DnaJ (Hsp40) homolog, subfamily B, member 11 (DNAJB11) - coding DNA reference sequence

(used for variant description)

(last modified May 8, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_016306.4 in the DNAJB11 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_034024.1, covering DNAJB11 transcript NM_016306.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5040
                     ttggctctcgcctaccgggggcttctctcaccgggactcg       c.-181

 .         .         .         .         .         .                g.5100
 ggactcccgggaagtggaccggcagaagagggggctagctagctgtctctgcggaccaag       c.-121

 .         .         .         .         .         .                g.5160
 gagacccccgcgcccccccggtgtgaggcggcctcacagggccgggtgggctggcgagcc       c.-61

 .         .         .         .         .         .                g.5220
 gacgcggcggcggaggaggctgtgaggagtgtgtggaacaggacccgggacagaggaacc       c.-1

          .         .         .         .         .         .       g.5280
 ATGGCTCCGCAGAACCTGAGCACCTTTTGCCTGTTGCTGCTATACCTCATCGGGGCGGTG       c.60
 M  A  P  Q  N  L  S  T  F  C  L  L  L  L  Y  L  I  G  A  V         p.20

          | 02         .         .         .         .         .    g.6469
 ATTGCCGG | ACGAGATTTCTATAAGATCTTGGGGGTGCCTCGAAGTGCCTCTATAAAGGAT    c.120
 I  A  G  |  R  D  F  Y  K  I  L  G  V  P  R  S  A  S  I  K  D      p.40

          .         .         .         .         .         .       g.6529
 ATTAAAAAGGCCTATAGGAAACTAGCCCTGCAGCTTCATCCCGACCGGAACCCTGATGAT       c.180
 I  K  K  A  Y  R  K  L  A  L  Q  L  H  P  D  R  N  P  D  D         p.60

          .         .         .         .      | 03  .         .    g.10177
 CCACAAGCCCAGGAGAAATTCCAGGATCTGGGTGCTGCTTATGAG | GTTCTGTCAGATAGT    c.240
 P  Q  A  Q  E  K  F  Q  D  L  G  A  A  Y  E   | V  L  S  D  S      p.80

          .         .         .         .         .         .       g.10237
 GAGAAACGGAAACAGTACGATACTTATGGTGAAGAAGGATTAAAAGATGGTCATCAGAGC       c.300
 E  K  R  K  Q  Y  D  T  Y  G  E  E  G  L  K  D  G  H  Q  S         p.100

          .         .    | 04    .         .         .         .    g.12027
 TCCCATGGAGACATTTTTTCACA | CTTCTTTGGGGATTTTGGTTTCATGTTTGGAGGAACC    c.360
 S  H  G  D  I  F  S  H  |  F  F  G  D  F  G  F  M  F  G  G  T      p.120

          .         .         .         .         .         .       g.12087
 CCTCGTCAGCAAGACAGAAATATTCCAAGAGGAAGTGATATTATTGTAGATCTAGAAGTC       c.420
 P  R  Q  Q  D  R  N  I  P  R  G  S  D  I  I  V  D  L  E  V         p.140

          .         .         .       | 05 .         .         .    g.15717
 ACTTTGGAAGAAGTATATGCAGGAAATTTTGTGGAA | GTAGTTAGAAACAAACCTGTGGCA    c.480
 T  L  E  E  V  Y  A  G  N  F  V  E   | V  V  R  N  K  P  V  A      p.160

          .         .         .         .         .         .       g.15777
 AGGCAGGCTCCTGGCAAACGGAAGTGCAATTGTCGGCAAGAGATGCGGACCACCCAGCTG       c.540
 R  Q  A  P  G  K  R  K  C  N  C  R  Q  E  M  R  T  T  Q  L         p.180

          .         .         .         .         .          | 06    g.16318
 GGCCCTGGGCGCTTCCAAATGACCCAGGAGGTGGTCTGCGACGAATGCCCTAATGTCAA | A    c.600
 G  P  G  R  F  Q  M  T  Q  E  V  V  C  D  E  C  P  N  V  K  |      p.200

          .         .         .         .         .         .       g.16378
 CTAGTGAATGAAGAACGAACGCTGGAAGTAGAAATAGAGCCTGGGGTGAGAGACGGCATG       c.660
 L  V  N  E  E  R  T  L  E  V  E  I  E  P  G  V  R  D  G  M         p.220

          .         .   | 07     .         .         .         .    g.17076
 GAGTACCCCTTTATTGGAGAAG | GTGAGCCTCACGTGGATGGGGAGCCTGGAGATTTACGG    c.720
 E  Y  P  F  I  G  E  G |   E  P  H  V  D  G  E  P  G  D  L  R      p.240

          .         . | 08       .         .         .         .    g.18227
 TTCCGAATCAAAGTTGTCAA | GCACCCAATATTTGAAAGGAGAGGAGATGATTTGTACACA    c.780
 F  R  I  K  V  V  K  |  H  P  I  F  E  R  R  G  D  D  L  Y  T      p.260

          .         .         .         .         .         .       g.18287
 AATGTGACAATCTCATTAGTTGAGTCACTGGTTGGCTTTGAGATGGATATTACTCACTTG       c.840
 N  V  T  I  S  L  V  E  S  L  V  G  F  E  M  D  I  T  H  L         p.280

          .   | 09     .         .         .         .         .    g.18800
 GATGGTCACAAG | GTACATATTTCCCGGGATAAGATCACCAGGCCAGGAGCGAAGCTATGG    c.900
 D  G  H  K   | V  H  I  S  R  D  K  I  T  R  P  G  A  K  L  W      p.300

          .         .         .         .         .         .       g.18860
 AAGAAAGGGGAAGGGCTCCCCAACTTTGACAACAACAATATCAAGGGCTCTTTGATAATC       c.960
 K  K  G  E  G  L  P  N  F  D  N  N  N  I  K  G  S  L  I  I         p.320

          .         .         .         .         .   | 10     .    g.19674
 ACTTTTGATGTGGATTTTCCAAAAGAACAGTTAACAGAGGAAGCGAGAGAAG | GTATCAAA    c.1020
 T  F  D  V  D  F  P  K  E  Q  L  T  E  E  A  R  E  G |   I  K      p.340

          .         .         .         .         .                 g.19731
 CAGCTACTGAAACAAGGGTCAGTGCAGAAGGTATACAATGGACTGCAAGGATATTGA          c.1077
 Q  L  L  K  Q  G  S  V  Q  K  V  Y  N  G  L  Q  G  Y  X            p.358

          .         .         .         .         .         .       g.19791
 gagtgaataaaattggactttgtttaaaataagtgaataagcgatatttattatctgcaa       c.*60

          .         .         .         .         .         .       g.19851
 ggtttttttgtgtgtgtttttgtttttattttcaatatgcaagttaggcttaattttttt       c.*120

          .         .         .         .         .         .       g.19911
 atctaatgatcatcatgaaatgaataagagggcttaagaatttgtccatttgcattcgga       c.*180

          .         .         .         .         .         .       g.19971
 aaagaatgaccagcaaaaggtttactaatacctctccctttggggatttaatgtctggtg       c.*240

          .         .         .         .         .         .       g.20031
 ctgccgcctgagtttcaagaattaaagctgcaagaggactccaggagcaaaagaaacaca       c.*300

          .         .         .         .         .         .       g.20091
 atatagagggttggagttgttagcaatttcattcaaaatgccaactggagaagtctgttt       c.*360

          .         .         .                                     g.20123
 ttaaatacattttgttgttatttttttcatga                                   c.*392

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The DnaJ (Hsp40) homolog, subfamily B, member 11 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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