dihydrolipoamide dehydrogenase (DLD) - coding DNA reference sequence

(used for variant description)

(last modified September 23, 2024)


This file was created to facilitate the description of sequence variants on transcript NM_000108.3 in the DLD gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000007.13, covering DLD transcript NM_000108.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5050
           gatgacgtaggctgcgcctgtgcatgcgcagggaggggagaccttggcgg       c.-61

 .         .         .         .         .         .                g.5110
 agcggcggaggcgcccagcggaggtgaaagtattggcggaaaggaaaatacagcggaaaa       c.-1

          .         .         .          | 02        .         .    g.7080
 ATGCAGAGCTGGAGTCGTGTGTACTGCTCCTTGGCCAAG | AGAGGCCATTTCAATCGAATA    c.60
 M  Q  S  W  S  R  V  Y  C  S  L  A  K   | R  G  H  F  N  R  I      p.20

          .         .         .         .         .         | 03    g.15599
 TCTCATGGCCTACAGGGACTTTCTGCAGTGCCTCTGAGAACTTACGCAGATCAGCCGA | TT    c.120
 S  H  G  L  Q  G  L  S  A  V  P  L  R  T  Y  A  D  Q  P  I |       p.40

          .         .         .         .         .         .       g.15659
 GATGCTGATGTAACAGTTATAGGTTCTGGTCCTGGAGGATATGTTGCTGCTATTAAAGCT       c.180
 D  A  D  V  T  V  I  G  S  G  P  G  G  Y  V  A  A  I  K  A         p.60

          .         | 04         .         .         .         .    g.16226
 GCCCAGTTAGGCTTCAAG | ACAGTCTGCATTGAGAAAAATGAAACACTTGGTGGAACATGC    c.240
 A  Q  L  G  F  K   | T  V  C  I  E  K  N  E  T  L  G  G  T  C      p.80

          .         .        | 05.         .         .         .    g.17370
 TTGAATGTTGGTTGTATTCCTTCTAAG | GCTTTATTGAACAACTCTCATTATTACCATATG    c.300
 L  N  V  G  C  I  P  S  K   | A  L  L  N  N  S  H  Y  Y  H  M      p.100

          .         .         .        | 06.         .         .    g.18840
 GCCCATGGAAAAGATTTTGCATCTAGAGGAATTGAAA | TGTCCGAAGTTCGCTTGAATTTA    c.360
 A  H  G  K  D  F  A  S  R  G  I  E  M |   S  E  V  R  L  N  L      p.120

          .         .         .         .         .         .       g.18900
 GACAAGATGATGGAGCAGAAGAGTACTGCAGTAAAAGCTTTAACAGGTGGAATTGCCCAC       c.420
 D  K  M  M  E  Q  K  S  T  A  V  K  A  L  T  G  G  I  A  H         p.140

          .         | 07         .         .         .         .    g.19262
 TTATTCAAACAGAATAAG | GTTGTTCATGTCAATGGATATGGAAAGATAACTGGCAAAAAT    c.480
 L  F  K  Q  N  K   | V  V  H  V  N  G  Y  G  K  I  T  G  K  N      p.160

          .         .         .         .         .         .       g.19322
 CAAGTCACTGCTACGAAAGCTGATGGCGGCACTCAGGTTATTGATACAAAGAACATTCTT       c.540
 Q  V  T  A  T  K  A  D  G  G  T  Q  V  I  D  T  K  N  I  L         p.180

          .         .         .         .   | 08     .         .    g.20144
 ATAGCCACGGGTTCAGAAGTTACTCCTTTTCCTGGAATCACG | ATAGATGAAGATACAATA    c.600
 I  A  T  G  S  E  V  T  P  F  P  G  I  T   | I  D  E  D  T  I      p.200

          .         .         .         .         .         .       g.20204
 GTGTCATCTACAGGTGCTTTATCTTTAAAAAAAGTTCCAGAAAAGATGGTTGTTATTGGT       c.660
 V  S  S  T  G  A  L  S  L  K  K  V  P  E  K  M  V  V  I  G         p.220

          .         .     | 09   .         .         .         .    g.29401
 GCAGGAGTAATAGGTGTAGAATTG | GGTTCAGTTTGGCAAAGACTTGGTGCAGATGTGACA    c.720
 A  G  V  I  G  V  E  L   | G  S  V  W  Q  R  L  G  A  D  V  T      p.240

          .         .         .         .         .         .       g.29461
 GCAGTTGAATTTTTAGGTCATGTAGGTGGAGTTGGAATTGATATGGAGATATCTAAAAAC       c.780
 A  V  E  F  L  G  H  V  G  G  V  G  I  D  M  E  I  S  K  N         p.260

