DDB1 and CUL4 associated factor 8-like 1 (DCAF8L1) - coding DNA reference sequence

(used for variant description)

(last modified October 21, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_001017930.1 in the DCAF8L1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000023.10, covering DCAF8L1 transcript NM_001017930.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5055
      gcttacctactgccttctccgaccgtccgtcctcggggcaggcgtgctctcttcc       c.-61

 .         .         .         .         .         .                g.5115
 ctgagcttttaggggttggcttttccagttccagatcagctacagcaaacatcgttcgag       c.-1

          .         .         .         .         .         .       g.5175
 ATGTCCCACCAAGAGGGCAGCACAGGTGGCTTACCAGACTTAGTGACTGAAAGCCTGTTC       c.60
 M  S  H  Q  E  G  S  T  G  G  L  P  D  L  V  T  E  S  L  F         p.20

          .         .         .         .         .         .       g.5235
 AGCAGCCCAGAGGAGCAGTCTGGAGTAGCAGCGGTGACGGCGGCCTCCTCAGACATTGAA       c.120
 S  S  P  E  E  Q  S  G  V  A  A  V  T  A  A  S  S  D  I  E         p.40

          .         .         .         .         .         .       g.5295
 ATGGCAGCCACAGAGCCATCGACCGGAGATGGTGGTGATACCAGGGATGGTGGTTTCCTG       c.180
 M  A  A  T  E  P  S  T  G  D  G  G  D  T  R  D  G  G  F  L         p.60

          .         .         .         .         .         .       g.5355
 AACGATGCCAGCACAGAAAATCAAAACACAGACTCAGAAAGTTCAAGTGAAGACGTCGAA       c.240
 N  D  A  S  T  E  N  Q  N  T  D  S  E  S  S  S  E  D  V  E         p.80

          .         .         .         .         .         .       g.5415
 CTTGAAAGCATGGGTGAAGGTTTATTTGGTTACCCGTTAGTGGGAGAGGAGACAGAAAGG       c.300
 L  E  S  M  G  E  G  L  F  G  Y  P  L  V  G  E  E  T  E  R         p.100

          .         .         .         .         .         .       g.5475
 GAGGAGGAAGAAGAAGAGATGGAGGAGGAAGGGGAGGAGGAAGAACAGCCTCGGATGTGT       c.360
 E  E  E  E  E  E  M  E  E  E  G  E  E  E  E  Q  P  R  M  C         p.120

          .         .         .         .         .         .       g.5535
 CCACGATGCGGTGGCACCAACCATGATCAGTGTTTGTTAGACGAGGATCAGGCGTTGGAG       c.420
 P  R  C  G  G  T  N  H  D  Q  C  L  L  D  E  D  Q  A  L  E         p.140

          .         .         .         .         .         .       g.5595
 GAGTGGATTTCCTCAGAGACATCTGCCCTGCCCCGATCTCGCTGGCAAGTCCTTACTGCT       c.480
 E  W  I  S  S  E  T  S  A  L  P  R  S  R  W  Q  V  L  T  A         p.160

          .         .         .         .         .         .       g.5655
 CTTCGCCAGCGGCAGCTGGGTTCAAGTGCCCGCTTTGTATATGAGGCCTGTGGGGCAAGA       c.540
 L  R  Q  R  Q  L  G  S  S  A  R  F  V  Y  E  A  C  G  A  R         p.180

          .         .         .         .         .         .       g.5715
 ACCTTTGTGCAGCGTTTCCGCCTGCAGTATCTTCTTGGAAGCCATGCCGGTTCTGTCAGT       c.600
 T  F  V  Q  R  F  R  L  Q  Y  L  L  G  S  H  A  G  S  V  S         p.200

          .         .         .         .         .         .       g.5775
 ACCATACACTTTAACCAGCGTGGCACCCGACTGGCCAGTAGCGGTGATGACTTAAGGGTG       c.660
 T  I  H  F  N  Q  R  G  T  R  L  A  S  S  G  D  D  L  R  V         p.220

          .         .         .         .         .         .       g.5835
 ATAGTGTGGGACTGGGTGCGGCAGAAGCCAGTACTGAACTTTGAGAGTGGTCACGATATT       c.720
 I  V  W  D  W  V  R  Q  K  P  V  L  N  F  E  S  G  H  D  I         p.240

          .         .         .         .         .         .       g.5895
 AATGTCATCCAGGCTAAGTTCTTTCCTAACTGTGGTGATTCCACTCTGGCCATGTGTGGC       c.780
 N  V  I  Q  A  K  F  F  P  N  C  G  D  S  T  L  A  M  C  G         p.260

