dicer 1, ribonuclease type III (DICER1) - coding DNA reference sequence

(used for variant description)

(last modified February 5, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_177438.2 in the DICER1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016311.1, covering DICER1 transcript NM_177438.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5058
   cggaggcgcggcgcaggctgctgcaggcccaggtgaatggagtaacctgacagcgggg       c.-181

 .         .         .         .         .         .                g.5118
 acgaggcgacggcgagcgcgaggaaatggcggcgggggcggcggcgccgggcggctccgg       c.-121

 .         .         .         .         .         .                g.5178
 gaggcctgggctgtgacgcgcgcgccggagcggggtccgatggttctcgaaggcccgcgg       c.-61

 .         .     | 02   .         .         .         .             g.28964
 cgccccgtgctgcag | taagctgtgctagaacaaaaatgcaatgaaagaaacactggatga    c.-1

          .         .         .         .         .         .       g.29024
 ATGAAAAGCCCTGCTTTGCAACCCCTCAGCATGGCAGGCCTGCAGCTCATGACCCCTGCT       c.60
 M  K  S  P  A  L  Q  P  L  S  M  A  G  L  Q  L  M  T  P  A         p.20

          .         .         .         .         .         .       g.29084
 TCCTCACCAATGGGTCCTTTCTTTGGACTGCCATGGCAACAAGAAGCAATTCATGATAAC       c.120
 S  S  P  M  G  P  F  F  G  L  P  W  Q  Q  E  A  I  H  D  N         p.40

          .         .     | 03   .         .         .         .    g.29781
 ATTTATACGCCAAGAAAATATCAG | GTTGAACTGCTTGAAGCAGCTCTGGATCATAATACC    c.180
 I  Y  T  P  R  K  Y  Q   | V  E  L  L  E  A  A  L  D  H  N  T      p.60

          .         .         .         .         .         .       g.29841
 ATCGTCTGTTTAAACACTGGCTCAGGGAAGACATTTATTGCAGTACTACTCACTAAAGAG       c.240
 I  V  C  L  N  T  G  S  G  K  T  F  I  A  V  L  L  T  K  E         p.80

          .         .         .         .         .         .       g.29901
 CTGTCCTATCAGATCAGGGGAGACTTCAGCAGAAATGGAAAAAGGACGGTGTTCTTGGTC       c.300
 L  S  Y  Q  I  R  G  D  F  S  R  N  G  K  R  T  V  F  L  V         p.100

         | 04.         .         .         .         .         .    g.30836
 AACTCTG | CAAACCAGGTTGCTCAACAAGTGTCAGCTGTCAGAACTCATTCAGATCTCAAG    c.360
 N  S  A |   N  Q  V  A  Q  Q  V  S  A  V  R  T  H  S  D  L  K      p.120

          .         .         .         .         .         .       g.30896
 GTTGGGGAATACTCAAACCTAGAAGTAAATGCATCTTGGACAAAAGAGAGATGGAACCAA       c.420
 V  G  E  Y  S  N  L  E  V  N  A  S  W  T  K  E  R  W  N  Q         p.140

          .         | 05         .         .         .         .    g.32272
 GAGTTTACTAAGCACCAG | GTTCTCATTATGACTTGCTATGTCGCCTTGAATGTTTTGAAA    c.480
 E  F  T  K  H  Q   | V  L  I  M  T  C  Y  V  A  L  N  V  L  K      p.160

          .         .         .         .         .         .       g.32332
 AATGGTTACTTATCACTGTCAGACATTAACCTTTTGGTGTTTGATGAGTGTCATCTTGCA       c.540
 N  G  Y  L  S  L  S  D  I  N  L  L  V  F  D  E  C  H  L  A         p.180

          .         .         .    | 06    .         .         .    g.32817
 ATCCTAGACCACCCCTATCGAGAAATTATGAAG | CTCTGTGAAAATTGTCCATCATGTCCT    c.600
 I  L  D  H  P  Y  R  E  I  M  K   | L  C  E  N  C  P  S  C  P      p.200

          .         .         .         .         .         .       g.32877
 CGCATTTTGGGACTAACTGCTTCCATTTTAAATGGGAAATGTGATCCAGAGGAATTGGAA       c.660
 R  I  L  G  L  T  A  S  I  L  N  G  K  C  D  P  E  E  L  E         p.220

          .         .         .         .         .         .       g.32937
 GAAAAGATTCAGAAACTAGAGAAAATTCTTAAGAGTAATGCTGAAACTGCAACTGACCTG       c.720
 E  K  I  Q  K  L  E  K  I  L  K  S  N  A  E  T  A  T  D  L         p.240

          .     | 07   .         .         .         .         .    g.35720
 GTGGTCTTAGACAG | GTATACTTCTCAGCCATGTGAGATTGTGGTGGATTGTGGACCATTT    c.780
 V  V  L  D  R  |  Y  T  S  Q  P  C  E  I  V  V  D  C  G  P  F      p.260

          .         .         .         .         .         .       g.35780
 ACTGACAGAAGTGGGCTTTATGAAAGACTGCTGATGGAATTAGAAGAAGCACTTAATTTT       c.840
 T  D  R  S  G  L  Y  E  R  L  L  M  E  L  E  E  A  L  N  F         p.280

