dachshund homolog 2 (Drosophila) (DACH2) - coding DNA reference sequence

(used for variant description)

(last modified July 4, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_053281.3 in the DACH2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012817.1, covering DACH2 transcript NM_053281.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5050
           actgtttgttgagcttgagcgtgagccggctgctgaagacttgcgaacag       c.-121

 .         .         .         .         .         .                g.5110
 ttcggagccagcgagagcgcgccagagagagcgagagtgagggagtgagtgcgaggggat       c.-61

 .         .         .         .         .         .                g.5170
 ctagaggagtcagggcgagaaagcgagggccggaggacccacgatagagacagagtgacc       c.-1

          .         .         .         .         .         .       g.5230
 ATGGCTGTCTCCGCATCTCCAGTGATCTCTGCAACTTCCAGCGGCGCCGGCGTCCCGGGG       c.60
 M  A  V  S  A  S  P  V  I  S  A  T  S  S  G  A  G  V  P  G         p.20

          .         .         .         .         .         .       g.5290
 GGCTTATTCCGGGCCGAACCCCTGTACTCGACTCCCAGAGAGCCCCCTCGTCTTACTCCT       c.120
 G  L  F  R  A  E  P  L  Y  S  T  P  R  E  P  P  R  L  T  P         p.40

          .         .         .         .         .         .       g.5350
 AATATGATCAATAGTTTCGTGGTTAATAACCACAGCAACAGTGCCGGAGGCGGCGGCAGG       c.180
 N  M  I  N  S  F  V  V  N  N  H  S  N  S  A  G  G  G  G  R         p.60

          .         .         .         .         .         .       g.5410
 GGCAACACCAACACCAACGAGTGCCGCATGGTCGACATGCACGGGATGAAGGTGGCTTCG       c.240
 G  N  T  N  T  N  E  C  R  M  V  D  M  H  G  M  K  V  A  S         p.80

          .         .         .         .         .         .       g.5470
 TTCCTGATGGACGGCCAGGAACTGATCTGCCTGCCGCAAGTCTTTGATCTTTTTCTCAAG       c.300
 F  L  M  D  G  Q  E  L  I  C  L  P  Q  V  F  D  L  F  L  K         p.100

          .         .         .         .         .         .       g.5530
 CACCTGGTGGGAGGCTTGCACACTGTGTACACCAAGCTGAAGAGACTGGATATATCCCCC       c.360
 H  L  V  G  G  L  H  T  V  Y  T  K  L  K  R  L  D  I  S  P         p.120

          .         .         .         .         .         .       g.5590
 GTGGTGTGTACTGTTGAGCAGGTCCGGATCCTCCGCGGGCTGGGGGCCATCCAGCCCGGG       c.420
 V  V  C  T  V  E  Q  V  R  I  L  R  G  L  G  A  I  Q  P  G         p.140

          .         .         .         .         .         .       g.5650
 GTAAACCGCTGCAAACTCATCACCAGGAAAGACTTCGAAACTTTGTTCACCGATTGCACC       c.480
 V  N  R  C  K  L  I  T  R  K  D  F  E  T  L  F  T  D  C  T         p.160

          | 02         .         .         .        | 03.         . g.370840
 AATGCCAG | AAGGAAGAGGCAAATGACAAGAAAACAAGCTGTTAACAG | TTCAAGACCCGGC c.540
 N  A  R  |  R  K  R  Q  M  T  R  K  Q  A  V  N  S  |  S  R  P  G   p.180

          .         .         .         .         .         .       g.370900
 AGGCCCCCTAAGCGTTCTTTGGGAGTGTTGCAGGAAAATGCCCGCCTTCTGACCCATGCA       c.600
 R  P  P  K  R  S  L  G  V  L  Q  E  N  A  R  L  L  T  H  A         p.200

          .         .         .         . | 04       .         .    g.507604
 GTCCCAGGCCTCTTATCGCCAGGACTTATCACTCCGACAG | GTATAACAGCTGCAGCGATG    c.660
 V  P  G  L  L  S  P  G  L  I  T  P  T  G |   I  T  A  A  A  M      p.220

          .         .         .         .         .         .       g.507664
 GCTGAGGCGATGAAACTTCAGAAGATGAAGCTTATGGCTATGAACACTCTTCAGGGAAAT       c.720
 A  E  A  M  K  L  Q  K  M  K  L  M  A  M  N  T  L  Q  G  N         p.240

          .         .         .         .         .   | 05     .    g.551577
 GGAAGCCAAAATGGGACCGAATCAGAGCCTGATGATCTTAATTCTAACACAG | GTGGAAGT    c.780
 G  S  Q  N  G  T  E  S  E  P  D  D  L  N  S  N  T  G |   G  S      p.260

          .         .         .         .         .         .       g.551637
 GAATCCTCCTGGGATAAAGATAAGATGCAGTCTCCATTTGCTGCACCTGGACCCCAACAT       c.840
 E  S  S  W  D  K  D  K  M  Q  S  P  F  A  A  P  G  P  Q  H         p.280

          .         .         .         .         .         .       g.551697
 GGAATTGCTCATGCAGCCCTAGCTGGCCAGCCAGGCATTGGGGGTGCTCCAACCCTCAAT       c.900
 G  I  A  H  A  A  L  A  G  Q  P  G  I  G  G  A  P  T  L  N         p.300

          .         .         .  | 06      .         .         .    g.571125
 CCACTGCAGCAGAACCACCTGCTAACCAATA | GACTGGATCTGCCATTTATGATGATGCCT    c.960
 P  L  Q  Q  N  H  L  L  T  N  R |   L  D  L  P  F  M  M  M  P      p.320

