doublecortin domain containing 2 (DCDC2) - coding DNA reference sequence

(used for variant description)

(last modified February 14, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_016356.3 in the DCDC2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012829.1, covering DCDC2 transcript NM_016356.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.30242
                                                           gt       c.-301

 .         .         .         .         .         .                g.30302
 ccaccttgattctgcccgtagcaggtgaacctggtgtggtgcgcgcactgcgggtcctga       c.-241

 .         .         .         .         .         .                g.30362
 ttggctgtgcacgccacggtgaaaaacttgagcgtctactccgagtcctgcaagctccta       c.-181

 .         .         .         .         .         .                g.30422
 gtgtctcctctgggtggacgcctaggcgcacggccgttacttctctttcacctgtggatt       c.-121

 .         .         .         .         .         .                g.30482
 cgtcagtttctcgttcgtttcaggaggcgatcccgcgccctgggtgcggtgaggccgctg       c.-61

 .         .         .         .         .         .                g.30542
 ggacagcggaggtgcctcccgacgcgaagcagcgagctgaggcggcggccagcggggaag       c.-1

          .         .         .         .         .         .       g.30602
 ATGAGCGGCAGCAGCGCCAGGTCCAGCCACCTGTCTCAGCCCGTCGTGAAGAGCGTGCTT       c.60
 M  S  G  S  S  A  R  S  S  H  L  S  Q  P  V  V  K  S  V  L         p.20

          .         .         .         .         .         .       g.30662
 GTGTACCGCAACGGGGACCCCTTCTACGCGGGGCGCCGCGTCGTCATCCATGAGAAGAAG       c.120
 V  Y  R  N  G  D  P  F  Y  A  G  R  R  V  V  I  H  E  K  K         p.40

          .         .         .         .         .         .       g.30722
 GTGTCCAGCTTCGAAGTCTTCCTGAAGGAGGTGACCGGCGGCGTTCAGGCACCCTTTGGG       c.180
 V  S  S  F  E  V  F  L  K  E  V  T  G  G  V  Q  A  P  F  G         p.60

          .         .         .         .         .         .       g.30782
 GCCGTCAGGAACATCTACACCCCGCGGACTGGCCACCGAATCCGGAAGCTAGACCAGATC       c.240
 A  V  R  N  I  Y  T  P  R  T  G  H  R  I  R  K  L  D  Q  I         p.80

          .         .         .         .         .    | 02    .    g.34676
 CAGAGCGGGGGCAATTACGTGGCTGGAGGCCAGGAAGCCTTCAAGAAACTCAA | TTACTTG    c.300
 Q  S  G  G  N  Y  V  A  G  G  Q  E  A  F  K  K  L  N  |  Y  L      p.100

          .         .         .         .         | 03         .    g.86260
 GACATAGGAGAAATCAAGAAAAGACCAATGGAAGTTGTTAATACAGAG | GTAAAACCAGTA    c.360
 D  I  G  E  I  K  K  R  P  M  E  V  V  N  T  E   | V  K  P  V      p.120

          .         .         .         .         .         .       g.86320
 ATCCATAGCAGGATCAACGTGTCAGCTCGCTTTAGAAAACCGCTTCAGGAGCCGTGCACT       c.420
 I  H  S  R  I  N  V  S  A  R  F  R  K  P  L  Q  E  P  C  T         p.140

       | 04  .         .         .         .         .         .    g.86501
 ATCTT | CTTGATTGCAAATGGAGACCTCATAAACCCAGCTTCTCGCCTCCTTATCCCCAGA    c.480
 I  F  |  L  I  A  N  G  D  L  I  N  P  A  S  R  L  L  I  P  R      p.160

          .         .         .         .         .         .       g.86561
 AAAACCTTGAATCAGTGGGATCATGTACTACAAATGGTCACAGAAAAAATCACTCTGAGG       c.540
 K  T  L  N  Q  W  D  H  V  L  Q  M  V  T  E  K  I  T  L  R         p.180

          .        | 05.         .         .         .         .    g.97257
 AGCGGGGCTGTTCACAG | GCTTTATACTTTAGAAGGAAAACTTGTTGAGAGTGGAGCAGAG    c.600
 S  G  A  V  H  R  |  L  Y  T  L  E  G  K  L  V  E  S  G  A  E      p.200