          .         .         .         .         .         .       g.35840
 ATCAATGATTGTAATATATCTGTACATTCAAAAGAAAGAGATTCTACTTTAATTTCGAAA       c.900
 I  N  D  C  N  I  S  V  H  S  K  E  R  D  S  T  L  I  S  K         p.300

     | 08    .         .         .         .         .         .    g.37811
 CAG | ATACTATCAGACTGTCGTGCCGTATTGGTAGTTCTGGGACCCTGGTGTGCAGATAAA    c.960
 Q   | I  L  S  D  C  R  A  V  L  V  V  L  G  P  W  C  A  D  K      p.320

          .         .         .         .         .         .       g.37871
 GTAGCTGGAATGATGGTAAGAGAACTACAGAAATACATCAAACATGAGCAAGAGGAGCTG       c.1020
 V  A  G  M  M  V  R  E  L  Q  K  Y  I  K  H  E  Q  E  E  L         p.340

          .         .         .         .         .         .       g.37931
 CACAGGAAATTTTTATTGTTTACAGACACTTTCCTAAGGAAAATACATGCACTATGTGAA       c.1080
 H  R  K  F  L  L  F  T  D  T  F  L  R  K  I  H  A  L  C  E         p.360

          .         .         .         .         .         .       g.37991
 GAGCACTTCTCACCTGCCTCACTTGACCTGAAATTTGTAACTCCTAAAGTAATCAAACTG       c.1140
 E  H  F  S  P  A  S  L  D  L  K  F  V  T  P  K  V  I  K  L         p.380

          .         .         .         .         .         .       g.38051
 CTCGAAATCTTACGCAAATATAAACCATATGAGCGACAGCAGTTTGAAAGCGTTGAGTGG       c.1200
 L  E  I  L  R  K  Y  K  P  Y  E  R  Q  Q  F  E  S  V  E  W         p.400

          .         .         .         .         .         .       g.38111
 TATAATAATAGAAATCAGGATAATTATGTGTCATGGAGTGATTCTGAGGATGATGATGAG       c.1260
 Y  N  N  R  N  Q  D  N  Y  V  S  W  S  D  S  E  D  D  D  E         p.420

          .         .         .         .         .         .       g.38171
 GATGAAGAAATTGAAGAAAAAGAGAAGCCAGAGACAAATTTTCCTTCTCCTTTTACCAAC       c.1320
 D  E  E  I  E  E  K  E  K  P  E  T  N  F  P  S  P  F  T  N         p.440

          .         .         .         .         .       | 09 .    g.44672
 ATTTTGTGCGGAATTATTTTTGTGGAAAGAAGATACACAGCAGTTGTCTTAAACAG | ATTG    c.1380
 I  L  C  G  I  I  F  V  E  R  R  Y  T  A  V  V  L  N  R  |  L      p.460

          .         .         .         .         .         .       g.44732
 ATAAAGGAAGCTGGCAAACAAGATCCAGAGCTGGCTTATATCAGTAGCAATTTCATAACT       c.1440
 I  K  E  A  G  K  Q  D  P  E  L  A  Y  I  S  S  N  F  I  T         p.480

          .         .         .         .         .         .       g.44792
 GGACATGGCATTGGGAAGAATCAGCCTCGCAACAAACAGATGGAAGCAGAATTCAGAAAA       c.1500
 G  H  G  I  G  K  N  Q  P  R  N  K  Q  M  E  A  E  F  R  K         p.500

           | 10        .         .         .         .         .    g.45778
 CAGGAAGAG | GTACTTAGGAAATTTCGAGCACATGAGACCAACCTGCTTATTGCAACAAGT    c.1560
 Q  E  E   | V  L  R  K  F  R  A  H  E  T  N  L  L  I  A  T  S      p.520

          .         .         .         .         .         .       g.45838
 ATTGTAGAAGAGGGTGTTGATATACCAAAATGCAACTTGGTGGTTCGTTTTGATTTGCCC       c.1620
 I  V  E  E  G  V  D  I  P  K  C  N  L  V  V  R  F  D  L  P         p.540

          .         .         .         .         .         .       g.45898
 ACAGAATATCGATCCTATGTTCAATCTAAAGGAAGAGCAAGGGCACCCATCTCTAATTAT       c.1680
 T  E  Y  R  S  Y  V  Q  S  K  G  R  A  R  A  P  I  S  N  Y         p.560

          .         .         .         .         .         .       g.45958
 ATAATGTTAGCGGATACAGACAAAATAAAAAGTTTTGAAGAAGACCTTAAAACCTACAAA       c.1740
 I  M  L  A  D  T  D  K  I  K  S  F  E  E  D  L  K  T  Y  K         p.580

          .   | 11     .         .         .         .         .    g.46649
 GCTATTGAAAAG | ATCTTGAGAAACAAGTGTTCCAAGTCGGTTGATACTGGTGAGACTGAC    c.1800
 A  I  E  K   | I  L  R  N  K  C  S  K  S  V  D  T  G  E  T  D      p.600

          .         .         .         .         .         .       g.46709
 ATTGATCCTGTCATGGATGATGATGACGTTTTCCCACCATATGTGTTGAGGCCTGACGAT       c.1860
 I  D  P  V  M  D  D  D  D  V  F  P  P  Y  V  L  R  P  D  D         p.620

