DiGeorge syndrome critical region gene 8 (DGCR8) - coding DNA reference sequence

(used for variant description)

(last modified February 7, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_022720.6 in the DGCR8 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000022.10, covering DGCR8 transcript NM_022720.6.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5009
                                                    aggcccgcc       c.-421

 .         .         .         .         .         .                g.5069
 ctccgctcgcccggcgcggcaggcgggtgccggcgaccggagagcctggacaggctttcc       c.-361

 .         .         .         .         .         .                g.5129
 agatggctgcggcggtcggtcggtgaggctttcccggctgtggtttggctgcgggcggct       c.-301

 .         .         .   | 02     .         .         .             g.10492
 tgggcagcccgcgggcgcctcag | gtagaagaagaaaggtgccactccggcatgaagacag    c.-241

 .         .         .         .         .         .                g.10552
 actcgcttagtcgccagtcacttaagctgagtgcattgtgatttccaataattgaggcag       c.-181

 .         .         .         .         .         .                g.10612
 tggttctaaaagctgtctacattaatgaaaagagcaatgtggccagcttgactaagccgc       c.-121

 .         .         .         .         .         .                g.10672
 cagcgcacagcgcggcaggacgcgcccgggtctcagcggacttgtgcatgttagctgtgt       c.-61

 .         .         .         .         .         .                g.10732
 agatttatgtgagggcttgtaaaactctggtcttgtaaactagtcttaagcgcttttaat       c.-1

          .         .         .         .         .         .       g.10792
 ATGGAGACAGATGAGAGCCCCTCTCCGCTCCCGTGTGGGCCCGCAGGAGAAGCGGTGATG       c.60
 M  E  T  D  E  S  P  S  P  L  P  C  G  P  A  G  E  A  V  M         p.20

          .         .         .         .         .         .       g.10852
 GAGAGCCGAGCTCGCCCCTTCCAAGCGCTGCCCCGTGAGCAGTCTCCACCACCTCCCCTG       c.120
 E  S  R  A  R  P  F  Q  A  L  P  R  E  Q  S  P  P  P  P  L         p.40

          .         .         .         .         .         .       g.10912
 CAAACGTCCAGTGGTGCAGAGGTAATGGACGTTGGCTCTGGTGGTGATGGACAGTCCGAA       c.180
 Q  T  S  S  G  A  E  V  M  D  V  G  S  G  G  D  G  Q  S  E         p.60

          .         .         .         .         .         .       g.10972
 CTCCCTGCTGAGGACCCCTTCAACTTCTACGGAGCTTCTCTTCTCTCCAAAGGATCCTTC       c.240
 L  P  A  E  D  P  F  N  F  Y  G  A  S  L  L  S  K  G  S  F         p.80

          .         .         .         .         .         .       g.11032
 TCTAAGGGCCGCCTCCTCATAGACCCGAACTGTAGTGGCCACAGCCCGCGCACCGCCCGG       c.300
 S  K  G  R  L  L  I  D  P  N  C  S  G  H  S  P  R  T  A  R         p.100

          .         .         .         .         .         .       g.11092
 CACGCACCTGCGGTCCGGAAGTTCTCCCCTGACCTTAAGTTGCTTAAGGATGTAAAGATT       c.360
 H  A  P  A  V  R  K  F  S  P  D  L  K  L  L  K  D  V  K  I         p.120

          .         .         .         .         .         .       g.11152
 AGCGTGAGCTTTACCGAGAGCTGCAGGAGTAAGGACAGGAAGGTGCTGTACACAGGAGCA       c.420
 S  V  S  F  T  E  S  C  R  S  K  D  R  K  V  L  Y  T  G  A         p.140

          .         .         .         .         .         .       g.11212
 GAGCGCGACGTGCGGGCGGAGTGCGGTCTGCTCCTTAGCCCTGTCAGTGGGGACGTGCAT       c.480
 E  R  D  V  R  A  E  C  G  L  L  L  S  P  V  S  G  D  V  H         p.160

          .         .         .         .         .         .       g.11272
 GCTTGTCCCTTTGGCGGGAGTGTTGGTGACGGGGTAGGCATAGGGGGTGAGAGTGCTGAT       c.540
 A  C  P  F  G  G  S  V  G  D  G  V  G  I  G  G  E  S  A  D         p.180

          .         .         .         .         .         .       g.11332
 AAGAAGGATGAGGAGAATGAGCTGGATCAGGAAAAGAGAGTGGAGTATGCAGTGCTCGAT       c.600
 K  K  D  E  E  N  E  L  D  Q  E  K  R  V  E  Y  A  V  L  D         p.200

