dipeptidyl-peptidase 6 (DPP6) - coding DNA reference sequence

(used for variant description)

(last modified June 18, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_130797.2 in the DPP6 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_033878.1, covering DPP6 transcript NM_130797.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.170367
                                                    gctgctgct       c.-121

 .         .         .         .         .         .                g.170427
 gctgctgcctccccaccgcctttttttttttttaatctggagcggggtggggagtgggaa       c.-61

 .         .         .         .         .         .                g.170487
 ccggagagaaagcaaaatattaaaaagccccaaagacagccagcaggagcgcggtgcccg       c.-1

          .         .         .         .         .         .       g.170547
 ATGGCTTCGCTGTACCAGAGGTTCACTGGCAAGATCAACACCTCGAGGTCCTTCCCCGCG       c.60
 M  A  S  L  Y  Q  R  F  T  G  K  I  N  T  S  R  S  F  P  A         p.20

          .         .         .         .         .         .       g.170607
 CCCCCGGAGGCGAGTCACCTCCTGGGCGGCCAGGGGCCCGAGGAGGACGGCGGCGCAGGA       c.120
 P  P  E  A  S  H  L  L  G  G  Q  G  P  E  E  D  G  G  A  G         p.40

          .         .         .         .         .         .       g.170667
 GCCAAGCCCCTCGGCCCGCGGGCGCAGGCGGCGGCGCCCCGGGAGCGCGGCGGCGGCGGC       c.180
 A  K  P  L  G  P  R  A  Q  A  A  A  P  R  E  R  G  G  G  G         p.60

          .         .         .         .         .         .       g.170727
 GGCGGCGCGGGTGGCCGGCCCCGGTTCCAGTACCAGGCGCGGAGCGATGGTGACGAGGAG       c.240
 G  G  A  G  G  R  P  R  F  Q  Y  Q  A  R  S  D  G  D  E  E         p.80

     | 02    .         .         .         .         .         .    g.563937
 GAC | GAGCTGGTGGGGAGTAACCCTCCGCAGAGGAATTGGAAAGGAATAGCAATTGCACTG    c.300
 D   | E  L  V  G  S  N  P  P  Q  R  N  W  K  G  I  A  I  A  L      p.100

          .         .         .         .         .         | 03    g.592607
 CTTGTCATTCTGGTCATCTGCTCCTTGATCGTCACCTCGGTCATACTTCTGACACCAG | CG    c.360
 L  V  I  L  V  I  C  S  L  I  V  T  S  V  I  L  L  T  P  A |       p.120

          .         .         .         .         .         .       g.592667
 GAAGATAATAGTCTGTCTCAAAAGAAGAAGGTCACTGTAGAAGATCTCTTCAGTGAAGAC       c.420
 E  D  N  S  L  S  Q  K  K  K  V  T  V  E  D  L  F  S  E  D         p.140

          .         .         .        | 04.         .         .    g.658221
 TTCAAAATTCATGACCCCGAGGCTAAGTGGATAAGTG | ATACAGAATTCATCTACAGAGAA    c.480
 F  K  I  H  D  P  E  A  K  W  I  S  D |   T  E  F  I  Y  R  E      p.160

          .         .         .         .         .         .       g.658281
 CAGAAAGGAACAGTGAGACTGTGGAATGTTGAAACAAATACTTCTACTGTCTTAATAGAA       c.540
 Q  K  G  T  V  R  L  W  N  V  E  T  N  T  S  T  V  L  I  E         p.180

          .   | 05     .         .         .         .         .    g.684556
 GGCAAAAAAATT | GAATCATTAAGAGCCATCAGATATGAAATATCTCCAGATAGAGAGTAT    c.600
 G  K  K  I   | E  S  L  R  A  I  R  Y  E  I  S  P  D  R  E  Y      p.200