          .         .         .         .         .         .       g.5955
 CATGATGGACAGGTACGGGTAGCAGAACTAATTAATGCATCATATTGCGAGAATACTAAG       c.840
 H  D  G  Q  V  R  V  A  E  L  I  N  A  S  Y  C  E  N  T  K         p.280

          .         .         .         .         .         .       g.6015
 CGTGTGGCCAAGCACAGGGGACCTGCCCACGAGTTGGCTCTGGAGCCAGACTCTCCTTAT       c.900
 R  V  A  K  H  R  G  P  A  H  E  L  A  L  E  P  D  S  P  Y         p.300

          .         .         .         .         .         .       g.6075
 AAGTTCCTCACTTCAGGTGAAGATGCCGTTGTGTTCACCATTGACCTCAGGCAAGACCGG       c.960
 K  F  L  T  S  G  E  D  A  V  V  F  T  I  D  L  R  Q  D  R         p.320

          .         .         .         .         .         .       g.6135
 CCAGCTTCAAAAGTTGTGGTAACAAGAGAAAATGATAAGAAAGTCGGACTGTATACAATC       c.1020
 P  A  S  K  V  V  V  T  R  E  N  D  K  K  V  G  L  Y  T  I         p.340

          .         .         .         .         .         .       g.6195
 TCTATGAATCCTGCCAATATTTACCAATTTGCAGTGGGTGGACATGATCAGTTTGTAAGG       c.1080
 S  M  N  P  A  N  I  Y  Q  F  A  V  G  G  H  D  Q  F  V  R         p.360

          .         .         .         .         .         .       g.6255
 ATTTATGACCAGAGGAGAATTGATAAGAAAGAAAACAATGGAGTACTCAAGAAATTCACT       c.1140
 I  Y  D  Q  R  R  I  D  K  K  E  N  N  G  V  L  K  K  F  T         p.380

          .         .         .         .         .         .       g.6315
 CCTCATCATCTGGTTTATTGTGATTTCCCAACAAACATCACCTGCGTTGTGTACAGCCAC       c.1200
 P  H  H  L  V  Y  C  D  F  P  T  N  I  T  C  V  V  Y  S  H         p.400

          .         .         .         .         .         .       g.6375
 GATGGCACAGAGCTCCTGGCCAGCTACAATGATGAAGATATTTACCTCTTCAACTCCTCT       c.1260
 D  G  T  E  L  L  A  S  Y  N  D  E  D  I  Y  L  F  N  S  S         p.420

          .         .         .         .         .         .       g.6435
 CTCAGTGATGGTGCTCAATATGTTAAGAGATATAAGGGGCACAGAAATAATGACACAATC       c.1320
 L  S  D  G  A  Q  Y  V  K  R  Y  K  G  H  R  N  N  D  T  I         p.440

          .         .         .         .         .         .       g.6495
 AAATGTGTTAATTTCTATGGCCCCCGGAGTGAGTTTGTCGTGAGCGGTAGTGATTGTGGG       c.1380
 K  C  V  N  F  Y  G  P  R  S  E  F  V  V  S  G  S  D  C  G         p.460

          .         .         .         .         .         .       g.6555
 CACGTCTTCTTCTGGGAGAAATCATCCTCCCAGATCATCCAGTTCATGGAGGGGGACAGA       c.1440
 H  V  F  F  W  E  K  S  S  S  Q  I  I  Q  F  M  E  G  D  R         p.480

          .         .         .         .         .         .       g.6615
 GGAGATATAGTAAACTGTCTTGAACCCCACCCTTACCTACCTGTGTTGGCGACCAGTGGC       c.1500
 G  D  I  V  N  C  L  E  P  H  P  Y  L  P  V  L  A  T  S  G         p.500

          .         .         .         .         .         .       g.6675
 CTAGATCAGCATGTCAGGATCTGGACACCCACAGCTAAAACTGCCACTGAGCTTACTGGG       c.1560
 L  D  Q  H  V  R  I  W  T  P  T  A  K  T  A  T  E  L  T  G         p.520

          .         .         .         .         .         .       g.6735
 TTAAAAGATGTGATTAAGAAGAACAAGCAGGAGCGAGATGAAGACAACTTGAACTATACG       c.1620
 L  K  D  V  I  K  K  N  K  Q  E  R  D  E  D  N  L  N  Y  T         p.540

          .         .         .         .         .         .       g.6795
 GACTCGTTTGACAACCGCATGCTTCGGTTCTTCGTGCGTCACCTGTTACAGAGAGCTCAT       c.1680
 D  S  F  D  N  R  M  L  R  F  F  V  R  H  L  L  Q  R  A  H         p.560

