deafness, autosomal recessive 31 (DFNB31) - coding DNA reference sequence

(used for variant description)

(last modified April 2, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_015404.3 in the DFNB31 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016700.1, covering DFNB31 transcript NM_015404.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5055
      ctcaacagttcgcaaagtccgggcttgcggccgggcggcgcagaggcgcggaggc       c.-601

 .         .         .         .         .         .                g.5115
 tccccgggcggctgcatcccggggctgccccggacatgccccgcaccccttgtcggacgc       c.-541

 .         .         .         .         .         .                g.5175
 ccgcgccgcttcaccggctgccactccccggagtgctctgggactagagcgccctccgcc       c.-481

 .         .         .         .         .         .                g.5235
 ccaacttctgactttggggtcccccagccctagaggaacgggcgcccggctgggggagcc       c.-421

 .         .         .         .         .         .                g.5295
 ccgggcatggtgtgacggggcagtcaggtcagctttgcggcgcccccaaactccagccac       c.-361

 .         .         .         .         .         .                g.5355
 ccgtcgtctccgtgccctccagaatgtagctgctgaccccgcgccccccggactccagca       c.-301

 .         .         .         .         .         .                g.5415
 gcagtctccgccacctccgggctccagcagccaactcttgtgtctctcaggaacccgccg       c.-241

 .         .         .         .         .         .                g.5475
 acgtctccgcgtcccccggattccaggttcgcgacccccgccgtcttcgcgcctccggga       c.-181

 .         .         .         .         .         .                g.5535
 ctctagcagcggtctccgcgaccccctaggatccagccactgtacccgtgctccccaaac       c.-121

 .         .         .         .         .         .                g.5595
 ccaggctccagccgtcgtctccgcgctcccggggatccagctgtcgcgccagtacccgcg       c.-61

 .         .         .         .         .         .                g.5655
 aggacagcggcaccgcccacaccccgcgcgctcagagcccggccgggcctcggcgtggag       c.-1

          .         .         .         .         .         .       g.5715
 ATGAACGCGCCGCTGGACGGCCTGTCGGTGAGCTCGTCCTCCACCGGCTCGCTGGGCTCG       c.60
 M  N  A  P  L  D  G  L  S  V  S  S  S  S  T  G  S  L  G  S         p.20

          .         .         .         .         .         .       g.5775
 GCGGCCGGGGCGGGCGGCGGCGGGGGCGCGGGGCTGCGGTTACTGTCTGCCAACGTGCGC       c.120
 A  A  G  A  G  G  G  G  G  A  G  L  R  L  L  S  A  N  V  R         p.40

          .         .         .         .         .         .       g.5835
 CAGCTGCACCAAGCGCTGACCGCGCTGCTGAGCGAGGCGGAGCGGGAGCAGTTCACCCAC       c.180
 Q  L  H  Q  A  L  T  A  L  L  S  E  A  E  R  E  Q  F  T  H         p.60

          .         .         .         .         .         .       g.5895
 TGCCTGAACGCTTACCACGCGCGCCGCAACGTCTTCGACCTGGTGCGCACCCTGCGCGTG       c.240
 C  L  N  A  Y  H  A  R  R  N  V  F  D  L  V  R  T  L  R  V         p.80

          .         .         .         .         .         .       g.5955
 CTGCTGGACAGTCCGGTCAAGCGGCGCCTGCTGCCCATGCTTCGTCTGGTCATCCCGCGC       c.300
 L  L  D  S  P  V  K  R  R  L  L  P  M  L  R  L  V  I  P  R         p.100

          .         .         .         .         .         .       g.6015
 TCCGACCAGCTGCTCTTCGACCAATACACGGCCGAGGGCCTCTACCTGCCCGCCACCACC       c.360
 S  D  Q  L  L  F  D  Q  Y  T  A  E  G  L  Y  L  P  A  T  T         p.120

          .         .         .         .         .         .       g.6075
 CCCTACAGGCAGCCCGCCTGGGGCGGCCCCGACAGCGCGGGGCCAGGGGAGGTGCGCCTG       c.420
 P  Y  R  Q  P  A  W  G  G  P  D  S  A  G  P  G  E  V  R  L         p.140

          .         .         .         .         .         .       g.6135
 GTGAGTTTGCGGCGTGCCAAGGCCCACGAGGGCTTGGGCTTCAGCATCCGTGGGGGCTCG       c.480
 V  S  L  R  R  A  K  A  H  E  G  L  G  F  S  I  R  G  G  S         p.160

