DOT1-like, histone H3 methyltransferase (S. cerevisiae) (DOT1L) - coding DNA reference sequence

(used for variant description)

(last modified November 4, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_032482.2 in the DOT1L gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000019.9, covering DOT1L transcript NM_032482.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5036
                         cccgcctagcatggtgcggcggccgcgcgcgcggac       c.-1

          .         .         .         .         .         .       g.5096
 ATGGGGGAGAAGCTGGAGCTGAGACTGAAGTCGCCCGTGGGGGCTGAGCCCGCCGTCTAC       c.60
 M  G  E  K  L  E  L  R  L  K  S  P  V  G  A  E  P  A  V  Y         p.20

          .         .  | 02      .         .         .         .    g.21603
 CCGTGGCCGCTGCCGGTCTAC | GATAAACATCACGATGCTGCTCATGAAATCATCGAGACC    c.120
 P  W  P  L  P  V  Y   | D  K  H  H  D  A  A  H  E  I  I  E  T      p.40

       | 03  .         .         .         .         .         .    g.26761
 ATCCG | ATGGGTCTGTGAAGAAATCCCGGATCTCAAGCTCGCTATGGAGAATTACGTTTTA    c.180
 I  R  |  W  V  C  E  E  I  P  D  L  K  L  A  M  E  N  Y  V  L      p.60

          .         . | 04       .         .         .         .    g.30623
 ATTGACTATGACACCAAAAG | CTTCGAGAGCATGCAGAGGCTCTGCGACAAGTACAACCGT    c.240
 I  D  Y  D  T  K  S  |  F  E  S  M  Q  R  L  C  D  K  Y  N  R      p.80

          .         .     | 05   .         .         .         .    g.31899
 GCCATCGACAGCATCCACCAGCTG | TGGAAGGGCACCACGCAGCCCATGAAGCTGAACACG    c.300
 A  I  D  S  I  H  Q  L   | W  K  G  T  T  Q  P  M  K  L  N  T      p.100

          .         .         .         .         .         .       g.31959
 CGGCCGTCCACTGGACTCCTGCGCCATATCCTGCAGCAGGTCTACAACCACTCGGTGACC       c.360
 R  P  S  T  G  L  L  R  H  I  L  Q  Q  V  Y  N  H  S  V  T         p.120

          .         .         .         .         .         .       g.32019
 GACCCCGAGAAGCTCAACAACTACGAGCCCTTCTCCCCCGAGGTGTACGGGGAGACCTCC       c.420
 D  P  E  K  L  N  N  Y  E  P  F  S  P  E  V  Y  G  E  T  S         p.140

          .         .         .         .         .         .       g.32079
 TTCGACCTGGTGGCCCAGATGATTGATGAGATCAAGATGACCGACGACGACCTGTTTGTG       c.480
 F  D  L  V  A  Q  M  I  D  E  I  K  M  T  D  D  D  L  F  V         p.160

          .    | 06    .         .         .         .         .    g.34587
 GACTTGGGGAGCG | GTGTGGGCCAGGTCGTGCTCCAGGTTGCTGCTGCCACCAACTGCAAA    c.540
 D  L  G  S  G |   V  G  Q  V  V  L  Q  V  A  A  A  T  N  C  K      p.180

          .         .         .         .         | 07         .    g.35378
 CATCACTATGGCGTCGAGAAAGCAGACATCCCGGCCAAGTATGCGGAG | ACCATGGACCGC    c.600
 H  H  Y  G  V  E  K  A  D  I  P  A  K  Y  A  E   | T  M  D  R      p.200

          .         .         .         .         .  | 08      .    g.40744
 GAGTTCAGGAAGTGGATGAAATGGTATGGAAAAAAGCATGCAGAATACACA | TTGGAGAGA    c.660
 E  F  R  K  W  M  K  W  Y  G  K  K  H  A  E  Y  T   | L  E  R      p.220

          .         .         .         .        | 09.         .    g.43564
 GGCGATTTCCTCTCAGAAGAGTGGAGGGAGCGAATCGCCAACACGAG | TGTTATATTTGTG    c.720
 G  D  F  L  S  E  E  W  R  E  R  I  A  N  T  S  |  V  I  F  V      p.240

