DIS3 mitotic control homolog (S. cerevisiae)-like 2 (DIS3L2) - coding DNA reference sequence

(used for variant description)

(last modified June 29, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_152383.4 in the DIS3L2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_032572.1, covering DIS3L2 transcript NM_152383.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5036
                         tttcgcccttgtcgcagctgaaccgccgactacgag       c.-241

 .         .         .         .         .         .                g.5096
 ctcctgcaccgcgcacacaccccgcgcgcttcgctctcggcctcgcccggccaccgtcgc       c.-181

 .         .         .         .         .         .                g.5156
 tctctagaacgccgcgcccgtgacccggaagagcattctccttagcaactgcgggactgc       c.-121

 .         .         .       | 02 .         .         .             g.58285
 ggcggcgccggcctccggggagaaacg | cgaatgacaacagagctgctcaaggcgggaact    c.-61

 .         .         .         .         .         .                g.58345
 ctgagctaagcagtggaggtttctctggatctggagagaagagtgaccttggagccaata       c.-1

          .         .         .         .         .   | 03     .    g.58939
 ATGAGCCATCCTGACTACAGAATGAACCTCCGGCCCCTGGGGACCCCCAGAG | GTGTGTCT    c.60
 M  S  H  P  D  Y  R  M  N  L  R  P  L  G  T  P  R  G |   V  S      p.20

          .         .         .         .         .         .       g.58999
 GCTGTGGCTGGTCCACATGACATTGGTGCTTCGCCAGGTGACAAAAAGTCAAAGAACAGG       c.120
 A  V  A  G  P  H  D  I  G  A  S  P  G  D  K  K  S  K  N  R         p.40

          .         .         .         .         .         .       g.59059
 TCCACACGAGGGAAGAAAAAGAGCATATTTGAAACTTACATGTCCAAGGAGGATGTTTCA       c.180
 S  T  R  G  K  K  K  S  I  F  E  T  Y  M  S  K  E  D  V  S         p.60

          .         .         . | 04       .         .         .    g.67724
 GAAGGCTTGAAGAGAGGAACACTCATCCAG | GGTGTATTGAGAATTAATCCAAAGAAGTTT    c.240
 E  G  L  K  R  G  T  L  I  Q   | G  V  L  R  I  N  P  K  K  F      p.80

          .         .     | 05   .         .         .         .    g.73432
 CATGAAGCCTTCATTCCTTCCCCG | GATGGTGATCGAGACATTTTTATTGATGGGGTTGTT    c.300
 H  E  A  F  I  P  S  P   | D  G  D  R  D  I  F  I  D  G  V  V      p.100

          .         .         .         .         .         .       g.73492
 GCTCGTAATAGAGCCTTAAATGGGGATCTGGTGGTCGTGAAACTGCTTCCCGAGGAGCAT       c.360
 A  R  N  R  A  L  N  G  D  L  V  V  V  K  L  L  P  E  E  H         p.120

        | 06 .         .         .         .         .         .    g.130958
 TGGAAG | GTAGTTAAACCAGAGAGCAATGACAAAGAAACAGAAGCTGCGTATGAATCAGAT    c.420
 W  K   | V  V  K  P  E  S  N  D  K  E  T  E  A  A  Y  E  S  D      p.140

          .         .         .         .         .         .       g.131018
 ATCCCCGAGGAGCTCTGTGGACACCATCTCCCGCAACAGTCCCTGAAAAGCTATAATGAC       c.480
 I  P  E  E  L  C  G  H  H  L  P  Q  Q  S  L  K  S  Y  N  D         p.160

          .         .         .         .         .         .       g.131078
 AGTCCTGATGTCATTGTAGAGGCTCAGTTTGATGGCAGCGACTCAGAAGATGGACATGGC       c.540
 S  P  D  V  I  V  E  A  Q  F  D  G  S  D  S  E  D  G  H  G         p.180

          .         .         .         .         .         .       g.131138
 ATCACACAAAATGTGCTGGTTGATGGTGTTAAGAAACTCTCAGTTTGTGTTTCTGAGAAA       c.600
 I  T  Q  N  V  L  V  D  G  V  K  K  L  S  V  C  V  S  E  K         p.200

   | 07      .         .         .         .         .         .    g.174095
 G | GAAGAGAGGATGGTGATGCACCGGTTACAAAAGATGAGACCACCTGCATTTCACAAGAC    c.660
 G |   R  E  D  G  D  A  P  V  T  K  D  E  T  T  C  I  S  Q  D      p.220

