.1578
 N  A  D  E  R  X                                                   p.525

          .         .         .         .         .         .       g.24182
 ctatattattgggttgtgcctttatcatgagaaaggtctttattttaagagatccttgtc       c.*60

          .         .         .         .         .         .       g.24242
 atttacaatttacagatcatgagttcaatatgcttgaatcccctagacctaatttttcct       c.*120

          .         .         .         .         .         .       g.24302
 tgatcccactgatcttgacatcaagtctaacaaagaaaaagttttgagttttgtattttc       c.*180

          .         .         .         .         .         .       g.24362
 ttttttcttttttctttattttttttttttgaaaccgtgtctcactctgtcgcccaggct       c.*240

          .         .         .         .         .         .       g.24422
 ggaggagtgcagtggtgtgatctcagctcactgcaacctccacctcccaggttcaagcaa       c.*300

          .         .         .         .         .         .       g.24482
 ttcttctgcctcagcctcccaagtagctgggattacaggtgcctgccaccatgcctggct       c.*360

          .         .         .         .         .         .       g.24542
 aatttttttgtatttttagtagaaacagggtgtcaccatgttggccagactggtctcaaa       c.*420

          .         .         .         .         .         .       g.24602
 ctcctgacctcaagtgatccacctgcctcagcctcccaaagtgctgggattatagtcgtg       c.*480

          .         .         .         .         .         .       g.24662
 agccaccacgcctggccagagttttttatttttatcaccaccatagatgttacagttggc       c.*540

          .         .         .         .         .         .       g.24722
 tgtggtcacaaaagtagttaattgtgtcagcacccaaataaacatctaacaggtttctca       c.*600

          .         .         .         .         .         .       g.24782
 acagaggaatccacagtccaattccacttcaattgatagacccaaaaaatataatttaat       c.*660

          .         .         .         .         .         .       g.24842
 caaagttctagagtttttgtttgtttgtttgagatggagtcttgctctgtcgcccaggct       c.*720

          .         .         .         .         .         .       g.24902
 ggaacgcagtggtgacatctcggctcactgcaacctccacctcccaggttcaagtgattc       c.*780

          .         .         .         .         .         .       g.24962
 tcctgcctcagcctcctgagtagctgggactacaggcgcctgccaccacgcccagctaat       c.*840

          .         .         .         .         .         .       g.25022
 ttttgtatttttagtagagatggggtttcaccatgttggccaggatggtcttgatctctt       c.*900

          .         .         .         .         .         .       g.25082
 gacctcgtgatctgcctgcctcggcctcccaaagtgctggcattacaggcatgagccacc       c.*960

          .         .         .         .         .         .       g.25142
 atgcctggcccaaagttctagaattttttaaaggtattcatggtgactcaggaatacaca       c.*1020

          .         .         .         .         .         .       g.25202
 catacacacacacacacacacacacacacacacacatacacacatataatttgaaagagg       c.*1080

          .         .         .         .         .         .       g.25262
 tgagtatgtactctgacttcagctctcaggttttaaaaattatattagtgggaccagtta       c.*1140

          .         .         .         .         .         .       g.25322
 tgacaagaataatcattatagtacttttcagattttataacctggagcagattattttaa       c.*1200

          .         .         .         .         .         .       g.25382
 gttgattagtaggttctgttacagtttttcttttgatcgtgcacttatagtcttcattta       c.*1260

          .         .         .         .         .         .       g.25442
 attcctcatagaatcccagtcacctttatatatcatattattggaagagattcatcttca       c.*1320

          .         .         .         .         .         .       g.25502
 taatctccagttttttcacagtgcctcacagagttaatcatgccttttggagctagaagg       c.*1380

          .         .         .         .         .         .       g.25562
 actttagaacttatctagttatgctcctttatattataagtaagggaatagaatcaataa       c.*1440

          .         .         .         .         .         .       g.25622
 gacagtttctgcccaaagtcatgttaccagttggtgacagagctggaaatacgtagagat       c.*1500

          .         .         .         .         .         .       g.25682
 ctatacccttaaatctctccactcacatgctgatatactttctactacaatatgctatag       c.*1560

          .         .         .         .         .         .       g.25742
 ctttatggaactcagggtgatgatcagacgtgtcattagaacatgagtcctctgcttctg       c.*1620

          .         .         .         .         .         .       g.25802
 attcaggcatacttttgggattcttccatctttaaaggaaaaaggaagccattcatctat       c.*1680

          .         .         .         .         .         .       g.25862
 atttagtaacccagtaatatctcacttagtttagggttagatctttagttaattcaacct       c.*1740

          .         .         .         .         .         .       g.25922
 tatagatcatacttatgaaggtgataactgacacgtgttcactgaattttaatttgatag       c.*1800

          .         .         .         .         .         .       g.25982
 gcaatacatctacccactccattattttttaaaacttcatttaatagtttaaacaagatt       c.*1860

          .         .         .         .         .         .       g.26042
 ggttttgttttcaatttttattcactcttcatagaatcacaattacctttatatatcata       c.*1920

          .         .         .         .         .         .       g.26102
 tgttattggaagagattcctcagtaatctccaatctctcatagtgcctcacagggttggt       c.*1980

          .         .         .         .         .         .       g.26162
 caatggcttttggaactggaaggaccttagaacttatctgttatgctcctgatagccaat       c.*2040

          .         .         .         .         .         .       g.26222
 agcagatagaagcttgcaatcaagagggtaggacatgtgttcttcaatggatatcaaagg       c.*2100

          .         .         .         .         .         .       g.26282
 aagaggttgcaaaccaaagccatttggcaagccctgtagcctgggccatttaagacaggg       c.*2160

          .         .         .         .         .         .       g.26342
 gcggtctcagccaaattgcacccatttaactatcccaaagagccacagtgcctacaaccc       c.*2220

          .         .         .         .         .         .       g.26402
 aggccctaagttgatgaagaaaaagtcaaggaaggaggtgatacaattggaaatattccc       c.*2280

          .         .         .         .         .         .       g.26462
 atcaaatggttaatcttatttagaaaatgggcatattagaaaaagtccttccaagatgat       c.*2340

          .         .         .         .         .         .       g.26522
 tttggataataaaagttgtatttgtggaaattggtattatctctgttttatgcacttaca       c.*2400

          .         .         .         .         .         .       g.26582
 tttatcccttacattttgtttttagtgaccctacatgacattaaatttaaagtaaaacat       c.*2460

          .         .         .         .         .         .       g.26642
 tgtttaatgttaccttttggcttgagaatgtctttcagctccagaattattgttactcat       c.*2520

          .         .         .         .         .         .       g.26702
 attttaatcagtaagtcatttaagctatgacagagtaggaattgagaaattatttcatat       c.*2580

          .         .         .         .         .         .       g.26762
 gctacagtattgaaatgtggatgctgccttgttttataagaagatgatcaaggtttgtgt       c.*2640

          .         .         .         .         .         .       g.26822
 gcccattacctttcctctgcctgaaagacgtgtctcaagaaaaataaattctattttaga       c.*2700

          .         .         .         .         .         .       g.26882
 tgcaggtactgcattttattctaagaattgatatcaattcaaaacatagaaaactgtaaa       c.*2760

          .         .         .         .         .         .       g.26942
 agataaatcaggagatggctgattcataatgggtaataaaataaatagcactttcgagct       c.*2820

                                                                    g.26944
 ga                                                                 c.*2822

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Cytochrome P450, family 4, subfamily V, polypeptide 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 25b
©2004-2020 Leiden University Medical Center