          .         .         .         .         .         .       g.6195
 GAGCACGGCGTGGGCATCTACGTGTCTCTGGTGGAACCAGGCTCTCTAGCTGAGAAGGAA       c.540
 E  H  G  V  G  I  Y  V  S  L  V  E  P  G  S  L  A  E  K  E         p.180

          .         .         .         .         .         .       g.6255
 GGACTGCGGGTCGGGGACCAGATTCTGCGCGTCAACGACAAATCCCTGGCCCGGGTGACC       c.600
 G  L  R  V  G  D  Q  I  L  R  V  N  D  K  S  L  A  R  V  T         p.200

          .         | 02         .         .         .         .    g.31727
 CACGCGGAGGCCGTCAAG | GCTCTGAAGGGCTCCAAGAAGCTGGTGCTGTCTGTGTACTCA    c.660
 H  A  E  A  V  K   | A  L  K  G  S  K  K  L  V  L  S  V  Y  S      p.220

          .         .         .         .         .         .       g.31787
 GCAGGGCGCATCCCTGGGGGCTACGTCACCAACCACATCTACACCTGGGTGGACCCGCAG       c.720
 A  G  R  I  P  G  G  Y  V  T  N  H  I  Y  T  W  V  D  P  Q         p.240

          .         .         .         .         .         .       g.31847
 GGCCGCAGCATCTCCCCACCCTCGGGCCTGCCCCAGCCCCACGGTGGTGCCCTGAGGCAG       c.780
 G  R  S  I  S  P  P  S  G  L  P  Q  P  H  G  G  A  L  R  Q         p.260

          .         .         .         .         .        | 03.    g.44067
 CAGGAGGGTGACCGGAGGAGCACCCTGCACCTCCTGCAAGGAGGGGATGAGAAAAAG | GTG    c.840
 Q  E  G  D  R  R  S  T  L  H  L  L  Q  G  G  D  E  K  K   | V      p.280

          .         .         .         .         .         .       g.44127
 AACCTGGTGCTGGGGGACGGCCGGTCCCTGGGCCTCACGATCCGTGGGGGAGCTGAGTAC       c.900
 N  L  V  L  G  D  G  R  S  L  G  L  T  I  R  G  G  A  E  Y         p.300

          .         .         .         .         .         .       g.44187
 GGCCTTGGCATTTACATCACTGGCGTGGACCCAGGCTCTGAAGCAGAAGGCAGCGGGCTC       c.960
 G  L  G  I  Y  I  T  G  V  D  P  G  S  E  A  E  G  S  G  L         p.320

     | 04    .         .         .         .         .         .    g.84100
 AAG | GTTGGGGACCAGATTCTAGAAGTGAATGGGCGGAGCTTTCTCAACATCCTACACGAC    c.1020
 K   | V  G  D  Q  I  L  E  V  N  G  R  S  F  L  N  I  L  H  D      p.340

          .         .         .         .         .         .       g.84160
 GAGGCTGTCAGGCTGCTTAAGTCATCTCGGCACCTCATCCTGACAGTGAAGGACGTCGGG       c.1080
 E  A  V  R  L  L  K  S  S  R  H  L  I  L  T  V  K  D  V  G         p.360

          .         .         .         .         .         .       g.84220
 AGGCTGCCCCGTGCCCGCACCACTGTGGACGAGACCAAGTGGATCGCCAGTTCCCGGATC       c.1140
 R  L  P  R  A  R  T  T  V  D  E  T  K  W  I  A  S  S  R  I         p.380

          .         .       | 05 .         .         .         .    g.85466
 AGGGAGACCATGGCGAACTCGGCAGG | GTTTCTTGGCGATCTCACAACAGAAGGAATAAAC    c.1200
 R  E  T  M  A  N  S  A  G  |  F  L  G  D  L  T  T  E  G  I  N      p.400

     | 06    .         .         .         .         .         .    g.85967
 AAG | CCAGGATTTTACAAGGGCCCAGCCGGCTCCCAGGTGACCCTGAGCAGCCTGGGGAAC    c.1260
 K   | P  G  F  Y  K  G  P  A  G  S  Q  V  T  L  S  S  L  G  N      p.420

          .         .         .         .         .         .       g.86027
 CAGACACGAGTGCTGCTGGAGGAGCAGGCTCGGCACCTGCTGAACGAGCAGGAACACGCC       c.1320
 Q  T  R  V  L  L  E  E  Q  A  R  H  L  L  N  E  Q  E  H  A         p.440

          .         .         .         .         .         .       g.86087
 ACCATGGCCTACTACCTGGATGAGTACCGTGGTGGCAGCGTCTCTGTGGAGGCCCTCGTC       c.1380
 T  M  A  Y  Y  L  D  E  Y  R  G  G  S  V  S  V  E  A  L  V         p.460

