DBF4 homolog B (S. cerevisiae) (DBF4B) - coding DNA reference sequence

(used for variant description)

(last modified May 19, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_145663.2 in the DBF4B gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000017.10, covering DBF4B transcript NM_145663.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5033
                            gtagggcggatctcgcagctacggcgttctttt       c.-181

 .         .         .         .         .         .                g.5093
 aggggtggagccggcaggaaatttaaactgaagccgcggccgaaaacgccaagagattga       c.-121

 .         .         .         .         .         .                g.5153
 tgctgtagctgccctgagataaccaggactgtggaatcgggaagagctcatggagctcgc       c.-61

 .         .         .         .         .         .                g.5213
 gaatgtaatacggaggcctctgaggaaggagtacggaggccgagaaggagccggcatttg       c.-1

          .          | 02        .         .         .         .    g.5737
 ATGAGCGAACCGGGAAAGG | GAGACGATTGCCTCGAGCTGGAGAGTTCCATGGCTGAGAGT    c.60
 M  S  E  P  G  K  G |   D  D  C  L  E  L  E  S  S  M  A  E  S      p.20

          .         .   | 03     .         .         .         .    g.19310
 AGGCTCCGGGCCCCGGACCTAG | GAGTTTCCAGGTGTCTAGGAAAATGCCAGAAGAACTCA    c.120
 R  L  R  A  P  D  L  G |   V  S  R  C  L  G  K  C  Q  K  N  S      p.40

          .         .         .         .         .         .       g.19370
 CCAGGTGCCAGGAAGCATCCCTTTTCCGGAAAGTCCTTTTACTTGGATCTGCCTGCTGGC       c.180
 P  G  A  R  K  H  P  F  S  G  K  S  F  Y  L  D  L  P  A  G         p.60

          .         .         .         .      | 04  .         .    g.26312
 AAGAATCTCCAGTTTTTGACGGGGGCCATTCAGCAACTGGGTGGG | GTAATTGAGGGTTTT    c.240
 K  N  L  Q  F  L  T  G  A  I  Q  Q  L  G  G   | V  I  E  G  F      p.80

          .         .         .         .         .         .       g.26372
 CTGAGCAAAGAAGTAAGTTACATCGTGTCCAGCCGCAGAGAAGTAAAGGCAGAGAGCAGT       c.300
 L  S  K  E  V  S  Y  I  V  S  S  R  R  E  V  K  A  E  S  S         p.100

          .         .         .         .         .         .       g.26432
 GGGAAAAGCCATAGAGGCTGCCCTAGCCCTAGCCCCAGTGAGGTCAGAGTGGAAACATCG       c.360
 G  K  S  H  R  G  C  P  S  P  S  P  S  E  V  R  V  E  T  S         p.120

          .         .         .         .         .        | 05.    g.27360
 GCCATGGTTGATCCAAAAGGCAGCCACCCCAGGCCTTCACGGAAACCCGTTGACTCG | GTG    c.420
 A  M  V  D  P  K  G  S  H  P  R  P  S  R  K  P  V  D  S   | V      p.140

          .         .         .         .         | 06         .    g.28582
 CCTCTAAGCAGAGGGAAGGAGCTGCTGCAGAAGGCTATCAGAAACCAG | GGGAGCATCAGT    c.480
 P  L  S  R  G  K  E  L  L  Q  K  A  I  R  N  Q   | G  S  I  S      p.160

          .         .         .         .         .         .       g.28642
 GGAGGAGGCAGTGGGGGCAGCAGCAGCCTCCTGACCAATGCCCGCTCTTGGGGAGTGAGG       c.540
 G  G  G  S  G  G  S  S  S  L  L  T  N  A  R  S  W  G  V  R         p.180

          .       | 07 .         .         .         .         .    g.30526
 ATTCTGCACGTGGATG | AAATGATGATGCACGTGCAACAGCTGTCTCTTGCGTCTTTATGT    c.600
 I  L  H  V  D  E |   M  M  M  H  V  Q  Q  L  S  L  A  S  L  C      p.200

          .         .         . | 08       .         .         .    g.33252
 GTGAAAAAACAACAGCCAAAGAAGCCAGAG | GGAACATGTCCAGCAGCAGAGTCAAGAACA    c.660
 V  K  K  Q  Q  P  K  K  P  E   | G  T  C  P  A  A  E  S  R  T      p.220

         | 09.         .         .         .         .    | 10    . g.37735
 CGGAAAG | TGGCCAGACTGAAGGCCCCGTTCCTCAAAATCGAAGATGAAAGCAG | GAAGTTT c.720
 R  K  V |   A  R  L  K  A  P  F  L  K  I  E  D  E  S  R  |  K  F   p.240