          .         .         .         .         .         .       g.97317
 TTGGAGAATGGGCAGTTTTATGTGGCTGTTGGCAGAGATAAGTTTAAGAAACTGCCTTAC       c.660
 L  E  N  G  Q  F  Y  V  A  V  G  R  D  K  F  K  K  L  P  Y         p.220

          .         .         .         .     | 06   .         .    g.99402
 AGTGAGTTACTTTTTGACAAGTCAACGATGAGAAGGCCTTTTGG | TCAGAAAGCTTCTTCA    c.720
 S  E  L  L  F  D  K  S  T  M  R  R  P  F  G  |  Q  K  A  S  S      p.240

          .         .         .          | 07        .         .    g.110102
 CTACCTCCTATTGTAGGATCCAGAAAGTCTAAAGGGAGT | GGAAATGATCGCCACTCTAAG    c.780
 L  P  P  I  V  G  S  R  K  S  K  G  S   | G  N  D  R  H  S  K      p.260

          .         .         .         .         .         .       g.110162
 TCAACAGTTGGATCCAGTGACAACTCATCTCCTCAGCCCCTGAAGAGGAAAGGGAAAAAA       c.840
 S  T  V  G  S  S  D  N  S  S  P  Q  P  L  K  R  K  G  K  K         p.280

          .         .         .         .         .         .       g.110222
 GAAGACGTGAATTCAGAAAAACTGACGAAATTGAAACAAAATGTAAAATTAAAGAATTCA       c.900
 E  D  V  N  S  E  K  L  T  K  L  K  Q  N  V  K  L  K  N  S         p.300

          .         .   | 08     .         .         .         .    g.183228
 CAAGAAACCATTCCAAATAGTG | ATGAAGGCATTTTCAAAGCTGGAGCAGAGAGGTCTGAA    c.960
 Q  E  T  I  P  N  S  D |   E  G  I  F  K  A  G  A  E  R  S  E      p.320

          .         .         .         .         .         .       g.183288
 ACACGGGGGGCAGCAGAAGTCCAAGAAGATGAAGATACTCAGGTTGAGGTTCCAGTCGAT       c.1020
 T  R  G  A  A  E  V  Q  E  D  E  D  T  Q  V  E  V  P  V  D         p.340

     | 09    .         .         .         .         .         .    g.209717
 CAG | AGGCCAGCAGAAATAGTAGACGAGGAAGAAGATGGAGAGAAGGCAAACAAGGATGCA    c.1080
 Q   | R  P  A  E  I  V  D  E  E  E  D  G  E  K  A  N  K  D  A      p.360

          .         .         .         .         .         .       g.209777
 GAACAGAAAGAAGACTTTTCAGGAATGAATGGTGACCTTGAAGAGGAAGGAGGTAGGGAG       c.1140
 E  Q  K  E  D  F  S  G  M  N  G  D  L  E  E  E  G  G  R  E         p.380

          .         .         .         .         .         .       g.209837
 GCTACAGATGCCCCTGAGCAAGTCGAGGAGATTCTGGATCACAGTGAGCAGCAGGCACGC       c.1200
 A  T  D  A  P  E  Q  V  E  E  I  L  D  H  S  E  Q  Q  A  R         p.400

          .         .         .         .         .         .       g.209897
 CCTGCTCGTGTAAATGGAGGCACCGATGAGGAGAATGGTGAGGAGCTGCAGCAGGTTAAT       c.1260
 P  A  R  V  N  G  G  T  D  E  E  N  G  E  E  L  Q  Q  V  N         p.420

          .         .         .         .         .         .       g.209957
 AATGAGCTTCAACTGGTCCTAGACAAGGAAAGAAAGTCTCAAGGAGCTGGCAGTGGACAA       c.1320
 N  E  L  Q  L  V  L  D  K  E  R  K  S  Q  G  A  G  S  G  Q         p.440

        | 10 .         .         .         .         .         .    g.213512
 GATGAG | GCTGATGTAGACCCTCAAAGACCACCAAGGCCAGAAGTAAAAATTACCAGTCCA    c.1380
 D  E   | A  D  V  D  P  Q  R  P  P  R  P  E  V  K  I  T  S  P      p.460

