DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 (DDX58) - coding DNA reference sequence

(used for variant description)

(last modified February 15, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_014314.3 in the DDX58 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000009.11, covering DDX58 transcript NM_014314.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5038
                       tagttattaaagttcctatgcagctccgcctcgcgtcc       c.-121

 .         .         .         .         .         .                g.5098
 ggcctcatttcctcggaaaatccctgctttccccgctcgccacgccctcctcctacccgg       c.-61

 .         .         .         .         .         .                g.5158
 ctttaaagctagtgaggcacagcctgcggggaacgtagctagctgcaagcagaggccggc       c.-1

          .         .         .         .         .         .       g.5218
 ATGACCACCGAGCAGCGACGCAGCCTGCAAGCCTTCCAGGATTATATCCGGAAGACCCTG       c.60
 M  T  T  E  Q  R  R  S  L  Q  A  F  Q  D  Y  I  R  K  T  L         p.20

          .         .         .         .       | 02 .         .    g.30399
 GACCCTACCTACATCCTGAGCTACATGGCCCCCTGGTTTAGGGAGG | AAGAGGTGCAGTAT    c.120
 D  P  T  Y  I  L  S  Y  M  A  P  W  F  R  E  E |   E  V  Q  Y      p.40

          .         .         .         .         .         .       g.30459
 ATTCAGGCTGAGAAAAACAACAAGGGCCCAATGGAGGCTGCCACACTTTTTCTCAAGTTC       c.180
 I  Q  A  E  K  N  N  K  G  P  M  E  A  A  T  L  F  L  K  F         p.60

          .         .         .         .         .         .       g.30519
 CTGTTGGAGCTCCAGGAGGAAGGCTGGTTCCGTGGCTTTTTGGATGCCCTAGACCATGCA       c.240
 L  L  E  L  Q  E  E  G  W  F  R  G  F  L  D  A  L  D  H  A         p.80

   | 03      .         .         .         .         .         .    g.37441
 G | GTTATTCTGGACTTTATGAAGCCATTGAAAGTTGGGATTTCAAAAAAATTGAAAAGTTG    c.300
 G |   Y  S  G  L  Y  E  A  I  E  S  W  D  F  K  K  I  E  K  L      p.100

          .         .         .         .         .         .       g.37501
 GAGGAGTATAGATTACTTTTAAAACGTTTACAACCAGAATTTAAAACCAGAATTATCCCA       c.360
 E  E  Y  R  L  L  L  K  R  L  Q  P  E  F  K  T  R  I  I  P         p.120

          .         .         .         .         .         .       g.37561
 ACCGATATCATTTCTGATCTGTCTGAATGTTTAATTAATCAGGAATGTGAAGAAATTCTA       c.420
 T  D  I  I  S  D  L  S  E  C  L  I  N  Q  E  C  E  E  I  L         p.140

     | 04    .         .         .         .         .         .    g.38843
 CAG | ATTTGCTCTACTAAGGGGATGATGGCAGGTGCAGAGAAATTGGTGGAATGCCTTCTC    c.480
 Q   | I  C  S  T  K  G  M  M  A  G  A  E  K  L  V  E  C  L  L      p.160

          .         .         .         .         .         .       g.38903
 AGATCAGACAAGGAAAACTGGCCCAAAACTTTGAAACTTGCTTTGGAGAAAGAAAGGAAC       c.540
 R  S  D  K  E  N  W  P  K  T  L  K  L  A  L  E  K  E  R  N         p.180

          .         .         .  | 05      .         .         .    g.39933
 AAGTTCAGTGAACTGTGGATTGTAGAGAAAG | GTATAAAAGATGTTGAAACAGAAGATCTT    c.600
 K  F  S  E  L  W  I  V  E  K  G |   I  K  D  V  E  T  E  D  L      p.200

          .         .         .         .         .         .       g.39993
 GAGGATAAGATGGAAACTTCTGACATACAGATTTTCTACCAAGAAGATCCAGAATGCCAG       c.660
 E  D  K  M  E  T  S  D  I  Q  I  F  Y  Q  E  D  P  E  C  Q         p.220