          .         .         .         .         .         .       g.37795
 CGTCCTTTCCATCATCAGTTTAAATCCTTTCCTGAAATTTCTTTTCTTGGACCCAAAGAT       c.780
 R  P  F  H  H  Q  F  K  S  F  P  E  I  S  F  L  G  P  K  D         p.260

          .         .         .         .         . | 11       .    g.43485
 GCAAGTCCCTTTGAGGCCCCGACGACCCTGGGCAGCATGCACCATACCAG | AGAATCCAAG    c.840
 A  S  P  F  E  A  P  T  T  L  G  S  M  H  H  T  R  |  E  S  K      p.280

          .         .         .         .         .         .       g.43545
 GATGGAGAGCCAAGCCCACGATCAGCTGCCCACACCATGCCCAGGAGGAAGAAAGGCTAC       c.900
 D  G  E  P  S  P  R  S  A  A  H  T  M  P  R  R  K  K  G  Y         p.300

          .         .         .          | 12        .         .    g.43804
 TGCGAGTGCTGTCAGGAGGCCTTCGAGGAGCTCCATGTG | CATCTTCAGAGTGCCCAGCAC    c.960
 C  E  C  C  Q  E  A  F  E  E  L  H  V   | H  L  Q  S  A  Q  H      p.320

          .         .         .         .         .         .       g.43864
 CGGAGCTTTGCCCTGGAAGCCCATCTATATGCAGAAGTGGACAGGATCATTGCTCAGCTC       c.1020
 R  S  F  A  L  E  A  H  L  Y  A  E  V  D  R  I  I  A  Q  L         p.340

          .         .         .         .     | 13   .         .    g.44749
 AGCCACAGCTTTGCAGACATCCCTTTCCAGGCTGGCCTCCCCAG | GTGGTCAGGTTCCCCA    c.1080
 S  H  S  F  A  D  I  P  F  Q  A  G  L  P  R  |  W  S  G  S  P      p.360

          .         .         .         .         .         .       g.44809
 GCTTCTGATTGTGACCCTCTCTGTCCTGAGACTCTGCACCCCCATCAGCCCTCCCATCCC       c.1140
 A  S  D  C  D  P  L  C  P  E  T  L  H  P  H  Q  P  S  H  P         p.380

          .         .         .         .          | 14        .    g.46998
 AGGGCAGCATCTCCCAGGATAAGGAAAGAAGACAGCTGCCAGGCATCAG | TGACCCAAGGC    c.1200
 R  A  A  S  P  R  I  R  K  E  D  S  C  Q  A  S  V |   T  Q  G      p.400

          .         .         .         .         .         .       g.47058
 AGGGCTGCGGGCCAGCAGCGATGGACAGAATCACTAGATGGTGTGATGGGACCTCCTGCA       c.1260
 R  A  A  G  Q  Q  R  W  T  E  S  L  D  G  V  M  G  P  P  A         p.420

          .         .         .         .         .         .       g.47118
 AGTCACACATGTGTGAGTGCCACAACCCTCCTGCCGGCCTTGCCCAAGGGCTCCAGGGAG       c.1320
 S  H  T  C  V  S  A  T  T  L  L  P  A  L  P  K  G  S  R  E         p.440

          .         .         .         .         .         .       g.47178
 CAGGGCTGCCTCTGTCCCTGCCCAGCCTCCTTTACCCAGTCTCATCTGGTCACTTCCTTG       c.1380
 Q  G  C  L  C  P  C  P  A  S  F  T  Q  S  H  L  V  T  S  L         p.460

          .         .         .         .         .         .       g.47238
 GCTCTGCTGCCTGGGGAGTGGTCGCCTGCAGAGGACATGCCCCTCCATCCCTCCCAAGAA       c.1440
 A  L  L  P  G  E  W  S  P  A  E  D  M  P  L  H  P  S  Q  E         p.480

          .         .         .         .         .         .       g.47298
 AACTCCTTTGCCCCGGCGGACATTCCTGTTAAGGGCCCACTCCTCTTCCCTGAAGCCAGA       c.1500
 N  S  F  A  P  A  D  I  P  V  K  G  P  L  L  F  P  E  A  R         p.500

