cytochrome P450, family 7, subfamily B, polypeptide 1 (CYP7B1) - coding DNA reference sequence

(used for variant description)

(last modified June 15, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_004820.3 in the CYP7B1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008338.1, covering CYP7B1 transcript NM_004820.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5024
                                     ggcggggagggggcagtccacgaa       c.-181

 .         .         .         .         .         .                g.5084
 cttttgtcattcagcctgggagaccacggtgacattcctgtctgcgctgcgggcaggcca       c.-121

 .         .         .         .         .         .                g.5144
 gcctctccggccctggactagggggcgccgccgagagaagccgccgcaggctgcagagtc       c.-61

 .         .         .         .         .         .                g.5204
 gccgaccgcgctgttcgcaggcagaccccgggctgcccaccgcggcctagcgcgcgccgg       c.-1

          .         .         .         .         .         .       g.5264
 ATGGCAGGAGAAGTGTCCGCGGCCACGGGCCGCTTTTCGCTGGAGCGGTTGGGCCTCCCG       c.60
 M  A  G  E  V  S  A  A  T  G  R  F  S  L  E  R  L  G  L  P         p.20

          .         .         .         .         .         .       g.5324
 GGCCTGGCCCTCGCCGCGGCCCTGCTGCTCCTGGCCCTCTGCTTGCTTGTCCGGCGCACC       c.120
 G  L  A  L  A  A  A  L  L  L  L  A  L  C  L  L  V  R  R  T         p.40

    | 02     .         .         .         .         .         .    g.179310
 AG | GAGACCCGGTGAGCCTCCATTGATAAAAGGTTGGCTTCCTTATCTTGGAGTGGTCCTG    c.180
 R  |  R  P  G  E  P  P  L  I  K  G  W  L  P  Y  L  G  V  V  L      p.60

          .         .         .         .         .         .       g.179370
 AACTTACGAAAAGACCCCTTAAGGTTCATGAAAACACTTCAAAAGCAACATGGTGACACT       c.240
 N  L  R  K  D  P  L  R  F  M  K  T  L  Q  K  Q  H  G  D  T         p.80

          .          | 03        .         .         .         .    g.187551
 TTCACAGTTCTTCTTGGTG | GAAAGTACATAACATTTATCCTGGACCCCTTCCAGTACCAG    c.300
 F  T  V  L  L  G  G |   K  Y  I  T  F  I  L  D  P  F  Q  Y  Q      p.100

          .         .         .         .         .         .       g.187611
 CTAGTGATAAAAAATCATAAACAATTAAGCTTTCGAGTATTTTCTAATAAATTATTAGAG       c.360
 L  V  I  K  N  H  K  Q  L  S  F  R  V  F  S  N  K  L  L  E         p.120

          .         .         .         .         .         .       g.187671
 AAAGCATTTAGCATCAGTCAGTTGCAAAAAAATCATGACATGAATGATGAGCTTCACCTC       c.420
 K  A  F  S  I  S  Q  L  Q  K  N  H  D  M  N  D  E  L  H  L         p.140

          .         .         .         .         .         .       g.187731
 TGCTATCAATTTTTGCAAGGCAAATCTTTGGACATACTCTTGGAAAGCATGATGCAGAAT       c.480
 C  Y  Q  F  L  Q  G  K  S  L  D  I  L  L  E  S  M  M  Q  N         p.160

          .         .         .         .         .         .       g.187791
 CTAAAACAAGTTTTTGAACCCCAGCTGTTAAAAACCACAAGTTGGGACACGGCAGAACTG       c.540
 L  K  Q  V  F  E  P  Q  L  L  K  T  T  S  W  D  T  A  E  L         p.180

          .         .         .         .         .         .       g.187851
 TATCCATTCTGCAGCTCAATAATATTTGAGATCACATTTACAACTATATATGGAAAAGTT       c.600
 Y  P  F  C  S  S  I  I  F  E  I  T  F  T  T  I  Y  G  K  V         p.200

          .         .         .         .         .         .       g.187911
 ATTGTTTGTGACAACAACAAATTTATTAGTGAGCTAAGAGATGATTTTTTAAAATTTGAT       c.660
 I  V  C  D  N  N  K  F  I  S  E  L  R  D  D  F  L  K  F  D         p.220

          .         .         .         .         .         .       g.187971
 GACAAGTTTGCATATTTAGTATCCAACATACCCATTGAGCTTCTAGGAAATGTCAAGTCT       c.720
 D  K  F  A  Y  L  V  S  N  I  P  I  E  L  L  G  N  V  K  S         p.240

          .         .         .         .         .         .       g.188031
 ATTAGAGAGAAAATTATAAAATGCTTCTCATCAGAAAAGTTAGCCAAGATGCAAGGATGG       c.780
 I  R  E  K  I  I  K  C  F  S  S  E  K  L  A  K  M  Q  G  W         p.260

          .         .         .         .         .         .       g.188091
 TCAGAAGTTTTTCAAAGCAGGCAAGATGTCCTGGAGAAATATTATGTGCACGAGGACCTT       c.840
 S  E  V  F  Q  S  R  Q  D  V  L  E  K  Y  Y  V  H  E  D  L         p.280

          . | 04       .         .         .         .         .    g.188609
 GAAATAGGAG | CACATCATTTAGGCTTTCTCTGGGCCTCTGTGGCAAACACTATTCCAACT    c.900
 E  I  G  A |   H  H  L  G  F  L  W  A  S  V  A  N  T  I  P  T      p.300