          .         .         .         .        | 12.         .    g.49211
 GGTGGTCCACGAGTCACAATCAACACGGCCATTGGACACATCAATAG | ATACTGTGCTAGA    c.1920
 G  G  P  R  V  T  I  N  T  A  I  G  H  I  N  R  |  Y  C  A  R      p.640

          .         .         .         .         .         .       g.49271
 TTACCAAGTGATCCGTTTACTCATCTAGCTCCTAAATGCAGAACCCGAGAGTTGCCTGAT       c.1980
 L  P  S  D  P  F  T  H  L  A  P  K  C  R  T  R  E  L  P  D         p.660

          .         .         .         .         .         .       g.49331
 GGTACATTTTATTCAACTCTTTATCTGCCAATTAACTCACCTCTTCGAGCCTCCATTGTT       c.2040
 G  T  F  Y  S  T  L  Y  L  P  I  N  S  P  L  R  A  S  I  V         p.680

  | 13       .         .         .         .         .         .    g.50235
  | GGTCCACCAATGAGCTGTGTACGATTGGCTGAAAGAGTTGTAGCTCTCATTTGCTGTGAG    c.2100
  | G  P  P  M  S  C  V  R  L  A  E  R  V  V  A  L  I  C  C  E      p.700

          .       | 14 .         .         .         .         .    g.51010
 AAACTGCACAAAATTG | GCGAACTGGATGACCATTTGATGCCAGTTGGGAAAGAGACTGTT    c.2160
 K  L  H  K  I  G |   E  L  D  D  H  L  M  P  V  G  K  E  T  V      p.720

          .         .         .         .         .         .       g.51070
 AAATATGAAGAGGAGCTTGATTTGCATGATGAAGAAGAGACCAGTGTTCCAGGAAGACCA       c.2220
 K  Y  E  E  E  L  D  L  H  D  E  E  E  T  S  V  P  G  R  P         p.740

          .         .         .       | 15 .         .         .    g.53943
 GGTTCCACGAAACGAAGGCAGTGCTACCCAAAAGCA | ATTCCAGAGTGTTTGAGGGATAGT    c.2280
 G  S  T  K  R  R  Q  C  Y  P  K  A   | I  P  E  C  L  R  D  S      p.760

          .         .         .         .         .         .       g.54003
 TATCCCAGACCTGATCAGCCCTGTTACCTGTATGTGATAGGAATGGTTTTAACTACACCT       c.2340
 Y  P  R  P  D  Q  P  C  Y  L  Y  V  I  G  M  V  L  T  T  P         p.780

          .         .         .         .         .         .       g.54063
 TTACCTGATGAACTCAACTTTAGAAGGCGGAAGCTCTATCCTCCTGAAGATACCACAAGA       c.2400
 L  P  D  E  L  N  F  R  R  R  K  L  Y  P  P  E  D  T  T  R         p.800

          .         .         .       | 16 .         .         .    g.54353
 TGCTTTGGAATACTGACGGCCAAACCCATACCTCAG | ATTCCACACTTTCCTGTGTACACA    c.2460
 C  F  G  I  L  T  A  K  P  I  P  Q   | I  P  H  F  P  V  Y  T      p.820

          .         .         .         .         .         .       g.54413
 CGCTCTGGAGAGGTTACCATATCCATTGAGTTGAAGAAGTCTGGTTTCATGTTGTCTCTA       c.2520
 R  S  G  E  V  T  I  S  I  E  L  K  K  S  G  F  M  L  S  L         p.840

          .         .         .         .         .         .       g.54473
 CAAATGCTTGAGTTGATTACAAGACTTCACCAGTATATATTCTCACATATTCTTCGGCTT       c.2580
 Q  M  L  E  L  I  T  R  L  H  Q  Y  I  F  S  H  I  L  R  L         p.860

          .         .         .         .         .         .       g.54533
 GAAAAACCTGCACTAGAATTTAAACCTACAGACGCTGATTCAGCATACTGTGTTCTACCT       c.2640
 E  K  P  A  L  E  F  K  P  T  D  A  D  S  A  Y  C  V  L  P         p.880

          . | 17       .         .         .         .         .    g.54711
 CTTAATGTTG | TTAATGACTCCAGCACTTTGGATATTGACTTTAAATTCATGGAAGATATT    c.2700
 L  N  V  V |   N  D  S  S  T  L  D  I  D  F  K  F  M  E  D  I      p.900

          .         .         .         .         .         .       g.54771
 GAGAAGTCTGAAGCTCGCATAGGCATTCCCAGTACAAAGTATACAAAAGAAACACCCTTT       c.2760
 E  K  S  E  A  R  I  G  I  P  S  T  K  Y  T  K  E  T  P  F         p.920

          .         .         .         .     | 18   .         .    g.56215
 GTTTTTAAATTAGAAGATTACCAAGATGCCGTTATCATTCCAAG | ATATCGCAATTTTGAT    c.2820
 V  F  K  L  E  D  Y  Q  D  A  V  I  I  P  R  |  Y  R  N  F  D      p.940

          .         .         .         .         .         .       g.56275
 CAGCCTCATCGATTTTATGTAGCTGATGTGTACACTGATCTTACCCCACTCAGTAAATTT       c.2880
 Q  P  H  R  F  Y  V  A  D  V  Y  T  D  L  T  P  L  S  K  F         p.960

