dipeptidyl-peptidase 6 (DPP6) - coding DNA reference sequence

(used for variant description)

(last modified June 18, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_001936.3 in the DPP6 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_033878.1, covering DPP6 transcript NM_001936.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.422981
        actaagcagcggcagcttcctgcttcggatcctctctctgctgcttgcattta       c.-181

 .         .         .         .         .         .                g.423041
 aagagcaaactcgtcttgtctacccaccctccctcccccatcctccccaaaatagccttg       c.-121

 .         .         .         .         .         .                g.423101
 tgatttcggaagtatggactaaaatcacactcctccttaccttaccgcttggactctggt       c.-61

 .         .         .         .         .         .                g.423161
 ggctcccaactcgccgtcagaccccacctgccccggtggtgggaagcgcctggacagacc       c.-1

          .         .         .         .         .        | 02.    g.563883
 ATGACCACAGCCAAGGAGCCAAGCGCTTCGGGGAAATCCGTGCAGCAGCAGGAACAG | GAG    c.60
 M  T  T  A  K  E  P  S  A  S  G  K  S  V  Q  Q  Q  E  Q   | E      p.20

          .         .         .         .         .         .       g.563943
 CTGGTGGGGAGTAACCCTCCGCAGAGGAATTGGAAAGGAATAGCAATTGCACTGCTTGTC       c.120
 L  V  G  S  N  P  P  Q  R  N  W  K  G  I  A  I  A  L  L  V         p.40

          .         .         .         .         .   | 03     .    g.592613
 ATTCTGGTCATCTGCTCCTTGATCGTCACCTCGGTCATACTTCTGACACCAG | CGGAAGAT    c.180
 I  L  V  I  C  S  L  I  V  T  S  V  I  L  L  T  P  A |   E  D      p.60

          .         .         .         .         .         .       g.592673
 AATAGTCTGTCTCAAAAGAAGAAGGTCACTGTAGAAGATCTCTTCAGTGAAGACTTCAAA       c.240
 N  S  L  S  Q  K  K  K  V  T  V  E  D  L  F  S  E  D  F  K         p.80

          .         .         .  | 04      .         .         .    g.658227
 ATTCATGACCCCGAGGCTAAGTGGATAAGTG | ATACAGAATTCATCTACAGAGAACAGAAA    c.300
 I  H  D  P  E  A  K  W  I  S  D |   T  E  F  I  Y  R  E  Q  K      p.100

          .         .         .         .         .         .       g.658287
 GGAACAGTGAGACTGTGGAATGTTGAAACAAATACTTCTACTGTCTTAATAGAAGGCAAA       c.360
 G  T  V  R  L  W  N  V  E  T  N  T  S  T  V  L  I  E  G  K         p.120

        | 05 .         .         .         .         .         .    g.684562
 AAAATT | GAATCATTAAGAGCCATCAGATATGAAATATCTCCAGATAGAGAGTATGCACTT    c.420
 K  I   | E  S  L  R  A  I  R  Y  E  I  S  P  D  R  E  Y  A  L      p.140

          .         .  | 06      .         .         .         .    g.755526
 TTTTCATACAATGTGGAACCC | ATATATCAACACTCGTATACTGGATATTACGTCCTGAGC    c.480
 F  S  Y  N  V  E  P   | I  Y  Q  H  S  Y  T  G  Y  Y  V  L  S      p.160

          .     | 07   .         .         .         .         .    g.787072
 AAAATTCCTCATGG | GGATCCTCAAAGTCTGGACCCACCAGAAGTCAGCAATGCAAAACTT    c.540
 K  I  P  H  G  |  D  P  Q  S  L  D  P  P  E  V  S  N  A  K  L      p.180

          .         .         .       | 08 .         .         .    g.845457
 CAGTATGCAGGATGGGGCCCTAAAGGCCAACAGCTG | ATATTTATTTTTGAAAACAATATC    c.600
 Q  Y  A  G  W  G  P  K  G  Q  Q  L   | I  F  I  F  E  N  N  I      p.200

          .         .         .         .         .         .       g.845517
 TACTACTGTGCACATGTCGGGAAACAGGCCATCCGTGTGGTCTCCACTGGCAAGGAAGGT       c.660
 Y  Y  C  A  H  V  G  K  Q  A  I  R  V  V  S  T  G  K  E  G         p.220

          .         .         .        | 09.         .         .    g.887106
 GTGATTTACAATGGCCTCAGTGACTGGCTGTATGAAG | AGGAGATTTTGAAGACACACATC    c.720
 V  I  Y  N  G  L  S  D  W  L  Y  E  E |   E  I  L  K  T  H  I      p.240