          .         .         .         .         .         .       g.6855
 CAACCCGGCTGGAGAGATCATGGAGCTGAGTTCCCAGATGAAGAAGAGTTGGATGAGTCT       c.1740
 Q  P  G  W  R  D  H  G  A  E  F  P  D  E  E  E  L  D  E  S         p.580

          .         .         .         .         .         .       g.6915
 TCCAGCACCTCAGATACATCCGAGGAGGAGGGCCAAGATCGAGTGCAGTGCATACCATCC       c.1800
 S  S  T  S  D  T  S  E  E  E  G  Q  D  R  V  Q  C  I  P  S         p.600

                                                                    g.6918
 TGA                                                                c.1803
 X                                                                  p.600

          .         .         .         .         .         .       g.6978
 aggcctcatatccagtccagctagatgccacctaagtacactggactttaaaattcagtt       c.*60

          .         .         .         .         .         .       g.7038
 tgactaatttagaattgtcaattgattaacagatttgctttttgtcttctgtttttgtta       c.*120

          .         .         .         .         .         .       g.7098
 ccccttatatgagtgcatacacaacttatttatgcctcttttcctttgttcccttataat       c.*180

          .         .         .         .         .         .       g.7158
 tgacctctaaaattgcataattttgttgaaaaaattaatggccttattagatgtatctac       c.*240

          .         .         .         .         .         .       g.7218
 tcatttcagacattctgaaagctattactttttagttttttcattttttaccaatttatt       c.*300

          .         .         .         .         .         .       g.7278
 ttgaagataaagttcttcagttgagttgaaaatttcataaacgtgtttattctttagagg       c.*360

          .         .         .         .         .         .       g.7338
 taaaataaggcaaaccatagttctttgaatactgacacacacatacacacagtctcagaa       c.*420

          .         .         .         .         .         .       g.7398
 aaggaaaagagaagtagtgtgtagattaattcctaacacttggccacacacacacacagc       c.*480

          .         .         .         .         .         .       g.7458
 ttcaaaagttgtagtaacaagagagaagaataagaaagtgggactgtatacaatctctat       c.*540

          .         .         .         .         .         .       g.7518
 gaatcctgccaatatttaccaattcgcagtgggtggacatgatcggtttttaaggattta       c.*600

          .         .         .         .         .         .       g.7578
 tgaccagaggagaattgatgagaaagaaaacaatggagtactcaagaaattcactcttca       c.*660

          .         .         .         .         .         .       g.7638
 tcatctggttaattgtgattttccaacaaacatcacctgcattgtgtacagccacgatgg       c.*720

          .         .         .         .         .         .       g.7698
 cacagagctcctggccagctatgcacacacacatacacacagagccttagaaaaggaaaa       c.*780

          .         .         .         .         .         .       g.7758
 caagaagtagtgtgtagatgaattcctaaccagataattcatctcctcagagcaaataac       c.*840

          .         .         .         .         .         .       g.7818
 ttgggattatccacattttctgaatcaatatgttaataatattgattaatttgagcacac       c.*900

          .         .         .         .         .         .       g.7878
 tgaagctggtaagaactaaattaaatttaatcacatgacattgtttactctatgcattaa       c.*960

          .         .         .         .         .         .       g.7938
 atgttcttgaagttttatggttgggaactcccacaggattacattccaggaagtcctcct       c.*1020

          .         .         .         .         .         .       g.7998
 ggcgcaagcatctcctataagataccagataggaatataaaaatctctcatatttgaaaa       c.*1080

          .         .         .         .         .         .       g.8058
 catttattttaattaacttttaagaataagttgcaataaaaattgtttatacttacacat       c.*1140

          .         .         .         .         .         .       g.8118
 aaccatttgatacagttggtagaaaaatcctatttaacatccatgcattgcttaaaattt       c.*1200

          .         .         .         .         .         .       g.8178
 agctgttttatgagtttgttttgaaaattgttgcaataaaaattgtttatacttacaagt       c.*1260

          .         .         .         .         .         .       g.8238
 gatgtagttggtagaaaaatcctatttgacatccatgcattgcttaaaatttagctgttt       c.*1320

          .         .         .         .         .         .       g.8298
 tatgagtttgttttaaaaattgttgcagtaaaaattgtttatacttacaagtgatgtagt       c.*1380

          .         .         .         .         .         .       g.8358
 tggtagaaaaatcctatttgacatccatggattgcttaaagttctctcagctgtcctcga       c.*1440

          .         .         .         .         .         .       g.8418
 gtttaaattgttttaaaaattgtcttaagctttacttaatataaatttaagttactagat       c.*1500

          .         .         .                                     g.8457
 gttaaattactgttcaataaaaatattcatttttatttt                            c.*1539

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The DDB1 and CUL4 associated factor 8-like 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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