dynamin 1 (DNM1) - coding DNA reference sequence

(used for variant description)

(last modified December 2, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_004408.2 in the DNM1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_029726.1, covering DNM1 transcript NM_004408.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5027
                                  gggcgcgcggctgcagcggcggagccg       c.-61

 .         .         .         .         .         .                g.5087
 gagtcggagccgggagcgctagcggcagccggatcgcagcctgcggggcccgccgcagcc       c.-1

          .         .         .         .         .         .       g.5147
 ATGGGCAACCGCGGCATGGAAGATCTCATCCCGCTGGTCAACCGGCTGCAAGACGCCTTC       c.60
 M  G  N  R  G  M  E  D  L  I  P  L  V  N  R  L  Q  D  A  F         p.20

          .         .         .         .         .         .       g.5207
 TCTGCCATCGGCCAGAACGCGGACCTCGACCTGCCGCAGATCGCTGTGGTGGGCGGCCAG       c.120
 S  A  I  G  Q  N  A  D  L  D  L  P  Q  I  A  V  V  G  G  Q         p.40

          .         .         .         .  | 02      .         .    g.19866
 AGCGCCGGCAAGAGCTCGGTGCTCGAGAATTTCGTAGGCAG | GGACTTCTTGCCTCGAGGA    c.180
 S  A  G  K  S  S  V  L  E  N  F  V  G  R  |  D  F  L  P  R  G      p.60

          .         .         .         .         .      | 03  .    g.20203
 TCTGGCATTGTCACCCGACGTCCCCTGGTCTTGCAGCTGGTCAATGCAACCACAG | AATAT    c.240
 S  G  I  V  T  R  R  P  L  V  L  Q  L  V  N  A  T  T  E |   Y      p.80

          .         .         .         .         .         .       g.20263
 GCCGAGTTCCTGCACTGCAAGGGAAAGAAATTCACCGACTTCGAGGAGGTGCGCCTTGAG       c.300
 A  E  F  L  H  C  K  G  K  K  F  T  D  F  E  E  V  R  L  E         p.100

          .         .         .         .         .         .       g.20323
 ATCGAGGCCGAGACCGACAGGGTCACCGGCACCAACAAGGGCATCTCGCCGGTGCCTATC       c.360
 I  E  A  E  T  D  R  V  T  G  T  N  K  G  I  S  P  V  P  I         p.120

          .         .      | 04  .         .         .         .    g.20700
 AACCTCCGCGTCTACTCGCCGCACG | TGCTGAACCTGACCCTGGTGGACCTGCCCGGAATG    c.420
 N  L  R  V  Y  S  P  H  V |   L  N  L  T  L  V  D  L  P  G  M      p.140

          .         .         .         .         .         .       g.20760
 ACCAAGGTCCCGGTGGGGGACCAACCTCCCGACATCGAGTTCCAGATCCGAGACATGCTT       c.480
 T  K  V  P  V  G  D  Q  P  P  D  I  E  F  Q  I  R  D  M  L         p.160

          .         .         .         .         .         .       g.20820
 ATGCAGTTTGTCACCAAGGAGAACTGCCTCATCCTGGCCGTGTCCCCCGCCAACTCTGAC       c.540
 M  Q  F  V  T  K  E  N  C  L  I  L  A  V  S  P  A  N  S  D         p.180

          .         .         .         .          | 05        .    g.21615
 CTGGCCAATTCTGACGCCCTCAAGGTCGCCAAGGAGGTGGACCCCCAGG | GCCAGCGCACC    c.600
 L  A  N  S  D  A  L  K  V  A  K  E  V  D  P  Q  G |   Q  R  T      p.200

          .         .         .         .         .         .       g.21675
 ATCGGGGTCATCACCAAGCTGGACCTGATGGACGAGGGCACAGATGCCCGTGATGTGCTG       c.660
 I  G  V  I  T  K  L  D  L  M  D  E  G  T  D  A  R  D  V  L         p.220