          .         .         .         .         .         .       g.11392
 GAGTTAGAAGATTTTACTGACAATTTGGAGCTAGATGAAGAAGGAGCAGGCGGGTTCACG       c.660
 E  L  E  D  F  T  D  N  L  E  L  D  E  E  G  A  G  G  F  T         p.220

          .         .         .         .         .         .       g.11452
 GCTAAAGCAATCGTTCAGAGAGACAGAGTGGATGAAGAGGCCTTGAATTTCCCCTACGAG       c.720
 A  K  A  I  V  Q  R  D  R  V  D  E  E  A  L  N  F  P  Y  E         p.240

  | 03       .         .         .         .         .         .    g.11990
  | GATGACTTTGACAACGATGTGGATGCTCTGCTGGAAGAAGGCCTTTGTGCCCCCAAAAAG    c.780
  | D  D  F  D  N  D  V  D  A  L  L  E  E  G  L  C  A  P  K  K      p.260

          .         .         .         .         .         .       g.12050
 AGGCGAACAGAGGAAAAATATGGCGGAGACAGCGACCATCCGTCCGATGGAGAGACAAGT       c.840
 R  R  T  E  E  K  Y  G  G  D  S  D  H  P  S  D  G  E  T  S         p.280

          .         .         .         . | 04       .         .    g.14457
 GTGCAGCCGATGATGACCAAGATTAAAACAGTGCTCAAAA | GTCGTGGCCGCCCACCTACA    c.900
 V  Q  P  M  M  T  K  I  K  T  V  L  K  S |   R  G  R  P  P  T      p.300

          .         .         .         .         .         .       g.14517
 GAGCCGCTGCCCGACGGGTGGATCATGACATTCCATAACTCTGGAGTCCCGGTGTACCTA       c.960
 E  P  L  P  D  G  W  I  M  T  F  H  N  S  G  V  P  V  Y  L         p.320

          .         .         .         .         .         .       g.14577
 CACAGAGAGTCTCGGGTGGTCACCTGGTCCAGGCCATACTTCTTGGGAACGGGAAGCATA       c.1020
 H  R  E  S  R  V  V  T  W  S  R  P  Y  F  L  G  T  G  S  I         p.340

     | 05    .         .         .         .         .         .    g.14801
 CGG | AAACACGACCCTCCTCTGAGTAGCATCCCTTGTCTGCATTATAAGAAAATGAAGGAC    c.1080
 R   | K  H  D  P  P  L  S  S  I  P  C  L  H  Y  K  K  M  K  D      p.360

          .         .         .         .         .         .       g.14861
 AACGAGGAACGGGAGCAAAGCAGTGACCTCACCCCTAGTGGGGATGTGTCCCCCGTCAAG       c.1140
 N  E  E  R  E  Q  S  S  D  L  T  P  S  G  D  V  S  P  V  K         p.380

          .         .         .         .         .         .       g.14921
 CCCCTGAGCCGATCTGCAGAGCTGGAGTTTCCCCTGGATGAGCCTGACTCTATGGGTGCT       c.1200
 P  L  S  R  S  A  E  L  E  F  P  L  D  E  P  D  S  M  G  A         p.400

          .         .         .         .         .         .       g.14981
 GACCCGGGGCCCCCGGACGAGAAAGACCCACTAGGGGCTGAGGCAGCCCCTGGGGCCCTG       c.1260
 D  P  G  P  P  D  E  K  D  P  L  G  A  E  A  A  P  G  A  L         p.420

          .         .         .         .       | 06 .         .    g.16217
 GGGCAGGTGAAGGCCAAAGTCGAGGTGTGCAAAGATGAATCCGTTG | ATCTCGAGGAATTT    c.1320
 G  Q  V  K  A  K  V  E  V  C  K  D  E  S  V  D |   L  E  E  F      p.440

          .         .         .         .         .         .       g.16277
 CGAAGCTACCTGGAGAAGCGTTTTGACTTTGAGCAAGTTACTGTGAAAAAATTCAGGACT       c.1380
 R  S  Y  L  E  K  R  F  D  F  E  Q  V  T  V  K  K  F  R  T         p.460

          .         .         .         .         .         .       g.16337
 TGGGCTGAGCGGCGGCAATTCAATCGGGAAATGAAGCGGAAGCAGGCGGAGTCCGAGAGG       c.1440
 W  A  E  R  R  Q  F  N  R  E  M  K  R  K  Q  A  E  S  E  R         p.480

