discs, large homolog 3 (Drosophila) (DLG3) - coding DNA reference sequence

(used for variant description)

(last modified June 8, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_021120.3 in the DLG3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000023.10, covering DLG3 transcript NM_021120.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5047
              ggggaccagagcagaagcggtcctcacagcacccattctctgcttga       c.-301

 .         .         .         .         .         .                g.5107
 gctcccgcttcttctttgccgctgggcctcggcccagaagccacgacgggcgacacggag       c.-241

 .         .         .         .         .         .                g.5167
 ccgccagtgctggagggggagccgtgggtgcggggcagcgtgggggccgaggccccggga       c.-181

 .         .         .         .         .         .                g.5227
 cgcccgcccggccccaggccccgctcagcccgggcgcccccacgggtgccccccccttct       c.-121

 .         .         .         .         .         .                g.5287
 tggtccgagcagtgtgagtgtgccagggagcccggcggcggcggcggcggtggtggcggc       c.-61

 .         .         .         .         .         .                g.5347
 ggtggcggcggcgtggaatccggcgtgggctggggggtccgagccgcggggggcagtgcc       c.-1

          .         .         .         .         .         .       g.5407
 ATGCACAAGCACCAGCACTGCTGTAAGTGCCCTGAGTGCTATGAGGTGACCCGCCTGGCC       c.60
 M  H  K  H  Q  H  C  C  K  C  P  E  C  Y  E  V  T  R  L  A         p.20

          .         .         .         .         .         .       g.5467
 GCCCTGCGGCGCCTCGAGCCTCCGGGCTACGGCGACTGGCAAGTCCCCGACCCTTACGGG       c.120
 A  L  R  R  L  E  P  P  G  Y  G  D  W  Q  V  P  D  P  Y  G         p.40

          .         .         .         .         .         .       g.5527
 CCAGGTGGGGGCAACGGCGCCAGCGCGGGTTATGGGGGCTACAGCTCGCAGACCTTGCCC       c.180
 P  G  G  G  N  G  A  S  A  G  Y  G  G  Y  S  S  Q  T  L  P         p.60

          .         .         .         .         .         .       g.5587
 TCGCAGGCGGGGGCCACCCCCACCCCTCGCACCAAGGCCAAGCTCATCCCCACCGGCCGG       c.240
 S  Q  A  G  A  T  P  T  P  R  T  K  A  K  L  I  P  T  G  R         p.80

          .         .         .         .         .         .       g.5647
 GATGTGGGGCCGGTGCCTCCTAAGCCAGTCCCGGGCAAGAGCACCCCCAAACTCAACGGC       c.300
 D  V  G  P  V  P  P  K  P  V  P  G  K  S  T  P  K  L  N  G         p.100

          .         .         .         .         .        | 02.    g.9061
 AGCGGCCCCAGCTGGTGGCCAGAGTGCACCTGTACCAACCGGGACTGGTATGAGCAG | GTG    c.360
 S  G  P  S  W  W  P  E  C  T  C  T  N  R  D  W  Y  E  Q   | V      p.120

          .         .         .         .         | 03         .    g.9516
 AATGGCAGTGATGGCATGTTCAAATATGAGGAAATCGTACTTGAGAGG | GGCAACTCTGGC    c.420
 N  G  S  D  G  M  F  K  Y  E  E  I  V  L  E  R   | G  N  S  G      p.140

          .         .         .         .         .         .       g.9576
 CTGGGCTTCAGTATCGCAGGTGGCATCGACAATCCCCATGTCCCTGATGACCCTGGCATC       c.480
 L  G  F  S  I  A  G  G  I  D  N  P  H  V  P  D  D  P  G  I         p.160

          .         .         .         .         .    | 04    .    g.9842
 TTTATTACCAAGATTATCCCTGGTGGAGCAGCTGCCATGGATGGGAGGCTGGG | GGTGAAT    c.540
 F  I  T  K  I  I  P  G  G  A  A  A  M  D  G  R  L  G  |  V  N      p.180

          .         .         .         .         .         .       g.9902
 GACTGTGTGCTGCGGGTGAATGAGGTGGACGTGTCGGAGGTGGTACACAGCCGGGCGGTG       c.600
 D  C  V  L  R  V  N  E  V  D  V  S  E  V  V  H  S  R  A  V         p.200

          .         .         .         .         .         .       g.9962
 GAGGCGCTGAAGGAGGCAGGCCCTGTGGTGCGATTGGTGGTGCGGAGGCGACAGCCTCCA       c.660
 E  A  L  K  E  A  G  P  V  V  R  L  V  V  R  R  R  Q  P  P         p.220