          .         .         .         .         .         .       g.887166
 GCACACTGGTGGTCTCCGGATGGCACGAGACTCGCCTACGCCGCCATCAATGATTCCCGT       c.780
 A  H  W  W  S  P  D  G  T  R  L  A  Y  A  A  I  N  D  S  R         p.260

          .         .         .         .         .         .       g.887226
 GTCCCCATCATGGAGCTCCCAACTTACACCGGCTCCATCTACCCCACCGTGAAGCCCTAC       c.840
 V  P  I  M  E  L  P  T  Y  T  G  S  I  Y  P  T  V  K  P  Y         p.280

          .   | 10     .         .         .         .         .    g.890559
 CACTATCCCAAG | GCTGGAAGTGAGAACCCCAGCATTTCCCTACACGTTATTGGCTTAAAT    c.900
 H  Y  P  K   | A  G  S  E  N  P  S  I  S  L  H  V  I  G  L  N      p.300

          .         .         .         .         . | 11       .    g.911755
 GGACCCACCCATGATCTGGAGATGATGCCGCCTGATGATCCACGGATGAG | GGAGTACTAC    c.960
 G  P  T  H  D  L  E  M  M  P  P  D  D  P  R  M  R  |  E  Y  Y      p.320

          .         .         .         .         .         .       g.911815
 ATCACCATGGTGAAGTGGGCCACCAGCACCAAGGTCGCCGTGACCTGGCTGAACCGGGCG       c.1020
 I  T  M  V  K  W  A  T  S  T  K  V  A  V  T  W  L  N  R  A         p.340

          .         .         .         .         .     | 12   .    g.913517
 CAGAACGTGTCCATCCTCACCCTCTGCGACGCCACCACGGGGGTCTGCACGAAG | AAACAC    c.1080
 Q  N  V  S  I  L  T  L  C  D  A  T  T  G  V  C  T  K   | K  H      p.360

          .         .         .    | 13    .         .         .    g.919048
 GAGGATGAAAGTGAGGCCTGGCTCCACAGACAG | AATGAAGAACCTGTGTTCTCCAAGGAT    c.1140
 E  D  E  S  E  A  W  L  H  R  Q   | N  E  E  P  V  F  S  K  D      p.380

          .         .         .         .         .         .       g.919108
 GGCCGAAAGTTTTTCTTCATCAGAGCCATCCCCCAGGGAGGACGAGGGAAATTCTATCAC       c.1200
 G  R  K  F  F  F  I  R  A  I  P  Q  G  G  R  G  K  F  Y  H         p.400

          .         .  | 14      .         .         .         .    g.921569
 ATCACGGTGTCCTCGTCCCAG | CCCAACAGCAGCAACGACAACATCCAGTCCATCACCTCC    c.1260
 I  T  V  S  S  S  Q   | P  N  S  S  N  D  N  I  Q  S  I  T  S      p.420

          .         .         .         .         .    | 15    .    g.922590
 GGGGACTGGGACGTGACCAAGATCCTAGCCTACGATGAGAAGGGGAATAAGAT | CTACTTC    c.1320
 G  D  W  D  V  T  K  I  L  A  Y  D  E  K  G  N  K  I  |  Y  F      p.440

          .         .         .         .  | 16      .         .    g.924679
 CTGAGCACGGAGGACCTGCCTCGGAGACGACAACTCTACAG | TGCCAACACGGTGGGCAAC    c.1380
 L  S  T  E  D  L  P  R  R  R  Q  L  Y  S  |  A  N  T  V  G  N      p.460

          .         .         .         .         .         .       g.924739
 TTCAACAGGCAGTGCCTCTCCTGTGACCTGGTTGAGAACTGCACCTACTTCAGCGCTTCC       c.1440
 F  N  R  Q  C  L  S  C  D  L  V  E  N  C  T  Y  F  S  A  S         p.480

          .         .         .         . | 17       .         .    g.971466
 TTCAGCCATAGCATGGACTTCTTCCTGCTCAAGTGCGAAG | GTCCTGGTGTTCCTATGGTG    c.1500
 F  S  H  S  M  D  F  F  L  L  K  C  E  G |   P  G  V  P  M  V      p.500

          .         .         | 18         .         .         .    g.985693
 ACGGTGCACAACACAACAGATAAGAAAA | AAATGTTTGACCTAGAAACAAATGAACATGTC    c.1560
 T  V  H  N  T  T  D  K  K  K |   M  F  D  L  E  T  N  E  H  V      p.520