          .         .         .         .         .                 g.213563
 GAAGAAAATGAAAACAACCAACAAAACAAGGACTATGCTGCCGTGGCTTAG                c.1431
 E  E  N  E  N  N  Q  Q  N  K  D  Y  A  A  V  A  X                  p.476

          .         .         .         .         .         .       g.213623
 aacatttttaaaaagagagtatatggatcgcaagaaaaatgaagggttatcatacttgaa       c.*60

          .         .         .         .         .         .       g.213683
 agataagcacatagttattgctgaatataatgtgacactatggtcgaatactacctacga       c.*120

          .         .         .         .         .         .       g.213743
 attataacattagaagcctagtggaaagaccagataactttaaatggctactaaaggata       c.*180

          .         .         .         .         .         .       g.213803
 attacttacttttattgcatgtgttttaaaagtcatatagaaatattaaataagacggac       c.*240

          .         .         .         .         .         .       g.213863
 agaggagaatttgcactggaagacaattgccacttgtaaaggatgaaaaataggatcact       c.*300

          .         .         .         .         .         .       g.213923
 cttattgtacgctttattataagtttagaaggcagtttattctaaataatttttctctag       c.*360

          .         .         .         .         .         .       g.213983
 gaaggcgtagaattttaaagaactggtaataggaaagcatgtactattttcttaaagcaa       c.*420

          .         .         .         .         .         .       g.214043
 taaactcttgaatgaacagattgcgatttactttcagacataatttggagatggcagtag       c.*480

          .         .         .         .         .         .       g.214103
 atcaaaatgtgtccatgacttgttaacatgcctttctttcttcctccttagccaaaatcc       c.*540

          .         .         .         .         .         .       g.214163
 acctttgaactacaaagacagagcaaggcgttcattttggtgggaggaagcattggttca       c.*600

          .         .         .         .         .         .       g.214223
 gagtgttagtgactagtatcgccatgccgtcacttaaatgctttcaggcttgcatgcttg       c.*660

          .         .         .         .         .         .       g.214283
 tggctccaatggcgcacactcaggaaggaattgtaaaggagcacccagttatattataaa       c.*720

          .         .         .         .         .         .       g.214343
 gcctggatgtatggtttgcagataatggaaatcctgtggattttcactgatccagtctat       c.*780

          .         .         .         .         .         .       g.214403
 ctttaccaatagtatctctctcttctcccttatgttattagagaacctgatattggctat       c.*840

          .         .         .         .         .         .       g.214463
 tccaaagattaaattattttcaaatagttttcaacaaaaataaaagtgtattaggaagaa       c.*900

          .         .         .         .         .         .       g.214523
 aaaagtagactatatgaagagtttgtgactgctcaatttaacttgttttttgccttattt       c.*960

          .         .         .         .         .         .       g.214583
 ctattaagactgttttactatgtttttgccctagggatatcagcaaatatttatttttcc       c.*1020

          .         .         .         .         .         .       g.214643
 tagcatgatatagttagaatttcaagcagatttctttgtaattagaaggcatctgataga       c.*1080

          .         .         .         .         .         .       g.214703
 aattgtaaaactttagaagttattataatgaaaccaattcctgaatcacaacttcatgga       c.*1140

          .         .         .         .         .         .       g.214763
 ctgactaaattgatttatagttgccttgtgaggtatgtatggggaaaacataaaaacata       c.*1200

          .         .         .         .         .         .       g.214823
 attaaaacataatttcgtcctttttatgaattcttaagagatgttcttccataaatatag       c.*1260

          .         .         .         .         .         .       g.214883
 aaataatatatttttcttaaaggatatatttttaattatgtggaagttgtaagcttgaaa       c.*1320

          .         .         .         .         .         .       g.214943
 ttttaacttctagtgcttttctaaaattcacaattacaagtttaaaacattttttctctt       c.*1380

          .         .         .         .         .         .       g.215003
 ccaggtttcatttggaataaagagttggcagttatataaagcacttaataatactataga       c.*1440

