delta-like 1 homolog (Drosophila) (DLK1) - coding DNA reference sequence

(used for variant description)

(last modified December 28, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_003836.5 in the DLK1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016863.1, covering DLK1 transcript NM_003836.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5024
                                     gaaaagggcggcgcgcgcggcggc       c.-181

 .         .         .         .         .         .                g.5084
 ggcggcagctccccggcagcggcggtggagagcgcagcgcgcagcccggtgcagccctgg       c.-121

 .         .         .         .         .         .                g.5144
 ctttcccctcgctgcgcgcccgcgccccctttcgcgtccgcaaccagaagcccagtgcgg       c.-61

 .         .         .         .         .         .                g.5204
 cgccaggagccggacccgcgcccgcaccgctcccgggaccgcgaccccggccgcccagag       c.-1

          .         .         .         .         .         .       g.5264
 ATGACCGCGACCGAAGCCCTCCTGCGCGTCCTCTTGCTCCTGCTGGCTTTCGGCCACAGC       c.60
 M  T  A  T  E  A  L  L  R  V  L  L  L  L  L  A  F  G  H  S         p.20

         | 02.         .         .         .         .         .    g.6584
 ACCTATG | GGGCTGAATGCTTCCCGGCCTGCAACCCCCAAAATGGATTCTGCGAGGATGAC    c.120
 T  Y  G |   A  E  C  F  P  A  C  N  P  Q  N  G  F  C  E  D  D      p.40

          .  | 03      .         .         .         .         .    g.7120
 AATGTTTGCAG | GTGCCAGCCTGGCTGGCAGGGTCCCCTTTGTGACCAGTGCGTGACCTCT    c.180
 N  V  C  R  |  C  Q  P  G  W  Q  G  P  L  C  D  Q  C  V  T  S      p.60

          .         .         .         .         .         .       g.7180
 CCCGGCTGCCTTCACGGACTCTGTGGAGAACCCGGGCAGTGCATTTGCACCGACGGCTGG       c.240
 P  G  C  L  H  G  L  C  G  E  P  G  Q  C  I  C  T  D  G  W         p.80

          .         .   | 04     .         .         .         .    g.10215
 GACGGGGAGCTCTGTGATAGAG | ATGTTCGGGCCTGCTCCTCGGCCCCCTGTGCCAACAAC    c.300
 D  G  E  L  C  D  R  D |   V  R  A  C  S  S  A  P  C  A  N  N      p.100

          .         .         .         .         .         .       g.10275
 GGGACCTGCGTGAGCCTGGACGATGGCCTCTATGAATGCTCCTGTGCCCCCGGGTACTCG       c.360
 G  T  C  V  S  L  D  D  G  L  Y  E  C  S  C  A  P  G  Y  S         p.120

          .         .         .         .     | 05   .         .    g.12300
 GGAAAGGACTGCCAGAAAAAGGACGGGCCCTGTGTGATCAACGG | CTCCCCCTGCCAGCAC    c.420
 G  K  D  C  Q  K  K  D  G  P  C  V  I  N  G  |  S  P  C  Q  H      p.140

          .         .         .         .         .         .       g.12360
 GGAGGCACCTGCGTGGATGATGAGGGCCGGGCCTCCCATGCCTCCTGCCTGTGCCCCCCT       c.480
 G  G  T  C  V  D  D  E  G  R  A  S  H  A  S  C  L  C  P  P         p.160

          .         .         .         .         .         .       g.12420
 GGCTTCTCAGGCAATTTCTGCGAGATCGTGGCCAACAGCTGCACCCCCAACCCATGCGAG       c.540
 G  F  S  G  N  F  C  E  I  V  A  N  S  C  T  P  N  P  C  E         p.180

          .         .         .         .         .         .       g.12480
 AACGACGGCGTCTGCACTGACATTGGGGGCGACTTCCGCTGCCGGTGCCCAGCCGGCTTC       c.600
 N  D  G  V  C  T  D  I  G  G  D  F  R  C  R  C  P  A  G  F         p.200

          .         .         .         .         .         .       g.12540
 ATCGACAAGACCTGCAGCCGCCCGGTGACCAACTGCGCCAGCAGCCCGTGCCAGAACGGG       c.660
 I  D  K  T  C  S  R  P  V  T  N  C  A  S  S  P  C  Q  N  G         p.220

          .         .         .         .         .         .       g.12600
 GGCACCTGCCTGCAGCACACCCAGGTGAGCTACGAGTGTCTGTGCAAGCCCGAGTTCACA       c.720
 G  T  C  L  Q  H  T  Q  V  S  Y  E  C  L  C  K  P  E  F  T         p.240

          .         .         .         .         .         .       g.12660
 GGTCTCACCTGTGTCAAGAAGCGCGCGCTGAGCCCCCAGCAGGTCACCCGTCTGCCCAGC       c.780
 G  L  T  C  V  K  K  R  A  L  S  P  Q  Q  V  T  R  L  P  S         p.260

          .         .         .         .         .         .       g.12720
 GGCTATGGGCTGGCCTACCGCCTGACCCCTGGGGTGCACGAGCTGCCGGTGCAGCAGCCG       c.840
 G  Y  G  L  A  Y  R  L  T  P  G  V  H  E  L  P  V  Q  Q  P         p.280

          .         .         .         .         .         .       g.12780
 GAGCACCGCATCCTGAAGGTGTCCATGAAAGAGCTCAACAAGAAAACCCCTCTCCTCACC       c.900
 E  H  R  I  L  K  V  S  M  K  E  L  N  K  K  T  P  L  L  T         p.300

          .         .         .         .         .         .       g.12840
 GAGGGCCAGGCCATCTGCTTCACCATCCTGGGCGTGCTCACCAGCCTGGTGGTGCTGGGC       c.960
 E  G  Q  A  I  C  F  T  I  L  G  V  L  T  S  L  V  V  L  G         p.320

          .         .         .         .         .         .       g.12900
 ACTGTGGGTATCGTCTTCCTCAACAAGTGCGAGACCTGGGTGTCCAACCTGCGCTACAAC       c.1020
 T  V  G  I  V  F  L  N  K  C  E  T  W  V  S  N  L  R  Y  N         p.340

          .         .         .         .         .         .       g.12960
 CACATGCTGCGGAAGAAGAAGAACCTGCTGCTTCAGTACAACAGCGGGGAGGACCTGGCC       c.1080
 H  M  L  R  K  K  K  N  L  L  L  Q  Y  N  S  G  E  D  L  A         p.360

          .         .         .         .         .         .       g.13020
 GTCAACATCATCTTCCCCGAGAAGATCGACATGACCACCTTCAGCAAGGAGGCCGGCGAC       c.1140
 V  N  I  I  F  P  E  K  I  D  M  T  T  F  S  K  E  A  G  D         p.380

          .                                                         g.13032
 GAGGAGATCTAA                                                       c.1152
 E  E  I  X                                                         p.383

          .         .         .         .         .         .       g.13092
 gcagcgttcccacagccccctctagattcttggagttccgcagagcttactatacgcggt       c.*60

          .         .         .         .         .         .       g.13152
 ctgtcctaatctttgtggtgttcgctatctcttgtgtcaaatctggtgaacgctacgctt       c.*120

          .         .         .         .         .         .       g.13212
 acatatattgtctttgtgctgctgtgtgacaaacgcaatgcaaaaacaatcctctttctc       c.*180

          .         .         .         .         .                 g.13266
 tctcttaatgcatgatacagaataataataagaatttcatctttaaatgagtaa             c.*234

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Delta-like 1 homolog (Drosophila) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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