          .         .         .         .         .         .       g.188669
 ATGTTCTGGGCAATGTATTATCTTCTGCGGCACCCAGAAGCTATGGCAGCAGTGCGTGAC       c.960
 M  F  W  A  M  Y  Y  L  L  R  H  P  E  A  M  A  A  V  R  D         p.320

          .         .         .         .         .         .       g.188729
 GAAATTGACCGTTTGCTGCAGTCAACAGGTCAAAAGAAAGGGTCTGGATTTCCCATCCAC       c.1020
 E  I  D  R  L  L  Q  S  T  G  Q  K  K  G  S  G  F  P  I  H         p.340

          .         .         .        | 05.         .         .    g.198957
 CTCACCAGAGAACAATTGGACAGCCTAATCTGCCTAG | AAAGCAGCATTTTTGAAGCTTTA    c.1080
 L  T  R  E  Q  L  D  S  L  I  C  L  E |   S  S  I  F  E  A  L      p.360

          .         .         .         .         .         .       g.199017
 CGACTGTCCTCATATTCAACCACCATTCGTTTTGTTGAGGAGGATTTGACTCTCAGTTCA       c.1140
 R  L  S  S  Y  S  T  T  I  R  F  V  E  E  D  L  T  L  S  S         p.380

          .         .         .         .         .         .       g.199077
 GAGACCGGGGACTACTGTGTGCGAAAGGGAGACTTGGTAGCCATCTTTCCTCCAGTCCTA       c.1200
 E  T  G  D  Y  C  V  R  K  G  D  L  V  A  I  F  P  P  V  L         p.400

          .         .         .    | 06    .         .         .    g.206889
 CATGGTGACCCTGAAATCTTTGAAGCTCCAGAG | GAGTTTAGATATGATCGTTTTATAGAA    c.1260
 H  G  D  P  E  I  F  E  A  P  E   | E  F  R  Y  D  R  F  I  E      p.420

          .         .         .         .         .         .       g.206949
 GATGGTAAGAAGAAAACCACCTTTTTCAAAAGAGGGAAAAAGCTGAAGTGTTACCTAATG       c.1320
 D  G  K  K  K  T  T  F  F  K  R  G  K  K  L  K  C  Y  L  M         p.440

          .         .         .         .         .         .       g.207009
 CCGTTTGGAACTGGAACCAGCAAATGTCCAGGCCGATTTTTTGCACTTATGGAAATAAAA       c.1380
 P  F  G  T  G  T  S  K  C  P  G  R  F  F  A  L  M  E  I  K         p.460

          .         .         .         .         .         .       g.207069
 CAATTGTTGGTTATACTTTTAACTTATTTTGATTTAGAAATAATTGATGATAAGCCCATA       c.1440
 Q  L  L  V  I  L  L  T  Y  F  D  L  E  I  I  D  D  K  P  I         p.480

          .         .         .         .         .         .       g.207129
 GGACTAAACTACAGCCGCTTGTTGTTTGGTATTCAGTATCCAGATTCTGATGTTTTATTT       c.1500
 G  L  N  Y  S  R  L  L  F  G  I  Q  Y  P  D  S  D  V  L  F         p.500

          .         .                                               g.207150
 AGATACAAAGTGAAATCTTAG                                              c.1521
 R  Y  K  V  K  S  X                                                p.506

          .         .         .         .         .         .       g.207210
 agaagctaaaaggaaagaaaataaatctatcaaaattaccctaaacatcctaagctcatc       c.*60

          .         .         .         .         .         .       g.207270
 tatttctttttaatttctgcaaatgtaattgatttatttgtttaaaaagcgctaatttct       c.*120

          .         .         .         .         .         .       g.207330
 atttgatctgatatcagtccagtttgtccttagtcacaaagcccatcataatataaaaca       c.*180

          .         .         .         .         .         .       g.207390
 ggatggtggcaggaaaatggacatcaaaatcaacttaagggtaggctcaaaacagggttg       c.*240

          .         .         .         .         .         .       g.207450
 ttgttgtttttttagtttctccttgttgtgattttcacctgttataataaatgtaccttc       c.*300

          .         .         .         .         .         .       g.207510
 acaccaatagattgggcactgtggaatttaaatcactcaaattgttctctaatatgtaaa       c.*360

          .         .         .         .         .         .       g.207570
 attacactttgaactactagaaaattgtgctggaaatggacacagtctaacaaattccaa       c.*420

          .         .         .         .         .         .       g.207630
 attctcacagaagaaggaaattgaatttccatgagttacactggatgaaaatgttccctt       c.*480

          .         .         .         .         .         .       g.207690
 caagtataatattaataatacctatatttccagggtatgtgtgcattaaatgagtttcac       c.*540

          .         .         .         .         .         .       g.207750
 agtagattgaatgcttcaacttcacttcaatatttaatcatgcataaatgttccttatta       c.*600

          .         .         .         .         .         .       g.207810
 ctttgtatactatggctcaatagaacaaaatttctggttacataagacctttcatgttca       c.*660

          .                                                         g.207820
 agttagatac                                                         c.*670

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Cytochrome P450, family 7, subfamily B, polypeptide 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 13
©2004-2015 Leiden University Medical Center