          .         .         .         .    | 05    .         .    g.10331
 CCCGAGACCATCATGGAGGTCAACCTGCTCAAAGGGCCCAAAG | GCCTGGGTTTCAGCATT    c.720
 P  E  T  I  M  E  V  N  L  L  K  G  P  K  G |   L  G  F  S  I      p.240

          .         .         .         .         .         .       g.10391
 GCTGGGGGTATTGGCAACCAGCACATCCCAGGAGACAACAGCATCTACATCACCAAGATC       c.780
 A  G  G  I  G  N  Q  H  I  P  G  D  N  S  I  Y  I  T  K  I         p.260

          .         .         .         .         .         .       g.10451
 ATTGAGGGGGGTGCTGCTCAGAAGGATGGACGCCTACAGATTGGGGACCGGCTGCTGGCG       c.840
 I  E  G  G  A  A  Q  K  D  G  R  L  Q  I  G  D  R  L  L  A         p.280

  | 06       .         .         .         .         .         .    g.10844
  | GTGAACAACACCAATCTGCAGGATGTGAGGCACGAGGAAGCTGTGGCCTCACTGAAGAAC    c.900
  | V  N  N  T  N  L  Q  D  V  R  H  E  E  A  V  A  S  L  K  N      p.300

          .         .         .         .         .         .       g.10904
 ACATCTGATATGGTGTATTTGAAGGTGGCCAAGCCAGGCAGCCTCCACCTCAACGACATG       c.960
 T  S  D  M  V  Y  L  K  V  A  K  P  G  S  L  H  L  N  D  M         p.320

          .         .      | 07  .         .         .         .    g.12047
 TACGCTCCCCCTGACTACGCCAGCA | CTTTTACTGCCTTGGCTGACAACCACATAAGCCAT    c.1020
 Y  A  P  P  D  Y  A  S  T |   F  T  A  L  A  D  N  H  I  S  H      p.340

          .         .         .         .         .         .       g.12107
 AATTCCAGCCTGGGTTATCTCGGGGCTGTGGAGAGCAAGGTCAGCTACCCTGCTCCTCCT       c.1080
 N  S  S  L  G  Y  L  G  A  V  E  S  K  V  S  Y  P  A  P  P         p.360

          .         .         .         .         .         .       g.12167
 CAGGTTCCCCCCACCCGCTACTCTCCTATTCCCAGGCACATGCTGGCTGAGGAGGACTTC       c.1140
 Q  V  P  P  T  R  Y  S  P  I  P  R  H  M  L  A  E  E  D  F         p.380

       | 08  .         .         .         .         .         .    g.13837
 ACCAG | AGAGCCTCGCAAGATCATCCTGCACAAAGGCTCCACAGGCCTGGGCTTCAACATC    c.1200
 T  R  |  E  P  R  K  I  I  L  H  K  G  S  T  G  L  G  F  N  I      p.400

          .         .         .         .         .         .       g.13897
 GTAGGAGGAGAGGATGGAGAAGGCATTTTTGTCTCCTTCATCCTGGCAGGAGGCCCAGCT       c.1260
 V  G  G  E  D  G  E  G  I  F  V  S  F  I  L  A  G  G  P  A         p.420

          .         .         .         .   | 09     .         .    g.14377
 GACCTGAGTGGGGAGCTGCGCAGGGGAGACCGGATCTTATCG | GTGAATGGAGTGAATCTG    c.1320
 D  L  S  G  E  L  R  R  G  D  R  I  L  S   | V  N  G  V  N  L      p.440

          .         .         .         .         .         .       g.14437
 AGGAATGCAACTCATGAGCAGGCTGCAGCTGCTCTGAAACGGGCCGGCCAGTCAGTCACC       c.1380
 R  N  A  T  H  E  Q  A  A  A  A  L  K  R  A  G  Q  S  V  T         p.460

          .         .      | 10  .         .         .         .    g.39330
 ATTGTGGCCCAGTACAGACCTGAAG | AATACAGTCGCTTTGAATCGAAGATACATGACTTA    c.1440
 I  V  A  Q  Y  R  P  E  E |   Y  S  R  F  E  S  K  I  H  D  L      p.480

          .         .         .         .         .         .       g.39390
 CGAGAACAAATGATGAACAGCAGCATGAGCTCTGGGTCTGGGTCCCTCCGAACAAGTGAA       c.1500
 R  E  Q  M  M  N  S  S  M  S  S  G  S  G  S  L  R  T  S  E         p.500

