damage-specific DNA binding protein 1, 127kDa (DDB1) - coding DNA reference sequence

(used for variant description)

(last modified April 2, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_001923.4 in the DDB1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_032697.2, covering DDB1 transcript NM_001923.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.14388
                                                         ggtg       c.-241

 .         .         .         .         .         .                g.14448
 cctccgggggcggggcctccttcggttggcggcctcgggcttcgggagtcctccaagagg       c.-181

 .         .         .         .         .         .                g.14508
 ccaggtgaggccgtcccgtgatgccccgcgccccggccgctctggcctgcaacgtgtctc       c.-121

 .         .         .         .         .         .                g.14568
 tggggcggaggcagcggcagtggagttcgctgcgcgctgttgggggccacctgtcttttc       c.-61

 .         .         .         .         .         .                g.14628
 gcttgtgtccctctttctagtgtcgcgctcgagtcccgacgggccgctccaagcctcgac       c.-1

          .         .         .         .         .         .       g.14688
 ATGTCGTACAACTACGTGGTAACGGCCCAGAAGCCCACCGCCGTGAACGGCTGCGTGACC       c.60
 M  S  Y  N  Y  V  V  T  A  Q  K  P  T  A  V  N  G  C  V  T         p.20

   | 02      .         .         .         .         .         .    g.15964
 G | GACACTTTACTTCGGCCGAAGACTTAAACCTGTTGATTGCCAAAAACACGAGATTAGAG    c.120
 G |   H  F  T  S  A  E  D  L  N  L  L  I  A  K  N  T  R  L  E      p.40

          .         .         .         .         .         .       g.16024
 ATCTATGTGGTCACCGCCGAGGGGCTTCGGCCCGTCAAAGAGGTGGGCATGTATGGGAAG       c.180
 I  Y  V  V  T  A  E  G  L  R  P  V  K  E  V  G  M  Y  G  K         p.60

          .         .         . | 03       .         .         .    g.17552
 ATTGCGGTCATGGAGCTTTTCAGGCCCAAG | GGGGAGAGCAAGGACCTGCTGTTTATCTTG    c.240
 I  A  V  M  E  L  F  R  P  K   | G  E  S  K  D  L  L  F  I  L      p.80

          .         .         .         .         .         .       g.17612
 ACAGCGAAGTACAATGCCTGCATCCTGGAGTATAAACAGAGTGGCGAGAGCATTGACATC       c.300
 T  A  K  Y  N  A  C  I  L  E  Y  K  Q  S  G  E  S  I  D  I         p.100

          .         .        | 04.         .         .         .    g.18045
 ATTACGCGAGCCCATGGCAATGTCCAG | GACCGCATTGGCCGCCCCTCAGAGACCGGCATT    c.360
 I  T  R  A  H  G  N  V  Q   | D  R  I  G  R  P  S  E  T  G  I      p.120

          .         .         .         .         .         .       g.18105
 ATTGGCATCATTGACCCTGAGTGCCGGATGATTGGCCTGCGTCTCTATGATGGCCTTTTC       c.420
 I  G  I  I  D  P  E  C  R  M  I  G  L  R  L  Y  D  G  L  F         p.140

          .         .         .         .         .         .       g.18165
 AAGGTTATTCCACTAGATCGCGATAATAAAGAACTCAAGGCCTTCAACATCCGCCTGGAG       c.480
 K  V  I  P  L  D  R  D  N  K  E  L  K  A  F  N  I  R  L  E         p.160

          .         .         .         .         .         .       g.18225
 GAGCTGCATGTCATTGATGTCAAGTTCCTATATGGTTGCCAAGCACCTACTATTTGCTTT       c.540
 E  L  H  V  I  D  V  K  F  L  Y  G  C  Q  A  P  T  I  C  F         p.180

           | 05        .         .         .         .         .    g.20754
 GTCTACCAG | GACCCTCAGGGGCGGCACGTAAAAACCTATGAGGTGTCTCTCCGAGAAAAG    c.600
 V  Y  Q   | D  P  Q  G  R  H  V  K  T  Y  E  V  S  L  R  E  K      p.200