          .         .         .         .         .         .       g.47358
 CCGTGGCTTATGTCTGCACGCTGCTGGGTTCGTCCCTTTCCTTTTGTGACATGGGGTTGC       c.1560
 P  W  L  M  S  A  R  C  W  V  R  P  F  P  F  V  T  W  G  C         p.520

          .         .         .         .         .         .       g.47418
 CTCATTCCCCATGACACCACCCCTCTGCATGAGGAAGTTTCCCCTTGCCCCTGTCTCAGA       c.1620
 L  I  P  H  D  T  T  P  L  H  E  E  V  S  P  C  P  C  L  R         p.540

          .         .         .         .         .         .       g.47478
 CTTGGATACCTTTACCTGCTGCTCACACAAAGCCTGTGGTGCCGGGTTCGGGTGCCCTCA       c.1680
 L  G  Y  L  Y  L  L  L  T  Q  S  L  W  C  R  V  R  V  P  S         p.560

          .         .         .         .         .         .       g.47538
 TTGTCAACTGCAGGACCCATTCCCCGAACCTCACATCCGTGTACCCTTGCCTTCCCCTCC       c.1740
 L  S  T  A  G  P  I  P  R  T  S  H  P  C  T  L  A  F  P  S         p.580

          .         .         .         .         .         .       g.47598
 TATCTCAATGATCATGACCTTGGACATCTCTGCCAGGCCAAACCCCAAGGCTGGAACACT       c.1800
 Y  L  N  D  H  D  L  G  H  L  C  Q  A  K  P  Q  G  W  N  T         p.600

          .         .         .         .                           g.47646
 CCTCAGCCATTTCTCCATTGCGGCTTCCTGGCTGTAGACTCAGGTTAG                   c.1848
 P  Q  P  F  L  H  C  G  F  L  A  V  D  S  G  X                     p.615

          .         .         .         .         .         .       g.47706
 aggtgaacccagaacacctgagacttgacccaggatggatgggtgctgcttgatgtgaat       c.*60

          .         .         .         .         .         .       g.47766
 gaggtcccgcagtggctccttggcgtgagcactgctcagactcctttccactccagcccc       c.*120

          .         .         .         .         .         .       g.47826
 ctttccacatcgcaccagatgacttttacccagacccagtgggcattgccttatcttgca       c.*180

          .         .         .         .         .         .       g.47886
 gtcagtcccttttcaacatgttgccgtttctttctgaagaggtgtcctccctccacaagt       c.*240

          .         .         .         .         .         .       g.47946
 cacactgtctgtccctggccctccagcccacctcgccaaccactcttgttggtttccttc       c.*300

          .         .         .         .         .         .       g.48006
 tcagacttgccacctttcccctctgccccaaaatgccatgctcctctcctggaaaacact       c.*360

          .         .         .         .         .         .       g.48066
 tgagttgattcagtaaatcgacttcaaatacttgaaggctcccaccttctgttctctggc       c.*420

          .         .         .         .         .         .       g.48126
 tccttcctgcggtctatacctaccgcctcctcttcacctccttcccttccacacttcctt       c.*480

          .         .         .         .         .         .       g.48186
 cctgggtagctctgcctgaagcattccactaagatcatctattccaaggtcatggacagg       c.*540

          .         .         .         .         .         .       g.48246
 ctactggtgaccaaagttggttccttttctcctttctttcctccttgaagcctggctccc       c.*600

          .         .         .         .         .         .       g.48306
 ttggtcgcagcagcccctcagtggcctggttctcctgtccccctgcccttcctcaccatt       c.*660

          .         .         .         .         .         .       g.48366
 gcccattccctcgttcgttcattcagcacaggccttgccgtctgccctgagtcagctccg       c.*720

          .         .         .         .         .         .       g.48426
 agacacctgaagagccctccagccctaactactttactcagactaggtccccaggccttt       c.*780

          .         .         .         .         .         .       g.48486
 gttcttgcctcttctcgctgagcctttcacttctcggcagatgtgaccgattggtagctc       c.*840

          .         .         .         .         .         .       g.48546
 caccccaactcccttctgctgggtggaatgcaggagctagctgcctccaactcactgtga       c.*900

          .         .         .         .         .         .       g.48606
 cctcagaaaaatgcctttattactcgggcctcagtttcctcgtctttaagtaaggggctt       c.*960

          .         .         .         .         .                 g.48662
 ggatgagatgatttcaggaccctttccaataataaaatactgtgactgccagcaaa           c.*1016

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The DBF4 homolog B (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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