          .         .         .  | 06      .         .         .    g.41902
 AATCTTAGTGAGAATTCATGTCCACCTTCAG | AAGTGTCTGATACAAACTTGTACAGCCCA    c.720
 N  L  S  E  N  S  C  P  P  S  E |   V  S  D  T  N  L  Y  S  P      p.240

          .         .         .         .         .         .       g.41962
 TTTAAACCAAGAAATTACCAATTAGAGCTTGCTTTGCCTGCTATGAAAGGAAAAAACACA       c.780
 F  K  P  R  N  Y  Q  L  E  L  A  L  P  A  M  K  G  K  N  T         p.260

          .          | 07        .         .         .         .    g.42478
 ATAATATGTGCTCCTACAG | GTTGTGGAAAAACCTTTGTTTCACTGCTTATATGTGAACAT    c.840
 I  I  C  A  P  T  G |   C  G  K  T  F  V  S  L  L  I  C  E  H      p.280

          .         .         .         .         .         .       g.42538
 CATCTTAAAAAATTCCCACAAGGACAAAAGGGGAAAGTTGTCTTTTTTGCGAATCAGATC       c.900
 H  L  K  K  F  P  Q  G  Q  K  G  K  V  V  F  F  A  N  Q  I         p.300

          .         .         .         .         .    | 08    .    g.43128
 CCAGTGTATGAACAGCAGAAATCTGTATTCTCAAAATACTTTGAAAGACATGG | GTATAGA    c.960
 P  V  Y  E  Q  Q  K  S  V  F  S  K  Y  F  E  R  H  G  |  Y  R      p.320

          .         .         .         .         .         .       g.43188
 GTTACAGGCATTTCTGGAGCAACAGCTGAGAATGTCCCAGTGGAACAGATTGTTGAGAAC       c.1020
 V  T  G  I  S  G  A  T  A  E  N  V  P  V  E  Q  I  V  E  N         p.340

          .         .         .         .         .         .       g.43248
 AATGACATCATCATTTTAACTCCACAGATTCTTGTGAACAACCTTAAAAAGGGAACGATT       c.1080
 N  D  I  I  I  L  T  P  Q  I  L  V  N  N  L  K  K  G  T  I         p.360

          .         .         .         .         .         .       g.43308
 CCATCACTATCCATCTTTACTTTGATGATATTTGATGAATGCCACAACACTAGTAAACAA       c.1140
 P  S  L  S  I  F  T  L  M  I  F  D  E  C  H  N  T  S  K  Q         p.380

          .         .         .         .         .         .       g.43368
 CACCCGTACAATATGATCATGTTTAATTATCTAGATCAGAAACTTGGAGGATCTTCAGGC       c.1200
 H  P  Y  N  M  I  M  F  N  Y  L  D  Q  K  L  G  G  S  S  G         p.400

          .   | 09     .         .         .         .         .    g.43739
 CCACTGCCCCAG | GTCATTGGGCTGACTGCCTCGGTTGGTGTTGGGGATGCCAAAAACACA    c.1260
 P  L  P  Q   | V  I  G  L  T  A  S  V  G  V  G  D  A  K  N  T      p.420

          .         .         .         .         .         .       g.43799
 GATGAAGCCTTGGATTATATCTGCAAGCTGTGTGCTTCTCTTGATGCGTCAGTGATAGCA       c.1320
 D  E  A  L  D  Y  I  C  K  L  C  A  S  L  D  A  S  V  I  A         p.440

          .         .         .         .         .      | 10  .    g.46050
 ACAGTCAAACACAATCTGGAGGAACTGGAGCAAGTTGTTTATAAGCCCCAGAAGT | TTTTC    c.1380
 T  V  K  H  N  L  E  E  L  E  Q  V  V  Y  K  P  Q  K  F |   F      p.460

