aspartyl-tRNA synthetase 2, mitochondrial (DARS2) - coding DNA reference sequence

(used for variant description)

(last modified February 28, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_018122.4 in the DARS2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000001.10, covering DARS2 transcript NM_018122.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5031
                              tagcgggcggagttgaagggcgcttggaccc       c.-541

 .         .         .         .         .         .                g.5091
 cagcggcgatctgtgtttgggttcgcgctctgggagaattttggctttgctcgccttcct       c.-481

 .         .         .         .         .         .                g.5151
 ctttcagaagactcgaaatcggccagcaggtctgcgagatttgaaacgcgactgttactc       c.-421

 .         .         .         .         .         .                g.5211
 cttgttttccggttctggccgcgggagcctctcgagaagcgtggaaagaggagaagggcg       c.-361

 .         .         .         .         .         .                g.5271
 tataccttgtgaccgcctctggttgtcttgggctcgcgcctggcgccgctacgtggagtc       c.-301

 .         .         .         .         .         .                g.5331
 gctctctcgtcgtcacttttggctgccgacttgttgagtagaagtgcagactgatgcttt       c.-241

 .         .         .         .         .         .                g.5391
 aagactcagggagaggtctttcccttatctccaccccagcaagcaccccagagaccttgg       c.-181

 .         .         .         .         .         .                g.5451
 agatttgtcttgtttctagacacgtgtactccaatgttgtgcggaggaggccttaaatat       c.-121

 .         .         .         .         .         .                g.5511
 tcgagaagagagtgggaactcctggaattttaagggatttctgtgtatttccaaaactga       c.-61

 .         .         .         .         .         .                g.5571
 cttttaactaccggcagcgtgggatttcgtgattgtttttcgccatcgtgtggctccaac       c.-1

          .         .         .         .         .         .       g.5631
 ATGTACTTCCCTTCTTGGTTAAGTCAGCTGTACAGGGGTTTATCCAGACCCATCAGAAGG       c.60
 M  Y  F  P  S  W  L  S  Q  L  Y  R  G  L  S  R  P  I  R  R         p.20

          .         .         .         .         .         .       g.5691
 ACCACCCAACCGATCTGGGGTTCTCTCTACAGAAGTCTGTTGCAGAGTTCACAGAGGAGA       c.120
 T  T  Q  P  I  W  G  S  L  Y  R  S  L  L  Q  S  S  Q  R  R         p.40

         | 02.         .         .         .         .         .    g.7081
 ATTCCAG | AATTCAGTAGCTTTGTTGTCCGGACCAACACATGTGGAGAGTTGCGTTCGTCT    c.180
 I  P  E |   F  S  S  F  V  V  R  T  N  T  C  G  E  L  R  S  S      p.60

          .         .         .         .        | 03.         .    g.8687
 CACTTAGGCCAAGAAGTCACCTTGTGTGGATGGATTCAGTACCGAAG | GCAAAACACATTC    c.240
 H  L  G  Q  E  V  T  L  C  G  W  I  Q  Y  R  R  |  Q  N  T  F      p.80

          .         .         .         .         .     | 04   .    g.11007
 TTGGTCCTAAGAGATTTCGATGGGCTTGTTCAAGTTATCATTCCCCAGGATGAG | TCGGCA    c.300
 L  V  L  R  D  F  D  G  L  V  Q  V  I  I  P  Q  D  E   | S  A      p.100

          .         .         .         .         .         .       g.11067
 GCCTCTGTGAAGAAGATTTTATGTGAAGCCCCTGTGGAATCTGTGGTGCAAGTGTCTGGT       c.360
 A  S  V  K  K  I  L  C  E  A  P  V  E  S  V  V  Q  V  S  G         p.120

          .         .         .       | 05 .         .         .    g.11900
 ACAGTCATTTCCCGTCCTGCAGGACAAGAGAATCCA | AAAATGCCAACAGGTGAGATTGAA    c.420
 T  V  I  S  R  P  A  G  Q  E  N  P   | K  M  P  T  G  E  I  E      p.140

          .         .         .         .         .         .       g.11960
 ATCAAAGTTAAAACAGCTGAGCTTCTGAATGCCTGCAAGAAGCTGCCCTTTGAAATTAAG       c.480
 I  K  V  K  T  A  E  L  L  N  A  C  K  K  L  P  F  E  I  K         p.160

          .   | 06     .         .         .         .         .    g.13765
 AACTTCGTGAAG | AAAACAGAGGCTCTTCGGTTGCAGTATCGCTACTTAGACTTGCGTAGT    c.540
 N  F  V  K   | K  T  E  A  L  R  L  Q  Y  R  Y  L  D  L  R  S      p.180

