dopa decarboxylase (aromatic L-amino acid decarboxylase) (DDC) - coding DNA reference sequence

(used for variant description)

(last modified January 1, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_000790.3 in the DDC gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008742.1, covering DDC transcript NM_000790.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.9412
                                   aactgtcactgtggagaggagagaga       c.-61

 .         .         .         .  | 02      .         .             g.26371
 gaggacagagagcaagtcactcccggctgcct | ttttcacctctgacagagcccagacacc    c.-1

          .         .         .         .         .         .       g.26431
 ATGAACGCAAGTGAATTCCGAAGGAGAGGGAAGGAGATGGTGGATTACATGGCCAACTAC       c.60
 M  N  A  S  E  F  R  R  R  G  K  E  M  V  D  Y  M  A  N  Y         p.20

          .         .         .         .         .         .       g.26491
 ATGGAAGGCATTGAGGGACGCCAGGTCTACCCTGACGTGGAGCCCGGGTACCTGCGGCCG       c.120
 M  E  G  I  E  G  R  Q  V  Y  P  D  V  E  P  G  Y  L  R  P         p.40

          .         .         .         .         .         .       g.26551
 CTGATCCCTGCCGCTGCCCCTCAGGAGCCAGACACGTTTGAGGACATCATCAACGACGTT       c.180
 L  I  P  A  A  A  P  Q  E  P  D  T  F  E  D  I  I  N  D  V         p.60

          .         .  | 03      .         .         .         .    g.30467
 GAGAAGATAATCATGCCTGGG | GTGACGCACTGGCACAGCCCCTACTTCTTCGCCTACTTC    c.240
 E  K  I  I  M  P  G   | V  T  H  W  H  S  P  Y  F  F  A  Y  F      p.80

          .         .         .         .         .         .       g.30527
 CCCACTGCCAGCTCGTACCCGGCCATGCTTGCGGACATGCTGTGCGGGGCCATTGGCTGC       c.300
 P  T  A  S  S  Y  P  A  M  L  A  D  M  L  C  G  A  I  G  C         p.100

          .      | 04  .         .         .         .         .    g.32522
 ATCGGCTTCTCCTGG | GCGGCAAGCCCAGCATGCACAGAGCTGGAGACTGTGATGATGGAC    c.360
 I  G  F  S  W   | A  A  S  P  A  C  T  E  L  E  T  V  M  M  D      p.120

          .         .         .         .         .         .       g.32582
 TGGCTCGGGAAGATGCTGGAACTACCAAAGGCATTTTTGAATGAGAAAGCTGGAGAAGGG       c.420
 W  L  G  K  M  L  E  L  P  K  A  F  L  N  E  K  A  G  E  G         p.140

          .      | 05  .         .         .         .         .    g.41159
 GGAGGAGTGATCCAG | GGAAGTGCCAGTGAAGCCACCCTGGTGGCCCTGCTGGCCGCTCGG    c.480
 G  G  V  I  Q   | G  S  A  S  E  A  T  L  V  A  L  L  A  A  R      p.160

          .         .         .         .         .         .       g.41219
 ACCAAAGTGATCCATCGGCTGCAGGCAGCGTCCCCAGAGCTCACACAGGCCGCTATCATG       c.540
 T  K  V  I  H  R  L  Q  A  A  S  P  E  L  T  Q  A  A  I  M         p.180

          .         .         . | 06       .         .         .    g.42206
 GAGAAGCTGGTGGCTTACTCATCCGATCAG | GCACACTCCTCAGTGGAAAGAGCTGGGTTA    c.600
 E  K  L  V  A  Y  S  S  D  Q   | A  H  S  S  V  E  R  A  G  L      p.200

          .         .         .         .         .         .       g.42266
 ATTGGTGGAGTGAAATTAAAAGCCATCCCCTCAGATGGCAACTTCGCCATGCGTGCGTCT       c.660
 I  G  G  V  K  L  K  A  I  P  S  D  G  N  F  A  M  R  A  S         p.220

          .         .         .         .         .     | 07   .    g.66403
 GCCCTGCAGGAAGCCCTGGAGAGAGACAAAGCGGCTGGCCTGATTCCTTTCTTT | ATGGTT    c.720
 A  L  Q  E  A  L  E  R  D  K  A  A  G  L  I  P  F  F   | M  V      p.240

          .         .         .         .         .         .       g.66463
 GCCACCCTGGGGACCACAACATGCTGCTCCTTTGACAATCTCTTAGAAGTCGGTCCTATC       c.780
 A  T  L  G  T  T  T  C  C  S  F  D  N  L  L  E  V  G  P  I         p.260

   | 08      .         .         .         .         .         .    g.71273
 T | GCAACAAGGAAGACATATGGCTGCACGTTGATGCAGCCTACGCAGGCAGTGCATTCATC    c.840
 C |   N  K  E  D  I  W  L  H  V  D  A  A  Y  A  G  S  A  F  I      p.280

