dynactin 1 (DCTN1) - coding DNA reference sequence

(used for variant description)

(last modified July 11, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_004082.4 in the DCTN1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008735.2, covering DCTN1 transcript NM_004082.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.16750
                                           agaggctagcacggttcc       c.-301

 .         .         .         .         .         .                g.16810
 tgacaagtctagagcagcactagcgcagagtgagactcatcagctggcaagcaggattct       c.-241

 .         .         .         .         .         .                g.16870
 gtgtctctgggttcaggaatcctcaggcagcagaggggacttgctcctcagcccccatca       c.-181

 .         .         .         .         .         .                g.16930
 ctgcccccacccctacccgtgtaggccaccgagtgaggcccatggactggggagggctgt       c.-121

 .         .         .         .         .         .                g.16990
 gcctgacgactcctgtgtccctctatgagggcccagcgccctgaccctcctgcctaggtt       c.-61

 .         .         .         .         .         .                g.17050
 tctaccttttctctctgtctttggccagctgggggagggggtagaggccgggtgagcaac       c.-1

          .         .         .    | 02    .         .         .    g.18869
 ATGGCACAGAGCAAGAGGCACGTGTACAGCCGG | ACGCCCAGCGGCAGCAGGATGAGTGCG    c.60
 M  A  Q  S  K  R  H  V  Y  S  R   | T  P  S  G  S  R  M  S  A      p.20

          .         .         .         .         .         .       g.18929
 GAGGCAAGCGCCCGGCCTCTGCGGGTGGGCTCCCGTGTAGAGGTGATTGGAAAAGGCCAC       c.120
 E  A  S  A  R  P  L  R  V  G  S  R  V  E  V  I  G  K  G  H         p.40

          .         .         .         .         .         .       g.18989
 CGAGGCACTGTGGCCTATGTTGGAGCCACACTGTTTGCCACTGGCAAATGGGTAGGCGTG       c.180
 R  G  T  V  A  Y  V  G  A  T  L  F  A  T  G  K  W  V  G  V         p.60

          .         .         .         .         .         .       g.19049
 ATTCTGGATGAAGCAAAGGGCAAAAATGATGGAACTGTTCAAGGCAGGAAGTACTTCACT       c.240
 I  L  D  E  A  K  G  K  N  D  G  T  V  Q  G  R  K  Y  F  T         p.80

          .         .         .          | 03        .         .    g.19382
 TGTGATGAAGGGCATGGCATCTTTGTGCGCCAGTCCCAG | ATCCAGGTATTTGAAGATGGA    c.300
 C  D  E  G  H  G  I  F  V  R  Q  S  Q   | I  Q  V  F  E  D  G      p.100

          .         .         .         .         .         | 04    g.19623
 GCAGATACTACTTCCCCAGAGACACCTGATTCTTCTGCTTCAAAAGTCCTCAAAAGAG | AG    c.360
 A  D  T  T  S  P  E  T  P  D  S  S  A  S  K  V  L  K  R  E |       p.120

          .         .         .    | 05    .         .     | 06   . g.22753
 GGAACTGATACAACTGCAAAGACTAGCAAACTG | CGGGGACTGAAGCCTAAGAAG | GCACCG c.420
 G  T  D  T  T  A  K  T  S  K  L   | R  G  L  K  P  K  K   | A  P   p.140

          .   | 07     .         .    | 08    .         .         . g.25386
 ACAGCCCGAAAG | ACCACAACTCGGCGACCCAAG | CCCACGCGCCCAGCCAGTACTGGGGTG c.480
 T  A  R  K   | T  T  T  R  R  P  K   | P  T  R  P  A  S  T  G  V   p.160

          .         .         .         .         .         .       g.25446
 GCTGGGGCCAGTAGCTCCCTGGGCCCCTCTGGCTCAGCGTCAGCAGGTGAGCTGAGCAGC       c.540
 A  G  A  S  S  S  L  G  P  S  G  S  A  S  A  G  E  L  S  S         p.180

          .         .         .         .         .         .       g.25506
 AGTGAGCCCAGCACCCCGGCTCAGACTCCGCTGGCAGCACCCATCATCCCCACGCCGGTC       c.600
 S  E  P  S  T  P  A  Q  T  P  L  A  A  P  I  I  P  T  P  V         p.200

          .         .         .         .      | 09  .         .    g.25926
 CTCACCTCTCCTGGAGCAGTCCCCCCGCTTCCTTCCCCATCCAAG | GAGGAGGAGGGACTA    c.660
 L  T  S  P  G  A  V  P  P  L  P  S  P  S  K   | E  E  E  G  L      p.220

