DnaJ (Hsp40) homolog, subfamily B, member 4 (DNAJB4) - coding DNA reference sequence

(used for variant description)

(last modified April 15, 2024)

This file was created to facilitate the description of sequence variants on transcript NM_007034.3 in the DNAJB4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000001.10, covering DNAJB4 transcript NM_007034.3.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                               .         .         .                g.5039
                      gagacgctgtctgcttgctgccttaagacagctagctga       c.-121

 .         .         .         .         .         .                g.5099
 attgctgattaacttttaaaatacccagcttggtttatttttcttagaatctgttgctaa       c.-61

 .         .         .         .         .         .                g.5159
 gactggggacgctgttttcttttacaaagggaaatctaagttaatttcaaggcattcgaa       c.-1

          .         .         .         .         .         .       g.5219
 ATGGGGAAAGACTATTATTGCATTTTGGGAATTGAGAAAGGAGCTTCAGATGAAGATATT       c.60
 M  G  K  D  Y  Y  C  I  L  G  I  E  K  G  A  S  D  E  D  I         p.20

          .         .         .         .         .         .       g.5279
 AAAAAGGCTTACCGAAAACAAGCCCTCAAATTTCATCCGGACAAGAACAAATCTCCTCAG       c.120
 K  K  A  Y  R  K  Q  A  L  K  F  H  P  D  K  N  K  S  P  Q         p.40

          .         .         .         .         .         .       g.5339
 GCAGAGGAAAAATTTAAAGAGGTCGCAGAAGCTTATGAAGTATTGAGTGATCCTAAAAAG       c.180
 A  E  E  K  F  K  E  V  A  E  A  Y  E  V  L  S  D  P  K  K         p.60

          .         .         .  | 02      .         .         .    g.13128
 AGAGAAATATATGATCAGTTTGGGGAGGAAG | GGTTGAAAGGAGGAGCAGGAGGTACTGAT    c.240
 R  E  I  Y  D  Q  F  G  E  E  G |   L  K  G  G  A  G  G  T  D      p.80

          .         .         .         .         .         .       g.13188
 GGACAAGGAGGTACCTTCCGGTACACCTTTCATGGCGATCCTCATGCTACATTTGCTGCA       c.300
 G  Q  G  G  T  F  R  Y  T  F  H  G  D  P  H  A  T  F  A  A         p.100

          .         .         .         .         .         .       g.13248
 TTTTTCGGAGGGTCCAACCCCTTTGAAATTTTCTTTGGAAGACGAATGGGTGGTGGTAGA       c.360
 F  F  G  G  S  N  P  F  E  I  F  F  G  R  R  M  G  G  G  R         p.120

          .         .         .         .         .         .       g.13308
 GATTCTGAAGAAATGGAAATAGATGGTGATCCTTTTAGTGCCTTTGGTTTCAGCATGAAT       c.420
 D  S  E  E  M  E  I  D  G  D  P  F  S  A  F  G  F  S  M  N         p.140

          .         .         .         .         .         .       g.13368
 GGATATCCAAGAGACAGGAATTCTGTGGGGCCATCCCGCCTCAAACAAGATCCTCCAGTT       c.480
 G  Y  P  R  D  R  N  S  V  G  P  S  R  L  K  Q  D  P  P  V         p.160

          .         .         .         .         .         .       g.13428
 ATTCATGAACTTAGAGTATCACTTGAAGAGATATATAGTGGTTGTACCAAACGGATGAAG       c.540
 I  H  E  L  R  V  S  L  E  E  I  Y  S  G  C  T  K  R  M  K         p.180

          .         .         .         .         .         .       g.13488
 ATTTCTCGAAAAAGGCTAAACGCTGATGGAAGGAGTTACAGATCTGAGGACAAAATTCTT       c.600
 I  S  R  K  R  L  N  A  D  G  R  S  Y  R  S  E  D  K  I  L         p.200

          .         .         .         .         .         .       g.13548
 ACCATTGAGATTAAAAAAGGGTGGAAAGAAGGCACCAAAATTACTTTTCCAAGAGAAGGA       c.660
 T  I  E  I  K  K  G  W  K  E  G  T  K  I  T  F  P  R  E  G         p.220

          .         .         .         .         .         .       g.13608
 GATGAAACACCAAATAGTATTCCAGCAGACATTGTTTTTATCATTAAAGACAAAGATCAT       c.720
 D  E  T  P  N  S  I  P  A  D  I  V  F  I  I  K  D  K  D  H         p.240