          .         .        | 06.         .         .         .    g.755520
 GCACTTTTTTCATACAATGTGGAACCC | ATATATCAACACTCGTATACTGGATATTACGTC    c.660
 A  L  F  S  Y  N  V  E  P   | I  Y  Q  H  S  Y  T  G  Y  Y  V      p.220

          .         . | 07       .         .         .         .    g.787066
 CTGAGCAAAATTCCTCATGG | GGATCCTCAAAGTCTGGACCCACCAGAAGTCAGCAATGCA    c.720
 L  S  K  I  P  H  G  |  D  P  Q  S  L  D  P  P  E  V  S  N  A      p.240

          .         .         .         .   | 08     .         .    g.845451
 AAACTTCAGTATGCAGGATGGGGCCCTAAAGGCCAACAGCTG | ATATTTATTTTTGAAAAC    c.780
 K  L  Q  Y  A  G  W  G  P  K  G  Q  Q  L   | I  F  I  F  E  N      p.260

          .         .         .         .         .         .       g.845511
 AATATCTACTACTGTGCACATGTCGGGAAACAGGCCATCCGTGTGGTCTCCACTGGCAAG       c.840
 N  I  Y  Y  C  A  H  V  G  K  Q  A  I  R  V  V  S  T  G  K         p.280

          .         .         .         .    | 09    .         .    g.887100
 GAAGGTGTGATTTACAATGGCCTCAGTGACTGGCTGTATGAAG | AGGAGATTTTGAAGACA    c.900
 E  G  V  I  Y  N  G  L  S  D  W  L  Y  E  E |   E  I  L  K  T      p.300

          .         .         .         .         .         .       g.887160
 CACATCGCACACTGGTGGTCTCCGGATGGCACGAGACTCGCCTACGCCGCCATCAATGAT       c.960
 H  I  A  H  W  W  S  P  D  G  T  R  L  A  Y  A  A  I  N  D         p.320

          .         .         .         .         .         .       g.887220
 TCCCGTGTCCCCATCATGGAGCTCCCAACTTACACCGGCTCCATCTACCCCACCGTGAAG       c.1020
 S  R  V  P  I  M  E  L  P  T  Y  T  G  S  I  Y  P  T  V  K         p.340

          .         | 10         .         .         .         .    g.890553
 CCCTACCACTATCCCAAG | GCTGGAAGTGAGAACCCCAGCATTTCCCTACACGTTATTGGC    c.1080
 P  Y  H  Y  P  K   | A  G  S  E  N  P  S  I  S  L  H  V  I  G      p.360

          .         .         .         .         .       | 11 .    g.911749
 TTAAATGGACCCACCCATGATCTGGAGATGATGCCGCCTGATGATCCACGGATGAG | GGAG    c.1140
 L  N  G  P  T  H  D  L  E  M  M  P  P  D  D  P  R  M  R  |  E      p.380

          .         .         .         .         .         .       g.911809
 TACTACATCACCATGGTGAAGTGGGCCACCAGCACCAAGGTCGCCGTGACCTGGCTGAAC       c.1200
 Y  Y  I  T  M  V  K  W  A  T  S  T  K  V  A  V  T  W  L  N         p.400

          .         .         .         .         .         .       g.911869
 CGGGCGCAGAACGTGTCCATCCTCACCCTCTGCGACGCCACCACGGGGGTCTGCACGAAG       c.1260
 R  A  Q  N  V  S  I  L  T  L  C  D  A  T  T  G  V  C  T  K         p.420

  | 12       .         .         .          | 13        .         . g.919042
  | AAACACGAGGATGAAAGTGAGGCCTGGCTCCACAGACAG | AATGAAGAACCTGTGTTCTCC c.1320
  | K  H  E  D  E  S  E  A  W  L  H  R  Q   | N  E  E  P  V  F  S   p.440

          .         .         .         .         .         .       g.919102
 AAGGATGGCCGAAAGTTTTTCTTCATCAGAGCCATCCCCCAGGGAGGACGAGGGAAATTC       c.1380
 K  D  G  R  K  F  F  F  I  R  A  I  P  Q  G  G  R  G  K  F         p.460