          .         . | 11       .         .         .         .    g.52292
 AAGAGGTCCTTGTATGTCAG | GGCCCTGTTTGATTATGATCGGACTCGGGACAGCTGCCTG    c.1560
 K  R  S  L  Y  V  R  |  A  L  F  D  Y  D  R  T  R  D  S  C  L      p.520

          .         .         .         .         .         .       g.52352
 CCAAGCCAGGGGCTCAGCTTCTCTTATGGTGACATTCTGCATGTCATTAATGCCTCTGAT       c.1620
 P  S  Q  G  L  S  F  S  Y  G  D  I  L  H  V  I  N  A  S  D         p.540

          .         .         .         .         .         .       g.52412
 GATGAGTGGTGGCAGGCAAGGCTGGTGACCCCACACGGAGAAAGTGAGCAGATCGGTGTG       c.1680
 D  E  W  W  Q  A  R  L  V  T  P  H  G  E  S  E  Q  I  G  V         p.560

          .        | 12.         .         .         .         .    g.52709
 ATCCCCAGTAAGAAGAG | GGTGGAAAAGAAAGAAAGAGCTCGATTGAAAACTGTGAAGTTC    c.1740
 I  P  S  K  K  R  |  V  E  K  K  E  R  A  R  L  K  T  V  K  F      p.580

          .         .         .    | 13    .         .         .    g.55580
 CATGCCAGGACGGGGATGATTGAGTCTAACAGG | GACTTCCCGGGGTTAAGTGACGATTAT    c.1800
 H  A  R  T  G  M  I  E  S  N  R   | D  F  P  G  L  S  D  D  Y      p.600

          .          | 14        .         .         .         .    g.58706
 TATGGAGCAAAGAACCTGA | AAGGACAAGAGGATGCTATTTTGTCATATGAGCCAGTGACA    c.1860
 Y  G  A  K  N  L  K |   G  Q  E  D  A  I  L  S  Y  E  P  V  T      p.620

          . | 15       .         .         .         .         .    g.59371
 CGGCAAGAAA | TTCACTATGCAAGGCCTGTGATCATCCTGGGCCCAATGAAGGACCGAGTC    c.1920
 R  Q  E  I |   H  Y  A  R  P  V  I  I  L  G  P  M  K  D  R  V      p.640

          .         .         .         .         .   | 16     .    g.60030
 AATGATGACCTGATCTCCGAATTTCCACATAAATTTGGATCCTGTGTGCCAC | ATACTACC    c.1980
 N  D  D  L  I  S  E  F  P  H  K  F  G  S  C  V  P  H |   T  T      p.660

          .         .         .         .         .         .       g.60090
 CGGCCTCGACGTGATAATGAGGTGGATGGACAAGACTACCACTTTGTGGTGTCCCGAGAA       c.2040
 R  P  R  R  D  N  E  V  D  G  Q  D  Y  H  F  V  V  S  R  E         p.680

          .         .         .         .         .         .       g.60150
 CAAATGGAGAAAGATATTCAGGACAACAAGTTCATCGAGGCGGGCCAATTTAATGATAAC       c.2100
 Q  M  E  K  D  I  Q  D  N  K  F  I  E  A  G  Q  F  N  D  N         p.700

          .         .         .         .      | 17  .         .    g.60631
 CTCTATGGGACCAGCATCCAGTCAGTGCGGGCAGTTGCAGAGAGG | GGCAAGCACTGCATC    c.2160
 L  Y  G  T  S  I  Q  S  V  R  A  V  A  E  R   | G  K  H  C  I      p.720

          .         .         .         .         .         .       g.60691
 TTAGATGTTTCCGGCAATGCTATCAAGAGACTGCAGCAAGCACAACTTTACCCCATTGCC       c.2220
 L  D  V  S  G  N  A  I  K  R  L  Q  Q  A  Q  L  Y  P  I  A         p.740

          .         .         .      | 18  .         .         .    g.61068
 ATTTTCATCAAGCCCAAGTCCATTGAAGCCCTTAT | GGAAATGAACCGAAGGCAGACATAT    c.2280
 I  F  I  K  P  K  S  I  E  A  L  M  |  E  M  N  R  R  Q  T  Y      p.760

          .         .         .         .         .         .       g.61128
 GAACAAGCAAATAAGATCTATGACAAAGCCATGAAACTGGAGCAGGAATTTGGAGAGTAC       c.2340
 E  Q  A  N  K  I  Y  D  K  A  M  K  L  E  Q  E  F  G  E  Y         p.780

         | 19.         .         .         .         .         .    g.62361
 TTTACAG | CCATTGTACAGGGTGACTCACTGGAAGAGATTTATAACAAAATCAAACAAATC    c.2400
 F  T  A |   I  V  Q  G  D  S  L  E  E  I  Y  N  K  I  K  Q  I      p.800

