dentin matrix acidic phosphoprotein 1 (DMP1) - coding DNA reference sequence

(used for variant description)

(last modified February 1, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_004407.3 in the DMP1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000004.11, covering DMP1 transcript NM_004407.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5044
                 ttcattgggcatagatttcctctttgagaacatcaacctgattt       c.-61

 .         .         .         .         | 02         .             g.11191
 ttgagactttttgaaaaaattctttgtgaactacggagg | gtagaggtatcacacccaact    c.-1

          .         .         .         .         .     | 03   .    g.11736
 ATGAAGATCAGCATCCTGCTCATGTTCCTTTGGGGATTATCCTGTGCTCTCCCA | GTAACC    c.60
 M  K  I  S  I  L  L  M  F  L  W  G  L  S  C  A  L  P   | V  T      p.20

          .         .         .         .   | 04     .         .    g.13936
 AGGTATCAAAATAATGAATCTGAGGATTCTGAAGAATGGAAG | GGTCATTTGGCTCAGGCA    c.120
 R  Y  Q  N  N  E  S  E  D  S  E  E  W  K   | G  H  L  A  Q  A      p.40

          .      | 05  .         .         .         .         .    g.14174
 CCAACACCACCCTTG | GAGAGCAGTGAGTCATCAGAAGGCAGTAAAGTTAGCTCAGAGGAA    c.180
 P  T  P  P  L   | E  S  S  E  S  S  E  G  S  K  V  S  S  E  E      p.60

     | 06    .         .         .         .         .         .    g.16717
 CAG | GCAAATGAAGACCCCAGTGACAGCACTCAGTCAGAGGAGGGCCTGGGCTCTGATGAT    c.240
 Q   | A  N  E  D  P  S  D  S  T  Q  S  E  E  G  L  G  S  D  D      p.80

          .         .         .         .         .         .       g.16777
 CATCAATACATTTATAGGCTAGCTGGTGGCTTCTCCAGGAGCACAGGAAAAGGAGGAGAT       c.300
 H  Q  Y  I  Y  R  L  A  G  G  F  S  R  S  T  G  K  G  G  D         p.100

          .         .         .         .         .         .       g.16837
 GATAAAGATGACGATGAAGATGACAGTGGAGATGACACCTTTGGTGACGATGACAGTGGC       c.360
 D  K  D  D  D  E  D  D  S  G  D  D  T  F  G  D  D  D  S  G         p.120

          .         .         .         .         .         .       g.16897
 CCAGGGCCCAAAGACAGACAAGAAGGAGGAAACTCCAGACTGGGAAGTGATGAGGACTCT       c.420
 P  G  P  K  D  R  Q  E  G  G  N  S  R  L  G  S  D  E  D  S         p.140

          .         .         .         .         .         .       g.16957
 GATGACACCATACAAGCCAGTGAAGAGAGTGCCCCACAAGGGCAAGACAGTGCCCAAGAT       c.480
 D  D  T  I  Q  A  S  E  E  S  A  P  Q  G  Q  D  S  A  Q  D         p.160

          .         .         .         .         .         .       g.17017
 ACCACCAGTGAGAGCAGGGAACTTGACAATGAGGACCGGGTGGACAGCAAGCCTGAGGGA       c.540
 T  T  S  E  S  R  E  L  D  N  E  D  R  V  D  S  K  P  E  G         p.180

          .         .         .         .         .         .       g.17077
 GGTGACTCCACTCAAGAGAGTGAGAGTGAAGAGCACTGGGTGGGAGGTGGCAGTGATGGG       c.600
 G  D  S  T  Q  E  S  E  S  E  E  H  W  V  G  G  G  S  D  G         p.200

          .         .         .         .         .         .       g.17137
 GAGAGCAGCCATGGAGACGGCTCCGAGTTGGACGATGAGGGAATGCAGAGTGATGACCCA       c.660
 E  S  S  H  G  D  G  S  E  L  D  D  E  G  M  Q  S  D  D  P         p.220

          .         .         .         .         .         .       g.17197
 GAGAGCATCAGGAGTGAAAGGGGAAACTCCAGAATGAACAGTGCAGGCATGAAATCAAAA       c.720
 E  S  I  R  S  E  R  G  N  S  R  M  N  S  A  G  M  K  S  K         p.240

          .         .         .         .         .         .       g.17257
 GAATCTGGAGAAAACAGTGAGCAAGCAAACACTCAAGATTCAGGTGGCAGCCAATTGCTG       c.780
 E  S  G  E  N  S  E  Q  A  N  T  Q  D  S  G  G  S  Q  L  L         p.260

          .         .         .         .         .         .       g.17317
 GAGCATCCCAGTAGGAAAATTTTTAGGAAGTCTCGCATCTCAGAGGAAGATGACAGAAGC       c.840
 E  H  P  S  R  K  I  F  R  K  S  R  I  S  E  E  D  D  R  S         p.280

          .         .         .         .         .         .       g.17377
 GAGCTTGATGACAACAACACAATGGAAGAAGTCAAGAGTGACTCTACAGAAAACAGCAAC       c.900
 E  L  D  D  N  N  T  M  E  E  V  K  S  D  S  T  E  N  S  N         p.300

          .         .         .         .         .         .       g.17437
 TCCAGAGACACTGGCCTCAGCCAACCCAGGAGAGACAGCAAGGGTGACTCTCAAGAAGAC       c.960
 S  R  D  T  G  L  S  Q  P  R  R  D  S  K  G  D  S  Q  E  D         p.320

          .         .         .         .         .         .       g.17497
 AGCAAGGAGAATCTGTCCCAGGAAGAGAGCCAAAACGTAGATGGTCCCAGCAGTGAGTCC       c.1020
 S  K  E  N  L  S  Q  E  E  S  Q  N  V  D  G  P  S  S  E  S         p.340