          .         .        | 14.         .         .         .    g.921563
 TATCACATCACGGTGTCCTCGTCCCAG | CCCAACAGCAGCAACGACAACATCCAGTCCATC    c.1440
 Y  H  I  T  V  S  S  S  Q   | P  N  S  S  N  D  N  I  Q  S  I      p.480

          .         .         .         .         .          | 15    g.922584
 ACCTCCGGGGACTGGGACGTGACCAAGATCCTAGCCTACGATGAGAAGGGGAATAAGAT | C    c.1500
 T  S  G  D  W  D  V  T  K  I  L  A  Y  D  E  K  G  N  K  I  |      p.500

          .         .         .         .        | 16.         .    g.924673
 TACTTCCTGAGCACGGAGGACCTGCCTCGGAGACGACAACTCTACAG | TGCCAACACGGTG    c.1560
 Y  F  L  S  T  E  D  L  P  R  R  R  Q  L  Y  S  |  A  N  T  V      p.520

          .         .         .         .         .         .       g.924733
 GGCAACTTCAACAGGCAGTGCCTCTCCTGTGACCTGGTTGAGAACTGCACCTACTTCAGC       c.1620
 G  N  F  N  R  Q  C  L  S  C  D  L  V  E  N  C  T  Y  F  S         p.540

          .         .         .         .       | 17 .         .    g.971460
 GCTTCCTTCAGCCATAGCATGGACTTCTTCCTGCTCAAGTGCGAAG | GTCCTGGTGTTCCT    c.1680
 A  S  F  S  H  S  M  D  F  F  L  L  K  C  E  G |   P  G  V  P      p.560

          .         .         .     | 18   .         .         .    g.985687
 ATGGTGACGGTGCACAACACAACAGATAAGAAAA | AAATGTTTGACCTAGAAACAAATGAA    c.1740
 M  V  T  V  H  N  T  T  D  K  K  K |   M  F  D  L  E  T  N  E      p.580

          .         .         .         .         .         .       g.985747
 CATGTCAAGAAGGCCATAAATGACCGACAGATGCCTAAAGTGGAATACAGGGACATTGAG       c.1800
 H  V  K  K  A  I  N  D  R  Q  M  P  K  V  E  Y  R  D  I  E         p.600

          .    | 19    .         .         .         .         .    g.990337
 ATTGATGATTACA | ACCTGCCCATGCAGATACTGAAGCCAGCAACCTTCACCGACACCACC    c.1860
 I  D  D  Y  N |   L  P  M  Q  I  L  K  P  A  T  F  T  D  T  T      p.620

          .         .    | 20    .         .         .         .    g.993609
 CACTACCCTCTGCTCCTGGTGGT | GGATGGCACCCCAGGCAGCCAGAGTGTGGCTGAGAAG    c.1920
 H  Y  P  L  L  L  V  V  |  D  G  T  P  G  S  Q  S  V  A  E  K      p.640

          .         .         .         .         .         .       g.993669
 TTCGAGGTGAGCTGGGAGACGGTGATGGTGAGCAGCCACGGCGCGGTGGTGGTAAAGTGT       c.1980
 F  E  V  S  W  E  T  V  M  V  S  S  H  G  A  V  V  V  K  C         p.660

          .         .         .         .         .         .       g.993729
 GACGGCCGTGGCAGCGGCTTCCAAGGGACCAAGCTCCTGCACGAAGTGAGGCGGCGGCTG       c.2040
 D  G  R  G  S  G  F  Q  G  T  K  L  L  H  E  V  R  R  R  L         p.680

          .         .         .         | 21         .         .    g.998576
 GGCTTGCTGGAGGAGAAGGACCAGATGGAGGCCGTGCG | GACGATGCTGAAGGAGCAGTAC    c.2100
 G  L  L  E  E  K  D  Q  M  E  A  V  R  |  T  M  L  K  E  Q  Y      p.700