          .         .         .         .         .         .       g.215063
 aaatagatgtgttttttcttaatatgattttggtattttccacagatcagaagtgtaaac       c.*1500

          .         .         .         .         .         .       g.215123
 agagagataatgtaacagtatttggaagagataatgacacaaggatatagtgatctggga       c.*1560

          .         .         .         .         .         .       g.215183
 gcatgaattagaaacagggtactatgtttctggtgtaaaatctaaattgtgctttctact       c.*1620

          .         .         .         .         .         .       g.215243
 agcgttactttttcaaatgggatgatataaagcactgtgggctataagcaacaatcttgg       c.*1680

          .         .         .         .         .         .       g.215303
 gttggtaggcaaatagaccaattgatctttattattattattattattattattattatt       c.*1740

          .         .         .         .         .         .       g.215363
 ttttgagatgaagtcttgctcttgtcgcccaggctgggtgcagtggcatgatcttggctt       c.*1800

          .         .         .         .         .         .       g.215423
 actgcaacctctgcctcctgggttcaagcacctgagcctcccgagtagctgggattacag       c.*1860

          .         .         .         .         .         .       g.215483
 gcatctgccaccacacctggctaatttttgtattttttgtagagacagatgtttcaccat       c.*1920

          .         .         .         .         .         .       g.215543
 gttggccaggctggtctcaaactcctgacctcaggtgatccgcccgcctttgcatcccaa       c.*1980

          .         .         .         .         .         .       g.215603
 aatgctgggattacaggtgtgagccacagcacccggtcccagttggtcttttaatattaa       c.*2040

          .         .         .         .         .         .       g.215663
 atttgtgcactattactgggtctggagttaatgatttcaaatagtttctaaaaataactg       c.*2100

          .         .         .         .         .         .       g.215723
 attaaatgtaagaaattataactaattatcaaggtgattctcttttgtttcttcaatgga       c.*2160

          .         .         .         .         .         .       g.215783
 gagtttctctttctcttttcctcctctaataaaaatatttctttttttcctgtcctttta       c.*2220

          .         .         .         .         .         .       g.215843
 ttcattatattatgaaacttaggttttaggaaacaccttaagcgtcattttaatgaagca       c.*2280

          .         .         .         .         .         .       g.215903
 caacattgatattttacatgaataataacgtttggtattttaaatatacttcaagggggt       c.*2340

          .         .         .         .         .         .       g.215963
 aataagccacaataactgtaccaaaaaaacttaaaaatggggacatattcatcccttgtg       c.*2400

          .         .         .         .         .         .       g.216023
 tgtgcatattttaccacttgttgacaagatacaattgtgacctactttgaggggatgaat       c.*2460

          .         .         .         .         .         .       g.216083
 aacgacttatcactttaagacactttgcaaacatgttactaaaaaaaggtgcctagccaa       c.*2520

          .         .         .         .         .         .       g.216143
 ggaaaaaaccattcacttggaattaaaattgtggatgtcacttcagagatgactttaaca       c.*2580

          .         .         .         .         .         .       g.216203
 taaatgctgaaagttcattcacctcacaaatgtggcagttttctctgtggagaatggtgg       c.*2640

          .         .         .         .         .         .       g.216263
 tctccgtggcagactggctctccaaattaaatgaaactcattgacagacctgggaccttt       c.*2700

          .         .         .         .         .         .       g.216323
 tatgtgagtggacagacaagatcttggtttggcttcatgtactgttttctagagagagtg       c.*2760

          .         .         .         .         .         .       g.216383
 ctacgaaaaacttatgatgcttttatgtgataaccaatataatgctttaatatgttaatt       c.*2820

          .         .         .         .         .         .       g.216443
 ctttgtgatgctatatacatagtttttatagttttatgaaaccactttgttaaacttatc       c.*2880

          .         .         .         .         .         .       g.216503
 tggattttaagacacttgtaaacaaatggtttgttagtaaaattggggcattaagagttt       c.*2940

          .         .         .                                     g.216538
 tacagagcaaataaagaagattttgacaaaagtca                                c.*2975

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Doublecortin domain containing 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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