          .         .         .         .         .         .       g.13825
 TTCCAAATGCAGTATAACCTGCGACTGAGGTCCCAGATGGTCATGAAAATGCGGGAATAT       c.600
 F  Q  M  Q  Y  N  L  R  L  R  S  Q  M  V  M  K  M  R  E  Y         p.200

          .       | 07 .         .         .         .         .    g.14858
 CTCTGTAATCTGCATG | GGTTTGTGGATATAGAAACCCCCACATTGTTTAAGAGGACCCCA    c.660
 L  C  N  L  H  G |   F  V  D  I  E  T  P  T  L  F  K  R  T  P      p.220

     | 08    .         .         .         .         .         .    g.17338
 GGG | GGTGCCAAAGAGTTTTTAGTACCATCCAGGGAACCTGGAAAGTTTTATTCTCTCCCT    c.720
 G   | G  A  K  E  F  L  V  P  S  R  E  P  G  K  F  Y  S  L  P      p.240

          .         .         .         .         . | 09       .    g.18541
 CAGAGTCCTCAACAGTTTAAGCAACTTCTGATGGTTGGCGGTTTAGACAG | ATATTTTCAG    c.780
 Q  S  P  Q  Q  F  K  Q  L  L  M  V  G  G  L  D  R  |  Y  F  Q      p.260

          .         .         .         .         .         .       g.18601
 GTTGCCCGATGTTATCGAGATGAAGGTTCAAGACCAGACAGACAGCCTGAGTTTACTCAG       c.840
 V  A  R  C  Y  R  D  E  G  S  R  P  D  R  Q  P  E  F  T  Q         p.280

  | 10       .         .         .         .         .         .    g.19768
  | ATTGACATAGAGATGTCATTTGTAGACCAGACTGGGATCCAGAGTTTAATTGAGGGTTTG    c.900
  | I  D  I  E  M  S  F  V  D  Q  T  G  I  Q  S  L  I  E  G  L      p.300

          .         .         .         .         .         .       g.19828
 CTCCAGTATTCCTGGCCCAATGACAAAGATCCTGTGGTTGTTCCTTTTCCTACTATGACT       c.960
 L  Q  Y  S  W  P  N  D  K  D  P  V  V  V  P  F  P  T  M  T         p.320

          .         .         .         .         .         .       g.19888
 TTTGCTGAGGTGCTGGCCACCTATGGAACTGATAAACCTGACACTCGCTTTGGAATGAAG       c.1020
 F  A  E  V  L  A  T  Y  G  T  D  K  P  D  T  R  F  G  M  K         p.340

  | 11       .         .         .         .         .         .    g.21267
  | ATTATAGATATCAGTGATGTGTTTAGAAACACAGAGATTGGATTTCTTCAAGATGCACTT    c.1080
  | I  I  D  I  S  D  V  F  R  N  T  E  I  G  F  L  Q  D  A  L      p.360

          .         .         .         .         | 12         .    g.25582
 AGTAAGCCCCATGGAACTGTGAAAGCCATATGTATCCCTGAAGGAGCA | AAATACTTAAAA    c.1140
 S  K  P  H  G  T  V  K  A  I  C  I  P  E  G  A   | K  Y  L  K      p.380

          .         .         .         .         .  | 13      .    g.30677
 AGGAAAGACATTGAATCCATTAGAAACTTTGCAGCTGACCATTTTAATCAG | GAAATCTTA    c.1200
 R  K  D  I  E  S  I  R  N  F  A  A  D  H  F  N  Q   | E  I  L      p.400

          .         .         .         .         .         .       g.30737
 CCTGTATTCCTTAACGCCAATAGAAACTGGAATTCTCCAGTTGCTAATTTCATAATGGAG       c.1260
 P  V  F  L  N  A  N  R  N  W  N  S  P  V  A  N  F  I  M  E         p.420

          .         .         .         .         .         .       g.30797
 TCACAAAGACTGGAATTAATCAGACTAATGGAGACCCAAGAGGAAGATGTGGTCCTACTA       c.1320
 S  Q  R  L  E  L  I  R  L  M  E  T  Q  E  E  D  V  V  L  L         p.440

          .         .     | 14   .         .         .         .    g.33726
 ACTGCTGGAGAGCACAATAAAGCA | TGCTCTTTGTTAGGAAAATTACGACTGGAATGTGCT    c.1380
 T  A  G  E  H  N  K  A   | C  S  L  L  G  K  L  R  L  E  C  A      p.460

          .         .         .         .         .         .       g.33786
 GACCTTCTAGAAACAAGAGGAGTGGTGCTCCGTGACCCCACTCTGTTCTCTTTCCTTTGG       c.1440
 D  L  L  E  T  R  G  V  V  L  R  D  P  T  L  F  S  F  L  W         p.480

