DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked (DDX3X) - coding DNA reference sequence

(used for variant description)

(last modified February 6, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_001356.3 in the DDX3X gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012830.2, covering DDX3X transcript NM_001356.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5015
                                              ctttccccttactcc       c.-841

 .         .         .         .         .         .                g.5075
 gctcccctcttttccctccctctcctccccttccctctgttctctcctcctcttcccctc       c.-781

 .         .         .         .         .         .                g.5135
 ccctcccccgtccggagcactctatattcaagccaccgtttcctgcttcacaaaatggcc       c.-721

 .         .         .         .         .         .                g.5195
 accgcacgcgacacctacggtcacgtggcctgccgccctctcagtttcgggaatctgcct       c.-661

 .         .         .         .         .         .                g.5255
 agctcccactaaggggaggctacccgcggaagagcgagggcagattagaccggagaaatc       c.-601

 .         .         .         .         .         .                g.5315
 ccaccacatctccaagcccgggaactgagagaggaagaagagtgaaggccagtgttagga       c.-541

 .         .         .         .         .         .                g.5375
 aaaaaaaaacaaaaacaaaaaaaacgaaaaacgaaagctgagtgcatagagttggaaagg       c.-481

 .         .         .         .         .         .                g.5435
 ggagcgaatgcgtaaggttggaaaggggggcgaagaggcctaggttaacattttcaggcg       c.-421

 .         .         .         .         .         .                g.5495
 tcttagccggtggaaagcgggagacgcaagttctcgcgagatctcgagaactccgaggct       c.-361

 .         .         .         .         .         .                g.5555
 gagactagggttttagcggagagcacgggaagtgtagctcgagagaactgggacagcatt       c.-301

 .         .         .         .         .         .                g.5615
 tcgcaccctaagctccaaggcaggactgctaggggcgacaggactaagtaggaaatccct       c.-241

 .         .         .         .         .         .                g.5675
 tgagcttagacctgagggagcgcgcagtagccgggcagaagtcgccgcgacagggaattg       c.-181

 .         .         .         .         .         .                g.5735
 cggtgtgagagggagggcacacgttgtacgtgctgacgtagccggctttccagcgggtat       c.-121

 .         .         .         .         .         .                g.5795
 attagatccgtggccgcgcggtgcgctccagagccgcagttctcccgtgagagggccttc       c.-61

 .         .         .         .         .         .                g.5855
 gcggtggaacaaacactcgcttagcagcggaagactccgagttctcggtactcttcaggg       c.-1

          .         .         .         .      | 02  .         .    g.9025
 ATGAGTCATGTGGCAGTGGAAAATGCGCTCGGGCTGGACCAGCAG | TTTGCTGGCCTAGAC    c.60
 M  S  H  V  A  V  E  N  A  L  G  L  D  Q  Q   | F  A  G  L  D      p.20

          .         .         .         .    | 03    .         .    g.10655
 CTGAACTCTTCAGATAATCAGAGTGGAGGAAGTACAGCCAGCA | AAGGGCGCTATATTCCT    c.120
 L  N  S  S  D  N  Q  S  G  G  S  T  A  S  K |   G  R  Y  I  P      p.40

          .         .         .  | 04      .         .         .    g.13115
 CCTCATTTAAGGAACCGAGAAGCTACTAAAG | GTTTCTACGATAAAGACAGTTCAGGGTGG    c.180
 P  H  L  R  N  R  E  A  T  K  G |   F  Y  D  K  D  S  S  G  W      p.60

          .         .         .         .         .         .       g.13175
 AGTTCTAGCAAAGATAAGGATGCGTATAGCAGTTTTGGATCTCGTAGTGATTCAAGAGGG       c.240
 S  S  S  K  D  K  D  A  Y  S  S  F  G  S  R  S  D  S  R  G         p.80

          .         .         .         .     | 05   .         .    g.14113
 AAGTCTAGCTTCTTCAGTGATCGTGGAAGTGGATCAAGGGGAAG | GTTTGATGATCGTGGA    c.300
 K  S  S  F  F  S  D  R  G  S  G  S  R  G  R  |  F  D  D  R  G      p.100