          .         .         .         .         .         .       g.985753
 AAGAAGGCCATAAATGACCGACAGATGCCTAAAGTGGAATACAGGGACATTGAGATTGAT       c.1620
 K  K  A  I  N  D  R  Q  M  P  K  V  E  Y  R  D  I  E  I  D         p.540

         | 19.         .         .         .         .         .    g.990343
 GATTACA | ACCTGCCCATGCAGATACTGAAGCCAGCAACCTTCACCGACACCACCCACTAC    c.1680
 D  Y  N |   L  P  M  Q  I  L  K  P  A  T  F  T  D  T  T  H  Y      p.560

          .        | 20.         .         .         .         .    g.993615
 CCTCTGCTCCTGGTGGT | GGATGGCACCCCAGGCAGCCAGAGTGTGGCTGAGAAGTTCGAG    c.1740
 P  L  L  L  V  V  |  D  G  T  P  G  S  Q  S  V  A  E  K  F  E      p.580

          .         .         .         .         .         .       g.993675
 GTGAGCTGGGAGACGGTGATGGTGAGCAGCCACGGCGCGGTGGTGGTAAAGTGTGACGGC       c.1800
 V  S  W  E  T  V  M  V  S  S  H  G  A  V  V  V  K  C  D  G         p.600

          .         .         .         .         .         .       g.993735
 CGTGGCAGCGGCTTCCAAGGGACCAAGCTCCTGCACGAAGTGAGGCGGCGGCTGGGCTTG       c.1860
 R  G  S  G  F  Q  G  T  K  L  L  H  E  V  R  R  R  L  G  L         p.620

          .         .         .   | 21     .         .         .    g.998582
 CTGGAGGAGAAGGACCAGATGGAGGCCGTGCG | GACGATGCTGAAGGAGCAGTACATTGAC    c.1920
 L  E  E  K  D  Q  M  E  A  V  R  |  T  M  L  K  E  Q  Y  I  D      p.640

          .         .        | 22.         .         .         .    g.1003332
 AGGACGCGCGTGGCCGTGTTTGGGAAG | GATTACGGTGGCTACCTGAGCACCTACATCCTC    c.1980
 R  T  R  V  A  V  F  G  K   | D  Y  G  G  Y  L  S  T  Y  I  L      p.660

          .         .         .         .         .         .       g.1003392
 CCAGCAAAGGGAGAAAATCAAGGCCAGACATTCACCTGCGGCTCTGCTCTCTCTCCAATA       c.2040
 P  A  K  G  E  N  Q  G  Q  T  F  T  C  G  S  A  L  S  P  I         p.680

          .          | 23        .         .         .         .    g.1005383
 ACAGACTTCAAACTCTATG | CCTCTGCGTTTTCCGAGAGGTACTTGGGCCTCCATGGACTT    c.2100
 T  D  F  K  L  Y  A |   S  A  F  S  E  R  Y  L  G  L  H  G  L      p.700

          .         | 24         .         .         .         .    g.1006980
 GACAACAGAGCATACGAG | ATGACCAAGGTAGCCCATCGAGTCTCCGCGCTGGAAGAACAG    c.2160
 D  N  R  A  Y  E   | M  T  K  V  A  H  R  V  S  A  L  E  E  Q      p.720

          .         .         .  | 25      .         .         .    g.1007152
 CAGTTCCTGATCATTCATCCCACTGCCGATG | AAAAAATTCATTTCCAGCACACAGCAGAA    c.2220
 Q  F  L  I  I  H  P  T  A  D  E |   K  I  H  F  Q  H  T  A  E      p.740

          .         .         .         .      | 26  .         .    g.1010015
 CTCATTACACAACTAATTAGGGGAAAGGCTAATTACAGCTTACAG | ATTTACCCGGACGAA    c.2280
 L  I  T  Q  L  I  R  G  K  A  N  Y  S  L  Q   | I  Y  P  D  E      p.760

          .         .         .         .         .         .       g.1010075
 AGCCATTACTTTACCAGCTCCAGCCTCAAACAGCATCTGTACCGGTCCATCATCAACTTC       c.2340
 S  H  Y  F  T  S  S  S  L  K  Q  H  L  Y  R  S  I  I  N  F         p.780

          .         .         .         .         .         .       g.1010135
 TTCGTGGAATGCTTCAGGATCCAGGACAAACTGCTGACAGTCACAGCGAAAGAGGACGAG       c.2400
 F  V  E  C  F  R  I  Q  D  K  L  L  T  V  T  A  K  E  D  E         p.800

          .                                                         g.1010147
 GAGGAGGACTAA                                                       c.2412
 E  E  D  X                                                         p.803

          .         .         .         .         .         .       g.1010207
 gctcaggtcgctctaagcacaaacgtggctctttctacaaccagatgcaaccgagggatt       c.*60

          .         .         .         .         .         .       g.1010267
 tccctgccctccctcttccctcggaggggcggggcggggcggggccgggtgttccatagc       c.*120