          .         .         .         .         .         .       g.571185
 CATCCCCTACTTCCAGTCAGCTTACCTCCTGCATCAGTTGCCATGGCAATGAATCAGATG       c.1020
 H  P  L  L  P  V  S  L  P  P  A  S  V  A  M  A  M  N  Q  M         p.340

          .         .         .         .         .         .       g.571245
 AACCATCTCAATACTATTGCCAACATGGCTGCTGCAGCACAGATTCACAGTCCACTCTCC       c.1080
 N  H  L  N  T  I  A  N  M  A  A  A  A  Q  I  H  S  P  L  S         p.360

          .         .     | 07   .         .         .         .    g.596331
 AGAGCTGGTACCTCTGTTATAAAG | GAGCGGATCCCAGAGAGTCCTTCTCCTGCTCCTTCT    c.1140
 R  A  G  T  S  V  I  K   | E  R  I  P  E  S  P  S  P  A  P  S      p.380

          .         .         .         .         .         .       g.596391
 CTAGAAGAGAATCATCGTCCTGGGAGCCAGACCTCTTCCCACACCAGCAGCAGTGTGTCC       c.1200
 L  E  E  N  H  R  P  G  S  Q  T  S  S  H  T  S  S  S  V  S         p.400

          .         .         .         . | 08       .         .    g.669424
 AGCTCTCCCTCTCAGATGGATCATCATTTGGAAAGAATGG | AAGAGGTACCAGTTCAAATT    c.1260
 S  S  P  S  Q  M  D  H  H  L  E  R  M  E |   E  V  P  V  Q  I      p.420

          .         .         .         .         .         .       g.669484
 CCAATAATGAAGTCACCCTTGGACAAGATACAGCTGACTCCTGGGCAGGCATTGCCCGCT       c.1320
 P  I  M  K  S  P  L  D  K  I  Q  L  T  P  G  Q  A  L  P  A         p.440

          .         .         .         .         .         .       g.669544
 GGATTCCCTGGACCATTCATTTTTGCTGATAGTCTGTCCTCCGTGGAGACTCTGTTGACC       c.1380
 G  F  P  G  P  F  I  F  A  D  S  L  S  S  V  E  T  L  L  T         p.460

           | 09        .         .         .         .         .    g.669729
 AACATTCAG | GGTCTGCTGAAAGTTGCTTTGGATAATGCTCGCATCCAGGAGAAGCAGATT    c.1440
 N  I  Q   | G  L  L  K  V  A  L  D  N  A  R  I  Q  E  K  Q  I      p.480

          .         .         .         .         .         .       g.669789
 CAACAAGAAAAGAAGGAGCTGCGACTGGAGCTCTATAGAGAGAGAGAAATTAGAGAAAAC       c.1500
 Q  Q  E  K  K  E  L  R  L  E  L  Y  R  E  R  E  I  R  E  N         p.500

          .         .         .        | 10.         .         .    g.671259
 CTTGAAAGACAACTTGCAGTTGAGCTTCAAAGCAGAA | CTACTATGCAAAAGCGCCTGAAG    c.1560
 L  E  R  Q  L  A  V  E  L  Q  S  R  T |   T  M  Q  K  R  L  K      p.520

          .         .         .         .         .         .       g.671319
 AAGGAGAAAAAAACCAAGAGAAAATTGCAGGAAGCCTTGGAATTTGAATCAAAGCGCCGG       c.1620
 K  E  K  K  T  K  R  K  L  Q  E  A  L  E  F  E  S  K  R  R         p.540

          .         .         .         .         .         .       g.671379
 GAGCAAGTGGAGCAGGCACTTAAGCAAGCCACCACTAGTGACAGTGGCCTGAGGATGTTA       c.1680
 E  Q  V  E  Q  A  L  K  Q  A  T  T  S  D  S  G  L  R  M  L         p.560

      | 11   .         .         .         .         .         .    g.672638
 AAAG | ATACTGGAATTCCAGATATTGAAATAGAAAACAATGGGACTCCTCATGATAGTGCT    c.1740
 K  D |   T  G  I  P  D  I  E  I  E  N  N  G  T  P  H  D  S  A      p.580

          . | 12       .         .         .         .         .    g.688704
 GCTATGCAAG | GAGGTAACTATTACTGTTTAGAAATGGCACAACAGTTGTATTCAGCCTGA    c.1800
 A  M  Q  G |   G  N  Y  Y  C  L  E  M  A  Q  Q  L  Y  S  A  X      p.599

          .         .         .         .         .         .       g.688764
 aaggtcctcgctggctttacataaatgaagatgcttgtgattccagtttatctctgaaac       c.*60

          .         .         .         .         .         .       g.688824
 tattcaacatggagttatttcagttttgtttatcagcaaagctttgtttactgaaggagc       c.*120

          .         .         .         .         .         .       g.688884
 tatttaatctatgttacattaaaaaagaaacgcgtgtacattttaaaagcaatgatgtaa       c.*180

          .         .         .         .         .         .       g.688944
 actttgttcttgcattagactgaccagtttaaaaatatgaactaaaacctaatggctaaa       c.*240

          .         .         .         .         .         .       g.689004
 gtaacttgaccatatttgatgcttttctatgctcatttcaacttggctttttgtctttta       c.*300

          .         .         .         .         .         .       g.689064
 aatttttaaaaaatgcagtagtgtgttagagactagaaagttatatgtatggtttccctg       c.*360

          .         .         .         .         .         .       g.689124
 ttctactatacataacgttaaagtacaccttctttgttaaaaatgtacttgctaaacttc       c.*420

          .         .                                               g.689151
 agcgtaaataaaaacattttgactttg                                        c.*447

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Dachshund homolog 2 (Drosophila) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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