discs, large homolog 4 (Drosophila) (DLG4) - coding DNA reference sequence

(used for variant description)

(last modified June 15, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_001365.3 in the DLG4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008391.2, covering DLG4 transcript NM_001365.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5001
                                                            a       c.-1201

 .         .         .         .         .         .                g.5061
 gaccttccgcccccgagcctcagcagctgccgccccaagctcgcggccatccgagccgcc       c.-1141

 .         .         .         .         .         .                g.5121
 tgcatctccgaatctctccgggcgccgctggctcgagctctgacccagctctggcgtcct       c.-1081

 .         .         .         .         .         .                g.5181
 gcacgcccacgtcctggcgcccctaaccctgactcatcgtccacagtgcaccgggcggcg       c.-1021

 .         .         .         .         .         .                g.5241
 gacggttgcgggccccggggcatgctgggagctgtagttccctggagcccggccctgcgt       c.-961

 .         .         .         .         .         .                g.5301
 tccgctgacttagagggatctccaagcgtccctcgtctcccccaaactccttaatcccgc       c.-901

 .         .         .         .         .         .                g.5361
 ccgtccgacctagagtctagtcctccgacggggtgatgggataggatgggacagaagagg       c.-841

 .         .         .         .         .         .                g.5421
 aaggggcttaagtcactgcagccagagggatggaggtggactgaagggagggcttctccg       c.-781

 .         .         .         .         .         .                g.5481
 gtggggttagaagggaaaagtagggaaagagaagtgtaaggtagatggcagaggcagaga       c.-721

 .         .         .         .         .         .                g.5541
 catggaaagacagactctagggttcctgatgaaatctatctcggccaacacaaaagggag       c.-661

 .         .         .         .         .         .                g.5601
 ggtacagtggtggggggcacccaagctagggtgtgagtaccctaagtgtattcttctgag       c.-601

 .         .         .         .         .         .                g.5661
 atgtaggccattcactaactcttggaacagctacagtttcacagtaggaagaccccccca       c.-541

 .         .         .         .         .         .                g.5721
 gattcactgcccctcccttagtaaagcctctgagaccttcctgaacattcccttctgtct       c.-481

 .         .         .         .         .         .                g.5781
 ttgccctctgttccttccagagaccatgtgcccaggcagatggattcctcccgggcctga       c.-421

 .         .         .         .         .         .                g.5841
 gaggaactgcaggaattctcctgcctcttacccgtaaaaccccaacttctctagccctag       c.-361

 .         .         .         .         .         .                g.5901
 ggcaggaagtcccaaacaatttctacccctttttctgcaattctcattggggtgagagga       c.-301

 .         .         .         .         .         .                g.5961
 ggcccaggaggagagagagctgggctcagcttctttttgagctgctggagccctctgtga       c.-241

 .         .         .         .         .         .                g.6021
 ggaggccctctttgctggcttctcaggagagcgtggctaggttctgcctgcctatgggaa       c.-181

 .         .         .         .         .         .                g.6081
 gagggggccagggtgtgtggagcaagatggtggcggtgctggtgccttgggacctggggg       c.-121

 .         .         .         .         .         .                g.6141
 aatgggacagctggtcggctcagagacggcctactttactcacagctggaatttagtggg       c.-61

 .         .         .         .         .         .                g.6201
 gagaagcagctcaactccaatcctggaggattagggagattaaagtgagagaagagagag       c.-1

          .          | 02        .         .         .         .    g.6452
 ATGTCCCAGAGACCAAGAG | CTCCCAGGTCAGCCCTCTGGCTCCTGGCACCCCCACTGCTG    c.60
 M  S  Q  R  P  R  A |   P  R  S  A  L  W  L  L  A  P  P  L  L      p.20

          .         .         .         .         .         | 03    g.6771
 CGGTGGGCACCCCCACTCCTCACAGTGCTGCATAGCGACCTCTTCCAGGCCTTGCTGG | AC    c.120
 R  W  A  P  P  L  L  T  V  L  H  S  D  L  F  Q  A  L  L  D |       p.40

          .         .         .          | 04        .         .    g.16832
 ATCCTGGACTATTATGAGGCTTCCCTCTCAGAGAGTCAG | AAATACCGCTACCAAGATGAA    c.180
 I  L  D  Y  Y  E  A  S  L  S  E  S  Q   | K  Y  R  Y  Q  D  E      p.60

