Duffy blood group, chemokine receptor (DARC) - coding DNA reference sequence

(used for variant description)

(last modified September 8, 2016)

This file was created to facilitate the description of sequence variants on transcript NM_002036.3 in the DARC gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000001.10, covering DARC transcript NM_002036.3.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                     .         .         .         .                g.5047
              cccccagtagaaatatgaatagaaatcaccctgtgggcaatggtccc       c.-901

 .         .         .         .         .         .                g.5107
 attttaaaatatgctgtcccattgtcccctagagcctactttaacttgtcagaccatgta       c.-841

 .         .         .         .         .         .                g.5167
 ttccacttcatatgcaagaggcatgcactgagcccataggtggctaggcaaacacccaat       c.-781

 .         .         .         .         .         .                g.5227
 agctccctgaaatggcttcattatgcagcctcgacagccaccccaaccctcccactctca       c.-721

 .         .         .         .         .         .                g.5287
 cactgaaacacccagacctagagatagctagacacacccagacacccgccaagcccctca       c.-661

 .         .         .         .         .         .                g.5347
 catacagatatgtgcacaatgatacacagcaaacgtacacagagttcagtacacacaaag       c.-601

 .         .         .         .         .         .                g.5407
 agctcacgcccacgtgcacacacccctcagttgggacagagttgaccaccaccacctttc       c.-541

 .         .         .         .         .         .                g.5467
 tcccaaacacatggcttttgaactgcctttccttggatccagttcaaggggatggaggag       c.-481

 .         .         .         .         .         .                g.5527
 cagtgagagtcagccgcccttccactccaatttcccagcacctcccttatctctgcctca       c.-421

 .         .         .         .         .         .                g.5587
 caagtcacccagcccccctctcttccttccttgtgcttgaagaatctctccttgctggaa       c.-361

 .         .         .         .         .         .                g.5647
 agccccctgttttctcaatctccctttccacttcggtaaaatctctacttgctggaaagc       c.-301

 .         .         .         .         .         .                g.5707
 cccctgttttctcaatctccctttccacttcggtaaaatgcccactttctggtccccacc       c.-241

 .         .         .         .         .         .                g.5767
 tttttcctgagtgtagtcccaaccagccaaatccaacctcaaaacaggaagacccaaggc       c.-181

 .         .         .         .         .         .                g.5827
 cagtgacccccataggcctgaggcttgtgcaggcagtgggcgtggggtaaggcttcctga       c.-121

 .         .         .         .         .         .                g.5887
 tgccccctgtccctgcccagaacctgatggccctcattagtccttggctcttatcttgga       c.-61

 .         .         .         .         .         .                g.5947
 agcacaggcgctgacagccgtcccagcccttctgtctgcgggcctgaaccaaacggtgcc       c.-1

          .         .  | 02      .         .         .         .    g.6487
 ATGGGGAACTGTCTGCACAGG | GCGGAGCTCTCCCCCTCAACTGAGAACTCAAGTCAGCTG    c.60
 M  G  N  C  L  H  R   | A  E  L  S  P  S  T  E  N  S  S  Q  L      p.20

          .         .         .         .         .         .       g.6547
 GACTTCGAAGATGTATGGAATTCTTCCTATGGTGTGAATGATTCCTTCCCAGATGGAGAC       c.120
 D  F  E  D  V  W  N  S  S  Y  G  V  N  D  S  F  P  D  G  D         p.40

          .         .         .         .         .         .       g.6607
 TATGGTGCCAACCTGGAAGCAGCTGCCCCCTGCCACTCCTGTAACCTGCTGGATGACTCT       c.180
 Y  G  A  N  L  E  A  A  A  P  C  H  S  C  N  L  L  D  D  S         p.60

          .         .         .         .         .         .       g.6667
 GCACTGCCCTTCTTCATCCTCACCAGTGTCCTGGGTATCCTAGCTAGCAGCACTGTCCTC       c.240
 A  L  P  F  F  I  L  T  S  V  L  G  I  L  A  S  S  T  V  L         p.80

