dynein, axonemal, intermediate chain 1 (DNAI1) - coding DNA reference sequence

(used for variant description)

(last modified October 23, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_012144.3 in the DNAI1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008127.1, covering DNAI1 transcript NM_012144.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.4953
                                               tcctttccgggccg       c.-241

 .         .         .         .         .         .                g.5013
 gctgggcgcgccgaagcgcctgcgccttggctgctggtcggttgctgggtaaccgcgtca       c.-181

 .         .         .         .         .         .                g.5073
 gggagttggattctatcctgcaagggcacggggacccacaacgacggctgtccctaaaga       c.-121

 .         .         .         .         .         .                g.5133
 accgttgcgactggtaactgaagtggaagagagtccagatttcttgtgtgtggtcaagga       c.-61

 .         .         .         .         .         .                g.5193
 gacggacaaactttttgtcttcagacgagggagcgttttgtaggctctccaggggttgag       c.-1

          .         .         .         .         | 02         .    g.29647
 ATGATTCCTGCTTCTGCGAAGGCTCCCCATAAACAGCCTCATAAGCAG | AGCATCAGCATA    c.60
 M  I  P  A  S  A  K  A  P  H  K  Q  P  H  K  Q   | S  I  S  I      p.20

          .         .  | 03      .         .         .         .    g.31368
 GGCAGAGGAACCAGGAAGAGA | GATGAAGATTCAGGGACTGAAGTGGGAGAAGGCACAGAT    c.120
 G  R  G  T  R  K  R   | D  E  D  S  G  T  E  V  G  E  G  T  D      p.40

          .         .         .         .         .         .       g.31428
 GAATGGGCCCAATCCAAAGCCACAGTTAGACCCCCTGACCAGCTGGAGTTGACCGATGCG       c.180
 E  W  A  Q  S  K  A  T  V  R  P  P  D  Q  L  E  L  T  D  A         p.60

  | 04       .         .         .         .         .         .    g.31684
  | GAGTTAAAGGAGGAGTTCACTCGGATTTTGACAGCCAACAACCCACACGCACCCCAGAAC    c.240
  | E  L  K  E  E  F  T  R  I  L  T  A  N  N  P  H  A  P  Q  N      p.80

          .         .  | 05      .         .         .         .    g.35549
 ATTGTCAGGTACAGCTTCAAA | GAAGGCACATATAAGCCTATTGGCTTTGTGAACCAACTG    c.300
 I  V  R  Y  S  F  K   | E  G  T  Y  K  P  I  G  F  V  N  Q  L      p.100

          .         .         .         .         .         .       g.35609
 GCAGTTCACTACACCCAGGTTGGGAACCTGATCCCCAAAGACTCAGATGAAGGACGGCGG       c.360
 A  V  H  Y  T  Q  V  G  N  L  I  P  K  D  S  D  E  G  R  R         p.120

          .         .         | 06         .         .         .    g.36231
 CAGCATTACCGCGATGAATTAGTGGCAG | GTTCTCAGGAGTCTGTCAAGGTGATTTCAGAA    c.420
 Q  H  Y  R  D  E  L  V  A  G |   S  Q  E  S  V  K  V  I  S  E      p.140

          .         .         .         .         .         .       g.36291
 ACAGGAAACCTCGAAGAAGACGAAGAGCCCAAGGAGTTAGAAACTGAGCCTGGGAGTCAA       c.480
 T  G  N  L  E  E  D  E  E  P  K  E  L  E  T  E  P  G  S  Q         p.160

          .         .  | 07      .         .         .         .    g.36595
 ACAGATGTGCCTGCAGCTGGG | GCAGCTGAAAAAGTGACTGAAGAAGAATTGATGACTCCT    c.540
 T  D  V  P  A  A  G   | A  A  E  K  V  T  E  E  E  L  M  T  P      p.180

          .         .         .         .         .         .       g.36655
 AAGCAGCCCAAGGAGAGAAAGCTCACTAACCAGTTCAACTTCAGTGAGAGGGCCTCACAG       c.600
 K  Q  P  K  E  R  K  L  T  N  Q  F  N  F  S  E  R  A  S  Q         p.200