          .         .         .         .      | 05  .         .    g.20813
 GACACGCCCCCTCTGGAGCACAGCCCGGCCCACCTCCCCAACCAG | GCCAATTCTCCCCCA    c.240
 D  T  P  P  L  E  H  S  P  A  H  L  P  N  Q   | A  N  S  P  P      p.80

          .         .         .          | 06        .         .    g.21004
 GTGATTGTCAACACAGATACCCTAGAAGCCCCAGGATAT | GAGTTGCAGGTGAACGGGACC    c.300
 V  I  V  N  T  D  T  L  E  A  P  G  Y   | E  L  Q  V  N  G  T      p.100

          .         .         .          | 07        .         .    g.21255
 GAGGGGGAGATGGAATACGAGGAAATCACATTGGAAAGG | GGTAACTCAGGTCTGGGCTTC    c.360
 E  G  E  M  E  Y  E  E  I  T  L  E  R   | G  N  S  G  L  G  F      p.120

          .         .         .         .         .         .       g.21315
 AGCATCGCAGGTGGCACTGACAACCCACACATCGGTGACGACCCATCCATTTTCATCACC       c.420
 S  I  A  G  G  T  D  N  P  H  I  G  D  D  P  S  I  F  I  T         p.140

          .         .         .         .     | 08   .         .    g.21473
 AAGATCATTCCTGGTGGGGCTGCGGCCCAGGATGGCCGCCTCAG | GGTCAACGACAGCATC    c.480
 K  I  I  P  G  G  A  A  A  Q  D  G  R  L  R  |  V  N  D  S  I      p.160

          .         .         .         .         .         .       g.21533
 CTGTTTGTAAATGAAGTGGACGTGCGCGAGGTGACCCACTCAGCGGCGGTGGAAGCCCTC       c.540
 L  F  V  N  E  V  D  V  R  E  V  T  H  S  A  A  V  E  A  L         p.180

          .         .         .         .         .         .       g.21593
 AAAGAGGCAGGCTCCATCGTTCGCCTCTATGTCATGCGCCGGAAGCCCCCGGCTGAGAAG       c.600
 K  E  A  G  S  I  V  R  L  Y  V  M  R  R  K  P  P  A  E  K         p.200

          .         .         .     | 09   .         .         .    g.21747
 GTCATGGAGATCAAGCTCATCAAGGGGCCTAAAG | GTCTTGGCTTCAGCATCGCAGGGGGC    c.660
 V  M  E  I  K  L  I  K  G  P  K  G |   L  G  F  S  I  A  G  G      p.220

          .         .         .         .         .         .       g.21807
 GTAGGGAACCAGCACATCCCAGGAGATAATAGCATCTATGTAACAAAGATCATCGAAGGG       c.720
 V  G  N  Q  H  I  P  G  D  N  S  I  Y  V  T  K  I  I  E  G         p.240

          .         .         .         .         .  | 10      .    g.22012
 GGTGCTGCCCACAAGGATGGGAGGTTGCAGATTGGAGACAAGATCCTGGCG | GTCAACAGT    c.780
 G  A  A  H  K  D  G  R  L  Q  I  G  D  K  I  L  A   | V  N  S      p.260

          .         .         .         .         .         .       g.22072
 GTGGGGCTAGAGGACGTCATGCATGAAGATGCTGTGGCAGCCCTGAAGAACACGTATGAT       c.840
 V  G  L  E  D  V  M  H  E  D  A  V  A  A  L  K  N  T  Y  D         p.280

          .         .         .         .         .         .       g.22132
 GTTGTCTACCTAAAGGTGGCCAAGCCCAGCAATGCCTACCTGAGTGACAGCTATGCTCCC       c.900
 V  V  Y  L  K  V  A  K  P  S  N  A  Y  L  S  D  S  Y  A  P         p.300

          .       | 11 .         .         .         .         .    g.28042
 CCAGACATCACAACCT | CTTATTCCCAGCACCTGGACAATGAGATCAGTCACAGCAGCTAC    c.960
 P  D  I  T  T  S |   Y  S  Q  H  L  D  N  E  I  S  H  S  S  Y      p.320

          .         .         .         .         .         .       g.28102
 CTGGGCACCGACTACCCCACAGCCATGACCCCCACTTCCCCTCGGCGCTACTCTCCAGTG       c.1020
 L  G  T  D  Y  P  T  A  M  T  P  T  S  P  R  R  Y  S  P  V         p.340

          .         .         .         .         .         .       g.28162
 GCCAAGGACCTGCTCGGGGAGGAAGACATTCCCCGAGAACCGAGGCGAATTGTGATCCAC       c.1080
 A  K  D  L  L  G  E  E  D  I  P  R  E  P  R  R  I  V  I  H         p.360