          .         .         .         .         .                 g.62415
 ATTGAGGACCAGTCTGGGCACTACATTTGGGTCCCATCCCCTGAAAAACTCTGA             c.2454
 I  E  D  Q  S  G  H  Y  I  W  V  P  S  P  E  K  L  X               p.817

          .         .         .         .         .         .       g.62475
 agaatcccctccaaccattctcttgtgaacagaagaaatcaagtccctcttccctcctcc       c.*60

          .         .         .         .         .         .       g.62535
 ctcttcattcctgtccccatggggagaacaaatgctactgttcttgtccccttttttaga       c.*120

          .         .         .         .         .         .       g.62595
 tatgtcaaaaaaaattaagttttctagtcctgttctttttttttttttaagtttttgttt       c.*180

          .         .         .         .         .         .       g.62655
 gtttcagtttattttttgggatgatgccatctcattcatcatgtgactgtgcccattcct       c.*240

          .         .         .         .         .         .       g.62715
 gcatggacctttcccaagcgctagcacaggtgcaaaatccatcagagccattgttttcat       c.*300

          .         .         .         .         .         .       g.62775
 aaaaaccaagcagaagtgaagagaaaagaggaggactgatggaaagacagactctggaca       c.*360

          .         .         .         .         .         .       g.62835
 gctgcacggcttgtgaagtgagctaaatgcaccacatgatgagatgctcctgggcatttc       c.*420

          .         .         .         .         .         .       g.62895
 tccctatctgtactgctgtcttgcagctctgaacggtgcaacgtaatggcgacagaaagt       c.*480

          .         .         .         .         .         .       g.62955
 atcttatttatatatagatatatatatgtaatttatataaaatatatagaaattattata       c.*540

          .         .         .         .         .         .       g.63015
 tatatatattatacactctcatataatatatatatattcacacacatttgggttagaaaa       c.*600

          .         .         .         .         .         .       g.63075
 tctatggagacttcatcaatggtactatgttattagagaaatgctttaattttcatattc       c.*660

          .         .         .         .         .         .       g.63135
 caatcagatggcatcttctatcccagctggttgggaagggattgaagatggtagcaagtg       c.*720

          .         .         .         .         .         .       g.63195
 ctgcactaagggcactcgcatttggtcattctcttgagagctaggaggggtcagcctgag       c.*780

          .         .         .         .         .         .       g.63255
 gccggagaggaagggcttttgcctggggtgagagggtgagagacttgacctgaaagcagc       c.*840

          .         .         .         .         .         .       g.63315
 tgctgcccctgaggtgcagccagagtcctgtgtgcggacagagagaatggctaatgatgc       c.*900

          .         .         .         .         .         .       g.63375
 tccgcgtggaattgcctattgttttatgccacctgatgtgtctgcatgagaggtttcctt       c.*960

          .         .         .         .         .         .       g.63435
 tttgttcctttttaagctgctgttaaaccaaaaccatgttgtgctactgtgtcagccttt       c.*1020

          .         .         .         .         .         .       g.63495
 tcattattgcaaattttacttttactatttaagtgaatgcatagaatccaatttgccaag       c.*1080

          .         .         .         .         .         .       g.63555
 gttctaaaggcttatgaggtcctgaaggagccaggccttgtgatggagtaggtgacacag       c.*1140

          .         .         .         .         .         .       g.63615
 gcctggttgtcctgtcagcagaagggaaagcaggggctgggctgagaggaggacacggag       c.*1200

          .         .         .         .         .         .       g.63675
 ggctctgctgaggttccttcctgggttccaccaacagggacagggagtcacttgccttcc       c.*1260

          .         .         .         .         .         .       g.63735
 agttctgtgctgggatggcgggacagcacttggcttgcttggccagctgcgtcatgagtt       c.*1320

          .         .         .         .         .         .       g.63795
 tgatttggtttttttttttttgcagctgcttcatatgctctgctccagcccctccccaac       c.*1380

          .         .         .         .         .         .       g.63855
 agctggtagcttatggtttcttcaagaggaaagtagactttatgctgtacatttgagctg       c.*1440

          .         .         .         .         .         .       g.63915
 tagagctaagattcgcttactggtgagctgtgaaaccttgttgctttttcccagagtctg       c.*1500

          .         .         .         .         .         .       g.63975
 atggcagtgactgtgatcaagggaatcttcaccgccacaagtgcaggcagcaggtgtggt       c.*1560