          .         .         .         .         .         .       g.46110
 AGGAAAGTGGAATCACGGATTAGCGACAAATTTAAATACATCATAGCTCAGCTGATGAGG       c.1440
 R  K  V  E  S  R  I  S  D  K  F  K  Y  I  I  A  Q  L  M  R         p.480

          .         .         .         . | 11       .         .    g.49847
 GACACAGAGAGTCTGGCAAAGAGAATCTGCAAAGACCTCG | AAAACTTATCTCAAATTCAA    c.1500
 D  T  E  S  L  A  K  R  I  C  K  D  L  E |   N  L  S  Q  I  Q      p.500

          .         .         .         .         .         .       g.49907
 AATAGGGAATTTGGAACACAGAAATATGAACAATGGATTGTTACAGTTCAGAAAGCATGC       c.1560
 N  R  E  F  G  T  Q  K  Y  E  Q  W  I  V  T  V  Q  K  A  C         p.520

          .         .         .         .         .         .       g.49967
 ATGGTGTTCCAGATGCCAGACAAAGATGAAGAGAGCAGGATTTGTAAAGCCCTGTTTTTA       c.1620
 M  V  F  Q  M  P  D  K  D  E  E  S  R  I  C  K  A  L  F  L         p.540

          .         | 12         .         .         .         .    g.51012
 TACACTTCACATTTGCGG | AAATATAATGATGCCCTCATTATCAGTGAGCATGCACGAATG    c.1680
 Y  T  S  H  L  R   | K  Y  N  D  A  L  I  I  S  E  H  A  R  M      p.560

          .         .         .         .         .         .       g.51072
 AAAGATGCTCTGGATTACTTGAAAGACTTCTTCAGCAATGTCCGAGCAGCAGGATTCGAT       c.1740
 K  D  A  L  D  Y  L  K  D  F  F  S  N  V  R  A  A  G  F  D         p.580

          .         .         .     | 13   .         .         .    g.54219
 GAGATTGAGCAAGATCTTACTCAGAGATTTGAAG | AAAAGCTGCAGGAACTAGAAAGTGTT    c.1800
 E  I  E  Q  D  L  T  Q  R  F  E  E |   K  L  Q  E  L  E  S  V      p.600

          .         .         .         .         .         .       g.54279
 TCCAGGGATCCCAGCAATGAGAATCCTAAACTTGAAGACCTCTGCTTCATCTTACAAGAA       c.1860
 S  R  D  P  S  N  E  N  P  K  L  E  D  L  C  F  I  L  Q  E         p.620

          .         .         .         .         .         .       g.54339
 GAGTACCACTTAAACCCAGAGACAATAACAATTCTCTTTGTGAAAACCAGAGCACTTGTG       c.1920
 E  Y  H  L  N  P  E  T  I  T  I  L  F  V  K  T  R  A  L  V         p.640

     | 14    .         .         .         .         .         .    g.58316
 GAC | GCTTTAAAAAATTGGATTGAAGGAAATCCTAAACTCAGTTTTCTAAAACCTGGCATA    c.1980
 D   | A  L  K  N  W  I  E  G  N  P  K  L  S  F  L  K  P  G  I      p.660

          .         .         .     | 15   .         .         .    g.63418
 TTGACTGGACGTGGCAAAACAAATCAGAACACAG | GAATGACCCTCCCGGCACAGAAGTGT    c.2040
 L  T  G  R  G  K  T  N  Q  N  T  G |   M  T  L  P  A  Q  K  C      p.680

          .         .         .         .         .         .       g.63478
 ATATTGGATGCATTCAAAGCCAGTGGAGATCACAATATTCTGATTGCCACCTCAGTTGCT       c.2100
 I  L  D  A  F  K  A  S  G  D  H  N  I  L  I  A  T  S  V  A         p.700

          .         .         .         .         .         .       g.63538
 GATGAAGGCATTGACATTGCACAGTGCAATCTTGTCATCCTTTATGAGTATGTGGGCAAT       c.2160
 D  E  G  I  D  I  A  Q  C  N  L  V  I  L  Y  E  Y  V  G  N         p.720