          .         .         .         .         .         .       g.25986
 AGGGCTCAGGTGCGGGACCTGGAGGAGAAACTAGAGACCCTGAGACTGAAACGGGCAGAA       c.720
 R  A  Q  V  R  D  L  E  E  K  L  E  T  L  R  L  K  R  A  E         p.240

          .         .         .         .         .         .       g.26046
 GACAAAGCAAAGCTAAAAGAGCTGGAGAAACACAAAATCCAGCTGGAGCAGGTGCAGGAA       c.780
 D  K  A  K  L  K  E  L  E  K  H  K  I  Q  L  E  Q  V  Q  E         p.260

          .         .         .         .         .         .       g.26106
 TGGAAGAGCAAAATGCAGGAGCAGCAGGCCGACCTGCAGCGGCGCCTCAAGGAGGCGAGA       c.840
 W  K  S  K  M  Q  E  Q  Q  A  D  L  Q  R  R  L  K  E  A  R         p.280

     | 10    .         .         .         .         .         .    g.26319
 AAG | GAAGCCAAGGAGGCGCTGGAGGCAAAGGAACGCTATATGGAGGAGATGGCTGATACT    c.900
 K   | E  A  K  E  A  L  E  A  K  E  R  Y  M  E  E  M  A  D  T      p.300

          .         .         .         .         .         .       g.26379
 GCTGATGCCATTGAGATGGCCACTTTGGACAAGGAGATGGCTGAAGAGCGGGCTGAGTCC       c.960
 A  D  A  I  E  M  A  T  L  D  K  E  M  A  E  E  R  A  E  S         p.320

          .         .         .         .         .         .       g.26439
 CTGCAGCAGGAGGTGGAGGCACTGAAGGAGCGGGTGGACGAGCTCACTACTGACTTAGAG       c.1020
 L  Q  Q  E  V  E  A  L  K  E  R  V  D  E  L  T  T  D  L  E         p.340

          .         .         | 11         .         .         .    g.26575
 ATCCTCAAGGCTGAGATTGAAGAGAAGG | GCTCAGATGGCGCTGCATCCAGTTATCAGCTC    c.1080
 I  L  K  A  E  I  E  E  K  G |   S  D  G  A  A  S  S  Y  Q  L      p.360

          .         .         .         .        | 12.         .    g.26755
 AAGCAGCTTGAGGAGCAGAATGCCCGCCTGAAGGATGCCCTGGTGAG | GATGCGGGATCTT    c.1140
 K  Q  L  E  E  Q  N  A  R  L  K  D  A  L  V  R  |  M  R  D  L      p.380

          .         .         .         .         .         .       g.26815
 TCTTCCTCAGAGAAGCAGGAGCATGTGAAGCTCCAGAAGCTCATGGAAAAGAAGAACCAA       c.1200
 S  S  S  E  K  Q  E  H  V  K  L  Q  K  L  M  E  K  K  N  Q         p.400

          .         .         .         .         .         .       g.26875
 GAGCTGGAAGTTGTGAGGCAACAGCGGGAGCGTCTGCAGGAGGAGCTAAGCCAGGCAGAG       c.1260
 E  L  E  V  V  R  Q  Q  R  E  R  L  Q  E  E  L  S  Q  A  E         p.420

          .         .        | 13.         .         .         .    g.27051
 AGCACCATTGATGAGCTCAAGGAGCAG | GTGGATGCTGCTCTGGGTGCTGAGGAGATGGTG    c.1320
 S  T  I  D  E  L  K  E  Q   | V  D  A  A  L  G  A  E  E  M  V      p.440

          .         .         .         .         .         .       g.27111
 GAGATGCTGACAGATCGGAACCTGAATCTGGAAGAGAAAGTGCGCGAGTTGAGGGAGACT       c.1380
 E  M  L  T  D  R  N  L  N  L  E  E  K  V  R  E  L  R  E  T         p.460

          .   | 14     .         .         .         .         .    g.27644
 GTGGGAGACTTG | GAAGCGATGAATGAGATGAACGATGAGCTGCAGGAGAATGCACGTGAG    c.1440
 V  G  D  L   | E  A  M  N  E  M  N  D  E  L  Q  E  N  A  R  E      p.480

          .         .         .         .         .         .       g.27704
 ACAGAACTGGAGCTGCGGGAGCAGCTGGACATGGCAGGCGCGCGGGTTCGTGAGGCCCAG       c.1500
 T  E  L  E  L  R  E  Q  L  D  M  A  G  A  R  V  R  E  A  Q         p.500