          .         .         .         .         .         .       g.14173
 CGGAGTGATTACGATGGCATTGGCAGCCGTGGTGACAGAAGTGGCTTTGGCAAATTTGAA       c.360
 R  S  D  Y  D  G  I  G  S  R  G  D  R  S  G  F  G  K  F  E         p.120

          .         .         .         .         .         .       g.14233
 CGTGGTGGAAACAGTCGCTGGTGTGACAAATCAGATGAAGATGATTGGTCAAAACCACTC       c.420
 R  G  G  N  S  R  W  C  D  K  S  D  E  D  D  W  S  K  P  L         p.140

          .         .    | 06    .         .         .         .    g.14376
 CCACCAAGTGAACGCTTGGAACA | GGAACTCTTTTCTGGAGGCAACACTGGGATTAATTTT    c.480
 P  P  S  E  R  L  E  Q  |  E  L  F  S  G  G  N  T  G  I  N  F      p.160

          .         .         .         .         .         .       g.14436
 GAGAAATACGATGACATTCCAGTTGAGGCAACAGGCAACAACTGTCCTCCACATATTGAA       c.540
 E  K  Y  D  D  I  P  V  E  A  T  G  N  N  C  P  P  H  I  E         p.180

     | 07    .         .         .         .         .         .    g.14875
 AGT | TTCAGTGATGTTGAGATGGGAGAAATTATCATGGGAAACATTGAGCTTACTCGTTAT    c.600
 S   | F  S  D  V  E  M  G  E  I  I  M  G  N  I  E  L  T  R  Y      p.200

          .         .         .         .         .         .       g.14935
 ACTCGCCCAACTCCAGTGCAAAAGCATGCTATTCCTATTATCAAAGAGAAAAGAGACTTG       c.660
 T  R  P  T  P  V  Q  K  H  A  I  P  I  I  K  E  K  R  D  L         p.220

          .          | 08        .         .         .         .    g.15380
 ATGGCTTGTGCCCAAACAG | GGTCTGGAAAAACTGCAGCATTTCTGTTGCCCATCTTGAGT    c.720
 M  A  C  A  Q  T  G |   S  G  K  T  A  A  F  L  L  P  I  L  S      p.240

          .         .         .         .      | 09  .         .    g.15647
 CAGATTTATTCAGATGGTCCAGGCGAGGCTTTGAGGGCCATGAAG | GAAAATGGAAGGTAT    c.780
 Q  I  Y  S  D  G  P  G  E  A  L  R  A  M  K   | E  N  G  R  Y      p.260

          .         .         .         .         .         .       g.15707
 GGGCGCCGCAAACAATACCCAATCTCCTTGGTATTAGCACCAACGAGAGAGTTGGCAGTA       c.840
 G  R  R  K  Q  Y  P  I  S  L  V  L  A  P  T  R  E  L  A  V         p.280

          .         .     | 10   .         .         .         .    g.15877
 CAGATCTACGAGGAAGCCAGAAAA | TTTTCATACCGATCTAGAGTTCGTCCTTGCGTGGTT    c.900
 Q  I  Y  E  E  A  R  K   | F  S  Y  R  S  R  V  R  P  C  V  V      p.300

          .         .         .         .         .         .       g.15937
 TATGGTGGTGCCGATATTGGTCAGCAGATTCGAGACTTGGAACGTGGATGCCATTTGTTA       c.960
 Y  G  G  A  D  I  G  Q  Q  I  R  D  L  E  R  G  C  H  L  L         p.320

          .         .         .         .         .         .       g.15997
 GTAGCCACTCCAGGACGTCTAGTGGATATGATGGAAAGAGGAAAGATTGGATTAGACTTT       c.1020
 V  A  T  P  G  R  L  V  D  M  M  E  R  G  K  I  G  L  D  F         p.340

       | 11  .         .         .         .         .         .    g.16837
 TGCAA | ATACTTGGTGTTAGATGAAGCTGATCGGATGTTGGATATGGGGTTTGAGCCTCAG    c.1080
 C  K  |  Y  L  V  L  D  E  A  D  R  M  L  D  M  G  F  E  P  Q      p.360