          .         .         .         .         .         .       g.29521
 TTTCAACGCATCCTTCAAAAACAGGGGTTTAAATTTAAATTGAATACAAAGGTTACTGGT       c.840
 F  Q  R  I  L  Q  K  Q  G  F  K  F  K  L  N  T  K  V  T  G         p.280

          .         .         .      | 10  .         .         .    g.30678
 GCTACCAAGAAGTCAGATGGAAAAATTGATGTTTC | TATTGAAGCTGCTTCTGGTGGTAAA    c.900
 A  T  K  K  S  D  G  K  I  D  V  S  |  I  E  A  A  S  G  G  K      p.300

          .         .         .         .         .         .       g.30738
 GCTGAAGTTATCACTTGTGATGTACTCTTGGTTTGCATTGGCCGACGACCCTTTACTAAG       c.960
 A  E  V  I  T  C  D  V  L  L  V  C  I  G  R  R  P  F  T  K         p.320

          .         .         .         .         .         .       g.30798
 AATTTGGGACTAGAAGAGCTGGGAATTGAACTAGATCCCAGAGGTAGAATTCCAGTCAAT       c.1020
 N  L  G  L  E  E  L  G  I  E  L  D  P  R  G  R  I  P  V  N         p.340

          .         .       | 11 .         .         .         .    g.31166
 ACCAGATTTCAAACTAAAATTCCAAA | TATCTATGCCATTGGTGATGTAGTTGCTGGTCCA    c.1080
 T  R  F  Q  T  K  I  P  N  |  I  Y  A  I  G  D  V  V  A  G  P      p.360

          .         .         .         .         .         .       g.31226
 ATGCTGGCTCACAAAGCAGAGGATGAAGGCATTATCTGTGTTGAAGGAATGGCTGGTGGT       c.1140
 M  L  A  H  K  A  E  D  E  G  I  I  C  V  E  G  M  A  G  G         p.380

          .         .         .         .         .         .       g.31286
 GCTGTGCACATTGACTACAATTGTGTGCCATCAGTGATTTACACACACCCTGAAGTTGCT       c.1200
 A  V  H  I  D  Y  N  C  V  P  S  V  I  Y  T  H  P  E  V  A         p.400

          .         .         .       | 12 .         .         .    g.31807
 TGGGTTGGCAAATCAGAAGAGCAGTTGAAAGAAGAG | GGTATTGAGTACAAAGTTGGGAAA    c.1260
 W  V  G  K  S  E  E  Q  L  K  E  E   | G  I  E  Y  K  V  G  K      p.420

          .         .         .         .         .         .       g.31867
 TTCCCATTTGCTGCTAACAGCAGAGCTAAGACAAATGCTGACACAGATGGCATGGTGAAG       c.1320
 F  P  F  A  A  N  S  R  A  K  T  N  A  D  T  D  G  M  V  K         p.440

          .         .         .         .         .     | 13   .    g.32875
 ATCCTTGGGCAGAAATCGACAGACAGAGTACTGGGAGCACATATTCTTGGACCA | GGTGCT    c.1380
 I  L  G  Q  K  S  T  D  R  V  L  G  A  H  I  L  G  P   | G  A      p.460

          .         .         .         .         .         .       g.32935
 GGAGAAATGGTAAATGAAGCTGCTCTTGCTTTGGAATATGGAGCATCCTGTGAAGATATA       c.1440
 G  E  M  V  N  E  A  A  L  A  L  E  Y  G  A  S  C  E  D  I         p.480

          .         .     | 14   .         .         .         .    g.33089
 GCTAGAGTCTGTCATGCACATCCG | ACCTTATCAGAAGCTTTTAGAGAAGCAAATCTTGCT    c.1500
 A  R  V  C  H  A  H  P   | T  L  S  E  A  F  R  E  A  N  L  A      p.500

          .         .         .                                     g.33119
 GCGTCATTTGGCAAATCAATCAACTTTTGA                                     c.1530
 A  S  F  G  K  S  I  N  F  X                                       p.509

          .         .         .         .         .         .       g.33179
 attagaagattatatatatttttttctgaaatttcctgggagcttttgtagaagtcacat       c.*60

          .         .         .         .         .         .       g.33239
 tcctgaacaggatattctcacagctccaagaatttctaggactgaattatgaaacttttg       c.*120

          .         .         .         .         .         .       g.33299
 gaaggtatttaataggtttggacaaaatggaatactcttatatctatattttacataaat       c.*180

          .         .         .         .         .         .       g.33359
 ttagtattttgtttcagtgcactaatgtgtaagacaaaaagctacttattgtagcatcct       c.*240