          .         .         .         .         .         .       g.56335
 CCTTCCCCTGAGTATGAAACTTTTGCAGAATATTATAAAACAAAGTACAACCTTGACCTA       c.2940
 P  S  P  E  Y  E  T  F  A  E  Y  Y  K  T  K  Y  N  L  D  L         p.980

          .         .         .         .        | 19.         .    g.56652
 ACCAATCTCAACCAGCCACTGCTGGATGTGGACCACACATCTTCAAG | ACTTAATCTTTTG    c.3000
 T  N  L  N  Q  P  L  L  D  V  D  H  T  S  S  R  |  L  N  L  L      p.1000

          .         .         .         .         .         .       g.56712
 ACACCTCGACATTTGAATCAGAAGGGGAAAGCGCTTCCTTTAAGCAGTGCTGAGAAGAGG       c.3060
 T  P  R  H  L  N  Q  K  G  K  A  L  P  L  S  S  A  E  K  R         p.1020

          .         .         .    | 20    .         .         .    g.57203
 AAAGCCAAATGGGAAAGTCTGCAGAATAAACAG | ATACTGGTTCCAGAACTCTGTGCTATA    c.3120
 K  A  K  W  E  S  L  Q  N  K  Q   | I  L  V  P  E  L  C  A  I      p.1040

          .         .         .         .         .         .       g.57263
 CATCCAATTCCAGCATCACTGTGGAGAAAAGCTGTTTGTCTCCCCAGCATACTTTATCGC       c.3180
 H  P  I  P  A  S  L  W  R  K  A  V  C  L  P  S  I  L  Y  R         p.1060

          .         .         .         .         .         .       g.57323
 CTTCACTGCCTTTTGACTGCAGAGGAGCTAAGAGCCCAGACTGCCAGCGATGCTGGCGTG       c.3240
 L  H  C  L  L  T  A  E  E  L  R  A  Q  T  A  S  D  A  G  V         p.1080

          .         .          | 21        .         .         .    g.58327
 GGAGTCAGATCACTTCCTGCGGATTTTAG | ATACCCTAACTTAGACTTCGGGTGGAAAAAA    c.3300
 G  V  R  S  L  P  A  D  F  R  |  Y  P  N  L  D  F  G  W  K  K      p.1100

          .         .         .         .         .         .       g.58387
 TCTATTGACAGCAAATCTTTCATCTCAATTTCTAACTCCTCTTCAGCTGAAAATGATAAT       c.3360
 S  I  D  S  K  S  F  I  S  I  S  N  S  S  S  A  E  N  D  N         p.1120

          .         .         .         .         .         .       g.58447
 TACTGTAAGCACAGCACAATTGTCCCTGAAAATGCTGCACATCAAGGTGCTAATAGAACC       c.3420
 Y  C  K  H  S  T  I  V  P  E  N  A  A  H  Q  G  A  N  R  T         p.1140

          .         .         .         .         .         .       g.58507
 TCCTCTCTAGAAAATCATGACCAAATGTCTGTGAACTGCAGAACGTTGCTCAGCGAGTCC       c.3480
 S  S  L  E  N  H  D  Q  M  S  V  N  C  R  T  L  L  S  E  S         p.1160

          .         .         .         .         .         .       g.58567
 CCTGGTAAGCTCCACGTTGAAGTTTCAGCAGATCTTACAGCAATTAATGGTCTTTCTTAC       c.3540
 P  G  K  L  H  V  E  V  S  A  D  L  T  A  I  N  G  L  S  Y         p.1180

          .         .         .         .         .         .       g.58627
 AATCAAAATCTCGCCAATGGCAGTTATGATTTAGCTAACAGAGACTTTTGCCAAGGAAAT       c.3600
 N  Q  N  L  A  N  G  S  Y  D  L  A  N  R  D  F  C  Q  G  N         p.1200

          .         .         .         .         .         .       g.58687
 CAGCTAAATTACTACAAGCAGGAAATACCCGTGCAACCAACTACCTCATATTCCATTCAG       c.3660
 Q  L  N  Y  Y  K  Q  E  I  P  V  Q  P  T  T  S  Y  S  I  Q         p.1220

          .         .         .         .         .         .       g.58747
 AATTTATACAGTTACGAGAACCAGCCCCAGCCCAGCGATGAATGTACTCTCCTGAGTAAT       c.3720
 N  L  Y  S  Y  E  N  Q  P  Q  P  S  D  E  C  T  L  L  S  N         p.1240

          .         .         .         .         .         .       g.58807
 AAATACCTTGATGGAAATGCTAACAAATCTACCTCAGATGGAAGTCCTGTGATGGCCGTA       c.3780
 K  Y  L  D  G  N  A  N  K  S  T  S  D  G  S  P  V  M  A  V         p.1260

          .         .         .         .         .         .       g.58867
 ATGCCTGGTACGACAGACACTATTCAAGTGCTCAAGGGCAGGATGGATTCTGAGCAGAGC       c.3840
 M  P  G  T  T  D  T  I  Q  V  L  K  G  R  M  D  S  E  Q  S         p.1280

          .         .         .         .         .         .       g.58927
 CCTTCTATTGGGTACTCCTCAAGGACTCTTGGCCCCAATCCTGGACTTATTCTTCAGGCT       c.3900
 P  S  I  G  Y  S  S  R  T  L  G  P  N  P  G  L  I  L  Q  A         p.1300