          .         .         .         .         .         .       g.27764
 AAGCGTGTGGAGGCAGCCCAGGAGACGGTTGCAGACTACCAGCAGACCATCAAGAAGTAC       c.1560
 K  R  V  E  A  A  Q  E  T  V  A  D  Y  Q  Q  T  I  K  K  Y         p.520

          .         .     | 15   .         .         .         .    g.27909
 CGCCAGCTGACCGCCCATCTACAG | GATGTGAATCGGGAACTGACAAACCAGCAGGAAGCA    c.1620
 R  Q  L  T  A  H  L  Q   | D  V  N  R  E  L  T  N  Q  Q  E  A      p.540

          .         .         .         .         .         .       g.27969
 TCTGTGGAGAGGCAACAGCAGCCACCTCCAGAGACCTTTGACTTCAAAATCAAGTTTGCT       c.1680
 S  V  E  R  Q  Q  Q  P  P  P  E  T  F  D  F  K  I  K  F  A         p.560

          .         .  | 16      .         .         .         .    g.28246
 GAGACTAAGGCCCATGCCAAG | GCAATTGAGATGGAATTGAGGCAGATGGAGGTGGCCCAG    c.1740
 E  T  K  A  H  A  K   | A  I  E  M  E  L  R  Q  M  E  V  A  Q      p.580

          .         .         .         .         .         .       g.28306
 GCCAATCGACACATGTCCCTGCTGACAGCCTTCATGCCTGACAGCTTCCTTCGGCCAGGT       c.1800
 A  N  R  H  M  S  L  L  T  A  F  M  P  D  S  F  L  R  P  G         p.600

          .         .         .         .         .     | 17   .    g.28962
 GGGGACCATGACTGCGTTCTGGTGCTGTTGCTCATGCCTCGTCTCATTTGCAAG | GCAGAG    c.1860
 G  D  H  D  C  V  L  V  L  L  L  M  P  R  L  I  C  K   | A  E      p.620

          .         .         .         .         .         .       g.29022
 CTGATCCGGAAGCAGGCCCAGGAGAAGTTTGAACTAAGTGAGAACTGTTCAGAGCGGCCT       c.1920
 L  I  R  K  Q  A  Q  E  K  F  E  L  S  E  N  C  S  E  R  P         p.640

          .         .         .         .         .         .       g.29082
 GGGCTGCGAGGAGCTGCTGGGGAGCAACTCAGCTTTGCTGCTGGACTGGTGTACTCGCTG       c.1980
 G  L  R  G  A  A  G  E  Q  L  S  F  A  A  G  L  V  Y  S  L         p.660

          .         .         .      | 18  .         .         .    g.29248
 AGCCTGCTGCAGGCCACGCTACACCGCTATGAGCA | TGCCCTCTCTCAGTGCAGTGTGGAT    c.2040
 S  L  L  Q  A  T  L  H  R  Y  E  H  |  A  L  S  Q  C  S  V  D      p.680

          .         .         .         .         .         .       g.29308
 GTGTATAAGAAAGTGGGCAGCCTGTACCCTGAGATGAGTGCCCATGAGCGCTCCTTGGAT       c.2100
 V  Y  K  K  V  G  S  L  Y  P  E  M  S  A  H  E  R  S  L  D         p.700

          .         .         .         .         .         .       g.29368
 TTCCTCATTGAACTGCTGCACAAGGATCAGCTGGATGAGACTGTCAATGTGGAGCCTCTC       c.2160
 F  L  I  E  L  L  H  K  D  Q  L  D  E  T  V  N  V  E  P  L         p.720

          .         .     | 19   .         .         .         .    g.29703
 ACCAAGGCCATCAAGTACTATCAG | CATCTGTACAGCATCCACCTTGCCGAACAGCCTGAG    c.2220
 T  K  A  I  K  Y  Y  Q   | H  L  Y  S  I  H  L  A  E  Q  P  E      p.740

          .         .         .    | 20    .         .         .    g.30007
 GACTGTACTATGCAGCTGGCTGACCACATTAAG | TTCACGCAGAGTGCTCTGGACTGCATG    c.2280
 D  C  T  M  Q  L  A  D  H  I  K   | F  T  Q  S  A  L  D  C  M      p.760

          .         .         .       | 21 .         .         .    g.30179
 AGTGTGGAGGTAGGACGGCTGCGTGCCTTCTTGCAG | GGTGGGCAGGAGGCTACAGATATT    c.2340
 S  V  E  V  G  R  L  R  A  F  L  Q   | G  G  Q  E  A  T  D  I      p.780