          .         .         .         .         .         .       g.33846
 GTGGTAGATTTCCCACTCTTCCTGCCCAAGGAGGAAAATCCCAGAGAGCTGGAATCGGCC       c.1500
 V  V  D  F  P  L  F  L  P  K  E  E  N  P  R  E  L  E  S  A         p.500

          .         .         .         .         .         .       g.33906
 CACCACCCATTTACTGCTCCCCACCCCAGTGACATACATCTCCTGTACACTGAGCCCAAA       c.1560
 H  H  P  F  T  A  P  H  P  S  D  I  H  L  L  Y  T  E  P  K         p.520

     | 15    .         .         .         .         .         .    g.34193
 AAG | GCCCGTAGCCAACACTATGACTTGGTTTTAAATGGCAATGAAATAGGAGGTGGTTCA    c.1620
 K   | A  R  S  Q  H  Y  D  L  V  L  N  G  N  E  I  G  G  G  S      p.540

          .         .         .         .         .     | 16   .    g.37013
 ATTCGAATTCACAATGCAGAGCTGCAGCGTTATATCCTGGCAACCTTACTAAAG | GAGGAT    c.1680
 I  R  I  H  N  A  E  L  Q  R  Y  I  L  A  T  L  L  K   | E  D      p.560

          .         .         .         .         .         .       g.37073
 GTGAAAATGCTCTCCCATCTGCTCCAGGCTTTAGATTATGGGGCACCCCCTCATGGAGGA       c.1740
 V  K  M  L  S  H  L  L  Q  A  L  D  Y  G  A  P  P  H  G  G         p.580

          . | 17       .         .         .         .         .    g.37909
 ATTGCCTTAG | GGTTAGACAGACTGATATGCCTTGTCACTGGATCTCCAAGCATCAGAGAT    c.1800
 I  A  L  G |   L  D  R  L  I  C  L  V  T  G  S  P  S  I  R  D      p.600

          .         .         .         .         .         .       g.37969
 GTCATAGCCTTCCCAAAGTCCTTCCGGGGACATGACCTCATGAGCAATACCCCAGATTCT       c.1860
 V  I  A  F  P  K  S  F  R  G  H  D  L  M  S  N  T  P  D  S         p.620

          .         .         .         .         .         .       g.38029
 GTCCCTCCTGAGGAACTGAAGCCCTATCATATCCGAGTCTCCAAGCCAACAGACTCCAAA       c.1920
 V  P  P  E  E  L  K  P  Y  H  I  R  V  S  K  P  T  D  S  K         p.640

          .                                                         g.38047
 GCAGAAAGAGCTCATTGA                                                 c.1938
 A  E  R  A  H  X                                                   p.645

          .         .         .         .         .         .       g.38107
 atcatgcataccatgcagaaagttgagcttttaggttttgtcctctttgcttccccaagg       c.*60

          .         .         .         .         .         .       g.38167
 ctaaagtcagatctagagttctgccacaggtctaacaatcaagtctttagatggaaggaa       c.*120

          .         .         .         .         .         .       g.38227
 tccaggcaacattcttcaccacaacgaagaaacagataaaagatacccaattttgacttg       c.*180

          .         .         .         .         .         .       g.38287
 atttcatgcatcatttggattttttttggttaggactttttttgaagttcctttttactt       c.*240

          .         .         .         .         .         .       g.38347
 aggtgtgaaagatggttctttgttgaaataatatagtggtttagtgttttcaaatcatgt       c.*300

          .         .         .         .         .         .       g.38407
 ttctcatacccagatagtagattattcacttaggacagaggtaatcaaattatgtgtgaa       c.*360

          .         .         .         .         .         .       g.38467
 atgtaggaaaatgcttgcccctgtaaactagtgagttgatggagcatttgcttcatcatc       c.*420

          .         .         .         .         .         .       g.38527
 ctcatcaagagaatcatataaattaagctttataatgacatttcaaccatcaacataata       c.*480

          .         .         .         .         .         .       g.38587
 tagtgaggagtagcataatattttttaataatgcagaaaacatcactgaaatgagagtca       c.*540

          .         .         .         .         .         .       g.38647
 caaatttttcttcagtgtttcagcctgagtaagttacataaacctcgcttagcctccctt       c.*600

          .         .         .         .         .         .       g.38707
 cctgctaatgtgtaaaatacatacttgccctggctacctcaccgggctgttattgctgga       c.*660

          .         .         .         .         .         .       g.38767
 atcagaggagataacatatatggaagataaagtgaataaaagtactttgaaaaactataa       c.*720

          .         .         .         .         .         .       g.38827
 agcattccacaaatatgagatgatggtattatccatccataaataggtagatatatctct       c.*780

          .         .         .         .         .                 g.38886
 attttatagtttcagattaaacaaaactgatatcaatagtaaaagtcattttacttatc        c.*839

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Aspartyl-tRNA synthetase 2, mitochondrial protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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