          .         .      | 16  .         .         .         .    g.64918
 GTCATCAAAATGATCCAAACCAGAG | GCAGAGGAAGAGCAAGAGGTAGCAAGTGCTTCCTT    c.2220
 V  I  K  M  I  Q  T  R  G |   R  G  R  A  R  G  S  K  C  F  L      p.740

          .         .         .         .         .         .       g.64978
 CTGACTAGTAATGCTGGTGTAATTGAAAAAGAACAAATAAACATGTACAAAGAAAAAATG       c.2280
 L  T  S  N  A  G  V  I  E  K  E  Q  I  N  M  Y  K  E  K  M         p.760

          .         .         .         .         .        | 17.    g.71813
 ATGAATGACTCTATTTTACGCCTTCAGACATGGGACGAAGCAGTATTTAGGGAAAAG | ATT    c.2340
 M  N  D  S  I  L  R  L  Q  T  W  D  E  A  V  F  R  E  K   | I      p.780

          .         .         .         .         .         .       g.71873
 CTGCATATACAGACTCATGAAAAATTCATCAGAGATAGTCAAGAAAAACCAAAACCTGTA       c.2400
 L  H  I  Q  T  H  E  K  F  I  R  D  S  Q  E  K  P  K  P  V         p.800

          .         .         .         .         .         .       g.71933
 CCTGATAAGGAAAATAAAAAACTGCTCTGCAGAAAGTGCAAAGCCTTGGCATGTTACACA       c.2460
 P  D  K  E  N  K  K  L  L  C  R  K  C  K  A  L  A  C  Y  T         p.820

          .         .  | 18      .         .         .         .    g.73945
 GCTGACGTAAGAGTGATAGAG | GAATGCCATTACACTGTGCTTGGAGATGCTTTTAAGGAA    c.2520
 A  D  V  R  V  I  E   | E  C  H  Y  T  V  L  G  D  A  F  K  E      p.840

          .         .         .         .         .         .       g.74005
 TGCTTTGTGAGTAGACCACATCCCAAGCCAAAGCAGTTTTCAAGTTTTGAAAAAAGAGCA       c.2580
 C  F  V  S  R  P  H  P  K  P  K  Q  F  S  S  F  E  K  R  A         p.860

          .         .         .         .         .         .       g.74065
 AAGATATTCTGTGCCCGACAGAACTGCAGCCATGACTGGGGAATCCATGTGAAGTACAAG       c.2640
 K  I  F  C  A  R  Q  N  C  S  H  D  W  G  I  H  V  K  Y  K         p.880

          .         .         .         .         .         .       g.74125
 ACATTTGAGATTCCAGTTATAAAAATTGAAAGTTTTGTGGTGGAGGATATTGCAACTGGA       c.2700
 T  F  E  I  P  V  I  K  I  E  S  F  V  V  E  D  I  A  T  G         p.900

          .         .         .         .         .         .       g.74185
 GTTCAGACACTGTACTCGAAGTGGAAGGACTTTCATTTTGAGAAGATACCATTTGATCCA       c.2760
 V  Q  T  L  Y  S  K  W  K  D  F  H  F  E  K  I  P  F  D  P         p.920

          .                                                         g.74203
 GCAGAAATGTCCAAATGA                                                 c.2778
 A  E  M  S  K  X                                                   p.925

          .         .         .         .         .         .       g.74263
 tatcaggtcctcaatcttcagctacagggaatgagtaactttgagtggagaagaaacaaa       c.*60

          .         .         .         .         .         .       g.74323
 catagtgggtataatcatggatcgcttgtacccctgtgaaaatatattttttaaaaatat       c.*120

          .         .         .         .         .         .       g.74383
 ctttagcagtttgtactatattatatatgcaaagcacaaatgagtgaatcacagcactga       c.*180

          .         .         .         .         .         .       g.74443
 gtattttgtaggccaacagagctcatagtacttgggaaaaattaaaaagcctcatttcta       c.*240

          .         .         .         .         .         .       g.74503
 gccttctttttagagtcaactgccaacaaacacacagtaatcactctgtacacactggga       c.*300