          .         .         .         .         .         .       g.58987
 TTGACTCTGTCAAACGCTAGTGATGGATTTAACCTGGAGCGGCTTGAAATGCTTGGCGAC       c.3960
 L  T  L  S  N  A  S  D  G  F  N  L  E  R  L  E  M  L  G  D         p.1320

          .         .         .         .         .         .       g.59047
 TCCTTTTTAAAGCATGCCATCACCACATATCTATTTTGCACTTACCCTGATGCGCATGAG       c.4020
 S  F  L  K  H  A  I  T  T  Y  L  F  C  T  Y  P  D  A  H  E         p.1340

          .         .         . | 22       .         .         .    g.62517
 GGCCGCCTTTCATATATGAGAAGCAAAAAG | GTCAGCAACTGTAATCTGTATCGCCTTGGA    c.4080
 G  R  L  S  Y  M  R  S  K  K   | V  S  N  C  N  L  Y  R  L  G      p.1360

          .         .         .         .         .         .       g.62577
 AAAAAGAAGGGACTACCCAGCCGCATGGTGGTGTCAATATTTGATCCCCCTGTGAATTGG       c.4140
 K  K  K  G  L  P  S  R  M  V  V  S  I  F  D  P  P  V  N  W         p.1380

          .         .         .         .         .         .       g.62637
 CTTCCTCCTGGTTATGTAGTAAATCAAGACAAAAGCAACACAGATAAATGGGAAAAAGAT       c.4200
 L  P  P  G  Y  V  V  N  Q  D  K  S  N  T  D  K  W  E  K  D         p.1400

        | 23 .         .         .         .         .         .    g.65763
 GAAATG | ACAAAAGACTGCATGCTGGCGAATGGCAAACTGGATGAGGATTACGAGGAGGAG    c.4260
 E  M   | T  K  D  C  M  L  A  N  G  K  L  D  E  D  Y  E  E  E      p.1420

          .         .         .         .         .         .       g.65823
 GATGAGGAGGAGGAGAGCCTGATGTGGAGGGCTCCGAAGGAAGAGGCTGACTATGAAGAT       c.4320
 D  E  E  E  E  S  L  M  W  R  A  P  K  E  E  A  D  Y  E  D         p.1440

          .         .         .         .         .         .       g.65883
 GATTTCCTGGAGTATGATCAGGAACATATCAGATTTATAGATAATATGTTAATGGGGTCA       c.4380
 D  F  L  E  Y  D  Q  E  H  I  R  F  I  D  N  M  L  M  G  S         p.1460

          .         .         .         .         .         .       g.65943
 GGAGCTTTTGTAAAGAAAATCTCTCTTTCTCCTTTTTCAACCACTGATTCTGCATATGAA       c.4440
 G  A  F  V  K  K  I  S  L  S  P  F  S  T  T  D  S  A  Y  E         p.1480

          .         .         .         .         .         .       g.66003
 TGGAAAATGCCCAAAAAATCCTCCTTAGGTAGTATGCCATTTTCATCAGATTTTGAGGAT       c.4500
 W  K  M  P  K  K  S  S  L  G  S  M  P  F  S  S  D  F  E  D         p.1500

          .         .         .         .         .         .       g.66063
 TTTGACTACAGCTCTTGGGATGCAATGTGCTATCTGGATCCTAGCAAAGCTGTTGAAGAA       c.4560
 F  D  Y  S  S  W  D  A  M  C  Y  L  D  P  S  K  A  V  E  E         p.1520

          .         .         .         .         .         .       g.66123
 GATGACTTTGTGGTGGGGTTCTGGAATCCATCAGAAGAAAACTGTGGTGTTGACACGGGA       c.4620
 D  D  F  V  V  G  F  W  N  P  S  E  E  N  C  G  V  D  T  G         p.1540

          .         .         .         .         .         .       g.66183
 AAGCAGTCCATTTCTTACGACTTGCACACTGAGCAGTGTATTGCTGACAAAAGCATAGCG       c.4680
 K  Q  S  I  S  Y  D  L  H  T  E  Q  C  I  A  D  K  S  I  A         p.1560

          .         .         .         .         .         .       g.66243
 GACTGTGTGGAAGCCCTGCTGGGCTGCTATTTAACCAGCTGTGGGGAGAGGGCTGCTCAG       c.4740
 D  C  V  E  A  L  L  G  C  Y  L  T  S  C  G  E  R  A  A  Q         p.1580

          .         .         .         .         .         .       g.66303
 CTTTTCCTCTGTTCACTGGGGCTGAAGGTGCTCCCGGTAATTAAAAGGACTGATCGGGAA       c.4800
 L  F  L  C  S  L  G  L  K  V  L  P  V  I  K  R  T  D  R  E         p.1600

          .         .         .         .         .         .       g.66363
 AAGGCCCTGTGCCCTACTCGGGAGAATTTCAACAGCCAACAAAAGAACCTTTCAGTGAGC       c.4860
 K  A  L  C  P  T  R  E  N  F  N  S  Q  Q  K  N  L  S  V  S         p.1620

          .         .         .         .         .         .       g.66423
 TGTGCTGCTGCTTCTGTGGCCAGTTCACGCTCTTCTGTATTGAAAGACTCGGAATATGGT       c.4920
 C  A  A  A  S  V  A  S  S  R  S  S  V  L  K  D  S  E  Y  G         p.1640