          .         .         .    | 22    .         .         .    g.1003326
 ATTGACAGGACGCGCGTGGCCGTGTTTGGGAAG | GATTACGGTGGCTACCTGAGCACCTAC    c.2160
 I  D  R  T  R  V  A  V  F  G  K   | D  Y  G  G  Y  L  S  T  Y      p.720

          .         .         .         .         .         .       g.1003386
 ATCCTCCCAGCAAAGGGAGAAAATCAAGGCCAGACATTCACCTGCGGCTCTGCTCTCTCT       c.2220
 I  L  P  A  K  G  E  N  Q  G  Q  T  F  T  C  G  S  A  L  S         p.740

          .         .      | 23  .         .         .         .    g.1005377
 CCAATAACAGACTTCAAACTCTATG | CCTCTGCGTTTTCCGAGAGGTACTTGGGCCTCCAT    c.2280
 P  I  T  D  F  K  L  Y  A |   S  A  F  S  E  R  Y  L  G  L  H      p.760

          .         .     | 24   .         .         .         .    g.1006974
 GGACTTGACAACAGAGCATACGAG | ATGACCAAGGTAGCCCATCGAGTCTCCGCGCTGGAA    c.2340
 G  L  D  N  R  A  Y  E   | M  T  K  V  A  H  R  V  S  A  L  E      p.780

          .         .         .        | 25.         .         .    g.1007146
 GAACAGCAGTTCCTGATCATTCATCCCACTGCCGATG | AAAAAATTCATTTCCAGCACACA    c.2400
 E  Q  Q  F  L  I  I  H  P  T  A  D  E |   K  I  H  F  Q  H  T      p.800

          .         .         .         .         .  | 26      .    g.1010009
 GCAGAACTCATTACACAACTAATTAGGGGAAAGGCTAATTACAGCTTACAG | ATTTACCCG    c.2460
 A  E  L  I  T  Q  L  I  R  G  K  A  N  Y  S  L  Q   | I  Y  P      p.820

          .         .         .         .         .         .       g.1010069
 GACGAAAGCCATTACTTTACCAGCTCCAGCCTCAAACAGCATCTGTACCGGTCCATCATC       c.2520
 D  E  S  H  Y  F  T  S  S  S  L  K  Q  H  L  Y  R  S  I  I         p.840

          .         .         .         .         .         .       g.1010129
 AACTTCTTCGTGGAATGCTTCAGGATCCAGGACAAACTGCTGACAGTCACAGCGAAAGAG       c.2580
 N  F  F  V  E  C  F  R  I  Q  D  K  L  L  T  V  T  A  K  E         p.860

          .                                                         g.1010147
 GACGAGGAGGAGGACTAA                                                 c.2598
 D  E  E  E  D  X                                                   p.865

          .         .         .         .         .         .       g.1010207
 gctcaggtcgctctaagcacaaacgtggctctttctacaaccagatgcaaccgagggatt       c.*60

          .         .         .         .         .         .       g.1010267
 tccctgccctccctcttccctcggaggggcggggcggggcggggccgggtgttccatagc       c.*120

          .         .         .         .         .         .       g.1010327
 atgtgtgtctcggatgcggaaggcagttttgcttgggaaacaagctccttccccggggtc       c.*180

          .         .         .         .         .         .       g.1010387
 atcactcacggcctccatggcaccagggacaacgctgtccccgcagcagcgcctcctccc       c.*240

          .         .         .         .         .         .       g.1010447
 ggcgcccgagagaccggcacgccacggcccctcccccaaggaacagagcaaaggatggtg       c.*300

          .         .         .         .         .         .       g.1010507
 gccgcaggccccacgcgagcccacaggacaccggcccctagattccagccaccaagcgga       c.*360

          .         .         .         .         .         .       g.1010567
 agcatgagacccgcccacactagcctctgtgttcccgttagggacatcacaccctgtctc       c.*420