          .         .         .         .         .         .       g.1010327
 atgtgtgtctcggatgcggaaggcagttttgcttgggaaacaagctccttccccggggtc       c.*180

          .         .         .         .         .         .       g.1010387
 atcactcacggcctccatggcaccagggacaacgctgtccccgcagcagcgcctcctccc       c.*240

          .         .         .         .         .         .       g.1010447
 ggcgcccgagagaccggcacgccacggcccctcccccaaggaacagagcaaaggatggtg       c.*300

          .         .         .         .         .         .       g.1010507
 gccgcaggccccacgcgagcccacaggacaccggcccctagattccagccaccaagcgga       c.*360

          .         .         .         .         .         .       g.1010567
 agcatgagacccgcccacactagcctctgtgttcccgttagggacatcacaccctgtctc       c.*420

          .         .         .         .         .         .       g.1010627
 acgtcgcagtgccatggacgcagcagttacagcaccattgttttagcagtgcgtgttcat       c.*480

          .         .         .         .         .         .       g.1010687
 atatgggcttgctacttcctgtaatgaggacgttcaacatggtgaggggctacaagaaaa       c.*540

          .         .         .         .         .         .       g.1010747
 cgcttttctgtacagagtcttactgtagctacgctaatggttaacctgatagaattaact       c.*600

          .         .         .         .         .         .       g.1010807
 cgtatttttctatggttttaacctgatgctccactgtctccgtcatggggttgttttgct       c.*660

          .         .         .         .         .         .       g.1010867
 gtttggggttgggccttgtttccctttcctttctccagtccacgtgtagactttgcgctt       c.*720

          .         .         .         .         .         .       g.1010927
 gatgaagaagcagatcggaagtaactgctccctcctcaaggttgtcttcagacgtcttgg       c.*780

          .         .         .         .         .         .       g.1010987
 ggacgttcctaaacactgagggggaagacagccaatagcacccattaaaagaaataccta       c.*840

          .         .         .         .         .         .       g.1011047
 aataaaacctctctcccactcagctatgctagggcttggctgtaggtgtgcactgtctat       c.*900

          .         .         .         .         .         .       g.1011107
 ttacatccgtccttacaaccatccttgtcctccttggtaccgtatcaagctctttcccat       c.*960

          .         .         .         .         .         .       g.1011167
 gacatttggtttaaaaaaaaaaaaaaaaaaaaaaaaaaaacagaaaaaagacaaagcgtc       c.*1020

          .         .         .         .         .         .       g.1011227
 aactccacccacaggcccgctgtgtgtgctcgggccacgggagtcctgagggttctgtgg       c.*1080

          .         .         .         .         .         .       g.1011287
 gcctgcgcgcatccctctcccatcgtgggggtggctccgtgaccttcctgccacgagcag       c.*1140

          .         .         .         .         .         .       g.1011347
 gaggttgatgatgtgctacgttagccttgtaagatacacccccaccaaatgtgcagccgg       c.*1200

          .         .         .         .         .         .       g.1011407
 tgttcccagtgtatatttcattctcttgtatataaaggaagcaatgtgtgtcaggcctct       c.*1260

          .         .         .         .         .         .       g.1011467
 gtgcagtcaacccagcctcctcccgccagtgctaaccccgtgttgagcctgcatgctgac       c.*1320

          .         .         .         .         .         .       g.1011527
 actgtggccgatctggactctagaagtgctagtttgaaatatatccattactgtcatttc       c.*1380

          .         .         .         .         .         .       g.1011587
 cttttgagcttgtggacaagctgaatgtcaggactgacttcgccagctcccagccctgcg       c.*1440

          .         .         .         .         .         .       g.1011647
 ggggtgtccttggcatcccatcagcagaggagatgcgtccctgttgcattttggcgtttg       c.*1500

          .         .         .         .         .         .       g.1011707
 gggctttgggtttatccacatgagctctgaacgtccgttatagttagggtgattggaagg       c.*1560

          .         .         .         .         .         .       g.1011767
 tctccatcactgggtgttttaaaggtgattcaccaccatttgtgaaaggaccaacgtgct       c.*1620

          .         .         .         .         .         .       g.1011827
 gataaacaggaccgatccgagtgctacatgactgtgcgtttgctatttcaatgggcctga       c.*1680

          .         .         .         .         .         .       g.1011887
 acgactacaaagccagctaggtctggaaggggaagccagctctggccacgacatctggtc       c.*1740

          .         .         .         .         .         .       g.1011947
 ggagggaagtggggatgtggcatggtagcgtctgttcatccatggaataaaacattattt       c.*1800

                                                                    g.1011952
 tacca                                                              c.*1805

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Dipeptidyl-peptidase 6 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 15
©2004-2016 Leiden University Medical Center