          .         .         .         .         .         .       g.43624
 AATAATTTTGCCTTTGGTCCTGAGGTGGATCACCAGCTGAAGGAGCGGTTTGCAAACATG       c.780
 N  N  F  A  F  G  P  E  V  D  H  Q  L  K  E  R  F  A  N  M         p.260

         | 10.         .         .         .         .         .    g.47633
 AAGGAAG | GTGGCAGAATCGTGTCCTCGAAACCCTTTGCACCTCTGAACTTCAGAATAAAC    c.840
 K  E  G |   G  R  I  V  S  S  K  P  F  A  P  L  N  F  R  I  N      p.280

          .       | 11 .         .         .         .         .    g.48469
 AGTAGAAACTTGAGTG | ACATCGGCACCATCATGCGCGTGGTGGAGCTCTCGCCCCTGAAG    c.900
 S  R  N  L  S  D |   I  G  T  I  M  R  V  V  E  L  S  P  L  K      p.300

          .         .         .         .         .         .       g.48529
 GGCTCGGTGTCGTGGACGGGGAAGCCAGTCTCCTACTACCTGCACACTATCGACCGCACC       c.960
 G  S  V  S  W  T  G  K  P  V  S  Y  Y  L  H  T  I  D  R  T         p.320

     | 12    .         .         .         .      | 13  .         . g.51266
 ATA | CTTGAAAACTATTTTTCTAGTCTGAAAAACCCAAAACTCAGG | GAGGAACAGGAGGCA c.1020
 I   | L  E  N  Y  F  S  S  L  K  N  P  K  L  R   | E  E  Q  E  A   p.340

          .         .         .         .         .         .       g.51326
 GCCCGGCGCCGCCAGCAGCGCGAGAGCAAGAGCAACGCGGCCACGCCCACTAAGGGCCCA       c.1080
 A  R  R  R  Q  Q  R  E  S  K  S  N  A  A  T  P  T  K  G  P         p.360

          .         .         .       | 14 .         .         .    g.51496
 GAGGGCAAGGTGGCCGGCCCCGCCGACGCCCCCATG | GACTCTGGTGCTGAGGAAGAGAAG    c.1140
 E  G  K  V  A  G  P  A  D  A  P  M   | D  S  G  A  E  E  E  K      p.380

          .         .         .         .         .         .       g.51556
 GCGGGAGCAGCCACCGTGAAGAAGCCGTCTCCCTCCAAAGCCCGCAAGAAGAAGCTAAAC       c.1200
 A  G  A  A  T  V  K  K  P  S  P  S  K  A  R  K  K  K  L  N         p.400

          .         .         .         .         .         .       g.51616
 AAGAAGGGGAGGAAGATGGCTGGCCGCAAGCGCGGGCGCCCCAAGAAGATGAACACTGCG       c.1260
 K  K  G  R  K  M  A  G  R  K  R  G  R  P  K  K  M  N  T  A         p.420

          .         .         .         .         .         .       g.51676
 AACCCCGAGCGGAAGCCCAAGAAGAACCAAACTGCACTGGATGCCCTGCACGCTCAGACC       c.1320
 N  P  E  R  K  P  K  K  N  Q  T  A  L  D  A  L  H  A  Q  T         p.440

          .         .         .  | 15      .         .         .    g.51979
 GTGTCTCAGACGGCGGCCTCCTCACCCCAGG | ATGCCTACAGATCCCCTCACAGCCCGTTC    c.1380
 V  S  Q  T  A  A  S  S  P  Q  D |   A  Y  R  S  P  H  S  P  F      p.460

          .         .         .         .         .         .       g.52039
 TACCAGCTACCTCCGAGCGTGCAGCGGCACTCCCCCAACCCGCTGCTGGTGGCGCCCACC       c.1440
 Y  Q  L  P  P  S  V  Q  R  H  S  P  N  P  L  L  V  A  P  T         p.480