          .         .  | 08      .         .         .         .    g.37721
 ACCTACAACAACCCTGTCCGG | GATCGAGAATGCCAGACGGAGCCTCCTCCCAGGACAAAC    c.660
 T  Y  N  N  P  V  R   | D  R  E  C  Q  T  E  P  P  P  R  T  N      p.220

          .         .  | 09      .         .         .         .    g.39420
 TTTTCAGCCACAGCCAATCAG | TGGGAGATCTATGATGCCTATGTAGAGGAACTTGAGAAG    c.720
 F  S  A  T  A  N  Q   | W  E  I  Y  D  A  Y  V  E  E  L  E  K      p.240

          .         .         .         .         .         .       g.39480
 CAGGAAAAGACCAAAGAGAAGGAGAAGGCAAAGACCCCAGTGGCTAAAAAATCAGGGAAG       c.780
 Q  E  K  T  K  E  K  E  K  A  K  T  P  V  A  K  K  S  G  K         p.260

          .         .         .       | 10 .         .         .    g.43326
 ATGGCCATGAGGAAGCTGACATCTATGGAGTCTCAG | ACTGATGATCTCATCAAATTGTCC    c.840
 M  A  M  R  K  L  T  S  M  E  S  Q   | T  D  D  L  I  K  L  S      p.280

          .         .         .         .         .         .       g.43386
 CAAGCTGCTAAGATCATGGAGCGGATGGTCAACCAGAATACATATGATGACATTGCTCAA       c.900
 Q  A  A  K  I  M  E  R  M  V  N  Q  N  T  Y  D  D  I  A  Q         p.300

   | 11      .         .         .         .         .         .    g.46968
 G | ATTTTAAGTACTATGACGATGCTGCTGATGAATACCGGGACCAGGTGGGTACCCTGCTG    c.960
 D |   F  K  Y  Y  D  D  A  A  D  E  Y  R  D  Q  V  G  T  L  L      p.320

          .         .         .         .         .          | 12    g.47326
 CCGCTCTGGAAGTTCCAAAATGACAAAGCCAAGCGCCTGTCCGTCACTGCCCTCTGCTG | G    c.1020
 P  L  W  K  F  Q  N  D  K  A  K  R  L  S  V  T  A  L  C  W  |      p.340

          .         .         .         .    | 13    .         .    g.52831
 AATCCAAAGTACAGGGATCTGTTTGCAGTGGGATATGGCTCTT | ATGACTTCATGAAGCAG    c.1080
 N  P  K  Y  R  D  L  F  A  V  G  Y  G  S  Y |   D  F  M  K  Q      p.360

          .         .         .         .         .         .       g.52891
 AGCCGGGGCATGCTGCTGCTCTACAGCCTGAAGAACCCCAGCTTCCCTGAGTACATGTTC       c.1140
 S  R  G  M  L  L  L  Y  S  L  K  N  P  S  F  P  E  Y  M  F         p.380

          .         .         .         .         .         .       g.52951
 AGCAGCAACAGCGGCGTCATGTGTCTCGACATCCACGTGGACCACCCCTACCTGGTGGCA       c.1200
 S  S  N  S  G  V  M  C  L  D  I  H  V  D  H  P  Y  L  V  A         p.400

          .         .         .         .         .         .       g.53011
 GTAGGCCACTATGACGGCAACGTGGCCATTTACAACCTCAAGAAGCCCCACTCCCAGCCC       c.1260
 V  G  H  Y  D  G  N  V  A  I  Y  N  L  K  K  P  H  S  Q  P         p.420

          .         .         .         .         .  | 14      .    g.58305
 TCCTTCTGCAGCTCAGCCAAGTCTGGCAAGCACTCAGACCCTGTGTGGCAG | GTCAAGTGG    c.1320
 S  F  C  S  S  A  K  S  G  K  H  S  D  P  V  W  Q   | V  K  W      p.440

          .         .         .         .         .         .       g.58365
 CAGAAGGATGACATGGACCAAAACCTTAACTTCTTCTCTGTGTCATCTGACGGCAGGATT       c.1380
 Q  K  D  D  M  D  Q  N  L  N  F  F  S  V  S  S  D  G  R  I         p.460

          .         .  | 15      .         .         .         .    g.58563
 GTGTCTTGGACTCTCGTGAAG | AGAAAGCTGGTTCACATAGATGTCATCAAGCTGAAGGTG    c.1440
 V  S  W  T  L  V  K   | R  K  L  V  H  I  D  V  I  K  L  K  V      p.480