          .         .         | 06         .         .         .    g.21829
 GAGAACAAGCTGCTCCCCCTGCGCAGAG | GCTACATTGGAGTGGTGAACCGGAGCCAGAAG    c.720
 E  N  K  L  L  P  L  R  R  G |   Y  I  G  V  V  N  R  S  Q  K      p.240

          .         .         .         .         .         .       g.21889
 GACATTGATGGCAAGAAGGACATTACCGCCGCCTTGGCTGCTGAACGAAAGTTCTTCCTC       c.780
 D  I  D  G  K  K  D  I  T  A  A  L  A  A  E  R  K  F  F  L         p.260

          .         .         .         .         .         .       g.21949
 TCCCATCCATCTTATCGCCACTTGGCTGACCGTATGGGCACGCCCTACCTGCAGAAGGTC       c.840
 S  H  P  S  Y  R  H  L  A  D  R  M  G  T  P  Y  L  Q  K  V         p.280

           | 07        .         .         .         .         .    g.23864
 CTCAATCAG | CAACTGACGAACCACATCCGGGACACACTGCCGGGGCTGCGGAACAAGCTG    c.900
 L  N  Q   | Q  L  T  N  H  I  R  D  T  L  P  G  L  R  N  K  L      p.300

          .         .         .         .         .         .       g.23924
 CAGAGCCAGCTACTGTCCATTGAGAAGGAGGTGGAGGAATACAAGAACTTCCGCCCTGAT       c.960
 Q  S  Q  L  L  S  I  E  K  E  V  E  E  Y  K  N  F  R  P  D         p.320

          .         .         .   | 08     .         .         .    g.24105
 GACCCAGCTCGCAAGACCAAGGCCCTGCTGCA | GATGGTCCAGCAGTTCGCCGTAGACTTT    c.1020
 D  P  A  R  K  T  K  A  L  L  Q  |  M  V  Q  Q  F  A  V  D  F      p.340

          .         .         .         .         .         .       g.24165
 GAGAAGCGCATTGAGGGCTCAGGAGATCAGATCGACACCTACGAACTGTCAGGGGGAGCC       c.1080
 E  K  R  I  E  G  S  G  D  Q  I  D  T  Y  E  L  S  G  G  A         p.360

          .         .         .         .         | 09         .    g.24421
 CGCATTAACCGAATCTTCCACGAGCGCTTCCCTTTCGAGCTGGTCAAG | ATGGAGTTTGAT    c.1140
 R  I  N  R  I  F  H  E  R  F  P  F  E  L  V  K   | M  E  F  D      p.380

          .         .         .         .         .       | 10 .    g.25871
 GAGAAGGAACTCCGAAGGGAGATCAGCTATGCTATCAAGAATATCCATGGCATTAG | AACG    c.1200
 E  K  E  L  R  R  E  I  S  Y  A  I  K  N  I  H  G  I  R  |  T      p.400

          .         .         .         .         .         .       g.25931
 GGGCTGTTTACCCCAGACATGGCCTTTGAGACCATTGTGAAAAAGCAGGTGAAGAAGATC       c.1260
 G  L  F  T  P  D  M  A  F  E  T  I  V  K  K  Q  V  K  K  I         p.420

          .         .         .         .         .         .       g.25991
 CGAGAACCGTGTCTCAAGTGTGTGGACATGGTTATCTCGGAGCTAATCAGCACCGTTAGA       c.1320
 R  E  P  C  L  K  C  V  D  M  V  I  S  E  L  I  S  T  V  R         p.440

          .      | 11  .         .         .         .         .    g.35682
 CAGTGCACCAAGAAG | CTCCAGCAGTACCCGCGGCTACGGGAGGAGATGGAGCGCATCGTG    c.1380
 Q  C  T  K  K   | L  Q  Q  Y  P  R  L  R  E  E  M  E  R  I  V      p.460