          .         .         .         .         .         .       g.64035
 tcaggtccccccccaccccactgtgctcctttgaagccaacgtgcctccctcgcctccat       c.*1620

          .         .         .         .         .         .       g.64095
 actggagggacgacgcaggggagaacagagaagtgcttggccctaggattgaggcacttg       c.*1680

          .         .         .         .         .         .       g.64155
 tttcctagcccgctgggttagggctggtgcaagcgaggcaatgttgaggatgctttaagc       c.*1740

          .         .         .         .         .         .       g.64215
 actaccagccgaatccgggaactctgttaacagttgtccaaccagcagaatgaggctaac       c.*1800

          .         .         .         .         .         .       g.64275
 tgtataaagcatgggacccaggatgaggataaggaaaggacagcggctttccctgggcag       c.*1860

          .         .         .         .         .         .       g.64335
 tacaatggcttgaaggcaaaaagggataaagtgacagccgactgtgactctggtgaggag       c.*1920

          .         .         .         .         .         .       g.64395
 gggtgagcagggaggttgattctctgatgttaactaagtggcaaagtctcaaccgtgctc       c.*1980

          .         .         .         .         .         .       g.64455
 agccctccccctcccagggaagagaaacaaagattcaaagtaagcatgatactagtgggt       c.*2040

          .         .         .         .         .         .       g.64515
 ttaccagtgtttcttccaaggagacatatattttttaataaacgatagttgcaatgaact       c.*2100

          .         .         .         .         .         .       g.64575
 gtggctcagagaccttcttaaagtagttgagaagggagggcgtgggcaaagcagtgggaa       c.*2160

          .         .         .         .         .         .       g.64635
 gaacatcccaaacttttgggggccagagggctctctccttagtgatgatcagctagccga       c.*2220

          .         .         .         .         .         .       g.64695
 gctgggccgtcctggggatcggtacagctccctggggtggtgacaggccctttgtgaaag       c.*2280

          .         .         .         .         .         .       g.64755
 ttgtgtgcttggtcttccaccccagccccagacactgcttcaaatagcaccaaccagatg       c.*2340

          .         .         .         .         .         .       g.64815
 ggagtccacatctgtggtggcaaaatgctgacattttcccaagaggtacacaaggtggga       c.*2400

          .         .         .         .         .         .       g.64875
 gaggcctgctgtagcagaggtgtgtgttagagaaagcaggggcctgatttagtagcagag       c.*2460

          .         .         .         .         .         .       g.64935
 aactgggtgagaaaaatggccagagaaagtgacctgccagctaccagtgtttccgaaaat       c.*2520

          .         .         .         .         .         .       g.64995
 gagggtgggatgggcccatttgcagagcaggacagcagtcatccccatagccctctgagg       c.*2580

          .         .         .         .         .         .       g.65055
 aggggagggatgcttagagcaggcagttctggcagttctgacgtggcaggtgccattgca       c.*2640

          .         .         .         .         .         .       g.65115
 acttgtgcggaggagtcttaggaagtgctgtcataattcataaggtcaagagcaacatct       c.*2700

          .         .         .         .         .         .       g.65175
 ggatgaatgagccacctgaaatgtgtgtgggctgagccacaggaagggtgagtcctcttg       c.*2760

          .         .         .         .         .         .       g.65235
 cttgtggtgctttatggtgtgcaggttgcttgctttcccacattctctcatttgcttgaa       c.*2820

          .         .         .         .         .         .       g.65295
 ggcagcctaacaaaagggagtccccaaagagctccatgagagcttaagaaaattcatctc       c.*2880

          .         .         .         .         .         .       g.65355
 ctgaggacaaagagaacaaagatctgtcctgtggtcacactgttgaggctctgtcttcac       c.*2940

          .         .         .         .         .         .       g.65415
 agctgatgttctcctagtggaggtacagctgaagaacattcagccccagcacgagaagat       c.*3000

          .         .         .         .         .         .       g.65475
 acagagcaacttggaaaccccaaagggagacacacccttaacactgccgtgctgtgctgt       c.*3060

          .         .         .         .         .         .       g.65535
 gccgtgtcctgaaggaggagagagccctatctcctcctggttttgttgctgacattgcag       c.*3120

          .         .         .         .         .         .       g.65595
 ctgatcatgccttgactccttcatctctaacagaggaagaactgtattatcaaaccttat       c.*3180

          .         .         .         .                           g.65636
 ggtctacccatgaataaataaaatatttgttcaagcacaaa                          c.*3221

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Discs, large homolog 3 (Drosophila) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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