          .         .         .         .         .         .       g.20814
 GAATTCAATAAGGGCCCTTGGAAACAGGAAAATGTCGAAGCTGAAGCTTCCATGGTGATC       c.660
 E  F  N  K  G  P  W  K  Q  E  N  V  E  A  E  A  S  M  V  I         p.220

      | 06   .         .         .         .         .         .    g.21944
 GCAG | TCCCAGAGCCCTTTGGGGGGGCCATCATCATTGGACAGGAGTCAATCACCTATCAC    c.720
 A  V |   P  E  P  F  G  G  A  I  I  I  G  Q  E  S  I  T  Y  H      p.240

          .         .         .         .   | 07     .         .    g.23477
 AATGGTGACAAATACCTGGCTATTGCCCCTCCTATCATCAAG | CAAAGCACGATTGTGTGC    c.780
 N  G  D  K  Y  L  A  I  A  P  P  I  I  K   | Q  S  T  I  V  C      p.260

          .         .         .         .         .         .       g.23537
 CACAATCGAGTGGACCCTAATGGCTCAAGATACCTGCTGGGAGACATGGAAGGCCGGCTC       c.840
 H  N  R  V  D  P  N  G  S  R  Y  L  L  G  D  M  E  G  R  L         p.280

          .         .         .         .         .         .       g.23597
 TTCATGCTGCTTTTGGAGAAGGAGGAACAGATGGATGGCACCGTCACTCTCAAGGATCTC       c.900
 F  M  L  L  L  E  K  E  E  Q  M  D  G  T  V  T  L  K  D  L         p.300

          .         .  | 08      .         .         .         .    g.24541
 CGTGTAGAACTCCTTGGAGAG | ACCTCTATTGCTGAGTGCTTGACATACCTTGATAATGGT    c.960
 R  V  E  L  L  G  E   | T  S  I  A  E  C  L  T  Y  L  D  N  G      p.320

          .         .         .         .      | 09  .         .    g.25199
 GTTGTGTTTGTCGGGTCTCGCCTGGGTGACTCCCAGCTTGTGAAG | CTCAACGTTGACAGT    c.1020
 V  V  F  V  G  S  R  L  G  D  S  Q  L  V  K   | L  N  V  D  S      p.340

          .         .         .         .         .         .       g.25259
 AATGAACAAGGCTCCTATGTAGTGGCCATGGAAACCTTTACCAACTTAGGACCCATTGTC       c.1080
 N  E  Q  G  S  Y  V  V  A  M  E  T  F  T  N  L  G  P  I  V         p.360

          .         .         .         .   | 10     .         .    g.25917
 GATATGTGCGTGGTGGACCTGGAGAGGCAGGGGCAGGGGCAG | CTGGTCACTTGCTCTGGG    c.1140
 D  M  C  V  V  D  L  E  R  Q  G  Q  G  Q   | L  V  T  C  S  G      p.380

          .         .         .         .         .         .       g.25977
 GCTTTCAAGGAAGGTTCTTTGCGGATCATCCGGAATGGAATTGGAATCCACGAGCATGCC       c.1200
 A  F  K  E  G  S  L  R  I  I  R  N  G  I  G  I  H  E  H  A         p.400

          .         .      | 11  .         .         .         .    g.31064
 AGCATTGACTTACCAGGCATCAAAG | GATTATGGCCACTGCGGTCTGACCCTAATCGTGAG    c.1260
 S  I  D  L  P  G  I  K  G |   L  W  P  L  R  S  D  P  N  R  E      p.420

          .         .         .         .  | 12      .         .    g.31222
 ACTGATGACACTTTGGTGCTCTCTTTTGTGGGCCAGACAAG | AGTTCTCATGTTAAATGGA    c.1320
 T  D  D  T  L  V  L  S  F  V  G  Q  T  R  |  V  L  M  L  N  G      p.440

          .         .         .         .         .         .       g.31282
 GAGGAGGTAGAAGAAACCGAACTGATGGGTTTCGTGGATGATCAGCAGACTTTCTTCTGT       c.1380
 E  E  V  E  E  T  E  L  M  G  F  V  D  D  Q  Q  T  F  F  C         p.460

          .         .         . | 13       .         .         .    g.33140
 GGCAACGTGGCTCATCAGCAGCTTATCCAG | ATCACTTCAGCATCGGTGAGGTTGGTCTCT    c.1440
 G  N  V  A  H  Q  Q  L  I  Q   | I  T  S  A  S  V  R  L  V  S      p.480