          .         .         .         .         .         .       g.1010627
 acgtcgcagtgccatggacgcagcagttacagcaccattgttttagcagtgcgtgttcat       c.*480

          .         .         .         .         .         .       g.1010687
 atatgggcttgctacttcctgtaatgaggacgttcaacatggtgaggggctacaagaaaa       c.*540

          .         .         .         .         .         .       g.1010747
 cgcttttctgtacagagtcttactgtagctacgctaatggttaacctgatagaattaact       c.*600

          .         .         .         .         .         .       g.1010807
 cgtatttttctatggttttaacctgatgctccactgtctccgtcatggggttgttttgct       c.*660

          .         .         .         .         .         .       g.1010867
 gtttggggttgggccttgtttccctttcctttctccagtccacgtgtagactttgcgctt       c.*720

          .         .         .         .         .         .       g.1010927
 gatgaagaagcagatcggaagtaactgctccctcctcaaggttgtcttcagacgtcttgg       c.*780

          .         .         .         .         .         .       g.1010987
 ggacgttcctaaacactgagggggaagacagccaatagcacccattaaaagaaataccta       c.*840

          .         .         .         .         .         .       g.1011047
 aataaaacctctctcccactcagctatgctagggcttggctgtaggtgtgcactgtctat       c.*900

          .         .         .         .         .         .       g.1011107
 ttacatccgtccttacaaccatccttgtcctccttggtaccgtatcaagctctttcccat       c.*960

          .         .         .         .         .         .       g.1011167
 gacatttggtttaaaaaaaaaaaaaaaaaaaaaaaaaaaacagaaaaaagacaaagcgtc       c.*1020

          .         .         .         .         .         .       g.1011227
 aactccacccacaggcccgctgtgtgtgctcgggccacgggagtcctgagggttctgtgg       c.*1080

          .         .         .         .         .         .       g.1011287
 gcctgcgcgcatccctctcccatcgtgggggtggctccgtgaccttcctgccacgagcag       c.*1140

          .         .         .         .         .         .       g.1011347
 gaggttgatgatgtgctacgttagccttgtaagatacacccccaccaaatgtgcagccgg       c.*1200

          .         .         .         .         .         .       g.1011407
 tgttcccagtgtatatttcattctcttgtatataaaggaagcaatgtgtgtcaggcctct       c.*1260

          .         .         .         .         .         .       g.1011467
 gtgcagtcaacccagcctcctcccgccagtgctaaccccgtgttgagcctgcatgctgac       c.*1320

          .         .         .         .         .         .       g.1011527
 actgtggccgatctggactctagaagtgctagtttgaaatatatccattactgtcatttc       c.*1380

          .         .         .         .         .         .       g.1011587
 cttttgagcttgtggacaagctgaatgtcaggactgacttcgccagctcccagccctgcg       c.*1440

          .         .         .         .         .         .       g.1011647
 ggggtgtccttggcatcccatcagcagaggagatgcgtccctgttgcattttggcgtttg       c.*1500

          .         .         .         .         .         .       g.1011707
 gggctttgggtttatccacatgagctctgaacgtccgttatagttagggtgattggaagg       c.*1560

          .         .         .         .         .         .       g.1011767
 tctccatcactgggtgttttaaaggtgattcaccaccatttgtgaaaggaccaacgtgct       c.*1620

          .         .         .         .         .         .       g.1011827
 gataaacaggaccgatccgagtgctacatgactgtgcgtttgctatttcaatgggcctga       c.*1680

          .         .         .         .         .         .       g.1011887
 acgactacaaagccagctaggtctggaaggggaagccagctctggccacgacatctggtc       c.*1740

          .         .         .         .         .         .       g.1011947
 ggagggaagtggggatgtggcatggtagcgtctgttcatccatggaataaaacattattt       c.*1800

                                                                    g.1011952
 tacca                                                              c.*1805

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Dipeptidyl-peptidase 6 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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