          .         .         .         .         .         .       g.13668
 CCAAAATTTAAAAGGGATGGATCAAATATAATTTATACTGCTAAAATTAGTTTACGAGAG       c.780
 P  K  F  K  R  D  G  S  N  I  I  Y  T  A  K  I  S  L  R  E         p.260

  | 03       .         .         .         .         .         .    g.16122
  | GCATTGTGTGGCTGCTCAATTAATGTACCAACACTGGATGGAAGAAACATACCTATGTCA    c.840
  | A  L  C  G  C  S  I  N  V  P  T  L  D  G  R  N  I  P  M  S      p.280

          .         .         .         .         .         .       g.16182
 GTAAATGATATTGTGAAACCCGGAATGAGGAGAAGAATTATTGGATATGGGCTGCCATTT       c.900
 V  N  D  I  V  K  P  G  M  R  R  R  I  I  G  Y  G  L  P  F         p.300

          .         .         .         .         .         .       g.16242
 CCAAAAAATCCTGACCAACGTGGTGACCTTCTAATAGAATTTGAGGTGTCCTTCCCAGAT       c.960
 P  K  N  P  D  Q  R  G  D  L  L  I  E  F  E  V  S  F  P  D         p.320

          .         .         .         .         .                 g.16296
 ACTATATCTTCTTCATCCAAAGAAGTACTTAGGAAACATCTTCCTGCCTCATAG             c.1014
 T  I  S  S  S  S  K  E  V  L  R  K  H  L  P  A  S  X               p.337

          .         .         .         .         .         .       g.16356
 aatgaagaactttgttacacatattttgataaggcactgaaaatataaaaggactggtag       c.*60

          .         .         .         .         .         .       g.16416
 tttactgatgtagatgtgaattctgtataaagatgtgtaaattcttttgagggttcatta       c.*120

          .         .         .         .         .         .       g.16476
 aattgcatgaatagagacgggtcaaataaataggcaaaagggatttttacagttagagat       c.*180

          .         .         .         .         .         .       g.16536
 aaaagagaaaaccattcactgtattttatttcatttctcctgattcagatatttttagta       c.*240

          .         .         .         .         .         .       g.16596
 atttgcttatatgtaaaagttgtttttgtggagtcagtggatatatttctaatgaagtgc       c.*300

          .         .         .         .         .         .       g.16656
 tagactatccaattacttaatttcttatacctttagataatcagtatgaaaagttcccat       c.*360

          .         .         .         .         .         .       g.16716
 ttataatggaaatgaaaattcttaactaaactatacatgtaatatgtatttctagaagag       c.*420

          .         .         .         .         .         .       g.16776
 aataaaaacccaagtcagttattagatttaaatcaccttctgaaatgctgctatagggct       c.*480

          .         .         .         .         .         .       g.16836
 ggtatctgtaaaagaatatcctgatgcatctgtttcaccattttgatttttaaagtatgc       c.*540

          .         .         .         .         .         .       g.16896
 tgtagcatttcttaataacatcgttgtgatgttcttaaggcagatctttcttcataaaaa       c.*600

          .         .         .         .         .         .       g.16956
 ggaaagtaatggcaatttctctcctgtggaaatcccaattgcttgaattactgatatttt       c.*660

          .         .         .         .         .         .       g.17016
 agaatagactttttaaaatgccatatgtaattttatgcaagttgactatatatcttgtac       c.*720

          .         .         .         .         .         .       g.17076
 ttaataaattataggctcattttgttctctgctagtttaaagtaattcgtttaataatag       c.*780

          .         .         .         .         .         .       g.17136
 atgtgtttttagaggaaatgctgttacttggaattaattttccagttatacagtcttcta       c.*840

          .         .         .         .         .         .       g.17196
 taacttactaataatattctatatgtactttatgtaatttccctaaaaagaatgaactac       c.*900

          .         .         .         .         .         .       g.17256
 cactacactatggtgttaaaccaaaatatagggaaaataaacactaactgctgcttatgg       c.*960

          .         .         .         .         .         .       g.17316
 ataatgttgcaactacttgttatgcatataaatattttactttttcacatgtatagattg       c.*1020

          .         .         .         .                           g.17363
 catttcttaggtgttttaattttttaaatatatttatgttttaaaaa                    c.*1067

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The DnaJ (Hsp40) homolog, subfamily B, member 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.