          .         .      | 16  .         .         .         .    g.52637
 CCGCCCGCGCTGCAGAAGCTTCTAG | AGTCCTTCAAGATCCAGTACCTGCAGTTCCTGGCA    c.1500
 P  P  A  L  Q  K  L  L  E |   S  F  K  I  Q  Y  L  Q  F  L  A      p.500

          .         .         .         .         .        | 17.    g.54393
 TACACAAAGACCCCCCAGTACAAGGCCAGCCTGCAGGAGCTGCTGGGCCAGGAGAAG | GAG    c.1560
 Y  T  K  T  P  Q  Y  K  A  S  L  Q  E  L  L  G  Q  E  K   | E      p.520

          .         .         .         .         .         .       g.54453
 AAGAACGCCCAGCTCCTGGGTGCGGCTCAGCAGCTCCTCAGCCACTGCCAGGCCCAGAAG       c.1620
 K  N  A  Q  L  L  G  A  A  Q  Q  L  L  S  H  C  Q  A  Q  K         p.540

          .         .         .          | 18        .         .    g.54721
 GAGGAGATCAGGAGGCTGTTTCAGCAAAAATTGGATGAG | CTGGGTGTGAAGGCGCTGACC    c.1680
 E  E  I  R  R  L  F  Q  Q  K  L  D  E   | L  G  V  K  A  L  T      p.560

          .         .         .         .         .         .       g.54781
 TACAACGACCTGATTCAAGCGCAGAAGGAGATCTCCGCCCATAACCAGCAGCTGCGGGAG       c.1740
 Y  N  D  L  I  Q  A  Q  K  E  I  S  A  H  N  Q  Q  L  R  E         p.580

          .         .         .         .         .        | 19.    g.55325
 CAGTCGGAGCAGCTGGAGCAGGACAACCGCGCGCTCCGCGGCCAGAGCTTGCAGCTG | CTC    c.1800
 Q  S  E  Q  L  E  Q  D  N  R  A  L  R  G  Q  S  L  Q  L   | L      p.600

          .         .         .         .         .         .       g.55385
 AAGGCTCGCTGCGAGGAGCTGCAGCTGGACTGGGCCACGCTGTCGCTGGAGAAGCTGTTG       c.1860
 K  A  R  C  E  E  L  Q  L  D  W  A  T  L  S  L  E  K  L  L         p.620

          .         .         .         .         .         .       g.55445
 AAGGAGAAGCAGGCCCTGAAGAGCCAGATCTCGGAGAAGCAGAGGCACTGCCTGGAGCTG       c.1920
 K  E  K  Q  A  L  K  S  Q  I  S  E  K  Q  R  H  C  L  E  L         p.640

     | 20    .         .         .         .         .         .    g.57189
 CAG | ATCAGCATTGTGGAGCTAGAGAAGAGCCAGCGGCAGCAGGAGCTCCTGCAGCTCAAG    c.1980
 Q   | I  S  I  V  E  L  E  K  S  Q  R  Q  Q  E  L  L  Q  L  K      p.660

          .         .         .         .         .         .       g.57249
 TCCTGTGTGCCGCCTGACGACGCCCTGTCCCTGCACCTGCGTGGGAAGGGCGCCCTGGGC       c.2040
 S  C  V  P  P  D  D  A  L  S  L  H  L  R  G  K  G  A  L  G         p.680

          .         .         .         .         .         .       g.57309
 CGCGAGCTGGAGCCTGACGCCAGCCGGCTGCACCTGGAGCTGGACTGCACCAAGTTCTCG       c.2100
 R  E  L  E  P  D  A  S  R  L  H  L  E  L  D  C  T  K  F  S         p.700

          .         .         .         .         .         .       g.57369
 CTGCCTCACTTGAGCAGCATGAGCCCGGAGCTCTCCATGAACGGCCAGGCTGCTGGCTAT       c.2160
 L  P  H  L  S  S  M  S  P  E  L  S  M  N  G  Q  A  A  G  Y         p.720

          .         .         .         .         .         .       g.57429
 GAGCTCTGCGGTGTGCTGAGCCGGCCTTCGTCGAAGCAGAACACGCCCCAGTACCTGGCC       c.2220
 E  L  C  G  V  L  S  R  P  S  S  K  Q  N  T  P  Q  Y  L  A         p.740

