downstream neighbor of SON (DONSON) - coding DNA reference sequence

(used for variant description)

(last modified March 14, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_017613.3 in the DONSON gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000021.8, covering DONSON transcript NM_017613.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5007
                                                      aggggcg       c.-61

 .         .         .         .         .         .                g.5067
 ggcccggcgcgcgcgggaagtctctgtagggcggccggctaccctcagccgccgcgcgtc       c.-1

          .         .         .         .         .         .       g.5127
 ATGGCCCTTTCGGTGCCCGGCTACTCACCGGGCTTCCGAAAGCCGCCCGAGGTAGTGCGG       c.60
 M  A  L  S  V  P  G  Y  S  P  G  F  R  K  P  P  E  V  V  R         p.20

          .         .         .         .         .         .       g.5187
 CTCCGACGGAAAAGGGCCCGGAGCCGTGGAGCTGCCGCCTCCCCGCCCCGTGAGCTGACG       c.120
 L  R  R  K  R  A  R  S  R  G  A  A  A  S  P  P  R  E  L  T         p.40

          .         .         .         .         .         .       g.5247
 GAGCCGGCGGCCCGCCGAGCCGCCCTGGTGGCGGGGCTGCCTCTTCGCCCTTTCCCTGCT       c.180
 E  P  A  A  R  R  A  A  L  V  A  G  L  P  L  R  P  F  P  A         p.60

          .         .         .         .         .         .       g.5307
 GCGGGGGGCAGAGGCGGTGGCAGCGGCGGCGGCCCGGCCGCTGCTCGGAGGAACCCCTTC       c.240
 A  G  G  R  G  G  G  S  G  G  G  P  A  A  A  R  R  N  P  F         p.80

          .         .         .         .         .         .       g.5367
 GCCCGCCTGGACAACCGACCGCGGGTCGCCGCGGAGCCCCCCGACGGGCCGGCCCGCGAG       c.300
 A  R  L  D  N  R  P  R  V  A  A  E  P  P  D  G  P  A  R  E         p.100

          .         .  | 02      .         .         .         .    g.6145
 CAGCCGGAGGCCCCGGTCCCG | TTTTTAGATTCTAATCAAGAAAATGATTTGCTATGGGAA    c.360
 Q  P  E  A  P  V  P   | F  L  D  S  N  Q  E  N  D  L  L  W  E      p.120

          .         .         .         .   | 03     .         .    g.7545
 GAGAAGTTTCCTGAAAGAACAACTGTTACTGAATTACCTCAG | ACTTCACATGTATCATTC    c.420
 E  K  F  P  E  R  T  T  V  T  E  L  P  Q   | T  S  H  V  S  F      p.140

          .         .         .         .         .         .       g.7605
 TCCGAGCCTGATATTCCGTCCTCAAAAAGTACTGAGTTACCTGTGGACTGGAGTATTAAA       c.480
 S  E  P  D  I  P  S  S  K  S  T  E  L  P  V  D  W  S  I  K         p.160

          .         .         .         .         .         .       g.7665
 ACGCGACTCCTTTTCACCTCTTCTCAACCCTTTACCTGGGCAGATCATTTGAAAGCACAG       c.540
 T  R  L  L  F  T  S  S  Q  P  F  T  W  A  D  H  L  K  A  Q         p.180

          .         .         .         .         .         .       g.7725
 GAAGAAGCTCAAGGTCTTGTCCAGCATTGTAGGGCAACAGAAGTTACTTTGCCTAAAAGT       c.600
 E  E  A  Q  G  L  V  Q  H  C  R  A  T  E  V  T  L  P  K  S         p.200

        | 04 .         .         .         .         .         .    g.8994
 ATACAG | GATCCCAAACTCTCCTCTGAGCTCCGTTGTACCTTCCAGCAGAGCCTTATCTAT    c.660
 I  Q   | D  P  K  L  S  S  E  L  R  C  T  F  Q  Q  S  L  I  Y      p.220

          .         .         .         .         .         .       g.9054
 TGGCTCCACCCTGCTTTGTCTTGGCTACCACTGTTCCCTCGTATTGGAGCTGATAGAAAA       c.720
 W  L  H  P  A  L  S  W  L  P  L  F  P  R  I  G  A  D  R  K         p.240

          .         .         .         .         .         .       g.9114
 ATGGCTGGAAAGACAAGTCCTTGGTCAAATGATGCAACCCTGCAGCATGTTTTAATGAGT       c.780
 M  A  G  K  T  S  P  W  S  N  D  A  T  L  Q  H  V  L  M  S         p.260

       | 05  .         .         .         .         .         .    g.10097
 GACTG | GTCTGTGAGCTTTACTTCTCTATATAATTTGCTGAAGACAAAACTTTGCCCCTAT    c.840
 D  W  |  S  V  S  F  T  S  L  Y  N  L  L  K  T  K  L  C  P  Y      p.280

          .         .         .         .         .         .       g.10157
 TTCTACGTTTGTACCTATCAGTTTACTGTCCTGTTCCGAGCAGCAGGATTAGCTGGAAGT       c.900
 F  Y  V  C  T  Y  Q  F  T  V  L  F  R  A  A  G  L  A  G  S         p.300

          .         .         .         .         .         .       g.10217
 GACTTAATCACAGCTCTCATATCTCCAACAACTCGAGGTTTAAGAGAAGCTATGAGAAAT       c.960
 D  L  I  T  A  L  I  S  P  T  T  R  G  L  R  E  A  M  R  N         p.320

      | 06   .         .         .         .         .         .    g.11518
 GAAG | GTATTGAATTTTCTCTGCCTTTAATAAAAGAAAGTGGCCATAAGAAGGAGACAGCA    c.1020
 E  G |   I  E  F  S  L  P  L  I  K  E  S  G  H  K  K  E  T  A      p.340

