aspartyl-tRNA synthetase (DARS) - coding DNA reference sequence

(used for variant description)

(last modified February 10, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_001349.2 in the DARS gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering DARS transcript NM_001349.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5004
                                                         atct       c.-181

 .         .         .         .         .         .                g.5064
 cgagatagccgcagctctcgcgatctttctggagccgcacctccacgcggagtccgagcg       c.-121

 .         .         .         .         .         .                g.5124
 cgtgtgctgagaccccagggtcgggagggcggagactgggagggagggagaagccccttt       c.-61

 .         .         .         .         .         .                g.5184
 ggcctgccttacggaagcctgcgagggagggtggtgtccactgcccagttccgtgtcccg       c.-1

          .         .         .         .         .         .       g.5244
 ATGCCCAGCGCCAGCGCCAGCCGCAAGAGTCAGGAGAAGCCGCGGGAGATCATGGACGCG       c.60
 M  P  S  A  S  A  S  R  K  S  Q  E  K  P  R  E  I  M  D  A         p.20

        | 02 .         .         .         .         .         .    g.7252
 GCGGAA | GATTATGCTAAAGAGAGATATGGAATATCTTCAATGATACAATCACAAGAAAAA    c.120
 A  E   | D  Y  A  K  E  R  Y  G  I  S  S  M  I  Q  S  Q  E  K      p.40

      | 03   .         .         .         .         .         .    g.11342
 CCAG | ATCGAGTTTTGGTTCGGGTTAGAGACTTGACAATACAAAAAGCTGATGAAGTTGTT    c.180
 P  D |   R  V  L  V  R  V  R  D  L  T  I  Q  K  A  D  E  V  V      p.60

          .         .         .        | 04.         .         .    g.29177
 TGGGTACGTGCAAGAGTTCATACAAGCAGAGCTAAAG | GGAAACAGTGCTTCTTAGTCCTA    c.240
 W  V  R  A  R  V  H  T  S  R  A  K  G |   K  Q  C  F  L  V  L      p.80

          .         .         .         .         .         .       g.29237
 CGTCAGCAGCAGTTTAATGTCCAGGCTCTTGTGGCGGTGGGAGACCATGCAAGCAAGCAG       c.300
 R  Q  Q  Q  F  N  V  Q  A  L  V  A  V  G  D  H  A  S  K  Q         p.100

          .         . | 05       .         .         .         .    g.47212
 ATGGTTAAATTTGCTGCCAA | CATCAACAAAGAGAGCATTGTGGATGTAGAAGGTGTTGTG    c.360
 M  V  K  F  A  A  N  |  I  N  K  E  S  I  V  D  V  E  G  V  V      p.120

          .         .         .         .         .         .       g.47272
 AGAAAAGTGAATCAGAAAATTGGAAGCTGTACACAGCAAGACGTTGAGTTACATGTTCAG       c.420
 R  K  V  N  Q  K  I  G  S  C  T  Q  Q  D  V  E  L  H  V  Q         p.140

     | 06    .         .         .         .         .         .    g.56719
 AAG | ATTTATGTGATCAGTTTGGCTGAACCCCGTCTGCCCCTGCAGCTGGATGATGCTGTT    c.480
 K   | I  Y  V  I  S  L  A  E  P  R  L  P  L  Q  L  D  D  A  V      p.160

          .         .     | 07   .         .         .         .    g.57846
 CGGCCTGAGGCAGAAGGAGAAGAG | GAAGGAAGAGCTACTGTTAACCAGGATACAAGATTA    c.540
 R  P  E  A  E  G  E  E   | E  G  R  A  T  V  N  Q  D  T  R  L      p.180

          .         .     | 08   .         .         .         .    g.66190
 GACAACAGAGTCATTGATCTTAGG | ACATCAACTAGTCAGGCAGTCTTCCGTCTCCAGTCT    c.600
 D  N  R  V  I  D  L  R   | T  S  T  S  Q  A  V  F  R  L  Q  S      p.200

          .         .         .         .         .         .       g.66250
 GGCATCTGCCATCTCTTCCGAGAAACTTTAATTAACAAAGGTTTTGTGGAAATCCAAACT       c.660
 G  I  C  H  L  F  R  E  T  L  I  N  K  G  F  V  E  I  Q  T         p.220

          .       | 09 .         .         .         .         .    g.67778
 CCTAAAATTATTTCAG | CTGCCAGTGAAGGAGGAGCCAATGTTTTTACTGTGTCATATTTT    c.720
 P  K  I  I  S  A |   A  S  E  G  G  A  N  V  F  T  V  S  Y  F      p.240

          .         .         .         .         .         .       g.67838
 AAAAATAATGCATACCTGGCTCAGTCCCCACAGCTATATAAGCAAATGTGCATTTGTGCT       c.780
 K  N  N  A  Y  L  A  Q  S  P  Q  L  Y  K  Q  M  C  I  C  A         p.260

          .         .         .  | 10      .         .         .    g.70081
 GATTTTGAGAAGGTTTTCTCTATTGGACCAG | TATTCAGAGCGGAAGACTCTAATACCCAT    c.840
 D  F  E  K  V  F  S  I  G  P  V |   F  R  A  E  D  S  N  T  H      p.280