          .         .         .         .         .         .       g.30239
 GCCCTCCTGCTCCGGGATCTGGAAACTTCATGCAGTGACATCCGCCAGTTCTGCAAGAAG       c.2400
 A  L  L  L  R  D  L  E  T  S  C  S  D  I  R  Q  F  C  K  K         p.800

          .         .         .         .         .         .       g.30299
 ATCCGAAGGCGAATGCCAGGGACAGATGCTCCTGGGATCCCAGCTGCACTGGCCTTTGGA       c.2460
 I  R  R  R  M  P  G  T  D  A  P  G  I  P  A  A  L  A  F  G         p.820

        | 22 .         .         .         .         .         .    g.30521
 CCACAG | GTATCTGACACGCTCCTAGACTGCAGGAAACACTTGACGTGGGTCGTGGCTGTG    c.2520
 P  Q   | V  S  D  T  L  L  D  C  R  K  H  L  T  W  V  V  A  V      p.840

          .         .         .         .         .         .       g.30581
 CTGCAGGAGGTGGCAGCTGCTGCTGCCCAGCTCATTGCCCCACTGGCAGAGAATGAGGGG       c.2580
 L  Q  E  V  A  A  A  A  A  Q  L  I  A  P  L  A  E  N  E  G         p.860

          .         .         .         .         | 23         .    g.30724
 CTACTTGTGGCTGCTCTGGAGGAACTGGCTTTCAAAGCAAGCGAGCAG | ATCTATGGGACC    c.2640
 L  L  V  A  A  L  E  E  L  A  F  K  A  S  E  Q   | I  Y  G  T      p.880

          .         .         .         .         .         .       g.30784
 CCCTCCAGCAGCCCCTATGAGTGTCTGCGCCAGTCATGCAACATCCTCATCAGTACCATG       c.2700
 P  S  S  S  P  Y  E  C  L  R  Q  S  C  N  I  L  I  S  T  M         p.900

          .         .         .         .         .         .       g.30844
 AACAAGCTGGCCACAGCCATGCAGGAGGGGGAGTATGATGCAGAGCGGCCCCCCAGCAAG       c.2760
 N  K  L  A  T  A  M  Q  E  G  E  Y  D  A  E  R  P  P  S  K         p.920

  | 24       .         .         .         .         .         .    g.31129
  | CCTCCACCGGTTGAACTGCGGGCTGCTGCCCTTCGTGCAGAGATCACAGATGCTGAAGGC    c.2820
  | P  P  P  V  E  L  R  A  A  A  L  R  A  E  I  T  D  A  E  G      p.940

          .         .         .         .         .         .       g.31189
 CTGGGTTTGAAGCTCGAAGATCGAGAGACAGTTATTAAGGAGTTGAAGAAGTCACTCAAG       c.2880
 L  G  L  K  L  E  D  R  E  T  V  I  K  E  L  K  K  S  L  K         p.960

        | 25 .         .         .         .         .         .    g.31484
 ATTAAG | GGAGAGGAGCTAAGTGAGGCCAATGTGCGGCTGAGCCTCCTGGAGAAGAAGTTG    c.2940
 I  K   | G  E  E  L  S  E  A  N  V  R  L  S  L  L  E  K  K  L      p.980

          .         .         .         .         .         .       g.31544
 GACAGTGCTGCCAAGGATGCAGATGAGCGCATCGAGAAAGTCCAGACTCGGCTGGAGGAG       c.3000
 D  S  A  A  K  D  A  D  E  R  I  E  K  V  Q  T  R  L  E  E         p.1000

          .         .          | 26        .         .         .    g.31877
 ACCCAGGCACTGCTGCGAAAGAAGGAGAA | AGAGTTTGAGGAGACAATGGATGCACTCCAG    c.3060
 T  Q  A  L  L  R  K  K  E  K  |  E  F  E  E  T  M  D  A  L  Q      p.1020

          .         .         .         .         .         .       g.31937
 GCTGACATCGACCAGCTGGAGGCAGAGAAGGCAGAACTAAAGCAGCGTCTGAACAGCCAG       c.3120
 A  D  I  D  Q  L  E  A  E  K  A  E  L  K  Q  R  L  N  S  Q         p.1040

          .         .         .         .         .         .       g.31997
 TCCAAACGCACGATTGAGGGACTCCGGGGCCCTCCTCCTTCAGGCATTGCTACTCTGGTC       c.3180
 S  K  R  T  I  E  G  L  R  G  P  P  P  S  G  I  A  T  L  V         p.1060