          .         .         .       | 07 .         .         .    g.86957
 ATGGCCCTGTTCAAGCTGCTCAACACCCACGCCAAG | TTCTCACTCCTCTCTGAGGTGAGA    c.1440
 M  A  L  F  K  L  L  N  T  H  A  K   | F  S  L  L  S  E  V  R      p.480

          .         .         .         .         .         .       g.87017
 GGCACCATTTCCCCGCAAGACCTAGAACGCTTCGACCACCTGGTGCTGAGGCGTGAGATT       c.1500
 G  T  I  S  P  Q  D  L  E  R  F  D  H  L  V  L  R  R  E  I         p.500

          .         .         .         .         .         .       g.87077
 GAGTCCATGAAGGCGCGGCAGCCCCCAGGCCCCGGGGCTGGGGACACCTACTCCATGGTC       c.1560
 E  S  M  K  A  R  Q  P  P  G  P  G  A  G  D  T  Y  S  M  V         p.520

          .         .         .         .         .         .       g.87137
 TCCTACAGTGACACGGGTTCATCCACAGGCAGCCACGGCACCTCCACCACCGTCAGCTCG       c.1620
 S  Y  S  D  T  G  S  S  T  G  S  H  G  T  S  T  T  V  S  S         p.540

        | 08 .         .         .         .         .         .    g.102492
 GCCAGG | AACACTCTGGACCTGGAGGAAACTGGCGAGGCTGTCCAGGGCAATATCAACGCC    c.1680
 A  R   | N  T  L  D  L  E  E  T  G  E  A  V  Q  G  N  I  N  A      p.560

          .         | 09         .         .         .         .    g.103606
 CTCCCAGATGTGTCCGTG | GATGATGTCAGATCCACCTCCCAGGGGCTGTCAAGCTTCAAG    c.1740
 L  P  D  V  S  V   | D  D  V  R  S  T  S  Q  G  L  S  S  F  K      p.580

          .         .         .         .         .         .       g.103666
 CCACTGCCTCGCCCACCACCTCTGGCCCAAGGCAACGACCTCCCACTAGGCCAGCCAAGG       c.1800
 P  L  P  R  P  P  P  L  A  Q  G  N  D  L  P  L  G  Q  P  R         p.600

          .         .         .         .         .         .       g.103726
 AAGCTGGGGAGAGAGGACCTCCAGCCACCTTCCTCCATGCCTTCCTGCTCGGGCACTGTC       c.1860
 K  L  G  R  E  D  L  Q  P  P  S  S  M  P  S  C  S  G  T  V         p.620

          .         .         .         .         .         .       g.103786
 TTCTCGGCTCCACAGAACCGCAGCCCGCCAGCGGGCACCGCACCCACCCCAGGGACCTCC       c.1920
 F  S  A  P  Q  N  R  S  P  P  A  G  T  A  P  T  P  G  T  S         p.640

          .         .         .         .         .         .       g.103846
 TCTGCACAGGACTTGCCCTCTTCCCCCATCTATGCCTCCGTCTCCCCTGCCAACCCCAGC       c.1980
 S  A  Q  D  L  P  S  S  P  I  Y  A  S  V  S  P  A  N  P  S         p.660

          .         .         .         .         .         .       g.103906
 TCCAAGAGGCCGCTGGACGCCCATCTGGCCCTGGTCAACCAACACCCCATCGGCCCCTTC       c.2040
 S  K  R  P  L  D  A  H  L  A  L  V  N  Q  H  P  I  G  P  F         p.680

          .         .         .         .         .         .       g.103966
 CCACGGGTCCAGTCACCCCCGCACCTGAAAAGCCCCTCTGCAGAGGCCACAGTGGCTGGG       c.2100
 P  R  V  Q  S  P  P  H  L  K  S  P  S  A  E  A  T  V  A  G         p.700

          .         .         .         .         .         .       g.104026
 GGCTGCCTTCTGCCCCCATCACCCTCTGGCCACCCAGACCAGACAGGCACAAACCAGCAC       c.2160
 G  C  L  L  P  P  S  P  S  G  H  P  D  Q  T  G  T  N  Q  H         p.720

          .         .         .         .         .         .       g.104086
 TTTGTCATGGTGGAGGTCCACCGCCCCGACAGCGAGCCAGACGTCAATGAAGTGAGGGCG       c.2220
 F  V  M  V  E  V  H  R  P  D  S  E  P  D  V  N  E  V  R  A         p.740