          .         .         .         .         .         .       g.57489
 TCACCCCTGGACCAGGAGGTGGTGCCCTGTACCCCTAGCCACGTCGGCCGGCCGCGCCTG       c.2280
 S  P  L  D  Q  E  V  V  P  C  T  P  S  H  V  G  R  P  R  L         p.760

          .         .         .         .         .         .       g.57549
 GAGAAGCTGTCTGGCCTAGCCGCACCCGACTACACTAGGCTGTCCCCGGCCAAGATTGTG       c.2340
 E  K  L  S  G  L  A  A  P  D  Y  T  R  L  S  P  A  K  I  V         p.780

          .         .         .         .         .         .       g.57609
 CTGAGGCGGCACCTGAGCCAGGACCACACGGTGCCCGGCAGGCCGGCTGCCAGTGAGCTG       c.2400
 L  R  R  H  L  S  Q  D  H  T  V  P  G  R  P  A  A  S  E  L         p.800

          | 21         .         .         .         .         .    g.57858
 CATTCGAG | AGCTGAGCACACCAAGGAGAACGGCCTTCCCTACCAGAGCCCCAGCGTGCCT    c.2460
 H  S  R  |  A  E  H  T  K  E  N  G  L  P  Y  Q  S  P  S  V  P      p.820

          .         .         .         .         .         .       g.57918
 GGCAGCATGAAGCTGAGCCCTCAGGACCCGCGGCCCCTGTCCCCTGGGGCCTTGCAGCTT       c.2520
 G  S  M  K  L  S  P  Q  D  P  R  P  L  S  P  G  A  L  Q  L         p.840

          .         .     | 22   .         .         .         .    g.58659
 GCTGGAGAGAAGAGCAGTGAGAAG | GGCCTGAGAGAGCGCGCCTACGGCAGCAGCGGGGAG    c.2580
 A  G  E  K  S  S  E  K   | G  L  R  E  R  A  Y  G  S  S  G  E      p.860

          .         .         .         .         .         .       g.58719
 CTCATCACCAGCCTGCCCATCAGCATCCCGCTCAGCACCGTGCAGCCCAACAAGCTCCCG       c.2640
 L  I  T  S  L  P  I  S  I  P  L  S  T  V  Q  P  N  K  L  P         p.880

          .         .         .         .         .  | 23      .    g.60968
 GTCAGCATTCCCCTGGCCAGCGTGGTGCTGCCCAGCCGCGCCGAGAGGGCG | AGGAGCACC    c.2700
 V  S  I  P  L  A  S  V  V  L  P  S  R  A  E  R  A   | R  S  T      p.900

          .         .         .         .         .         .       g.61028
 CCCAGTCCCGTGCTGCAGCCCCGTGACCCCTCGTCCACACTTGAAAAGCAGATTGGTGCT       c.2760
 P  S  P  V  L  Q  P  R  D  P  S  S  T  L  E  K  Q  I  G  A         p.920

          .         .         .         .       | 24 .         .    g.62841
 AATGCCCACGGTGCTGGGAGCAGAAGCCTTGCCCTGGCCCCCGCAG | GCTTCTCCTACGCT    c.2820
 N  A  H  G  A  G  S  R  S  L  A  L  A  P  A  G |   F  S  Y  A      p.940

          .         .         .         .         .         .       g.62901
 GGCTCGGTGGCCATCAGCGGGGCCTTGGCGGGCAGCCCGGCCTCTCTCACACCTGGAGCC       c.2880
 G  S  V  A  I  S  G  A  L  A  G  S  P  A  S  L  T  P  G  A         p.960

          .         .         .         .         .         .       g.62961
 GAGCCGGCCACCTTGGATGAGTCCTCCAGCTCTGGGAGCCTTTTTGCCACCGTGGGGTCC       c.2940
 E  P  A  T  L  D  E  S  S  S  S  G  S  L  F  A  T  V  G  S         p.980

          .         .         .         .         .         .       g.63021
 CGCAGCTCCACGCCACAGCACCCCCTGCTGCTGGCACAGCCCCGGAACTCGCTTCCTGCC       c.3000
 R  S  S  T  P  Q  H  P  L  L  L  A  Q  P  R  N  S  L  P  A         p.1000