          .         .         .         .         .         .       g.28222
 CGGGGCTCCACGGGCCTGGGCTTCAACATCGTGGGTGGCGAGGACGGTGAAGGCATCTTC       c.1140
 R  G  S  T  G  L  G  F  N  I  V  G  G  E  D  G  E  G  I  F         p.380

          .         .         .         .         .         .       g.28282
 ATCTCCTTTATCCTGGCCGGGGGCCCTGCAGACCTCAGTGGGGAGCTGCGGAAGGGGGAC       c.1200
 I  S  F  I  L  A  G  G  P  A  D  L  S  G  E  L  R  K  G  D         p.400

          .   | 12     .         .         .         .         .    g.28523
 CAGATCCTGTCG | GTCAACGGTGTGGACCTCCGAAATGCCAGCCATGAGCAGGCTGCCATT    c.1260
 Q  I  L  S   | V  N  G  V  D  L  R  N  A  S  H  E  Q  A  A  I      p.420

          .         .         .         .         .      | 13  .    g.28721
 GCCCTGAAGAATGCGGGTCAGACGGTCACGATCATCGCTCAGTATAAACCAGAAG | AGTAC    c.1320
 A  L  K  N  A  G  Q  T  V  T  I  I  A  Q  Y  K  P  E  E |   Y      p.440

          .         .         .         .         .         .       g.28781
 AGCCGATTCGAGGCCAAGATCCACGACCTTCGGGAACAGCTCATGAACAGCAGCCTGGGC       c.1380
 S  R  F  E  A  K  I  H  D  L  R  E  Q  L  M  N  S  S  L  G         p.460

          .         .         .         .         . | 14       .    g.30565
 TCAGGGACTGCGTCCCTGCGGAGCAACCCCAAAAGGGGTTTCTACATCAG | GGCCCTGTTT    c.1440
 S  G  T  A  S  L  R  S  N  P  K  R  G  F  Y  I  R  |  A  L  F      p.480

          .         .         .         .         .         .       g.30625
 GATTACGACAAGACCAAGGACTGCGGCTTCCTGAGCCAGGCCCTGAGCTTCCGCTTTGGG       c.1500
 D  Y  D  K  T  K  D  C  G  F  L  S  Q  A  L  S  F  R  F  G         p.500

          .         .         .         .         .         .       g.30685
 GATGTGCTGCATGTCATCGATGCTAGTGATGAGGAGTGGTGGCAGGCACGGCGGGTCCAC       c.1560
 D  V  L  H  V  I  D  A  S  D  E  E  W  W  Q  A  R  R  V  H         p.520

          .         .         .         .        | 15.         .    g.31063
 TCTGACAGTGAGACCGACGACATTGGGTTCATCCCCAGCAAACGGCG | GGTTGAGCGACGA    c.1620
 S  D  S  E  T  D  D  I  G  F  I  P  S  K  R  R  |  V  E  R  R      p.540

          .         .     | 16   .         .         .   | 17     . g.31344
 GAGTGGTCAAGGTTAAAGGCCAAG | GACTGGGGCTCCAGCTCTGGATCGCAGG | GTCGAGAA c.1680
 E  W  S  R  L  K  A  K   | D  W  G  S  S  S  G  S  Q  G |   R  E   p.560

          .         .         .         . | 18       .         .    g.31486
 GACTCGGTTCTGAGCTACGAGACAGTGACGCAGATGGAAG | TGCACTATGCTCGCCCCATC    c.1740
 D  S  V  L  S  Y  E  T  V  T  Q  M  E  V |   H  Y  A  R  P  I      p.580

          .         .         .         .         .         .       g.31546
 ATCATCCTTGGGCCCACCAAGGACCGCGCCAACGATGATCTTCTCTCCGAGTTCCCCGAC       c.1800
 I  I  L  G  P  T  K  D  R  A  N  D  D  L  L  S  E  F  P  D         p.600

          .         .   | 19     .         .         .         .    g.31971
 AAGTTTGGATCCTGTGTTCCCC | ATACGACACGGCCCAAGCGGGAGTATGAGATAGATGGC    c.1860
 K  F  G  S  C  V  P  H |   T  T  R  P  K  R  E  Y  E  I  D  G      p.620