          .         .         .         .         .         .       g.16897
 ATTCGTAGAATAGTCGAACAAGATACTATGCCTCCAAAGGGTGTCCGCCACACTATGATG       c.1140
 I  R  R  I  V  E  Q  D  T  M  P  P  K  G  V  R  H  T  M  M         p.380

          .         .         . | 12       .         .         .    g.17036
 TTTAGTGCTACTTTTCCTAAGGAAATACAG | ATGCTGGCTCGTGATTTCTTAGATGAATAT    c.1200
 F  S  A  T  F  P  K  E  I  Q   | M  L  A  R  D  F  L  D  E  Y      p.400

          .         .         .         .         .         .       g.17096
 ATCTTCTTGGCTGTAGGAAGAGTTGGCTCTACCTCTGAAAACATCACACAGAAAGTAGTT       c.1260
 I  F  L  A  V  G  R  V  G  S  T  S  E  N  I  T  Q  K  V  V         p.420

          .         .         .         .         .      | 13  .    g.17836
 TGGGTGGAAGAATCAGACAAACGGTCATTTCTGCTTGACCTCCTAAATGCAACAG | GCAAG    c.1320
 W  V  E  E  S  D  K  R  S  F  L  L  D  L  L  N  A  T  G |   K      p.440

          .         .         .         .         .         .       g.17896
 GATTCACTGACCTTAGTGTTTGTGGAGACCAAAAAGGGTGCAGATTCTCTGGAGGATTTC       c.1380
 D  S  L  T  L  V  F  V  E  T  K  K  G  A  D  S  L  E  D  F         p.460

          .         .         .         .         .         .       g.17956
 TTATACCATGAAGGATACGCATGTACCAGCATCCATGGAGACCGTTCTCAGAGGGATAGA       c.1440
 L  Y  H  E  G  Y  A  C  T  S  I  H  G  D  R  S  Q  R  D  R         p.480

          .         .         .         .         .        | 14.    g.18110
 GAAGAGGCCCTTCACCAGTTCCGCTCAGGAAAAAGCCCAATTTTAGTGGCTACAGCA | GTA    c.1500
 E  E  A  L  H  Q  F  R  S  G  K  S  P  I  L  V  A  T  A   | V      p.500

          .         .         .         .         .         .       g.18170
 GCAGCAAGAGGACTGGACATTTCAAATGTGAAACATGTTATCAATTTTGACTTGCCAAGT       c.1560
 A  A  R  G  L  D  I  S  N  V  K  H  V  I  N  F  D  L  P  S         p.520

          .         .         .         .         .      | 15  .    g.18466
 GATATTGAAGAATATGTACATCGTATTGGTCGTACGGGACGTGTAGGAAACCTTG | GCCTG    c.1620
 D  I  E  E  Y  V  H  R  I  G  R  T  G  R  V  G  N  L  G |   L      p.540

          .         .         .         .         .         .       g.18526
 GCAACCTCATTCTTTAACGAGAGGAACATAAATATTACTAAGGATTTGTTGGATCTTCTT       c.1680
 A  T  S  F  F  N  E  R  N  I  N  I  T  K  D  L  L  D  L  L         p.560

          .         .         .         .         .         .       g.18586
 GTTGAAGCTAAACAAGAAGTGCCGTCTTGGTTAGAAAACATGGCTTATGAACACCACTAC       c.1740
 V  E  A  K  Q  E  V  P  S  W  L  E  N  M  A  Y  E  H  H  Y         p.580

          .         .          | 16        .         .         .    g.18945
 AAGGGTAGCAGTCGTGGACGTTCTAAGAG | TAGCAGATTTAGTGGAGGGTTTGGTGCCAGA    c.1800
 K  G  S  S  R  G  R  S  K  S  |  S  R  F  S  G  G  F  G  A  R      p.600