          .         .         .         .         .         .       g.16397
 CCCATCTTGCCAGCCAATCAGAAGCTCATTACTTTATCAGTGCAAGATGCACCCACAAAG       c.1500
 P  I  L  P  A  N  Q  K  L  I  T  L  S  V  Q  D  A  P  T  K         p.500

      | 07   .         .         .         .         .         .    g.16693
 AAAG | AGTTTGTTATTAACCCCAACGGGAAATCCGAGGTCTGCATCCTGCACGAGTACATG    c.1560
 K  E |   F  V  I  N  P  N  G  K  S  E  V  C  I  L  H  E  Y  M      p.520

          .         .         .         .       | 08 .         .    g.17591
 CAGCGTGTCCTCAAGGTCCGCCCTGTCTATAATTTCTTTGAATGTG | AGAACCCAAGTGAG    c.1620
 Q  R  V  L  K  V  R  P  V  Y  N  F  F  E  C  E |   N  P  S  E      p.540

          .         .         .         .         .         .       g.17651
 CCTTTTGGTGCCTCGGTGACCATTGATGGTGTGACTTACGGATCTGGAACTGCAAGCAGC       c.1680
 P  F  G  A  S  V  T  I  D  G  V  T  Y  G  S  G  T  A  S  S         p.560

          .         .      | 09  .         .         .         .    g.19516
 AAAAAACTTGCGAAGAATAAAGCTG | CCCGAGCTACACTGGAAATCCTCATCCCTGACTTT    c.1740
 K  K  L  A  K  N  K  A  A |   R  A  T  L  E  I  L  I  P  D  F      p.580

          .         .         .         .         | 10         .    g.30957
 GTTAAACAGACCTCTGAAGAGAAGCCCAAAGACAGTGAAGAACTCGAG | TATTTTAACCAC    c.1800
 V  K  Q  T  S  E  E  K  P  K  D  S  E  E  L  E   | Y  F  N  H      p.600

          .         .         .         .         .         .       g.31017
 ATCAGCATCGAGGACTCGCGGGTCTACGAGCTGACCAGCAAGGCTGGGCTGTTGTCTCCA       c.1860
 I  S  I  E  D  S  R  V  Y  E  L  T  S  K  A  G  L  L  S  P         p.620

          .         .          | 11        .         .         .    g.31391
 TATCAGATCCTCCACGAGTGCCTTAAAAG | AAACCATGGGATGGGTGACACGTCTATCAAG    c.1920
 Y  Q  I  L  H  E  C  L  K  R  |  N  H  G  M  G  D  T  S  I  K      p.640

          .         .         .         .         .         .       g.31451
 TTTGAAGTGGTTCCTGGGAAAAACCAGAAGAGTGAATACGTCATGGCGTGTGGCAAGCAC       c.1980
 F  E  V  V  P  G  K  N  Q  K  S  E  Y  V  M  A  C  G  K  H         p.660

          .       | 12 .         .         .         .         .    g.32083
 ACAGTGCGCGGGTGGT | GTAAGAACAAGAGAGTTGGAAAGCAGTTAGCCTCACAGAAGATC    c.2040
 T  V  R  G  W  C |   K  N  K  R  V  G  K  Q  L  A  S  Q  K  I      p.680

          .         .         .         .         .         .       g.32143
 CTTCAGCTGCTGCACCCACATGTCAAGAACTGGGGGTCTTTACTGCGCATGTATGGCCGT       c.2100
 L  Q  L  L  H  P  H  V  K  N  W  G  S  L  L  R  M  Y  G  R         p.700

          .         .     | 13   .         .         .         .    g.33694
 GAGAGCAGCAAGATGGTCAAGCAG | GAGACATCGGACAAGAGTGTGATTGAGCTGCAGCAG    c.2160
 E  S  S  K  M  V  K  Q   | E  T  S  D  K  S  V  I  E  L  Q  Q      p.720

          .         .         .         .         .         .       g.33754
 TATGCCAAGAAGAACAAGCCCAACCTGCACATCCTCAGCAAGCTCCAAGAGGAGATGAAG       c.2220
 Y  A  K  K  N  K  P  N  L  H  I  L  S  K  L  Q  E  E  M  K         p.740

          .         | 14         .         .         .         .    g.34835
 AGGCTAGCTGAGGAAAGG | GAGGAGACTCGAAAGAAGCCCAAGATGTCCATTGTGGCGTCC    c.2280
 R  L  A  E  E  R   | E  E  T  R  K  K  P  K  M  S  I  V  A  S      p.760

          .         .         .         .                           g.34877
 GCCCAGCCTGGCGGTGAGCCCCTGTGCACCGTGGACGTGTGA                         c.2322
 A  Q  P  G  G  E  P  L  C  T  V  D  V  X                           p.773

          .         .         .         .         .         .       g.34937
 gggaggtggcacgggccagggcgcgggggccgccagccgcacttctgaggagaccagcag       c.*60