          .         .         .         .         .         .       g.33419
 ggaatatctccgtcaactcatattttcatgctgttcatgaaagattcaatgcccctgaat       c.*300

          .         .         .         .         .         .       g.33479
 ttaaatagcttttttctctgatacagaaaagttgaattttacatggctggagctagaatt       c.*360

          .         .         .         .         .         .       g.33539
 tgatatgtgaacagttgtgtttgaagcacagtgatcaagttatttttaatttggttttca       c.*420

          .         .         .         .         .         .       g.33599
 cattggaaacaagtcagtcattcagatatgattcaaatgtctataaaccgaactgatgta       c.*480

          .         .         .         .         .         .       g.33659
 agtaaacggtctctcacttgttttatttaacctctaaattctttcattttaggggtagca       c.*540

          .         .         .         .         .         .       g.33719
 tttgtgttgaagaggttttaaagcttccattgttgtctgcaactctgaagggtaattata       c.*600

          .         .         .         .         .         .       g.33779
 tagttacccaaattaagagagtctatttacggaactcaaatacgtgggcattcaaatgta       c.*660

          .         .         .         .         .         .       g.33839
 ttacagtggggaatgaagatactgaaataaacgtcttaaatattcatttactggttatca       c.*720

          .         .         .         .         .         .       g.33899
 tgagtacgtgttgagatggtcatagttttttttatgactacttctagtgtatattctaat       c.*780

          .         .         .         .         .         .       g.33959
 ttcttttctaggcctgaatgtatctttattttcatgttataggacaatattaaggcattt       c.*840

          .         .         .         .         .         .       g.34019
 taaaggtcatcatcctttcatctattttagatacacctactaaatgtttaatatatactt       c.*900

          .         .         .         .         .         .       g.34079
 ttggagaagtacaacataagggagtctttaatctgtgttttccttggctgggttaatgac       c.*960

          .         .         .         .         .         .       g.34139
 tgtttatttaaagagtgttgtaaaattggatgtgtggtgtttaaaatggccatgtcctga       c.*1020

          .         .         .         .         .         .       g.34199
 ggaaacttaagtaacaaagtactaaatgctaagtaggcttttgcatattgtaactaaatt       c.*1080

          .         .         .         .         .         .       g.34259
 taagaataattcagattaagtagttctgaaatttggtatagatagcatagattgtctcat       c.*1140

          .         .         .         .         .         .       g.34319
 gctcatgagtgacataatgaccctggattctgttacatacttctaaagaaaattgattgt       c.*1200

          .         .         .         .         .         .       g.34379
 tgtcttaggaggcagttaacttggctgaacaccaactccacactctgtcttgtttgtagg       c.*1260

          .         .         .         .         .         .       g.34439
 tggcagcagctgaaatctcttctcagttgttttagctttagctatgctgctggaagtctt       c.*1320

          .         .         .         .         .         .       g.34499
 tcccatgcaagtgtgtagttcaggggtcaaccagagtttgggcagaaggaagtctgcccc       c.*1380

          .         .         .         .         .         .       g.34559
 ttctgtgcctcctgttttttgggggtttcccctttatgttccagctgttgtggttgcccc       c.*1440

          .         .         .         .         .         .       g.34619
 atattctgccttctgatccttaaccaataaaacttggcttttgtttccccctcaagtgag       c.*1500

          .         .         .         .         .         .       g.34679
 aacccgttaaaaatgagacattgagccagtgctgttcactttttaagtgccaacttccct       c.*1560

          .         .         .         .         .         .       g.34739
 ctactttccacttgtttatagttgtttccagtgcctttagttttttctaaaatatatttg       c.*1620

          .         .         .         .         .         .       g.34799
 ttcagagtttgcagttgctatcagcaggagggttggtctgatatctgtgtgctactttgc       c.*1680

          .         .         .         .         .         .       g.34859
 cattattggaagtgaactctgcatctttttaaaaatttgaaatcccggtatcatgtgaag       c.*1740

          .         .         .         .         .         .       g.34919
 tgctgtttatgtaaatctcaacatatcccttactcagggaaaaaaaagtttttagttagg       c.*1800

          .         .         .         .         .         .       g.34979
 gaatagtgaaatataatttaatatggaattctagctgtagagttaaatccatctttaagt       c.*1860

          .         .         .         .         .         .       g.35039
 gtttacattcagtatgagaatgcaaatttatctgtatggggaataaagtcctaggaataa       c.*1920

          .                                                         g.35058
 aacaagttttaagtgttca                                                c.*1939

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Dihydrolipoamide dehydrogenase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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