          .         .         .         .         .         .       g.63081
 TCTCCCGCCCACCAGCTCTCCTCCAGTCCCCGGCTTGGTGGGGCCGCCCAGGGCCCGTTG       c.3060
 S  P  A  H  Q  L  S  S  S  P  R  L  G  G  A  A  Q  G  P  L         p.1020

          .         .         .         .         .         .       g.63141
 CCCGAGGCCAGCAAGGGAGACCTGCCCTCCGATTCCGGCTTCTCAGATCCTGAGAGTGAA       c.3120
 P  E  A  S  K  G  D  L  P  S  D  S  G  F  S  D  P  E  S  E         p.1040

          .         .         .         .         .         .       g.63201
 GCCAAGAGGAGGATTGTGTTCACCATCACCACTGGTGCGGGCAGTGCCAAGCAGTCGCCC       c.3180
 A  K  R  R  I  V  F  T  I  T  T  G  A  G  S  A  K  Q  S  P         p.1060

          .         .         .         .         .         .       g.63261
 TCCAGCAAGCACAGCCCCCTGACCGCCAGCGCCCGTGGGGACTGTGTGCCGAGCCACGGG       c.3240
 S  S  K  H  S  P  L  T  A  S  A  R  G  D  C  V  P  S  H  G         p.1080

          .         .         .         .         .         .       g.63321
 CAGGACAGTCGCAGGCGCGGCCGGCGGAAGCGAGCATCTGCGGGGACGCCCAGCTTGAGC       c.3300
 Q  D  S  R  R  R  G  R  R  K  R  A  S  A  G  T  P  S  L  S         p.1100

          .         .         .         .         .         .       g.63381
 GCAGGCGTGTCCCCCAAGCGCCGAGCCCTGCCGTCCGTCGCTGGCCTTTTCACACAGCCT       c.3360
 A  G  V  S  P  K  R  R  A  L  P  S  V  A  G  L  F  T  Q  P         p.1120

          .         .         . | 25       .         .         .    g.64162
 TCGGGGTCTCCCCTCAACCTCAACTCCATG | GTCAGTAACATCAACCAGCCCCTGGAGATT    c.3420
 S  G  S  P  L  N  L  N  S  M   | V  S  N  I  N  Q  P  L  E  I      p.1140

          .         .         .         .         .         .       g.64222
 ACAGCCATCTCGTCCCCGGAGACCTCCCTGAAGAGCTCCCCTGTGCCCTACCAGGACCAC       c.3480
 T  A  I  S  S  P  E  T  S  L  K  S  S  P  V  P  Y  Q  D  H         p.1160

          .         .         .         .         .         .       g.64282
 GACCAGCCCCCCGTGCTCAAGAAGGAGCGGCCTCTGAGCCAGACCAATGGGGCACACTAC       c.3540
 D  Q  P  P  V  L  K  K  E  R  P  L  S  Q  T  N  G  A  H  Y         p.1180

          .         .         .         .         .       | 26 .    g.66243
 TCCCCACTCACCTCAGACGAGGAGCCAGGCTCTGAGGACGAGCCCAGCAGTGCTCG | AATT    c.3600
 S  P  L  T  S  D  E  E  P  G  S  E  D  E  P  S  S  A  R  |  I      p.1200

          .         .         .         .         .         .       g.66303
 GAGAGAAAAATTGCAACAATCTCCTTAGAAAGCAAATCTCCCCCGAAAACCTTGGAAAAT       c.3660
 E  R  K  I  A  T  I  S  L  E  S  K  S  P  P  K  T  L  E  N         p.1220

   | 27      .         .         .         .         .         .    g.67093
 G | GTGGTGGCTTGGCGGGAAGGAAGCCCGCGCCCGCCGGCGAGCCAGTCAATAGCAGCAAG    c.3720
 G |   G  G  L  A  G  R  K  P  A  P  A  G  E  P  V  N  S  S  K      p.1240