          .         .         .         .         .         .       g.66483
 TGTTTGAAGATTCCACCAAGATGTATGTTTGATCATCCAGATGCAGATAAAACACTGAAT       c.4980
 C  L  K  I  P  P  R  C  M  F  D  H  P  D  A  D  K  T  L  N         p.1660

          .         .         .         .         .         .       g.66543
 CACCTTATATCGGGGTTTGAAAATTTTGAAAAGAAAATCAACTACAGATTCAAGAATAAG       c.5040
 H  L  I  S  G  F  E  N  F  E  K  K  I  N  Y  R  F  K  N  K         p.1680

          .         .         .         .         .      | 24  .    g.68271
 GCTTACCTTCTCCAGGCTTTTACACATGCCTCCTACCACTACAATACTATCACTG | ATTGT    c.5100
 A  Y  L  L  Q  A  F  T  H  A  S  Y  H  Y  N  T  I  T  D |   C      p.1700

          .         .         .         .         .         .       g.68331
 TACCAGCGCTTAGAATTCCTGGGAGATGCGATTTTGGACTACCTCATAACCAAGCACCTT       c.5160
 Y  Q  R  L  E  F  L  G  D  A  I  L  D  Y  L  I  T  K  H  L         p.1720

          .         .         .         .         .         .       g.68391
 TATGAAGACCCGCGGCAGCACTCCCCGGGGGTCCTGACAGACCTGCGGTCTGCCCTGGTC       c.5220
 Y  E  D  P  R  Q  H  S  P  G  V  L  T  D  L  R  S  A  L  V         p.1740

          .         .         .         .         .         .       g.68451
 AACAACACCATCTTTGCATCGCTGGCTGTAAAGTACGACTACCACAAGTACTTCAAAGCT       c.5280
 N  N  T  I  F  A  S  L  A  V  K  Y  D  Y  H  K  Y  F  K  A         p.1760

          .         .         .         .         .         .       g.68511
 GTCTCTCCTGAGCTCTTCCATGTCATTGATGACTTTGTGCAGTTTCAGCTTGAGAAGAAT       c.5340
 V  S  P  E  L  F  H  V  I  D  D  F  V  Q  F  Q  L  E  K  N         p.1780

          .         .     | 25   .         .         .         .    g.71093
 GAAATGCAAGGAATGGATTCTGAG | CTTAGGAGATCTGAGGAGGATGAAGAGAAAGAAGAG    c.5400
 E  M  Q  G  M  D  S  E   | L  R  R  S  E  E  D  E  E  K  E  E      p.1800

          .         .         .         .         .         .       g.71153
 GATATTGAAGTTCCAAAGGCCATGGGGGATATTTTTGAGTCGCTTGCTGGTGCCATTTAC       c.5460
 D  I  E  V  P  K  A  M  G  D  I  F  E  S  L  A  G  A  I  Y         p.1820

          .         .         .         .         .         .       g.71213
 ATGGATAGTGGGATGTCACTGGAGACAGTCTGGCAGGTGTACTATCCCATGATGCGGCCA       c.5520
 M  D  S  G  M  S  L  E  T  V  W  Q  V  Y  Y  P  M  M  R  P         p.1840

         | 26.         .         .         .         .         .    g.71366
 CTAATAG | AAAAGTTTTCTGCAAATGTACCCCGTTCCCCTGTGCGAGAATTGCTTGAAATG    c.5580
 L  I  E |   K  F  S  A  N  V  P  R  S  P  V  R  E  L  L  E  M      p.1860

          .         .    | 27    .         .         .         .    g.71796
 GAACCAGAAACTGCCAAATTTAG | CCCGGCTGAGAGAACTTACGACGGGAAGGTCAGAGTC    c.5640
 E  P  E  T  A  K  F  S  |  P  A  E  R  T  Y  D  G  K  V  R  V      p.1880

          .         .         .         .         .         .       g.71856
 ACTGTGGAAGTAGTAGGAAAGGGGAAATTTAAAGGTGTTGGTCGAAGTTACAGGATTGCC       c.5700
 T  V  E  V  V  G  K  G  K  F  K  G  V  G  R  S  Y  R  I  A         p.1900

          .         .         .         .         .         .       g.71916
 AAATCTGCAGCAGCAAGAAGAGCCCTCCGAAGCCTCAAAGCTAATCAACCTCAGGTTCCC       c.5760
 K  S  A  A  A  R  R  A  L  R  S  L  K  A  N  Q  P  Q  V  P         p.1920

                                                                    g.71925
 AATAGCTGA                                                          c.5769
 N  S  X                                                            p.1922

          .         .         .         .         .         .       g.71985
 aaccgctttttaaaattcaaaacaagaaacaaaacaaaaaaaattaaggggaaaattatt       c.*60

          .         .         .         .         .         .       g.72045
 taaatcggaaaggaagacttaaagttgttagtgagtggaatgaattgaaggcagaattta       c.*120

          .         .         .         .         .         .       g.72105
 aagtttggttgataacaggatagataacagaataaaacatttaacatatgtataaaattt       c.*180

          .         .         .         .         .         .       g.72165
 tggaactaattgtagttttagttttttgcgcaaacacaatcttatcttctttcctcactt       c.*240

          .         .         .         .         .         .       g.72225
 ctgctttgtttaaatcacaagagtgctttaatgatgacatttagcaagtgctcaaaataa       c.*300