          .         .         .         .         .         .       g.34997
 tcatgcatcgtgcaccacagtgtcaggcctccaacccacgctccttccctgtggccaacc       c.*120

          .         .         .         .         .         .       g.35057
 tgtgggcccggccttagggtggaggctttagtgtacagggacagccatggccacacagca       c.*180

          .         .         .         .         .         .       g.35117
 cacatgtggagcagcggctctccctggaaagctccaggcctgaatggatggactcagcga       c.*240

          .         .         .         .         .         .       g.35177
 ctgcaccagtggcagctggtgactgtggacagtggtggaccctgcttctgtgcacctgct       c.*300

          .         .         .         .         .         .       g.35237
 gcaggctctttttatgaaggctttcatgaattttagtatgtaatacgcactgacgacaca       c.*360

          .         .         .         .         .         .       g.35297
 tgatgcttggatgacagatgagaggggatggctgagtcctgtggctggcccgtgatgcca       c.*420

          .         .         .         .         .         .       g.35357
 ggtggcccatgtgcccagggcgcctgcagggctgctacagggacctggtcaggaggtgca       c.*480

          .         .         .         .         .         .       g.35417
 catggtgccctgccctcacccaccctctgtgtttccccttctttgaaaaggtagaagaga       c.*540

          .         .         .         .         .         .       g.35477
 aaggaatattttaaacctttttggcttaaacagaattttagcatcagaactagctttctg       c.*600

          .         .         .         .         .         .       g.35537
 ggattggaggcaaaccatcaaggtggtccctctccagtctggacacgatgccagcaagga       c.*660

          .         .         .         .         .         .       g.35597
 tgacgtcctgccacctcctggagttaccctggcctcctagggtccctttttctgatgaag       c.*720

          .         .         .         .         .         .       g.35657
 tcttaattccctaaaagcgcctctttggacactgaggccctctctgcctttcctggcctc       c.*780

          .         .         .         .         .         .       g.35717
 cggcaacagttttttacaaagattttttgcagtcgagtccatatgtccacccattgattt       c.*840

          .         .         .         .         .         .       g.35777
 ttaaagcttttgtgatattttagcattttgaaagactttcacagtgagagtagaaggtag       c.*900

          .         .         .         .         .         .       g.35837
 atttggaatcatgcattttagcaagtggacttgttgaaacaggaagcaagggccttcagt       c.*960

          .         .         .         .         .         .       g.35897
 gtagcccattcttgatccagagctgttgcctgtgacagcggtttctctggatgtcaaagg       c.*1020

          .         .         .         .         .         .       g.35957
 cagctgcctggtgcccagcttgcttctcgactggtggcccctatgggtgggtgtgcgatg       c.*1080

          .         .         .         .         .         .       g.36017
 gaaatgtgttcctgccggagtctgaggcaccagggtgtgctcaaaggctggccctggtgg       c.*1140

          .         .         .         .         .         .       g.36077
 tggactggcacctgtgcagagtgccgtgtgcttgtggtgcgccatctgaagcaagagtcc       c.*1200

          .         .         .         .         .         .       g.36137
 agcgttctgccgtgtctgtcccccaccatgccccctacaggcggtactgatggcgctttt       c.*1260

          .         .         .         .         .         .       g.36197
 ttttttttttctgtcaggaaaacaatgttggcctgtgggccgcccacaacatatccttcc       c.*1320

          .         .         .         .         .         .       g.36257
 ctcactacctgtgtgaccaaggttggcttctgttgacctttaaaaaagaaaccctcaact       c.*1380

          .         .         .         .         .         .       g.36317
 caaattgctataattagacacttgcttctgtcttgcctcctgtctgcagctgtgaatagt       c.*1440

          .         .         .         .         .         .       g.36377
 catttgactgtgactgttgcccttagccagccagatgcgcctgtgaaccaaagcttcgtg       c.*1500

          .         .         .         .         .         .       g.36437
 cacatgtgttcccctaaaggttggggagcctcgctgtgtcttgctgttcccaggcaccac       c.*1560

          .         .         .         .         .         .       g.36497
 cacagcaggtgctgccatactcttgtggtctctgtgcgccccccccccccccccacccgt       c.*1620

          .         .         .         .         .         .       g.36557
 ctgccaagcatgggtatgaatcgtgcacacagccatgcttcaaggccggggcaggggagc       c.*1680

          .         .         .         .         .         .       g.36617
 ctgtgctgatgccatccagggcactgggctgtgcctggaaggcgagccttgattgtctga       c.*1740

          .         .                                               g.36646
 acacataaagcaaactgtccagaagggaa                                      c.*1769

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The DiGeorge syndrome critical region gene 8 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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