          .         .         .         .         .         .       g.19005
 GACTACCGACAAAGTAGCGGTGCCAGCAGTTCCAGCTTCAGCAGCAGCCGCGCAAGCAGC       c.1860
 D  Y  R  Q  S  S  G  A  S  S  S  S  F  S  S  S  R  A  S  S         p.620

          .         .         .         .          | 17        .    g.19253
 AGCCGCAGTGGCGGAGGTGGCCACGGTAGCAGCAGAGGATTTGGTGGAG | GTGGCTATGGA    c.1920
 S  R  S  G  G  G  G  H  G  S  S  R  G  F  G  G  G |   G  Y  G      p.640

          .         .         .         .         .         .       g.19313
 GGCTTTTACAACAGTGATGGATATGGAGGAAATTATAACTCCCAGGGGGTTGACTGGTGG       c.1980
 G  F  Y  N  S  D  G  Y  G  G  N  Y  N  S  Q  G  V  D  W  W         p.660

                                                                    g.19322
 GGTAACTGA                                                          c.1989
 G  N  X                                                            p.662

          .         .         .         .         .         .       g.19382
 gcctgctttgcagtaggtcaccctgccaaacaagctaatatggaaaccacatgtaactta       c.*60

          .         .         .         .         .         .       g.19442
 gccagactataccttgtgtagcttcaagaactcgcagtacattaccagctgtgattctcc       c.*120

          .         .         .         .         .         .       g.19502
 actgaaattttttttttaagggagctcaaggtcacaagaagaaatgaaaggaacaatcag       c.*180

          .         .         .         .         .         .       g.19562
 cagccctgttcagaaggtggtttgaagacttcattgctgtagtttggattaactcccctc       c.*240

          .         .         .         .         .         .       g.19622
 ccgcctacccccatcccaaactgcatttataattttgtgactgaggatcatttgtttgtt       c.*300

          .         .         .         .         .         .       g.19682
 aatgtactgtgcctttaactttagacaactttttattttgatgtcctgttggctcagtaa       c.*360

          .         .         .         .         .         .       g.19742
 tgctcaagatatcaattgttttgacaaaataaatttactgaacttgggctaaaatcaaac       c.*420

          .         .         .         .         .         .       g.19802
 cttggcacacaggtgtgatacaacttaacaggaatcatcgattcatccataaataatata       c.*480

          .         .         .         .         .         .       g.19862
 aggaaaaacttatgcggtagcctgcattagggctttttgatacttgcagattgggggaaa       c.*540

          .         .         .         .         .         .       g.19922
 acaacaaatgtcttgaagcatattaatggaattagtttctaatgtggcaaactgtattaa       c.*600

          .         .         .         .         .         .       g.19982
 gttaaagttctgatttgctcactctatcctggataggtatttagaacctgatagtcttta       c.*660

          .         .         .         .         .         .       g.20042
 agccattccagtcatgatgaggtgatgtatgaatacatgcatacattcaaagcactgttt       c.*720

          .         .         .         .         .         .       g.20102
 tcaaagttaatgcaagtaaatacagcaattcctctttcaacgtttaggcagatcattaat       c.*780

          .         .         .         .         .         .       g.20162
 tatgagctagccaaatgtgggcatactattacagggaaagtttaaaggtctgataacttg       c.*840

          .         .         .         .         .         .       g.20222
 aaataggtttttaggagaattcatctacttagactttttaaatgcctgccataaatgaaa       c.*900

          .         .         .         .         .         .       g.20282
 ttgaaatggtagaatggctgaccacagcaatgaccagccctcattagggccctggatgat       c.*960

          .         .         .         .         .         .       g.20342
 ttttggtctaataacgcatgctagtgttgatgttttttggtcaagagggtatgaacagga       c.*1020

          .         .         .         .         .         .       g.20402
 agaattaaatgcagcaggctttattttaaatgccgattcacattactctgttcaagctgc       c.*1080