          .         .         .         .         .         .       g.72285
 ttgacaggttttgtttttttttttttgagtttatgtcagctttgcttagtgttagaaggc       c.*360

          .         .         .         .         .         .       g.72345
 catggagcttaaacctccagcagtccctaggatgatgtagattcttctccatctctccgt       c.*420

          .         .         .         .         .         .       g.72405
 gtgtgcagtagtgccagtcctgcagtagttgataagctgaatagaaagataaggttttcg       c.*480

          .         .         .         .         .         .       g.72465
 agaggagaagtgcgccaatgttgtcttttctttccacgttatactgtgtaaggtgatgtt       c.*540

          .         .         .         .         .         .       g.72525
 cccggtcgctgttgcacctgatagtaagggacagatttttaatgaacattggctggcatg       c.*600

          .         .         .         .         .         .       g.72585
 ttggtgaatcacattttagttttctgatgccacatagtcttgcataaaaaagggttcttg       c.*660

          .         .         .         .         .         .       g.72645
 ccttaaaagtgaaaccttcatggatagtctttaatctctgatctttttggaacaaactgt       c.*720

          .         .         .         .         .         .       g.72705
 tttacattcctttcattttattatgcattagacgttgagacagcgtgatacttacaactc       c.*780

          .         .         .         .         .         .       g.72765
 actagtatagttgtaacttattacaggatcatactaaaatttctgtcatatgtatactga       c.*840

          .         .         .         .         .         .       g.72825
 agacattttaaaaaccagaatatgtagtctacggatattttttatcataaaaatgatctt       c.*900

          .         .         .         .         .         .       g.72885
 tggctaaacaccccattttactaaagtcctcctgccaggtagttcccactgatggaaatg       c.*960

          .         .         .         .         .         .       g.72945
 tttatggcaaataattttgccttctaggctgttgctctaacaaaataaaccttagacata       c.*1020

          .         .         .         .         .         .       g.73005
 tcacacctaaaatatgctgcagattttataattgattggttacttatttaagaagcaaaa       c.*1080

          .         .         .         .         .         .       g.73065
 cacagcacctttacccttagtctcctcacataaatttcttactatacttttcataatgtt       c.*1140

          .         .         .         .         .         .       g.73125
 gcatgcatatttcacctaccaaagctgtgctgttaatgccgtgaaagtttaacgtttgcg       c.*1200

          .         .         .         .         .         .       g.73185
 ataaactgccgtaattttgatacatctgtgatttaggtcattaatttagataaactagct       c.*1260

          .         .         .         .         .         .       g.73245
 cattatttccatctttggaaaaggaaaaaaaaaaaaacttctttaggcatttgcctaagt       c.*1320

          .         .         .         .         .         .       g.73305
 ttctttaattagacttgtaggcactcttcacttaaatacctcagttcttcttttcttttg       c.*1380

          .         .         .         .         .         .       g.73365
 catgcatttttcccctgtttggtgctatgtttatgtattatgcttgaaattttaattttt       c.*1440

          .         .         .         .         .         .       g.73425
 ttttttttgcactgtaactataatacctcttaatttacctttttaaaagctgtgggtcag       c.*1500

          .         .         .         .         .         .       g.73485
 tcttgcactcccatcaacataccagtagaggtttgctgcaatttgccccgttaattatgc       c.*1560

          .         .         .         .         .         .       g.73545
 ttgaagtttaagaaagctgagcagaggtgtctcatatttcccagcacatgattctgaact       c.*1620

          .         .         .         .         .         .       g.73605
 tgatgcttcgtggaatgctgcatttatatgtaagtgacatttgaatactgtccttcctgc       c.*1680

          .         .         .         .         .         .       g.73665
 tttatctgcatcatccacccacagagaaatgcctctgtgcgagtgcaccgacagaaaact       c.*1740

          .         .         .         .         .         .       g.73725
 gtcagctctgctttctaaggaaccctgagtgaggggggtattaagcttctccagtgtttt       c.*1800

          .         .         .         .         .         .       g.73785
 ttgttgtctccaatcttaaacttaaattgagatctaaattattaaacgagtttttgagca       c.*1860

          .         .         .         .         .         .       g.73845
 aattaggtgacttgttttaaaaatatttaattccgatttggaaccttagatgtctatttg       c.*1920

          .         .         .         .         .         .       g.73905
 attttttaaaaaaccttaatgtaagatatgaccagttaaaacaaagcaattcttgaatta       c.*1980

          .         .         .         .         .         .       g.73965
 tataactgtaaaagtgtgcagttaacaaggctggatgtgaattttattctgagggtgatt       c.*2040

          .         .         .         .         .         .       g.74025
 tgtgatcaagtttaatcacaaatctcttaatatttataaactacctgatgccaggagctt       c.*2100

          .         .         .         .         .         .       g.74085
 agggctttgcattgtgtctaatacattgatcccagtgttacgggattctcttgattcctg       c.*2160

          .         .         .         .         .         .       g.74145
 gcaccaaaatcagattgttttcacagttatgattcccagtgggagaaaaatgcctcaata       c.*2220

          .         .         .         .         .         .       g.74205
 tatttgtaaccttaagaagagtatttttttgttaatactaagatgttcaaacttagacat       c.*2280