          .         .         .         .         .         .       g.67153
 TGGAAGTCCACCTTCTCGCCCATCTCCGACATCGGCCTGGCCAAGTCGGCGGACAGCCCG       c.3780
 W  K  S  T  F  S  P  I  S  D  I  G  L  A  K  S  A  D  S  P         p.1260

          .         .         .         .         .         .       g.67213
 CTGCAGGCCAGCTCCGCCCTCAGCCAGAACTCCCTGTTCACGTTCCGGCCCGCCCTGGAG       c.3840
 L  Q  A  S  S  A  L  S  Q  N  S  L  F  T  F  R  P  A  L  E         p.1280

          .         .         .         .         .         .       g.67273
 GAGCCCTCTGCCGATGCCAAGCTGGCCGCTCACCCCAGGAAAGGCTTTCCCGGCTCCCTG       c.3900
 E  P  S  A  D  A  K  L  A  A  H  P  R  K  G  F  P  G  S  L         p.1300

          .         .         .         .         .         .       g.67333
 TCGGGGGCTGACGGACTCAGCCCGGGCACCAACCCTGCCAACGGCTGCACCTTCGGCGGG       c.3960
 S  G  A  D  G  L  S  P  G  T  N  P  A  N  G  C  T  F  G  G         p.1320

          .         .         .         .         .         .       g.67393
 GGCCTGGCCGCGGACCTGAGTTTACACAGCTTCAGTGATGGTGCTTCTCTTCCCCACAAG       c.4020
 G  L  A  A  D  L  S  L  H  S  F  S  D  G  A  S  L  P  H  K         p.1340

          .         .         .         .         .         .       g.67453
 GGCCCCGAGGCGGCCGGCCTGAGCTCCCCGCTGAGCTTCCCCTCGCAGCGCGGCAAGGAG       c.4080
 G  P  E  A  A  G  L  S  S  P  L  S  F  P  S  Q  R  G  K  E         p.1360

          .         .         .         .         .         .       g.67513
 GGCTCGGACGCCAACCCTTTCCTGAGCAAGAGGCAGCTGGACGGCCTGGCTGGGCTGAAG       c.4140
 G  S  D  A  N  P  F  L  S  K  R  Q  L  D  G  L  A  G  L  K         p.1380

          .         .         .         .         .         .       g.67573
 GGCGAGGGCAGCCGCGGCAAGGAGGCAGGGGAGGGCGGCCTACCGCTGTGCGGGCCCACG       c.4200
 G  E  G  S  R  G  K  E  A  G  E  G  G  L  P  L  C  G  P  T         p.1400

          .         .         .         .         .         .       g.67633
 GACAAGACCCCACTGCTGAGCGGCAAGGCCGCCAAGGCCCGGGACCGCGAGGTCGACCTC       c.4260
 D  K  T  P  L  L  S  G  K  A  A  K  A  R  D  R  E  V  D  L         p.1420

          .         .         .         .         .         .       g.67693
 AAGAATGGCCACAACCTCTTCATCTCTGCGGCGGCCGTGCCTCCCGGAAGCCTCCTCAGC       c.4320
 K  N  G  H  N  L  F  I  S  A  A  A  V  P  P  G  S  L  L  S         p.1440

          .         .         .         .         .         .       g.67753
 GGCCCCGGCCTGGCCCCGGCGGCGTCCTCCGCAGGCGGCGCGGCGTCCTCCGCCCAGACG       c.4380
 G  P  G  L  A  P  A  A  S  S  A  G  G  A  A  S  S  A  Q  T         p.1460

          .         .         .         .         .         .       g.67813
 CACCGGTCCTTCCTGGGCCCCTTCCCGCCGGGACCGCAGTTCGCGCTCGGCCCCATGTCC       c.4440
 H  R  S  F  L  G  P  F  P  P  G  P  Q  F  A  L  G  P  M  S         p.1480

          .         .         .         .         .         .       g.67873
 CTGCAGGCCAACCTCGGCTCCGTGGCCGGCTCCTCCGTGCTGCAGTCGCTGTTCAGCTCT       c.4500
 L  Q  A  N  L  G  S  V  A  G  S  S  V  L  Q  S  L  F  S  S         p.1500