          .         .         .       | 09 .         .         .    g.75063
 TGCCCTGAGTTCCGGCACCTTCTGAATGGAGTGGAG | TTTGCAGATTCATTCAACTTTAAT    c.900
 C  P  E  F  R  H  L  L  N  G  V  E   | F  A  D  S  F  N  F  N      p.300

          .         .         .         .     | 10   .         .    g.90609
 CCCCACAAATGGCTATTGGTGAATTTTGACTGTTCTGCCATGTG | GGTGAAAAAGAGAACA    c.960
 P  H  K  W  L  L  V  N  F  D  C  S  A  M  W  |  V  K  K  R  T      p.320

          .         .         .         .         .         .       g.90669
 GACTTAACGGGAGCCTTTAGACTGGACCCCACTTACCTGAAGCACAGCCATCAGGATTCA       c.1020
 D  L  T  G  A  F  R  L  D  P  T  Y  L  K  H  S  H  Q  D  S         p.340

   | 11      .         .  | 12      .         .         .         . g.100324
 G | GGCTTATCACTGACTACCGG | CATTGGCAGATACCACTGGGCAGAAGATTTCGCTCTTTG c.1080
 G |   L  I  T  D  Y  R   | H  W  Q  I  P  L  G  R  R  F  R  S  L   p.360

          .         .         .         .         .         .       g.100384
 AAAATGTGGTTTGTATTTAGGATGTATGGAGTCAAAGGACTGCAGGCTTATATCCGCAAG       c.1140
 K  M  W  F  V  F  R  M  Y  G  V  K  G  L  Q  A  Y  I  R  K         p.380

  | 13       .         .         .         .         .         .    g.103201
  | CATGTCCAGCTGTCCCATGAGTTTGAGTCACTGGTGCGCCAGGATCCCCGCTTTGAAATC    c.1200
  | H  V  Q  L  S  H  E  F  E  S  L  V  R  Q  D  P  R  F  E  I      p.400

          .         .         .         .   | 14     .         .    g.107043
 TGTGTGGAAGTCATTCTGGGGCTTGTCTGCTTTCGGCTAAAG | GGTTCCAACAAAGTGAAT    c.1260
 C  V  E  V  I  L  G  L  V  C  F  R  L  K   | G  S  N  K  V  N      p.420

          .         .         .         .         .         .       g.107103
 GAAGCTCTTCTGCAAAGAATAAACAGTGCCAAAAAAATCCACTTGGTTCCATGTCACCTC       c.1320
 E  A  L  L  Q  R  I  N  S  A  K  K  I  H  L  V  P  C  H  L         p.440

          .         .         .         .         .         .       g.107163
 AGGGACAAGTTTGTCCTGCGCTTTGCCATCTGTTCTCGCACGGTGGAATCTGCCCATGTG       c.1380
 R  D  K  F  V  L  R  F  A  I  C  S  R  T  V  E  S  A  H  V         p.460

          .         .         .         .         .         .       g.107223
 CAGCGGGCCTGGGAACACATCAAAGAGCTGGCGGCCGACGTGCTGCGAGCAGAGAGGGAG       c.1440
 Q  R  A  W  E  H  I  K  E  L  A  A  D  V  L  R  A  E  R  E         p.480

                                                                g.107226
 TAG |                                                             c.1444
 X                                                               p.480

          .         | 15         .         .         .         .    g.111655
 gagtgaagccagctgcag | gaatcaaaaattgaagagagatatatctgaaaactggaataa    c.*60

          .         .         .         .         .         .       g.111715
 gaagcaaataaatatcatcctgccttcatggaactcagctgtctgtggcttcccatgtct       c.*120

          .         .         .         .         .         .       g.111775
 ttctccaaagttatccagagggttgtgattttgtctgcttagtatctcatcaacaaagaa       c.*180

          .         .         .         .         .         .       g.111835
 atattatttgctaattaaaaagttaatcttcatggccatagcttttattcattagctgtg       c.*240

          .         .         .         .         .         .       g.111895
 atttttgttgattaaaacattatagattttcatgttcttgcagtcatcagaagtggtagg       c.*300

          .         .         .         .         .         .       g.111955
 aaagcctcactgatatattttccagggcaatcaatgttcacgcaacttgaaattatatct       c.*360

          .         .         .         .         .         .       g.112015
 gtggtcttcaaattgtcttttgtcatgtggctaaatgcctaataaacaattcaagtgaaa       c.*420

                                                                    g.112021
 tactaa                                                             c.*426

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Dopa decarboxylase (aromatic L-amino acid decarboxylase) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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