          .       | 27 .         .  | 28      .         .         . g.33689
 TCTGGCATTGCTGGTG | AAGAACAGCAGCGAG | GAGCCATCCCTGGGCAGGCTCCAGGGTCT c.3240
 S  G  I  A  G  E |   E  Q  Q  R  G |   A  I  P  G  Q  A  P  G  S   p.1080

          .         .         .         .         .         .       g.33749
 GTGCCAGGCCCAGGGCTGGTGAAGGACTCACCACTGCTGCTTCAGCAGATCTCTGCCATG       c.3300
 V  P  G  P  G  L  V  K  D  S  P  L  L  L  Q  Q  I  S  A  M         p.1100

          .         .         .         .      | 29  .         .    g.33925
 AGGCTGCACATCTCCCAGCTCCAGCATGAGAACAGCATCCTCAAG | GGAGCCCAGATGAAG    c.3360
 R  L  H  I  S  Q  L  Q  H  E  N  S  I  L  K   | G  A  Q  M  K      p.1120

          .         .         .         .         .         .       g.33985
 GCATCCTTGGCATCCCTGCCCCCTCTGCATGTTGCAAAGCTATCCCATGAGGGCCCTGGC       c.3420
 A  S  L  A  S  L  P  P  L  H  V  A  K  L  S  H  E  G  P  G         p.1140

          .         .         .         .         .         .       g.34045
 AGTGAGTTACCAGCTGGAGCGCTGTATCGTAAGACCAGCCAGCTGCTGGAGACATTGAAT       c.3480
 S  E  L  P  A  G  A  L  Y  R  K  T  S  Q  L  L  E  T  L  N         p.1160

          .         .         .         .          | 30        .    g.34369
 CAATTGAGCACACACACGCACGTAGTAGACATCACTCGCACCAGCCCTG | CTGCCAAGAGC    c.3540
 Q  L  S  T  H  T  H  V  V  D  I  T  R  T  S  P  A |   A  K  S      p.1180

          .         .         .         .         .         .       g.34429
 CCGTCGGCCCAACTTATGGAGCAAGTGGCTCAGCTTAAGTCCCTGAGTGACACCGTCGAG       c.3600
 P  S  A  Q  L  M  E  Q  V  A  Q  L  K  S  L  S  D  T  V  E         p.1200

           | 31        .         .         .         .         .    g.34997
 AAGCTCAAG | GATGAGGTCCTCAAGGAGACAGTATCTCAGCGCCCTGGAGCCACAGTACCC    c.3660
 K  L  K   | D  E  V  L  K  E  T  V  S  Q  R  P  G  A  T  V  P      p.1220

          .         .         .          | 32        .         .    g.35472
 ACTGACTTTGCCACCTTCCCTTCATCAGCCTTCCTCAGG | GCCAAGGAGGAGCAGCAGGAT    c.3720
 T  D  F  A  T  F  P  S  S  A  F  L  R   | A  K  E  E  Q  Q  D      p.1240

          .         .         .         .         .         .       g.35532
 GACACAGTCTACATGGGCAAAGTGACCTTCTCATGTGCGGCTGGTTTTGGACAGCGACAC       c.3780
 D  T  V  Y  M  G  K  V  T  F  S  C  A  A  G  F  G  Q  R  H         p.1260

          .         .         .         .         .                 g.35589
 CGGCTGGTGCTGACCCAGGAGCAGCTGCACCAGCTTCACAGTCGCCTCATCTCCTAA          c.3837
 R  L  V  L  T  Q  E  Q  L  H  Q  L  H  S  R  L  I  S  X            p.1278

          .         .         .         .         .         .       g.35649
 gcactcctttcccctgctgtccccttcgaccctcagccctctggtgccgctctgcccgat       c.*60

          .         .         .         .         .         .       g.35709
 gcacagccacctcagccagcccccaggtagaaacgtgggttaagctcttcctgccccgtt       c.*120

          .         .         .         .         .         .       g.35769
 cagcttcactcccaccctttcagcgtcctgccccttcaccttgacccgggttcccccact       c.*180

          .         .         .         .         .         .       g.35829
 cccattccctggcctctgccataatttgttgttcaactgctccctccttcctgaggggcc       c.*240

          .         .         .         .         .         .       g.35889
 tcagggcttgtggggggtaggctgagaccccaccaccaaaggttaagtgaggtccccttg       c.*300

          .         .         .         .                           g.35934
 attgaggacttcaccccttgattaaagcaacttctgcttcagtgc                      c.*345

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Dynactin 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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