          .         .         .         .         .         .       g.67933
 GTGCCGGCCGCCGCAGGCCTGGTGCACGTGTCGTCCGCTGCCACCAGACTGACCAACTCG       c.4560
 V  P  A  A  A  G  L  V  H  V  S  S  A  A  T  R  L  T  N  S         p.1520

          .         .         .         .       | 28 .              g.70650
 CACGCCATGGGCAGCTTTTCCGGGGTGGCAGGCGGCACAGTTGGAG | GTAACTAG          c.4614
 H  A  M  G  S  F  S  G  V  A  G  G  T  V  G  G |   N  X            p.1537

          .         .         .         .         .         .       g.70710
 gatttctacctcaaccgcgagacctatgcaaggacggtgtggaccaactcgcgcccgcgg       c.*60

          .         .         .         .         .         .       g.70770
 catggtgcccgccggcctgccgggctcccacccctggacggcagaggcaaggacggacgg       c.*120

          .         .         .         .         .         .       g.70830
 gagctccactgtgaatcggcggcacgcgccgcaggaggctgggactggtccagtttgtac       c.*180

          .         .         .         .         .         .       g.70890
 tgtcgatagttttagataaagtatttatcattttttaaaaagtataaacaattctgactt       c.*240

          .         .         .         .         .         .       g.70950
 attttattccatctaagtggtaaaaggcaacttattgagaaatataaatatctatatatg       c.*300

          .         .         .         .         .         .       g.71010
 agagctctatataaagacacgtgtctgcagggcgggcccgccagcggattcgccacagcc       c.*360

          .         .         .         .         .         .       g.71070
 tgccccggtgctatctcgtccccaggcccgcgcctgcctccacccgcttggtgctgacta       c.*420

          .         .         .         .         .         .       g.71130
 gacgctgacaacgccgaaccccgttctcggaaacgccgcccggccggctcccccgacgcg       c.*480

          .         .         .         .         .         .       g.71190
 ctgctcccgtaccaaaggcaggcccgtcgccaccacattcctcggaggcctccccgcggc       c.*540

          .         .         .         .         .         .       g.71250
 ctgagccccttcctgagcgccctggcgcctgccctgagctcttcacctttaccccggcac       c.*600

          .         .         .         .         .         .       g.71310
 tgtgaacccccagactgttcaccctccggggcgtgggttgcgcccttgcatgtgaagggg       c.*660

          .         .         .         .         .         .       g.71370
 cctgcgcggtgacgcagctggccatgtgctgcgcgatggtgctgtgaggacggcgcgggc       c.*720

          .         .         .         .         .         .       g.71430
 acgttgaacaagtgcatttacttttgtatttctcggctgtccatggctcgcagcatgccc       c.*780

          .         .         .         .         .         .       g.71490
 tgcgatgcggggcaggcctgtcgtgggtcccttggtgtttctgtacaggagagagtcaca       c.*840

          .         .         .         .         .         .       g.71550
 ctaatgagtggcagtattttatagagatgtgatgagaatttataaatttcatagatttga       c.*900

          .         .         .         .         .         .       g.71610
 cagcttttatttttagatggtataatgcacagtgaagaggaaagaaaagcgaggggaaaa       c.*960

          .         .         .         .         .         .       g.71670
 aaccttatttattcaaacagtgcacaaaatggccccagcgtcagccccgaccctagaccc       c.*1020

          .         .         .         .         .         .       g.71730
 ctcagttgcagctcccagcagcccagacagagctgccggcgcccctgcctgccccacatc       c.*1080

          .         .         .         .         .         .       g.71790
 ccttcctgtcagggccacgcctggcacccatcccttggagcctgtgctggttctcccagc       c.*1140

          .         .         .         .         .         .       g.71850
 tgctgtgggtgtgctggggccagggtgcactgctgaaacctggcctctctggccctaggc       c.*1200

          .         .         .         .         .         .       g.71910
 cccagggtgacgtcggccccccactctgcagccttggcgggtgcctgggactgggtgtgg       c.*1260

          .         .         .         .         .         .       g.71970
 aaggagaggagctgaggccggggtgtagcaggcaggcagggccactccagtgcttctgga       c.*1320