          .         .         .         .         .         .       g.32031
 CGGGATTACCACTTTGTGTCGTCCCGGGAGAAAATGGAGAAGGACATTCAGGCGCACAAG       c.1920
 R  D  Y  H  F  V  S  S  R  E  K  M  E  K  D  I  Q  A  H  K         p.640

          .         .         .         .         .         .       g.32091
 TTCATTGAGGCCGGCCAGTACAACAGCCACCTCTATGGGACCAGCGTCCAGTCCGTGCGA       c.1980
 F  I  E  A  G  Q  Y  N  S  H  L  Y  G  T  S  V  Q  S  V  R         p.660

          .      | 20  .         .         .         .         .    g.33093
 GAGGTGGCAGAGCAG | GGGAAGCACTGCATCCTCGATGTCTCGGCCAATGCCGTGCGGCGG    c.2040
 E  V  A  E  Q   | G  K  H  C  I  L  D  V  S  A  N  A  V  R  R      p.680

          .         .         .         .         .         .       g.33153
 CTGCAGGCGGCCCACCTGCACCCCATCGCCATCTTCATCCGCCCCCGCTCCCTGGAGAAT       c.2100
 L  Q  A  A  H  L  H  P  I  A  I  F  I  R  P  R  S  L  E  N         p.700

       | 21  .         .         .         .         .         .    g.33747
 GTGCT | AGAGATTAACAAGCGGATCACAGAGGAGCAAGCCCGCAAAGCCTTCGACAGAGCC    c.2160
 V  L  |  E  I  N  K  R  I  T  E  E  Q  A  R  K  A  F  D  R  A      p.720

          .         .         .        | 22.         .         .    g.34259
 ACCAAGCTGGAGCAGGAGTTCACAGAGTGCTTCTCAG | CCATCGTGGAGGGTGACAGCTTT    c.2220
 T  K  L  E  Q  E  F  T  E  C  F  S  A |   I  V  E  G  D  S  F      p.740

          .         .         .         .         .         .       g.34319
 GAGGAGATCTACCACAAGGTGAAGCGTGTCATCGAGGACCTCTCAGGCCCCTACATCTGG       c.2280
 E  E  I  Y  H  K  V  K  R  V  I  E  D  L  S  G  P  Y  I  W         p.760

          .         .                                               g.34343
 GTTCCAGCCCGAGAGAGACTCTGA                                           c.2304
 V  P  A  R  E  R  L  X                                             p.767

          .         .         .         .         .         .       g.34403
 ttcctgccctggcttggcctggactcgccctgcctccatcacctgggcccttggtctgga       c.*60

          .         .         .         .         .         .       g.34463
 ctgaattgcccaagcccttggctccccccggcctccctcccaccccttcttatttatttc       c.*120

          .         .         .         .         .         .       g.34523
 ctttctaactggatccagcctgttggaggggggacactcctctgcatgtatccccgcacc       c.*180

          .         .         .         .         .         .       g.34583
 ccagaactgggctcctgaacgccaggaacctggggtctgggggggagctgggctccttgt       c.*240

          .         .         .         .         .         .       g.34643
 tccgagcccttgctccttaggatccccgcccccacctgcccccaatgcacacacagaccc       c.*300

          .         .         .         .         .         .       g.34703
 accgggggccacctgccctcccccatcctctcccacacacattccagaagtcagggcccc       c.*360

          .         .         .         .         .         .       g.34763
 ctcgaggagcacccgctgcagggatgcagggccacaggcctccgctctctcctaaggcag       c.*420

          .         .         .         .         .         .       g.34823
 ggtctggggtcacccctgccctcatcgtaattccccatgttccttgatttctcatttatt       c.*480

          .         .         .         .         .         .       g.34883
 ttttccactttttttcttctcaaaggtggttttttggggggagaagcaggggactccgca       c.*540

          .         .         .         .         .         .       g.34943
 gcgggcccctgccttccacatgcccccaccatttttctttgccggtttgcatgagtggaa       c.*600

          .         .         .         .         .         .       g.35003
 ggtctaaatgtggcttttttttttttttttcctgggaatttttttggggaaaagggaggg       c.*660

          .         .         .         .         .         .       g.35063
 atgggtctagggagtgggaaatgcgggagggagggtggggggcaggggtcgggggtcggg       c.*720

          .         .         .         .         .         .       g.35123
 tgtccgggagccagggaagactggaaatgctgccgccttctgcaatttatttattttttt       c.*780

          .         .         .                                     g.35161
 cttttgagagagtgaaaggaagagacagatacttgaaa                             c.*818

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Discs, large homolog 4 (Drosophila) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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