          .         .         .         .         .         .       g.33200
 CAAGAACCCAAAGCTCTGGTCAGTGAATGGAAGGAGCCTCAGGCCAAGAACATCAGTGTG       c.1500
 Q  E  P  K  A  L  V  S  E  W  K  E  P  Q  A  K  N  I  S  V         p.500

          .         .         .         .         .         .       g.33260
 GCCTCCTGCAATAGCAGCCAGGTGGTGGTGGCTGTAGGCAGGGCCCTCTACTATCTGCAG       c.1560
 A  S  C  N  S  S  Q  V  V  V  A  V  G  R  A  L  Y  Y  L  Q         p.520

          .         .          | 14        .         .         .    g.33417
 ATCCATCCTCAGGAGCTCCGGCAGATCAG | CCACACAGAGATGGAACATGAAGTGGCTTGC    c.1620
 I  H  P  Q  E  L  R  Q  I  S  |  H  T  E  M  E  H  E  V  A  C      p.540

          .         .         .         .         .         .       g.33477
 TTGGACATCACCCCATTAGGAGACAGCAATGGACTGTCCCCTCTTTGTGCCATTGGCCTC       c.1680
 L  D  I  T  P  L  G  D  S  N  G  L  S  P  L  C  A  I  G  L         p.560

          .         .         .         .         .         .       g.33537
 TGGACGGACATCTCGGCTCGTATCTTGAAGTTGCCCTCTTTTGAACTACTGCACAAGGAG       c.1740
 W  T  D  I  S  A  R  I  L  K  L  P  S  F  E  L  L  H  K  E         p.580

          .    | 15    .         .         .         .         .    g.33674
 ATGCTGGGTGGAG | AGATCATTCCTCGCTCCATCCTGATGACCACCTTTGAGAGTAGCCAT    c.1800
 M  L  G  G  E |   I  I  P  R  S  I  L  M  T  T  F  E  S  S  H      p.600

          .         .         .         .         .         .       g.33734
 TACCTCCTTTGTGCCTTGGGAGATGGAGCGCTTTTCTACTTTGGGCTCAACATTGAGACA       c.1860
 Y  L  L  C  A  L  G  D  G  A  L  F  Y  F  G  L  N  I  E  T         p.620

   | 16      .         .         .         .         .         .    g.33949
 G | GTCTGTTGAGCGACCGTAAGAAGGTGACTTTGGGCACCCAGCCCACCGTATTGAGGACT    c.1920
 G |   L  L  S  D  R  K  K  V  T  L  G  T  Q  P  T  V  L  R  T      p.640

          .         .         .         .         .         .       g.34009
 TTTCGTTCTCTTTCTACCACCAACGTCTTTGCTTGTTCTGACCGCCCCACTGTCATCTAT       c.1980
 F  R  S  L  S  T  T  N  V  F  A  C  S  D  R  P  T  V  I  Y         p.660

          .         .         .         .         .         .       g.34069
 AGCAGCAACCACAAATTGGTCTTCTCAAATGTCAACCTCAAGGAAGTGAACTACATGTGT       c.2040
 S  S  N  H  K  L  V  F  S  N  V  N  L  K  E  V  N  Y  M  C         p.680

          .         .          | 17        .         .         .    g.35543
 CCCCTCAATTCAGATGGCTATCCTGACAG | CCTGGCGCTGGCCAACAATAGCACCCTCACC    c.2100
 P  L  N  S  D  G  Y  P  D  S  |  L  A  L  A  N  N  S  T  L  T      p.700

          .         .         .         .         .         .       g.35603
 ATTGGCACCATCGATGAGATCCAGAAGCTGCACATTCGCACAGTTCCCCTCTATGAGTCT       c.2160
 I  G  T  I  D  E  I  Q  K  L  H  I  R  T  V  P  L  Y  E  S         p.720

       | 18  .         .         .         .         .         .    g.35756
 CCAAG | GAAGATCTGCTACCAGGAAGTGTCCCAGTGTTTCGGGGTCCTCTCCAGCCGCATT    c.2220
 P  R  |  K  I  C  Y  Q  E  V  S  Q  C  F  G  V  L  S  S  R  I      p.740