          .         .         .         .         .         .       g.72030
 gccctgagcagtcagggcctgggttgtctgagcagtggtggctctgtgccctccctggag       c.*1380

          .         .         .         .         .         .       g.72090
 gatgggatctgggagtctgagctccccgcatctggccctgggctgtgtggcacttgctga       c.*1440

          .         .         .         .         .         .       g.72150
 gcccaccttctcaagtgcttgctcctgtgagatggcatcggggagccccttccccaaggt       c.*1500

          .         .         .         .         .         .       g.72210
 gccacagatccaccctccagggagctgccagccctgtgttctggttcccaagggcaggat       c.*1560

          .         .         .         .         .         .       g.72270
 ggacacacgtcacatccctaccacgtggcctccaaagggagccacggaggaaaggcttct       c.*1620

          .         .         .         .         .         .       g.72330
 gtggttgctaggtgggggagtcctgtgtgggagggcctgaagacccctgcttgtgcctgg       c.*1680

          .         .         .         .         .         .       g.72390
 tgaggggggtgctgcctcccccagcccccaacaacctctcagacccccaccctccaacat       c.*1740

          .         .         .         .         .         .       g.72450
 agctgagttctgaagatggtgctccggacctgtcctcttaagtggtgcccagtgccctcc       c.*1800

          .         .         .         .         .         .       g.72510
 ccaccccacgttggtgctctcagctagaaggtgctgtgcctctgcctgagccccaagccc       c.*1860

          .         .         .         .         .         .       g.72570
 cgagcctggccttcaggacaggcagcctgctctgtgtcgccacgggccggatacgccaca       c.*1920

          .         .         .         .         .         .       g.72630
 gggttgatggcagagacggccgagtccctggtctagaacaagacacattctttaaacact       c.*1980

          .         .         .         .         .         .       g.72690
 gtattacttctgcctccctctaggtgacagtggcagtccgggtgccatcacgggtcctgc       c.*2040

          .         .         .         .         .         .       g.72750
 agatggccatgcagggctcctgcccacgcaggccaccgtatgttcaggacacgcactggg       c.*2100

          .         .         .         .         .         .       g.72810
 tctcagagccactggcccaggcagaagtctccttgagcccactgggtcatatgcgtgtca       c.*2160

          .         .         .         .         .         .       g.72870
 ccacacgtgaactagtgtggtggctgcctgcggacaccctcctgttctgagccctgggcc       c.*2220

          .         .         .         .         .         .       g.72930
 tgtgttcttctcagacactcccagactgaggggtggtgtgtggcgggtggcagggtggct       c.*2280

          .         .         .         .         .         .       g.72990
 gtggagactggggatctggagcctggtgctggcacctggcctgagtttccgtgggcagct       c.*2340

          .         .         .         .         .         .       g.73050
 ggcggggacctgtgctgctgctgctgactgtgggtgggcgggcggcgcctgggagtggct       c.*2400

          .         .         .         .         .         .       g.73110
 cttgctcaggaattgataggaaccctaaaaactaggataccccctcctcggcccatgagg       c.*2460

          .         .         .         .         .         .       g.73170
 cacgcacagtgacttatttaagacttcccccttaatttatctgcccccaggatgcgtcag       c.*2520

          .         .         .         .         .         .       g.73230
 tctgttcagtggtcagcaggccccccaccccccgccgactgccctcgccatcgtggtcag       c.*2580

          .         .         .         .         .         .       g.73290
 acccccctcccaacacaacacgctgctggtctgtgtcagcctttgtaacgtgggaggctc       c.*2640

          .         .         .         .         .         .       g.73350
 tgccgtgtcttccgggtgaactgtatttggattgcgcgcattgtcacggtccgcccctgg       c.*2700

          .         .         .         .         .         .       g.73410
 gctgcaggcgccccttcctctgggcacccctgcattctgcatccccacctctagacgctg       c.*2760

          .         .                                               g.73436
 taataaacagactgttttcactcgga                                         c.*2786

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The DOT1-like, histone H3 methyltransferase (S. cerevisiae) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 29
©2004-2023 Leiden University Medical Center