          .         .         .         .         .         .       g.70141
 AGACATCTAACTGAGTTTGTTGGTTTGGACATTGAAATGGCTTTTAATTACCATTACCAC       c.900
 R  H  L  T  E  F  V  G  L  D  I  E  M  A  F  N  Y  H  Y  H         p.300

          .         .         .         .         .          | 11    g.74281
 GAAGTTATGGAAGAAATTGCTGACACCATGGTACAAATATTCAAAGGACTTCAAGAAAG | G    c.960
 E  V  M  E  E  I  A  D  T  M  V  Q  I  F  K  G  L  Q  E  R  |      p.320

          .         .         .         .         .         .       g.74341
 TTTCAGACTGAAATTCAAACAGTGAATAAACAGTTCCCATGTGAGCCATTCAAATTTTTG       c.1020
 F  Q  T  E  I  Q  T  V  N  K  Q  F  P  C  E  P  F  K  F  L         p.340

          .         .         .         .         .         .       g.74401
 GAGCCAACTCTAAGACTAGAATATTGTGAAGCATTGGCTATGCTTAGGGAAGCTGGAGTC       c.1080
 E  P  T  L  R  L  E  Y  C  E  A  L  A  M  L  R  E  A  G  V         p.360

          .         .       | 12 .         .         .         .    g.76175
 GAAATGGGAGATGAAGACGATCTGAG | CACACCAAATGAAAAGCTGTTGGGTCATTTGGTA    c.1140
 E  M  G  D  E  D  D  L  S  |  T  P  N  E  K  L  L  G  H  L  V      p.380

           | 13        .         .         .         .         .    g.78137
 AAGGAAAAG | TATGATACAGATTTTTATATTCTTGATAAATATCCATTGGCTGTAAGACCT    c.1200
 K  E  K   | Y  D  T  D  F  Y  I  L  D  K  Y  P  L  A  V  R  P      p.400

          .         .         . | 14       .         .         .    g.79189
 TTCTATACCATGCCTGACCCAAGAAATCCC | AAACAGTCCAACTCTTACGATATGTTCATG    c.1260
 F  Y  T  M  P  D  P  R  N  P   | K  Q  S  N  S  Y  D  M  F  M      p.420

          .         .         .         .         .         .       g.79249
 AGAGGAGAAGAAATATTGTCAGGAGCTCAAAGAATACATGATCCTCAACTGCTAACAGAG       c.1320
 R  G  E  E  I  L  S  G  A  Q  R  I  H  D  P  Q  L  L  T  E         p.440

          .         .   | 15     .         .         .         .    g.79480
 AGAGCTTTACATCATGGAATTG | ATTTGGAGAAAATTAAGGCTTACATTGATTCCTTCCGC    c.1380
 R  A  L  H  H  G  I  D |   L  E  K  I  K  A  Y  I  D  S  F  R      p.460

          .         .         .     | 16   .         .         .    g.83271
 TTTGGAGCCCCTCCTCATGCTGGTGGAGGCATTG | GATTGGAACGAGTTACTATGCTGTTT    c.1440
 F  G  A  P  P  H  A  G  G  G  I  G |   L  E  R  V  T  M  L  F      p.480

          .         .         .         .         .         .       g.83331
 CTGGGATTGCATAATGTTCGTCAGACCTCCATGTTCCCTCGTGATCCCAAACGACTCACT       c.1500
 L  G  L  H  N  V  R  Q  T  S  M  F  P  R  D  P  K  R  L  T         p.500

                                                                    g.83337
 CCTTAA                                                             c.1506
 P  X                                                               p.501

          .         .         .         .         .         .       g.83397
 attcacactttgccacttaactccagtgtggatgacagagcgagaccctgcctcaaaaaa       c.*60

          .         .         .         .         .         .       g.83457
 aaaaaaaaaaaaagaaagccacacttattcttttcagtaacctgctagtgcacaggctgt       c.*120

          .         .         .         .         .         .       g.83517
 actttaggtacttaaaatatgcactagaataaatttgcaaggccctaaaatatcactgtt       c.*180

          .         .         .         .         .         .       g.83577
 atttttggagtaattcagtataggttcgtttaaaagagatttttataacttcagacatgc       c.*240

          .         .         .         .         .         .       g.83637
 atcagtaggaaataacttgagaaattcatatggttatgttacaaattcatattctgttac       c.*300

          .         .         .         .         .         .       g.83697
 tacagtaaacgttaagagttttaaacagttaagattgtacaatttttcttcttttctata       c.*360

          .         .         .         .         .         .       g.83757
 ttacaagggccccagtgttaatgtcttagattttcagtatttgaacttatttttttaaat       c.*420

          .         .         .         .         .         .       g.83817
 tctgtcattgagataagaataattcaggtagcatctgaaattttaatgaatgtataattg       c.*480

          .         .         .         .         .         .       g.83877
 gcatatcatggaaaattaaccagaaagtatcagttcttaaaagttatgcctagaaattat       c.*540

          .         .         .         .         .         .       g.83937
 gtaaagctaaactactggttagaaagtattcagtgtaatattgtattaatttgttaaatt       c.*600

          .         .         .                                     g.83969
 ctaaacttgaatttcaataaaattttaaagct                                   c.*632

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Aspartyl-tRNA synthetase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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