          .         .         .         .         .        | 19.    g.37181
 GAAGTCCAAGACACGAGTGGGGGCACGACAGCCTTGAGGCCCAGCGCTAGCACCCAG | GCT    c.2280
 E  V  Q  D  T  S  G  G  T  T  A  L  R  P  S  A  S  T  Q   | A      p.760

          .         .         .         .         .         .       g.37241
 CTGTCCAGCAGTGTAAGCTCCAGCAAGCTGTTCTCCAGCAGCACTGCTCCTCATGAGACC       c.2340
 L  S  S  S  V  S  S  S  K  L  F  S  S  S  T  A  P  H  E  T         p.780

          .         .         .         .         .         .       g.37301
 TCCTTTGGAGAAGAGGTGGAGGTGCACAACCTACTTATCATTGACCAACACACCTTTGAA       c.2400
 S  F  G  E  E  V  E  V  H  N  L  L  I  I  D  Q  H  T  F  E         p.800

   | 20      .         .         .         .         .         .    g.37695
 G | TGCTTCATGCCCACCAGTTTCTGCAGAATGAATATGCCCTCAGTCTGGTTTCCTGCAAG    c.2460
 V |   L  H  A  H  Q  F  L  Q  N  E  Y  A  L  S  L  V  S  C  K      p.820

          .         .         .         .         .         .       g.37755
 CTGGGCAAAGACCCCAACACTTACTTCATTGTGGGCACAGCAATGGTGTATCCTGAAGAG       c.2520
 L  G  K  D  P  N  T  Y  F  I  V  G  T  A  M  V  Y  P  E  E         p.840

          .         .         .         .       | 21 .         .    g.38533
 GCAGAGCCCAAGCAGGGTCGCATTGTGGTCTTTCAGTATTCGGATG | GAAAACTACAGACT    c.2580
 A  E  P  K  Q  G  R  I  V  V  F  Q  Y  S  D  G |   K  L  Q  T      p.860

          .         .         .         .         .         .       g.38593
 GTGGCTGAAAAGGAAGTGAAAGGGGCCGTGTACTCTATGGTGGAATTTAACGGGAAGCTG       c.2640
 V  A  E  K  E  V  K  G  A  V  Y  S  M  V  E  F  N  G  K  L         p.880

          .         .  | 22      .         .         .         .    g.43600
 TTAGCCAGCATCAATAGCACG | GTGCGGCTCTATGAGTGGACAACAGAGAAGGAGCTGCGC    c.2700
 L  A  S  I  N  S  T   | V  R  L  Y  E  W  T  T  E  K  E  L  R      p.900

          .         .         .         .         .         .       g.43660
 ACTGAGTGCAACCACTACAACAACATCATGGCCCTCTACCTGAAGACCAAGGGCGACTTC       c.2760
 T  E  C  N  H  Y  N  N  I  M  A  L  Y  L  K  T  K  G  D  F         p.920

          .         .         .         .         .         .       g.43720
 ATCCTGGTGGGCGACCTTATGCGCTCAGTGCTGCTGCTTGCCTACAAGCCCATGGAAGGA       c.2820
 I  L  V  G  D  L  M  R  S  V  L  L  L  A  Y  K  P  M  E  G         p.940

          .   | 23     .         .         .         .         .    g.44489
 AACTTTGAAGAG | ATTGCTCGAGACTTTAATCCCAACTGGATGAGTGCTGTGGAAATCTTG    c.2880
 N  F  E  E   | I  A  R  D  F  N  P  N  W  M  S  A  V  E  I  L      p.960

          .         .         .         .         .         .       g.44549
 GATGATGACAATTTTCTGGGGGCTGAAAATGCCTTTAACTTGTTTGTGTGTCAAAAGGAT       c.2940
 D  D  D  N  F  L  G  A  E  N  A  F  N  L  F  V  C  Q  K  D         p.980

    | 24     .         .         .         .         .         .    g.44903
 AG | CGCTGCCACCACTGACGAGGAGCGGCAGCACCTCCAGGAGGTTGGTCTTTTCCACCTG    c.3000
 S  |  A  A  T  T  D  E  E  R  Q  H  L  Q  E  V  G  L  F  H  L      p.1000