          .         .         .         .         .         .       g.17557
 AGCCAAGAGGCCAACCTGTCATCTCAAGAGAACAGCAGTGAGTCTCAGGAAGAGGTGGTG       c.1080
 S  Q  E  A  N  L  S  S  Q  E  N  S  S  E  S  Q  E  E  V  V         p.360

          .         .         .         .         .         .       g.17617
 AGTGAGTCCAGGGGAGATAACCCCGACCCCACAACTAGTTATGTAGAAGACCAGGAAGAC       c.1140
 S  E  S  R  G  D  N  P  D  P  T  T  S  Y  V  E  D  Q  E  D         p.380

          .         .         .         .         .         .       g.17677
 AGTGACTCCAGCGAGGAGGACAGCTCGCACACACTCTCCCACTCAAAAAGTGAATCCAGA       c.1200
 S  D  S  S  E  E  D  S  S  H  T  L  S  H  S  K  S  E  S  R         p.400

          .         .         .         .         .         .       g.17737
 GAGGAGCAAGCAGACAGCGAATCCAGTGAGAGCCTCAACTTCTCAGAGGAAAGCCCGGAG       c.1260
 E  E  Q  A  D  S  E  S  S  E  S  L  N  F  S  E  E  S  P  E         p.420

          .         .         .         .         .         .       g.17797
 TCCCCTGAGGATGAGAACAGCTCCAGCCAGGAGGGCCTCCAGTCTCACAGCAGCTCAGCA       c.1320
 S  P  E  D  E  N  S  S  S  Q  E  G  L  Q  S  H  S  S  S  A         p.440

          .         .         .         .         .         .       g.17857
 GAGAGTCAGAGCGAGGAAAGCCATTCTGAGGAAGACGACAGTGACTCTCAAGACAGCAGC       c.1380
 E  S  Q  S  E  E  S  H  S  E  E  D  D  S  D  S  Q  D  S  S         p.460

          .         .         .         .         .         .       g.17917
 AGATCCAAAGAAGATAGCAACTCCACGGAGAGCAAATCAAGCAGTGAGGAAGATGGCCAG       c.1440
 R  S  K  E  D  S  N  S  T  E  S  K  S  S  S  E  E  D  G  Q         p.480

          .         .         .         .         .         .       g.17977
 TTGAAAAACATTGAGATAGAGAGCCGGAAATTAACAGTTGATGCCTATCACAACAAACCC       c.1500
 L  K  N  I  E  I  E  S  R  K  L  T  V  D  A  Y  H  N  K  P         p.500

          .         .         .         .                           g.18019
 ATTGGGGACCAAGATGACAATGACTGCCAAGACGGCTATTAG                         c.1542
 I  G  D  Q  D  D  N  D  C  Q  D  G  Y  X                           p.513

          .         .         .         .         .         .       g.18079
 catcagctgtcctaagaagcagttgtcacataaaggagtcttagggacttgaaaatgtat       c.*60

          .         .         .         .         .         .       g.18139
 catgataactataatttattgatgttttgatcaaaagaataaccagatgccatatttttc       c.*120

          .         .         .         .         .         .       g.18199
 ctgaaaggaattgctggacattacacttgtttttagggtgtcatcatttcacagaggttt       c.*180

          .         .         .         .         .         .       g.18259
 aaatactgtggagtgacaccagaacacagccaaagaggctagaagcaagaaaggatctgc       c.*240

          .         .         .         .         .         .       g.18319
 atgataactttgcagctgagatagttcctaattcatcaacgtaacaaacaaagctattgg       c.*300

          .         .         .         .         .         .       g.18379
 gtgtccatgatataccaggcactatgctaggtgttgagaatgtaaagcaggttaagactt       c.*360

          .         .         .         .         .         .       g.18439
 gtttcttgctcctgaggagcgtatagaaggacccacaaagctacagagttaaagagggat       c.*420

          .         .         .         .         .         .       g.18499
 atgtataagagaaacaagaattgttacaacccagtatggtgagtgccaagacagagagct       c.*480

          .         .         .         .         .         .       g.18559
 atgaacacgatatctatctgggaacactgagaagggtgaccaatgcgttggagaacgagg       c.*540

          .         .         .         .         .         .       g.18619
 gagggcttcatagcagaagacattggagttggaaggttgcatagggtttcctcattggag       c.*600

          .         .         .         .         .         .       g.18679
 accgggaaattctattcttgggataaataatagtaaattctataggattcaatacttagt       c.*660

          .         .         .         .         .         .       g.18739
 ttgcaaaagcactttgaaattatggcacagtgagttgttttggataagaaaatctttttc       c.*720

          .         .         .         .         .         .       g.18799
 tcccaattaatttaccaattcatcatttttttttttttgtagaactcccataaacatcac       c.*780

          .         .         .         .         .         .       g.18859
 cttactaatcactggtgatgataagaaggattgggtcaggaagagtgggagaaagaaatt       c.*840

          .         .         .         .         .         .       g.18919
 cctctttacgtagatactttttagctttattttttctaaaatcagtttgcgtgcaatgct       c.*900

          .         .         .         .         .         .       g.18979
 agaaaaaaactgttctctgagtcctttacagagcaaaattctgtatgtaagattcaattg       c.*960

          .         .         .         .         .         .       g.19039
 atttttgacaaataccatttgaaatattacctcaacataaaatacttgttttgtaataaa       c.*1020

          .         .                                               g.19060
 gattataatacccagaagaaa                                              c.*1041

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Dentin matrix acidic phosphoprotein 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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