          .         .         .         .          | 16        .    g.59310
 GAAGGCAGCACCACGGAAGTTCCTGAGGGGTTGCAGCTGCACCCAGTGG | GTTGTGGCACT    c.1500
 E  G  S  T  T  E  V  P  E  G  L  Q  L  H  P  V  G |   C  G  T      p.500

          .         .         .         .         .         .       g.59370
 GCCTTTGACTTCCACAAAGAGATTGACTACATGTTCCTAGTGGGCACAGAGGAGGGAAAA       c.1560
 A  F  D  F  H  K  E  I  D  Y  M  F  L  V  G  T  E  E  G  K         p.520

           | 17        .         .         .         .         .    g.60632
 ATCTACAAG | TGCTCTAAATCCTACTCCAGCCAATTCCTCGACACCTATGACGCCCACAAC    c.1620
 I  Y  K   | C  S  K  S  Y  S  S  Q  F  L  D  T  Y  D  A  H  N      p.540

          .         .         .         .         .         .       g.60692
 ATGTCAGTGGACACTGTGTCCTGGAACCCATACCACACCAAGGTCTTCATGTCCTGCAGC       c.1680
 M  S  V  D  T  V  S  W  N  P  Y  H  T  K  V  F  M  S  C  S         p.560

          .         .         .         | 18         .         .    g.60849
 TCCGACTGGACAGTGAAGATCTGGGACCACACCATCAA | GACCCCGATGTTCATCTATGAC    c.1740
 S  D  W  T  V  K  I  W  D  H  T  I  K  |  T  P  M  F  I  Y  D      p.580

          .         .         .         .         .         .       g.60909
 CTGAACTCAGCCGTGGGTGATGTGGCCTGGGCGCCATACTCTTCTACTGTGTTCGCAGCA       c.1800
 L  N  S  A  V  G  D  V  A  W  A  P  Y  S  S  T  V  F  A  A         p.600

          .         | 19         .         .         .         .    g.63514
 GTCACCACAGATGGGAAG | GCCCACATATTTGACTTAGCCATCAACAAGTATGAGGCCATC    c.1860
 V  T  T  D  G  K   | A  H  I  F  D  L  A  I  N  K  Y  E  A  I      p.620

          .         .         .         .         .         .       g.63574
 TGCAACCAGCCTGTGGCGGCCAAAAAGAACAGGCTCACCCACGTGCAGTTCAATCTCATC       c.1920
 C  N  Q  P  V  A  A  K  K  N  R  L  T  H  V  Q  F  N  L  I         p.640

          .         .         .         .         .         .       g.63634
 CACCCCATCATCATTGTGGGCGATGACCGTGGGCACATCATCAGCCTCAAGCTCTCACCC       c.1980
 H  P  I  I  I  V  G  D  D  R  G  H  I  I  S  L  K  L  S  P         p.660

          .         .  | 20      .         .         .         .    g.66884
 AATTTGCGCAAGATGCCAAAG | GAAAAGAAGGGGCAGGAGGTGCAGAAGGGTCCAGCTGTG    c.2040
 N  L  R  K  M  P  K   | E  K  K  G  Q  E  V  Q  K  G  P  A  V      p.680

          .         .         .         .         .         .       g.66944
 GAGATTGCGAAACTGGACAAACTGCTGAACCTGGTGAGGGAAGTGAAAATCAAGACCTGA       c.2100
 E  I  A  K  L  D  K  L  L  N  L  V  R  E  V  K  I  K  T  X         p.699

          .         .         .         .         .         .       g.67004
 ggggctggcctcagtctctgtcccatcgcttgaatacagtactcctagggcttgaccctg       c.*60

          .         .         .         .         .         .       g.67064
 gtacccagcccagccttagcacccagcatgtgaccccactcctgatcaggtcccagcatc       c.*120

          .         .         .         .         .         .       g.67124
 ttcccttcttgttctgttccttaaggtcccagcaccttaccccaggacttggtcttcaac       c.*180

          .         .         .         .         .                 g.67177
 caccattacccctctaactttgcacaaataaacctgtgtagaaacccacccca              c.*233

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Dynein, axonemal, intermediate chain 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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