          .         .         .         .   | 08     .         .    g.179907
 ACAAGAGCTTTATCGGAGAAATCCCTGCAAAGATCAGCAAAG | GTGGTTTACATCTTGGAG    c.720
 T  R  A  L  S  E  K  S  L  Q  R  S  A  K   | V  V  Y  I  L  E      p.240

          .         .         .         .         .         .       g.179967
 AAAAAACATTCTCGAGCAGCAACCGGCTTCCTCAAACTCTTGGCTGATAAGAACAGCGAA       c.780
 K  K  H  S  R  A  A  T  G  F  L  K  L  L  A  D  K  N  S  E         p.260

          .         .         .         .         .         .       g.180027
 CTGTTTAGGAAATACGCCCTGTTTTCTCCCTCAGACCACCGAGTGCCTAGAATTTATGTG       c.840
 L  F  R  K  Y  A  L  F  S  P  S  D  H  R  V  P  R  I  Y  V         p.280

          .         .         .         .         .         .       g.180087
 CCTCTCAAGGACTGTCCCCAGGACTTTGTGGCACGGCCTAAAGATTATGCCAACACACTG       c.900
 P  L  K  D  C  P  Q  D  F  V  A  R  P  K  D  Y  A  N  T  L         p.300

          .         .         .         .         . | 09       .    g.206886
 TTCATCTGCCGCATTGTGGACTGGAAGGAGGACTGCAATTTTGCCCTGGG | GCAGCTGGCT    c.960
 F  I  C  R  I  V  D  W  K  E  D  C  N  F  A  L  G  |  Q  L  A      p.320

          .         .         .         .         .         .       g.206946
 AAGAGTCTTGGGCAGGCTGGTGAAATTGAGCCTGAAACAGAAGGAATACTAACAGAGTAT       c.1020
 K  S  L  G  Q  A  G  E  I  E  P  E  T  E  G  I  L  T  E  Y         p.340

          .         .         .         .         .         .       g.207006
 GGCGTGGATTTCTCTGATTTCTCTTCAGAAGTTCTAGAATGTCTTCCTCAAGGCCTGCCA       c.1080
 G  V  D  F  S  D  F  S  S  E  V  L  E  C  L  P  Q  G  L  P         p.360

          .         .         .         .     | 10   .         .    g.253759
 TGGACAATTCCACCAGAGGAGTTCAGCAAGAGAAGGGATTTAAG | AAAAGACTGTATCTTC    c.1140
 W  T  I  P  P  E  E  F  S  K  R  R  D  L  R  |  K  D  C  I  F      p.380

          .         .         .         .         .         .       g.253819
 ACCATTGACCCATCAACCGCCCGAGACCTCGATGATGCCCTCTCCTGCAAGCCACTCGCT       c.1200
 T  I  D  P  S  T  A  R  D  L  D  D  A  L  S  C  K  P  L  A         p.400

      | 11   .         .         .         .         .         .    g.282006
 GACG | GCAACTTCAAAGTGGGAGTTCACATTGCTGACGTGAGTTACTTTGTTCCGGAGGGA    c.1260
 D  G |   N  F  K  V  G  V  H  I  A  D  V  S  Y  F  V  P  E  G      p.420

          .         .         .         .         .        | 12.    g.292659
 TCTGATCTGGATAAAGTGGCTGCCGAGAGGGCTACAAGCGTCTACTTGGTTCAAAAG | GTG    c.1320
 S  D  L  D  K  V  A  A  E  R  A  T  S  V  Y  L  V  Q  K   | V      p.440

          .         .         .         .         .         .       g.292719
 GTCCCCATGCTTCCCAGGCTGCTGTGTGAGGAGCTGTGCAGCCTCAACCCCATGTCCGAC       c.1380
 V  P  M  L  P  R  L  L  C  E  E  L  C  S  L  N  P  M  S  D         p.460