          .         .         .         .         .         .       g.6727
 TTCATGCTTTTCAGACCTCTCTTCCGCTGGCAGCTCTGCCCTGGCTGGCCTGTCCTGGCA       c.300
 F  M  L  F  R  P  L  F  R  W  Q  L  C  P  G  W  P  V  L  A         p.100

          .         .         .         .         .         .       g.6787
 CAGCTGGCTGTGGGCAGTGCCCTCTTCAGCATTGTGGTGCCCGTCTTGGCCCCAGGGCTA       c.360
 Q  L  A  V  G  S  A  L  F  S  I  V  V  P  V  L  A  P  G  L         p.120

          .         .         .         .         .         .       g.6847
 GGTAGCACTCGCAGCTCTGCCCTGTGTAGCCTGGGCTACTGTGTCTGGTATGGCTCAGCC       c.420
 G  S  T  R  S  S  A  L  C  S  L  G  Y  C  V  W  Y  G  S  A         p.140

          .         .         .         .         .         .       g.6907
 TTTGCCCAGGCTTTGCTGCTAGGGTGCCATGCCTCCCTGGGCCACAGACTGGGTGCAGGC       c.480
 F  A  Q  A  L  L  L  G  C  H  A  S  L  G  H  R  L  G  A  G         p.160

          .         .         .         .         .         .       g.6967
 CAGGTCCCAGGCCTCACCCTGGGGCTCACTGTGGGAATTTGGGGAGTGGCTGCCCTACTG       c.540
 Q  V  P  G  L  T  L  G  L  T  V  G  I  W  G  V  A  A  L  L         p.180

          .         .         .         .         .         .       g.7027
 ACACTGCCTGTCACCCTGGCCAGTGGTGCTTCTGGTGGACTCTGCACCCTGATATACAGC       c.600
 T  L  P  V  T  L  A  S  G  A  S  G  G  L  C  T  L  I  Y  S         p.200

          .         .         .         .         .         .       g.7087
 ACGGAGCTGAAGGCTTTGCAGGCCACACACACTGTAGCCTGTCTTGCCATCTTTGTCTTG       c.660
 T  E  L  K  A  L  Q  A  T  H  T  V  A  C  L  A  I  F  V  L         p.220

          .         .         .         .         .         .       g.7147
 TTGCCATTGGGTTTGTTTGGAGCCAAGGGGCTGAAGAAGGCATTGGGTATGGGGCCAGGC       c.720
 L  P  L  G  L  F  G  A  K  G  L  K  K  A  L  G  M  G  P  G         p.240

          .         .         .         .         .         .       g.7207
 CCCTGGATGAATATCCTGTGGGCCTGGTTTATTTTCTGGTGGCCTCATGGGGTGGTTCTA       c.780
 P  W  M  N  I  L  W  A  W  F  I  F  W  W  P  H  G  V  V  L         p.260

          .         .         .         .         .         .       g.7267
 GGACTGGATTTCCTGGTGAGGTCCAAGCTGTTGCTGTTGTCAACATGTCTGGCCCAGCAG       c.840
 G  L  D  F  L  V  R  S  K  L  L  L  L  S  T  C  L  A  Q  Q         p.280

          .         .         .         .         .         .       g.7327
 GCTCTGGACCTGCTGCTGAACCTGGCAGAAGCCCTGGCAATTTTGCACTGTGTGGCTACG       c.900
 A  L  D  L  L  L  N  L  A  E  A  L  A  I  L  H  C  V  A  T         p.300

          .         .         .         .         .         .       g.7387
 CCCCTGCTCCTCGCCCTATTCTGCCACCAGGCCACCCGCACCCTCTTGCCCTCTCTGCCC       c.960
 P  L  L  L  A  L  F  C  H  Q  A  T  R  T  L  L  P  S  L  P         p.320

          .         .         .         .         .                 g.7438
 CTCCCTGAAGGATGGTCTTCTCATCTGGACACCCTTGGAAGCAAATCCTAG                c.1011
 L  P  E  G  W  S  S  H  L  D  T  L  G  S  K  S  X                  p.336

          .         .         .         .         .                 g.7488
 ttctcttcccacctgtcaacctgaattaaagtctacactgcctttgtgaa                 c.*50

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Duffy blood group, chemokine receptor protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.