          .         .       | 07 .         .         .         .    g.11687
 TCTGGAACAAGCTTGGGATATGGGGA | GGAGCAAGCCATCAGTGATGAGGATGAAGAGGAA    c.1080
 S  G  T  S  L  G  Y  G  E  |  E  Q  A  I  S  D  E  D  E  E  E      p.360

          .         .         .         .         .         .       g.11747
 AGTTTTTCCTGGCTGGAAGAGATGGGTGTGCAAGATAAAATTAAAAAGCCAGACATACTT       c.1140
 S  F  S  W  L  E  E  M  G  V  Q  D  K  I  K  K  P  D  I  L         p.380

          .  | 08      .         .         .         .         .    g.12257
 TCTATCAAGCT | GCGTAAAGAGAAACATGAAGTACAAATGGATCACAGACCTGAATCTGTT    c.1200
 S  I  K  L  |  R  K  E  K  H  E  V  Q  M  D  H  R  P  E  S  V      p.400

          .         .         .         .         .         .       g.12317
 GTGTTGGTAAAAGGAATCAACACCTTTACATTGCTCAATTTTTTGATTAACTCTAAGAGT       c.1260
 V  L  V  K  G  I  N  T  F  T  L  L  N  F  L  I  N  S  K  S         p.420

          .         .         .         .         .         .       g.12377
 TTAGTTGCTACCTCAGGTCCACAGGCAGGACTTCCTCCAACCCTCTTGTCCCCTGTTGCT       c.1320
 L  V  A  T  S  G  P  Q  A  G  L  P  P  T  L  L  S  P  V  A         p.440

          .         .         . | 09       .         .         .    g.14176
 TTCCGAGGTGCCACAATGCAAATGCTTAAG | GCACGGAGTGTGAATGTGAAGACACAAGCT    c.1380
 F  R  G  A  T  M  Q  M  L  K   | A  R  S  V  N  V  K  T  Q  A      p.460

          .         .         .         .         .         .       g.14236
 CTTTCTGGATACAGAGACCAATTTAGTTTGGAGATTACAGGTCCTATCATGCCTCATTCT       c.1440
 L  S  G  Y  R  D  Q  F  S  L  E  I  T  G  P  I  M  P  H  S         p.480

          .         .         .         .         .         .       g.14296
 CTGCATTCACTGACCATGCTGCTCAAATCTTCACAGAGTGGATCTTTCTCTGCAGTACTG       c.1500
 L  H  S  L  T  M  L  L  K  S  S  Q  S  G  S  F  S  A  V  L         p.500

          .         .         .         .         .         .       g.14356
 TATCCACACGAGCCAACTGCTGTATTTAACATCTGCCTGCAAATGGACAAAGTACTTGAT       c.1560
 Y  P  H  E  P  T  A  V  F  N  I  C  L  Q  M  D  K  V  L  D         p.520

     | 10    .         .         .         .         .         .    g.15321
 ATG | GAGGTTGTTCATAAGGAGCTTACTAACTGTGGTTTGCACCCTAACACTCTGGAGCAA    c.1620
 M   | E  V  V  H  K  E  L  T  N  C  G  L  H  P  N  T  L  E  Q      p.540

          .         .         .         .         .         .       g.15381
 CTTAGTCAAATACCGTTACTTGGGAAATCATCTTTACGGAATGTGGTGCTGAGAGACTAC       c.1680
 L  S  Q  I  P  L  L  G  K  S  S  L  R  N  V  V  L  R  D  Y         p.560

          .         .                                               g.15402
 ATTTATAATTGGAGATCCTGA                                              c.1701
 I  Y  N  W  R  S  X                                                p.566

          .         .         .         .         .         .       g.15462
 acaccaaagtaagcctaaaaggaatctttgaggaaaaaagccttctagcaaggaaattca       c.*60

          .         .         .         .         .         .       g.15522
 agattcttgaagttgaaggaatatactgaaatgtttataaacataacttttactacagta       c.*120

          .         .         .         .         .         .       g.15582
 gcatctaaggttttaaatgtgttttactattttcagattagatttttagatataaagatg       c.*180

          .         .         .         .         .         .       g.15642
 aaaaactcagataactcaaatgagatatctatatccctacaacctaattgtatattgagc       c.*240

          .         .         .         .         .         .       g.15702
 agaaactgaattaatatgcttccttgcaaatgggaaatcacatagcagttaccccatggc       c.*300

          .         .         .         .         .         .       g.15762
 attgtgactaatggcatcagggcaaaaatatgttactttacgatttacctgttagcaggt       c.*360

          .         .         .         .         .         .       g.15822
 tcttgtttcataaaggtagaaaataaatacagacaacatctactgagctagttgattggt       c.*420

          .         .         .         .         .         .       g.15882
 gatgcttctaccttaatatctttcctactgatttataattcctttattttcacatatact       c.*480

          .         .         .         .         .         .       g.15942
 aaaactttttaaatgcatgttaattcagataaaaaggcattttgtattccacatagaata       c.*540

          .         .         .         .         .         .       g.16002
 gtgttaagaattgtgaagtacactgagctgtcacggcaaagtagtatttaatgtgcttat       c.*600

          .         .         .         .         .         .       g.16062
 aggggtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgt       c.*660

          .         .         .         .         .         .       g.16122
 gtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtagggggggactgtataat       c.*720

          .         .         .                                     g.16158
 tcacatttttaaaataaaagtgcttaaaaatcaaaa                               c.*756

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Downstream neighbor of SON protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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