          .         .         .         .         .         .       g.44963
 GGCGAGTTTGTCAATGTCTTTTGCCACGGCTCTCTGGTAATGCAGAATCTGGGTGAGACT       c.3060
 G  E  F  V  N  V  F  C  H  G  S  L  V  M  Q  N  L  G  E  T         p.1020

          .         .         .         .         .   | 25     .    g.45245
 TCCACCCCCACACAAGGCTCGGTGCTCTTCGGCACGGTCAACGGCATGATAG | GGCTGGTG    c.3120
 S  T  P  T  Q  G  S  V  L  F  G  T  V  N  G  M  I  G |   L  V      p.1040

          .         .         .         .         .         .       g.45305
 ACCTCACTGTCAGAGAGCTGGTACAACCTCCTGCTGGACATGCAGAATCGACTCAATAAA       c.3180
 T  S  L  S  E  S  W  Y  N  L  L  L  D  M  Q  N  R  L  N  K         p.1060

          .         .         .      | 26  .         .         .    g.46689
 GTCATCAAAAGTGTGGGGAAGATCGAGCACTCCTT | CTGGAGATCCTTTCACACCGAGCGG    c.3240
 V  I  K  S  V  G  K  I  E  H  S  F  |  W  R  S  F  H  T  E  R      p.1080

          .         .         .         .         .         .       g.46749
 AAGACAGAACCAGCCACAGGTTTCATCGACGGTGACTTGATTGAGAGTTTCCTGGATATT       c.3300
 K  T  E  P  A  T  G  F  I  D  G  D  L  I  E  S  F  L  D  I         p.1100

          .         .         .          | 27        .         .    g.47398
 AGCCGCCCCAAGATGCAGGAGGTGGTGGCAAACCTACAG | TATGACGATGGCAGCGGTATG    c.3360
 S  R  P  K  M  Q  E  V  V  A  N  L  Q   | Y  D  D  G  S  G  M      p.1120

          .         .         .         .         .         .       g.47458
 AAGCGAGAGGCCACTGCAGACGACCTCATCAAGGTTGTGGAGGAGCTAACTCGGATCCAT       c.3420
 K  R  E  A  T  A  D  D  L  I  K  V  V  E  E  L  T  R  I  H         p.1140

                                                                    g.47461
 TAG                                                                c.3423
 X                                                                  p.1140

          .         .         .         .         .         .       g.47521
 ccaagggcagggggcccctttgctgaccctccccaaaggctttgccctgctgccctcccc       c.*60

          .         .         .         .         .         .       g.47581
 ctcctctccaccatcgtcttcttggccatgggaggcctttccctaagccagctgccccca       c.*120

          .         .         .         .         .         .       g.47641
 gagccacagttcccctatgtggaagtggggcgggcttcatagagacttgggaatgagctg       c.*180

          .         .         .         .         .         .       g.47701
 aaggtgaaacattttctccctggatttttaccagtctcacatgattccagccatcacctt       c.*240

          .         .         .         .         .         .       g.47761
 agaccaccaagccttgattggtgttgccagttgtcctccttccggggaaggattttgcag       c.*300

          .         .         .         .         .         .       g.47821
 ttctttggctgaaaggaagctgtgcgtgtgtgtgtgtgtatgtgtgtgtgtgtatgtgta       c.*360

          .         .         .         .         .         .       g.47881
 tctcacactcatgcattgtcctctttttatttagattggcagtgtagggagttgtgggta       c.*420

          .         .         .         .         .         .       g.47941
 gtggggaagagggttaggagggtttcattgtctgtgaagtgagaccttccttttactttt       c.*480

          .         .         .         .         .         .       g.48001
 cttctattgcctctgagagcatcaggcctagaggcctgactgccaagccatgggtagcct       c.*540

          .         .         .         .         .         .       g.48061
 gggtgtaaaacctggagatggtggatgatccccacgccacagcccttttgtctctgcaaa       c.*600

          .         .         .         .         .         .       g.48121
 ctgccttcttcggaaagaagaaggtgggaggatgtgaattgttagtttctgagttttacc       c.*660

          .         .                                               g.48150
 aaataaagtagaatataagaagaaaggta                                      c.*689

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Damage-specific DNA binding protein 1, 127kDa protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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