          .         .         .         .   | 12     .         .    g.41079
 ACCACCCACATCCGGGAGCGCGAGGGCCGCACTAAGGAGCAG | GTCATGCTTCTCATCGAT    c.1440
 T  T  H  I  R  E  R  E  G  R  T  K  E  Q   | V  M  L  L  I  D      p.480

          .         .         .         .         .    | 13    .    g.41351
 ATCGAGCTGGCTTACATGAACACCAACCATGAGGACTTCATAGGCTTTGCCAA | TGCTCAG    c.1500
 I  E  L  A  Y  M  N  T  N  H  E  D  F  I  G  F  A  N  |  A  Q      p.500

          .         .         .         .      | 14  .        | 15. g.43851
 CAGAGGAGCAACCAGATGAACAAGAAGAAGACTTCAGGGAACCAG | GATGAGATTCTG | GTC c.1560
 Q  R  S  N  Q  M  N  K  K  K  T  S  G  N  Q   | D  E  I  L   | V   p.520

          .         .         .         .         .         .       g.43911
 ATCCGCAAGGGCTGGCTGACTATCAATAATATTGGCATCATGAAAGGGGGCTCCAAGGAG       c.1620
 I  R  K  G  W  L  T  I  N  N  I  G  I  M  K  G  G  S  K  E         p.540

          .         .         .         .         .  | 16      .    g.48019
 TACTGGTTTGTGCTGACTGCTGAGAATCTGTCCTGGTACAAGGATGATGAG | GAGAAAGAG    c.1680
 Y  W  F  V  L  T  A  E  N  L  S  W  Y  K  D  D  E   | E  K  E      p.560

          .         .         .         .         .         .       g.48079
 AAGAAATACATGCTGTCTGTGGACAACCTCAAGCTGCGGGACGTGGAGAAGGGCTTTATG       c.1740
 K  K  Y  M  L  S  V  D  N  L  K  L  R  D  V  E  K  G  F  M         p.580

          .         .         .         .  | 17      .         .    g.49010
 TCGAGCAAGCATATCTTTGCCCTCTTTAACACGGAGCAGAG | GAATGTCTACAAGGATTAT    c.1800
 S  S  K  H  I  F  A  L  F  N  T  E  Q  R  |  N  V  Y  K  D  Y      p.600

          .         .         .         .         .         .       g.49070
 CGGCAGCTGGAGCTAGCCTGTGAGACACAGGAGGAGGTGGACAGCTGGAAGGCCTCCTTC       c.1860
 R  Q  L  E  L  A  C  E  T  Q  E  E  V  D  S  W  K  A  S  F         p.620

          .         .         .    | 18    .      | 19  .         . g.50214
 CTGAGGGCTGGCGTGTACCCTGAGCGTGTTGGG | GACAAAGAGAAA | GCCAGCGAGACCGAG c.1920
 L  R  A  G  V  Y  P  E  R  V  G   | D  K  E  K   | A  S  E  T  E   p.640

          .         .         .         .         .         .       g.50274
 GAGAATGGCTCCGACAGCTTCATGCATTCCATGGACCCACAGCTGGAACGGCAAGTGGAG       c.1980
 E  N  G  S  D  S  F  M  H  S  M  D  P  Q  L  E  R  Q  V  E         p.660

          .         .         .         .         .         .       g.50334
 ACCATCCGGAATCTTGTGGACTCATACATGGCCATTGTCAACAAGACCGTGAGGGACCTC       c.2040
 T  I  R  N  L  V  D  S  Y  M  A  I  V  N  K  T  V  R  D  L         p.680

          .         .         .       | 20 .         .         .    g.51755
 ATGCCCAAGACCATCATGCACCTCATGATTAACAAT | ACCAAGGAGTTCATCTTCTCGGAG    c.2100
 M  P  K  T  I  M  H  L  M  I  N  N   | T  K  E  F  I  F  S  E      p.700

          .         .         .         .         .         .       g.51815
 CTGCTGGCCAACCTGTACTCGTGTGGGGACCAGAACACGCTGATGGAGGAGTCGGCGGAG       c.2160
 L  L  A  N  L  Y  S  C  G  D  Q  N  T  L  M  E  E  S  A  E         p.720