          .       | 10 .         .         .         .         .    g.106423
 CTGCCCCAGACGCGCA | CAGCCTCTACGCTCTCCCACCTCTCGGACAGCGGGCAGACTCTA    c.2280
 L  P  Q  T  R  T |   A  S  T  L  S  H  L  S  D  S  G  Q  T  L      p.760

          .         .         .         .         .         .       g.106483
 AGCGAGGACAGTGGTGTGGATGCTGGCGAGGCAGAGGCCAGCGCCCCAGGCCGAGGAAGG       c.2340
 S  E  D  S  G  V  D  A  G  E  A  E  A  S  A  P  G  R  G  R         p.780

          .         .         .         .         .         .       g.106543
 CAGTCGGTGTCCACCAAGAGCAGGAGTAGCAAGGAGCTGCCTCGGAACGAGAGGCCCACA       c.2400
 Q  S  V  S  T  K  S  R  S  S  K  E  L  P  R  N  E  R  P  T         p.800

          .         | 11         .         .         .         .    g.107159
 GATGGGGCCAACAAACCG | CCTGGACTTCTGGAGCCCACGTCCACTCTGGTCCGTGTGAAG    c.2460
 D  G  A  N  K  P   | P  G  L  L  E  P  T  S  T  L  V  R  V  K      p.820

          .         .         .         .         .         .       g.107219
 AAAAGTGCGGCCACCCTGGGCATCGCCATCGAGGGTGGCGCCAACACCCGCCAGCCCCTG       c.2520
 K  S  A  A  T  L  G  I  A  I  E  G  G  A  N  T  R  Q  P  L         p.840

          .         .  | 12      .         .         .         .    g.107559
 CCTAGGATTGTCACTATTCAG | AGAGGCGGCTCAGCTCACAACTGTGGGCAGCTCAAGGTG    c.2580
 P  R  I  V  T  I  Q   | R  G  G  S  A  H  N  C  G  Q  L  K  V      p.860

          .         .         .         .         .         .       g.107619
 GGCCACGTGATTCTGGAAGTGAATGGGCTGACGCTTCGGGGCAAGGAGCACCGGGAGGCC       c.2640
 G  H  V  I  L  E  V  N  G  L  T  L  R  G  K  E  H  R  E  A         p.880

          .         .         .         .         .         .       g.107679
 GCCCGCATTATCGCCGAGGCCTTCAAGACTAAGGACCGTGACTACATTGACTTTCTGGTC       c.2700
 A  R  I  I  A  E  A  F  K  T  K  D  R  D  Y  I  D  F  L  V         p.900

          .         .                                               g.107703
 ACTGAGTTCAATGTGATGCTCTAG                                           c.2724
 T  E  F  N  V  M  L  X                                             p.907

          .         .         .         .         .         .       g.107763
 aggccaaggcctgagggcctcccaccactgcccagcccctggtcccagtccctttccacc       c.*60

          .         .         .         .         .         .       g.107823
 gttggcttcatcaagctccttgcggggttggggctgcatggccagggtggcaggaagaca       c.*120

          .         .         .         .         .         .       g.107883
 tcccccctccatcccagcccactggaccagaactgggagaggaagagagcaggacaaggc       c.*180

          .         .         .         .         .         .       g.107943
 agacagaaggtcaggtcaggaactggtgctgtactgggtacacagtaggcgcccaggaca       c.*240

          .         .         .         .         .         .       g.108003
 agtgggttgcaagacaggaagaaaggaaaaggaagggcagagtgctggtttctccaggtt       c.*300

          .         .         .         .         .         .       g.108063
 gggttgggggcactgctgtcccccctccagctaggacccagcccatccccagatgcctga       c.*360

          .         .         .         .         .         .       g.108123
 gcctttgtccaaagtgaggtcactcgagaattcatggacacggcccccagtcagggggca       c.*420

          .         .         .         .         .         .       g.108183
 tcttgcaagacctttagtgccacaaataagcatcgagcacctccccattcacacccccat       c.*480

          .         .         .         .         .         .       g.108243
 tcctcctggctccttatcccccatggtgtttattatttatttccctccccatgcccctgg       c.*540

          .         .         .         .         .         .       g.108303
 ggaccccaaggccccagcttccctctgcacccccagcctatcccagaggccttgcaggtg       c.*600

          .         .         .         .         .         .       g.108363
 accagcagtgtcattgtatttatatacagagcttatgactttaatttttcaataaagaaa       c.*660

          .                                                         g.108377
 tctgaacaaggtta                                                     c.*674

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Deafness, autosomal recessive 31 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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