          .         .         .         .         .         .       g.20462
 gttgagatgttaaactggcttactatagacttcgtaaaaatggctccagaagagtaacaa       c.*1140

          .         .         .         .         .         .       g.20522
 actgaaatctttgagatcacacaggttggaaatatgtacataactgcacaaggtgtcaat       c.*1200

          .         .         .         .         .         .       g.20582
 tctgctctacagtgcagttttagtcagttttagttgcataggtttccattgtatttatag       c.*1260

          .         .         .         .         .         .       g.20642
 tctgtttatgctaaatctggccaaagatgagcattgtccaccactaaaatgcctctgcca       c.*1320

          .         .         .         .         .         .       g.20702
 ctttgaattctgtgctaattttgtggccagaatgcggtgatcaaaacgctccatcttttt       c.*1380

          .         .         .         .         .         .       g.20762
 acagtggcataggaagacggcaaaaatttcctaaagtgcaatagattttcaagtgtattg       c.*1440

          .         .         .         .         .         .       g.20822
 tgccttgttctaaaacttttattaagtaggtgcacttgacagtattgaggtcatttgtta       c.*1500

          .         .         .         .         .         .       g.20882
 tggtgctatttcaattagtctaggtttaggcccttgtacattttgcccataactttttac       c.*1560

          .         .         .         .         .         .       g.20942
 aaagtacttcttttattgcacattcagagaattttatatatatgtcttgtgtgcgtgtcc       c.*1620

          .         .         .         .         .         .       g.21002
 ttaaacttccaatcttactttgtctcttggagattgttgaacgcagcttgtctaggaagg       c.*1680

          .         .         .         .         .         .       g.21062
 ggatgggactagattctaaaatttatttgggaccatgggaatgatagttgggaagaaaac       c.*1740

          .         .         .         .         .         .       g.21122
 tatttgcacacgacagatttctagatactttttgctgctagttttatgtaatatttattg       c.*1800

          .         .         .         .         .         .       g.21182
 aacattttgacaaatatttatttttgtaagcctaaaagtgattctttgaaagtttaaaga       c.*1860

          .         .         .         .         .         .       g.21242
 aacttgaccaaaagacagtacaaaaacactggcacttgaatgttgaatgtcaccgtatgc       c.*1920

          .         .         .         .         .         .       g.21302
 gtgaaattatatatttcggggtagtgtgagcttttaatgtttaagtcatattaaactctt       c.*1980

          .         .         .         .         .         .       g.21362
 aagtcaaattaagcagacccggcgttggcagtgtagccataactttctgatgttagtaaa       c.*2040

          .         .         .         .         .         .       g.21422
 aacaaaattggcgacttgaaattaaatcatgccaaggttttgatacacttgtcttaagat       c.*2100

          .         .         .         .         .         .       g.21482
 attaatgaaacacttcaaaacactgatgtgaagtgtccagattctcagatgtttgttgtg       c.*2160

          .         .         .         .         .         .       g.21542
 tggattttgtttagttgtgtgtttttttttttttttcagtgaatgtctggcacattgcaa       c.*2220

          .         .         .         .         .         .       g.21602
 tcctcaaacatgtggttatctttgttgtattggcataatcagtgacttgtacattcagca       c.*2280

          .         .         .         .         .         .       g.21662
 atagcatttgagcaagttttatcagcaagcaatattttcagttaataaggtttcaaaaat       c.*2340

          .         .         .         .         .         .       g.21722
 catgtaaggatttaaacttgctgaatgtaaagattgaacctcaagtcactgtagctttag       c.*2400

          .         .         .         .         .         .       g.21782
 taattgcttattgtattagtttagatgctagcactgcatgtgctgtgcatattctgattt       c.*2460

          .         .         .         .         .         .       g.21842
 tattaaaataaaaagttgaactgcacagtctcctttgttgttgtcaattgtggtttattt       c.*2520

          .         .         .                                     g.21877
 tcagaggtgtaaataaagtgctcttgcctgaaaaa                                c.*2555

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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