          .         .         .         .         .         .       g.74563
 tagatgaatgaatggaatgttgggaatttttatctccctttgtctccttaacctactgta       c.*360

          .         .         .         .         .         .       g.74623
 aactggcttttgcccttaacaatctactgaaattgttcttttgaaggttaccagtgactc       c.*420

          .         .         .         .         .         .       g.74683
 tggttgccaaatccactgggcacttcttaaccttctatttgacctctgcgcatttggccc       c.*480

          .         .         .         .         .         .       g.74743
 tgttgagcactcttcttgaagctctccctgggcttctctctcttctagttctattctagt       c.*540

          .         .         .         .         .         .       g.74803
 ctttttttattgagtcctcctctttgctgatcccttccaagggttcaatatatatacatg       c.*600

          .         .         .         .         .         .       g.74863
 tatatactgtacatatgtatatgtaactaatatacatacatacaggtatgtatatgtaat       c.*660

          .         .         .         .         .         .       g.74923
 ggttatatgtactcatgttcctggtgtagcaacgtgtggtatggctacacagagaacatg       c.*720

          .         .         .         .         .         .       g.74983
 agaacataaagccatttttatgcttactactaaaagctgtccactgtagagttgctgtat       c.*780

          .         .         .         .         .         .       g.75043
 gtagcaatgtgtatccactctacagtggtcagcttttagtagagagcataaaaatgataa       c.*840

          .         .         .         .         .         .       g.75103
 aatacttcttgaaaacttagtttactatacatcttgccctattaatatgttctcttaacg       c.*900

          .         .         .         .         .         .       g.75163
 tgtgccattgttctctttgaccattttcctataatgatgttgatgttcaacacctggact       c.*960

          .         .         .         .         .         .       g.75223
 gaatgtctgttctcagatcccttggatgttacagatgaggcagtctgactgtcctttcta       c.*1020

          .         .         .         .         .         .       g.75283
 cttgaaagattagaatatgtatccaaatggcattcacgtgtcacttagcaaggtttgctg       c.*1080

          .         .         .         .         .         .       g.75343
 atgcttcaaagagcttagtttgcggtttcctggacgtggaaacaagtatctgagttccct       c.*1140

          .         .         .         .         .         .       g.75403
 ggagatcaacgggatgaggtgttacagctgcctccctcttcatgcaatctggtgagcagt       c.*1200

          .         .         .         .         .         .       g.75463
 ggtgcaggcggggagccagagaaacttgccagttatataacttctctttggcttttcttc       c.*1260

          .         .         .         .         .         .       g.75523
 atctgtaaaacaaggataatactgaactgtaagggttagtggagagtttttaattaaaag       c.*1320

          .         .         .         .         .         .       g.75583
 aatgtgtgaaaagtacatgacacagtagttgcttgataatagttactagtagtagtattc       c.*1380

          .         .         .         .         .         .       g.75643
 ttactaagacccaatacaaatggattatttaaaccaagtttatgagttggttttttttca       c.*1440

          .         .         .         .         .         .       g.75703
 ttttctatttgtattttattaagagtgtcttttcttatgtgattttttttaattgctatt       c.*1500

          .         .         .         .         .         .       g.75763
 tgatatggtttggctatatgtccccacccaaatctcatcttgaattataatccccatgtg       c.*1560

          .         .         .         .         .         .       g.75823
 tcaagggagggacctgacgggaggtgattggatcacgggggcagttgtccccatgctgtt       c.*1620

          .         .         .         .         .         .       g.75883
 cttgggatagtgagttagttctcatgagatctgatggttttataagtgtttgacaattcc       c.*1680

          .         .         .         .         .         .       g.75943
 tcctttacacacactctctctctcatctgctgccatgtaagacttgcctgcttccccttc       c.*1740

          .         .         .         .         .         .       g.76003
 tgccatgattgtaagtttcctgaggcctcctcagccatgtggaactgtgaatctattaag       c.*1800

          .         .                                               g.76023
 cctcttttctttataaatga                                               c.*1820

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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