          .         .         .         .         .         .       g.74265
 gattaggtcatacattctcaggggttcaaatttccttctaccattcaaatgttttatcaa       c.*2340

          .         .         .         .         .         .       g.74325
 cagcaaacttcagccgtttcactttttgttggagaaaaatagtagattttaatttgactc       c.*2400

          .         .         .         .         .         .       g.74385
 acagtttgaagcattctgtgatcccctggttactgagttaaaaaataaaaaagtacgagt       c.*2460

          .         .         .         .         .         .       g.74445
 tagacatatgaaatggttatgaacgcttttgtgctgctgatttttaatgctgtaaagttt       c.*2520

          .         .         .         .         .         .       g.74505
 tcctgtgtttagcttgttgaaatgttttgcatctgtcaattaaggaaaaaaaaaatcact       c.*2580

          .         .         .         .         .         .       g.74565
 ctatgttgccccactttagagccctgtgtgccaccctgtgttcctgtgattgcaatgtga       c.*2640

          .         .         .         .         .         .       g.74625
 gaccgaatgtaatatggaaaacctaccagtggggtgtggttgtgccctgagcacgtgtgt       c.*2700

          .         .         .         .         .         .       g.74685
 aaaggactggggaggcgtgtcttgaaaaagcaactgcagaaattccttatgatgattgtg       c.*2760

          .         .         .         .         .         .       g.74745
 tgcaagttagttaacatgaaccttcatttgtaaattttttaaaatttcttttataatatg       c.*2820

          .         .         .         .         .         .       g.74805
 ctttccgcagtcctaactatgctgcgttttataatagctttttcccttctgttctgttca       c.*2880

          .         .         .         .         .         .       g.74865
 tgtagcacagataagcattgcacttggtaccatgctttacctcatttcaagaaaatatgc       c.*2940

          .         .         .         .         .         .       g.74925
 ttaacagagaggaaaaaaatgtggtttggccttgctgctgttttgatttatggaatttga       c.*3000

          .         .         .         .         .         .       g.74985
 aaaagataattataatgcctgcaatgtgtcatatactcgcacaacttaaataggtcattt       c.*3060

          .         .         .         .         .         .       g.75045
 ttgtctgtggcatttttactgtttgtgaaagtatgaaacagatttgttaactgaactctt       c.*3120

          .         .         .         .         .         .       g.75105
 aattatgtttttaaaatgtttgttatatttcttttcttttttcttttatattacgtgaag       c.*3180

          .         .         .         .         .         .       g.75165
 tgatgaaatttagaatgacctctaacactcctgtaattgtcttttaaaatactgatattt       c.*3240

          .         .         .         .         .         .       g.75225
 ttatttgttaataatactttgccctcagaaagattctgataccctgccttgacaacatga       c.*3300

          .         .         .         .         .         .       g.75285
 aacttgaggctgctttggttcatgaatccaggtgttcccccggcagtcggcttcttcagt       c.*3360

          .         .         .         .         .         .       g.75345
 cgctccctggaggcaggtgggcactgcagaggatcactggaatccagatcgagcgcagtt       c.*3420

          .         .         .         .         .         .       g.75405
 catgcacaaggccccgttgatttaaaatattggatcttgctctgttagggtgtctaatcc       c.*3480

          .         .         .         .         .         .       g.75465
 ctttacacaagattgaagccaccaaactgagaccttgatacctttttttaactgcatctg       c.*3540

          .         .         .         .         .         .       g.75525
 aaattatgttaagagtctttaacccatttgcattatctgcagaagagaaactcatgtcat       c.*3600

          .         .         .         .         .         .       g.75585
 gtttattacctatatggttgttttaattacatttgaataattatatttttccaaccactg       c.*3660

          .         .         .         .         .         .       g.75645
 attacttttcaggaatttaattatttccagataaatttctttattttatattgtacatga       c.*3720

          .         .         .         .         .         .       g.75705
 aaagttttaaagatatgtttaagaccaagactattaaaatgatttttaaagttgttggag       c.*3780

          .         .         .         .         .         .       g.75765
 acgccaatagcaatatctaggaaatttgcattgagaccattgtattttccactagcagtg       c.*3840

          .         .         .         .         .         .       g.75825
 aaaatgatttttcacaactaacttgtaaatatattttaatcattacttctttttttctag       c.*3900

          .         .         .         .         .         .       g.75885
 tccatttttatttggacatcaaccacagacaatttaaattttatagatgcactaagaatt       c.*3960

          .         .         .         .         .         .       g.75945
 cactgcagcagcaggttacatagcaaaaatgcaaaggtgaacaggaagtaaatttctggc       c.*4020

          .         .         .         .         .         .       g.76005
 ttttctgctgtaaatagtgaaggaaaattactaaaatcaagtaaaactaatgcatattat       c.*4080

          .         .         .         .         .         .       g.76065
 ttgattgacaataaaatatttaccatcacatgctgcagctgttttttaaggaacatgatg       c.*4140

          .         .         .         .         .         .       g.76125
 tcattcattcatacagtaatcatgctgcagaaatttgcagtctgcaccttatggatcaca       c.*4200

          .         .         .         .         .         .       g.76185
 attacctttagttgttttttttgtaataattgtagccaagtaaatctccaataaagttat       c.*4260

          .                                                         g.76195
 cgtctgttca                                                         c.*4270

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Dicer 1, ribonuclease type III protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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