          .         .         .         .      | 13  .         .    g.306639
 AAGCTGACCTTCTCTGTGATCTGGACACTGACTCCAGAGGGCAAG | ATCCTTGATGAATGG    c.1440
 K  L  T  F  S  V  I  W  T  L  T  P  E  G  K   | I  L  D  E  W      p.480

          .         .         .         .         .         .       g.306699
 TTTGGCCGGACCATCATCCGCTCCTGCACCAAACTTAGCTACGAGCATGCACAGAGCATG       c.1500
 F  G  R  T  I  I  R  S  C  T  K  L  S  Y  E  H  A  Q  S  M         p.500

          .         .         .         .         .         .       g.306759
 ATTGAAAGCCCAACTGAGAAAATCCCTGCGAAAGAGCTGCCCCCCATTTCCCCAGAGCAT       c.1560
 I  E  S  P  T  E  K  I  P  A  K  E  L  P  P  I  S  P  E  H         p.520

          .         .         .         .         .         .       g.306819
 AGCAGCGAGGAGGTACACCAGGCCGTCTTGAATCTCCACGGAATTGCCAAGCAGTTACGC       c.1620
 S  S  E  E  V  H  Q  A  V  L  N  L  H  G  I  A  K  Q  L  R         p.540

          .         .         .          | 14        .         .    g.343478
 CAGCAGCGCTTTGTGGACGGCGCACTTCGTTTGGATCAG | CTAAAGCTTGCTTTCACTCTG    c.1680
 Q  Q  R  F  V  D  G  A  L  R  L  D  Q   | L  K  L  A  F  T  L      p.560

          .         .         .         .         .          | 15    g.373231
 GACCACGAGACCGGATTGCCTCAAGGATGTCATATCTATGAGTACCGCGAGAGCAACAA | G    c.1740
 D  H  E  T  G  L  P  Q  G  C  H  I  Y  E  Y  R  E  S  N  K  |      p.580

          .         .         .         .         .         .       g.373291
 CTCGTGGAGGAGTTCATGCTCTTGGCCAACATGGCAGTGGCCCACAAGATCCACCGCGCC       c.1800
 L  V  E  E  F  M  L  L  A  N  M  A  V  A  H  K  I  H  R  A         p.600

          .         .         .         .         .         .       g.373351
 TTCCCCGAGCAGGCCCTGCTGCGCCGGCACCCCCCGCCCCAAACAAGGATGCTCAGTGAC       c.1860
 F  P  E  Q  A  L  L  R  R  H  P  P  P  Q  T  R  M  L  S  D         p.620

          .         .         .         .         .         .       g.373411
 CTGGTGGAATTCTGCGACCAGATGGGGCTGCCCGTGGACTTCAGCTCCGCAGGAGCCCTC       c.1920
 L  V  E  F  C  D  Q  M  G  L  P  V  D  F  S  S  A  G  A  L         p.640

     | 16    .         .         .         .         .         .    g.374164
 AAT | AAAAGCCTGACCCAAACATTTGGAGATGACAAGTACTCACTGGCCCGCAAGGAGGTG    c.1980
 N   | K  S  L  T  Q  T  F  G  D  D  K  Y  S  L  A  R  K  E  V      p.660

          .         .         . | 17       .         .         .    g.377287
 CTCACCAACATGTGCTCCCGGCCCATGCAG | ATGGCACTGTACTTCTGCTCGGGGCTGCTG    c.2040
 L  T  N  M  C  S  R  P  M  Q   | M  A  L  Y  F  C  S  G  L  L      p.680

          .         .         .         .         .         .       g.377347
 CAGGACCCAGCGCAGTTCCGGCACTACGCGCTCAATGTGCCCCTGTACACACACTTCACC       c.2100
 Q  D  P  A  Q  F  R  H  Y  A  L  N  V  P  L  Y  T  H  F  T         p.700

          .         .         .         .         .         | 18    g.377788
 TCGCCCATCCGCCGCTTTGCCGACGTCCTGGTGCACCGCCTCCTGGCTGCCGCGTTAG | GC    c.2160
 S  P  I  R  R  F  A  D  V  L  V  H  R  L  L  A  A  A  L  G |       p.720