          .         .         .         .         .         .       g.51875
 CAGGCACAGCGGCGCGACGAGATGCTGCGCATGTACCACGCACTGAAGGAGGCGCTCAGC       c.2220
 Q  A  Q  R  R  D  E  M  L  R  M  Y  H  A  L  K  E  A  L  S         p.740

          .         .         .         .         .         .       g.51935
 ATCATCGGCGACATCAACACGACCACCGTCAGCACGCCCATGCCCCCGCCCGTGGACGAC       c.2280
 I  I  G  D  I  N  T  T  T  V  S  T  P  M  P  P  P  V  D  D         p.760

          .         .         .         | 21         .         .    g.52363
 TCCTGGCTGCAGGTGCAGAGCGTACCGGCCGGACGCAG | GTCGCCCACGTCCAGCCCCACG    c.2340
 S  W  L  Q  V  Q  S  V  P  A  G  R  R  |  S  P  T  S  S  P  T      p.780

          .         .         .         .         .         .       g.52423
 CCGCAGCGCCGAGCCCCCGCCGTGCCCCCAGCCCGGCCCGGGTCGCGGGGCCCTGCTCCT       c.2400
 P  Q  R  R  A  P  A  V  P  P  A  R  P  G  S  R  G  P  A  P         p.800

          .         .         .         .         .         .       g.52483
 GGGCCTCCGCCTGCTGGGTCCGCCCTGGGGGGGGCGCCCCCCGTGCCCTCCAGGCCGGGG       c.2460
 G  P  P  P  A  G  S  A  L  G  G  A  P  P  V  P  S  R  P  G         p.820

          .         .         .         .         .         .       g.52543
 GCTTCCCCTGACCCTTTCGGCCCTCCCCCTCAGGTGCCCTCGCGCCCCAACCGCGCCCCG       c.2520
 A  S  P  D  P  F  G  P  P  P  Q  V  P  S  R  P  N  R  A  P         p.840

          .     | 22   .         .         .         .         .    g.56316
 CCCGGGGTCCCCAG | CCGATCGGGTCAGGCAAGTCCATCCCGTCCTGAGAGCCCCAGGCCC    c.2580
 P  G  V  P  S  |  R  S  G  Q  A  S  P  S  R  P  E  S  P  R  P      p.860

          .                                                         g.56331
 CCCTTCGACCTCTAA                                                    c.2595
 P  F  D  L  X                                                      p.864

          .         .         .         .         .         .       g.56391
 acagatccctcctcttctcggagacctccctttccaagcctgcctggacggctgttctgt       c.*60

          .         .         .         .         .         .       g.56451
 gacttgacagtggctcccccagccccaaagccagcccccttcatctgtgacttaatctgt       c.*120

          .         .         .         .         .         .       g.56511
 tgtagtggtgagctgatacattcaggtgtgaccgttggtgaaaacttgtgccccttctgt       c.*180

          .         .         .         .         .         .       g.56571
 ggtatgcccttgccctgttctataaatatctataaatactcatatatatacacacctaca       c.*240

          .         .         .         .         .         .       g.56631
 catggccaaccgcctcgcctctagcgctgggaatcagtcactgtgctatccttgtggagt       c.*300

          .         .         .         .         .         .       g.56691
 cttgtggcccaactaccagagaacgctgtcccccgacatcccactccaaagtgtgccacc       c.*360

          .         .         .         .         .         .       g.56751
 tccagtgagcctccttgtcatgcccggcctgtggacagccagcccccgccatccctccca       c.*420

          .         .         .         .         .         .       g.56811
 ccccctaccaagcatgggggtgctgtgcaggcagccgtgtggcctgacagtttctaccag       c.*480

          .         .         .         .         .                 g.56865
 tcctgctgtccctcggctgagaataaaacccatttctggatgatggggaatgtc             c.*534

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Dynamin 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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