          .         .         .         .         .         .       g.377848
 TATAGGGAGCGACTAGACATGGCGCCCGATACCCTGCAGAAACAGGCGGACCACTGTAAC       c.2220
 Y  R  E  R  L  D  M  A  P  D  T  L  Q  K  Q  A  D  H  C  N         p.740

          .         .         .         .         .         .       g.377908
 GACCGCCGCATGGCGTCCAAGCGCGTGCAGGAGCTCAGTACCAGTCTCTTCTTTGCTGTT       c.2280
 D  R  R  M  A  S  K  R  V  Q  E  L  S  T  S  L  F  F  A  V         p.760

           | 19        .         .         .         .         .    g.378099
 CTGGTCAAG | GAGAGTGGCCCCCTGGAGTCAGAAGCCATGGTGATGGGCATCCTGAAGCAA    c.2340
 L  V  K   | E  S  G  P  L  E  S  E  A  M  V  M  G  I  L  K  Q      p.780

          .         .         .         .         .     | 20   .    g.379196
 GCCTTCGACGTGCTGGTGCTGCGCTACGGCGTGCAGAAGCGCATCTACTGCAAC | GCACTG    c.2400
 A  F  D  V  L  V  L  R  Y  G  V  Q  K  R  I  Y  C  N   | A  L      p.800

          .         .         .         .         .         .       g.379256
 GCCCTGCGGTCCCACCACTTCCAGAAGGTGGGCAAGAAGCCGGAACTCACGCTGGTCTGG       c.2460
 A  L  R  S  H  H  F  Q  K  V  G  K  K  P  E  L  T  L  V  W         p.820

          .         .         .       | 21 .         .         .    g.379910
 GAGCCTGAGGACATGGAGCAGGAGCCAGCACAGCAG | GTCATCACCATCTTCAGCCTGGTG    c.2520
 E  P  E  D  M  E  Q  E  P  A  Q  Q   | V  I  T  I  F  S  L  V      p.840

          .         .         .         .         .         .       g.379970
 GAGGTGGTCCTGCAGGCAGAGTCCACAGCCCTCAAGTACAGCGCCATCCTGAAGCGGCCA       c.2580
 E  V  V  L  Q  A  E  S  T  A  L  K  Y  S  A  I  L  K  R  P         p.860

          .         .         .         .         .         .       g.380030
 GGCACCCAGGGCCACCTGGGCCCTGAGAAGGAGGAGGAGGAGTCTGACGGTGAGCCCGAG       c.2640
 G  T  Q  G  H  L  G  P  E  K  E  E  E  E  S  D  G  E  P  E         p.880

          .                                                         g.380048
 GACTCAAGCACCAGCTGA                                                 c.2658
 D  S  S  T  S  X                                                   p.885

          .         .         .         .         .         .       g.380108
 gctccaccagccgcctgccccgcctgccccgcctgcctgtcccgccacactggctttagg       c.*60

          .         .         .         .         .         .       g.380168
 acctgttgacacggaggggggtttttaatttggtttttaacaactcaggggtttgttttt       c.*120

          .         .         .         .         .         .       g.380228
 atttttatttaatttttgcagctcaacttttaaacaaactgcaggggagagggtggggct       c.*180

          .         .         .         .         .         .       g.380288
 ggaaggaaggctgaggcctggtcagcagtgaccccagcagagcaggccccagtcctcctg       c.*240

          .         .         .         .         .         .       g.380348
 ggaggctggccccccttttttctgggccctactgccctcctctgcccaggaaatgggggg       c.*300

          .         .         .         .         .         .       g.380408
 gtttcagcaactcagtgtcacagaataaaatcaagtgtggagtgccatctggtgtgtagg       c.*360

          .         .         .         .         .         .       g.380468
 gcgcctctgggaagcctgggcagcagaatgccccttgcacccagggcaagggacccagtt       c.*420

          .         .         .         .         .         .       g.380528
 caggcttcacccctcgctgctgagccgatgtcaacacctggaactttcctgtcagttcca       c.*480

          .         .         .         .         .         .       g.380588
 acacgattcagagctggctgcctggcagatgattgatactggagtctcattctgcctgat       c.*540

          .         .                                               g.380616
 taaaaatggaattagtatgcaacactga                                       c.*568

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The DIS3 mitotic control homolog (S. cerevisiae)-like 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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