dpy-19-like 2 (C. elegans) (DPY19L2) - coding DNA reference sequence

(used for variant description)

(last modified November 5, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_173812.4 in the DPY19L2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_031909.1, covering DPY19L2 transcript NM_173812.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5001
                                                            a       c.-181

 .         .         .         .         .         .                g.5061
 atggcttccaacgcatgcgccccaccccacatttcacagtcgccatgacgaccgggaggt       c.-121

 .         .         .         .         .         .                g.5121
 ccgcaacggctgcggggacaagtccgttgaggctgccaggcgagtcaggtctctctggac       c.-61

 .         .         .         .         .         .                g.5181
 ctcgcctgactcggctgggctgtgcctgaaattgacccagctccaccatactccttgatt       c.-1

          .         .         .         .         .         .       g.5241
 ATGAGAAAACAAGGAGTAAGCTCAAAGCGGCTGCAATCTTCCGGCCGCAGCCAGTCTAAG       c.60
 M  R  K  Q  G  V  S  S  K  R  L  Q  S  S  G  R  S  Q  S  K         p.20

          .         .         .         .         .         .       g.5301
 GGGCGGCGCGGGGCCTCCCTCGCCCGGGAGCCGGAGGTAGAGGAGGAGATGGAAAAGTCG       c.120
 G  R  R  G  A  S  L  A  R  E  P  E  V  E  E  E  M  E  K  S         p.40

          .         .         .         .         .         .       g.5361
 GCCCTAGGCGGCGGGAAACTGCCAAGGGGCTCCTGGAGGTCCTCCCCGGGGAGGATCCAA       c.180
 A  L  G  G  G  K  L  P  R  G  S  W  R  S  S  P  G  R  I  Q         p.60

          .         .         .         .         .         .       g.5421
 AGTCTGAAAGAGCGAAAAGGCTTGGAGCTAGAGGTGGTGGCCAAGACCTTTCTTCTCGGC       c.240
 S  L  K  E  R  K  G  L  E  L  E  V  V  A  K  T  F  L  L  G         p.80

          .         .         .         .         .         .       g.5481
 CCCTTCCAGTTCGTCCGTAATTCCCTGGCGCAGCTCCGGGAAAAGGTGCAGGAACTGCAG       c.300
 P  F  Q  F  V  R  N  S  L  A  Q  L  R  E  K  V  Q  E  L  Q         p.100

          .         .         .        | 02.         .         .    g.7738
 GCGCGGCGGTTCTCCAGCAGAACCACTCTCGGCATCG | CTGTCTTTGTGGCAATTTTACAT    c.360
 A  R  R  F  S  S  R  T  T  L  G  I  A |   V  F  V  A  I  L  H      p.120

    | 03     .         .         .         .         .         .    g.9787
 TG | GTTACATTTAGTAACACTTTTTGAAAATGATCGTCATTTCTCTCACCTCTCATCTTTG    c.420
 W  |  L  H  L  V  T  L  F  E  N  D  R  H  F  S  H  L  S  S  L      p.140

          .         .         . | 04       .         .         .    g.12123
 GAACGGGAGATGACTTTTCGCACTGAAATG | GGACTTTATTATTCATACTTCAAGACCATT    c.480
 E  R  E  M  T  F  R  T  E  M   | G  L  Y  Y  S  Y  F  K  T  I      p.160

          .         .         .         .         .         .       g.12183
 ATTGAAGCACCTTCGTTTTTGGAAGGACTGTGGATGATTATGAATGACAGGCTTACTGAA       c.540
 I  E  A  P  S  F  L  E  G  L  W  M  I  M  N  D  R  L  T  E         p.180

          .         .         .         .         | 05         .    g.26221
 TATCCTCTTATAATTAATGCAATAAAACGCTTCCATCTTTATCCAGAG | GTAATCATAGCC    c.600
 Y  P  L  I  I  N  A  I  K  R  F  H  L  Y  P  E   | V  I  I  A      p.200

          .         .         .         .         .         .       g.26281
 TCCTGGTATTGCACATTCATGGGAATAATGAATTTATTTGGACTAGAAACTAAGACCTGC       c.660
 S  W  Y  C  T  F  M  G  I  M  N  L  F  G  L  E  T  K  T  C         p.220

          .         .         .         .          | 06        .    g.29089
 TGGAATGTCACCAGAATAGAACCTCTTAATGAAGTTCAAAGCTGTGAAG | GATTGGGAGAT    c.720
 W  N  V  T  R  I  E  P  L  N  E  V  Q  S  C  E  G |   L  G  D      p.240

          .         .         .         .         .         .       g.29149
 CCTGCTTGCTTTTATGTTGGTGTAATCTTTATTTTAAATGGACTAATGATGGGATTGTTC       c.780
 P  A  C  F  Y  V  G  V  I  F  I  L  N  G  L  M  M  G  L  F         p.260

          .         .    | 07    .         .         .         .    g.47085
 TTCATGTATGGAGCATACCTGAG | TGGGACTCAACTGGGAGGTCTTATTACAGTACTGTGC    c.840
 F  M  Y  G  A  Y  L  S  |  G  T  Q  L  G  G  L  I  T  V  L  C      p.280

          .         .  | 08      .         .         .         .    g.49482
 TTCTTTTTCAACCATGGAGAG | GCCACCCGTGTGATGTGGACACCACCTCTCCGTGAAAGT    c.900
 F  F  F  N  H  G  E   | A  T  R  V  M  W  T  P  P  L  R  E  S      p.300

          .         .         .         .         .    | 09    .    g.52244
 TTTTCCTATCCTTTCCTTGTACTTCAGATGTGTATTTTAACTTTGATTCTCAG | GACCTCA    c.960
 F  S  Y  P  F  L  V  L  Q  M  C  I  L  T  L  I  L  R  |  T  S      p.320

          .         .         .         .         .         .       g.52304
 AGCAATGATAGAAGGCCCTTCATTGCACTCTGTCTTTCCAATGTTGCTTTTATGCTTCCC       c.1020
 S  N  D  R  R  P  F  I  A  L  C  L  S  N  V  A  F  M  L  P         p.340

          .         .         .    | 10    .         .         .    g.55373
 TGGCAATTTGCTCAGTTTATACTTTTTACACAG | ATAGCATCATTATTTCCCATGTATGTT    c.1080
 W  Q  F  A  Q  F  I  L  F  T  Q   | I  A  S  L  F  P  M  Y  V      p.360

          .         .         .         .         .  | 11      .    g.56193
 GTGGGATACATTGAACCAAGCAAATTTCAGAAGATCATTTATATGAACATG | ATTTCAGTT    c.1140
 V  G  Y  I  E  P  S  K  F  Q  K  I  I  Y  M  N  M   | I  S  V      p.380

          .         .         .         .         .         .       g.56253
 ACCCTTAGTTTCATTTTGATGTTTGGAAATTCAATGTACTTATCTTCTTATTATTCTTCA       c.1200
 T  L  S  F  I  L  M  F  G  N  S  M  Y  L  S  S  Y  Y  S  S         p.400

          .         | 12         .         .         .         .    g.64941
 TCTTTGTTAATGACGTGG | GCAATAATTCTAAAGAGAAATGAAATTCAAAAACTGGGAGTA    c.1260
 S  L  L  M  T  W   | A  I  I  L  K  R  N  E  I  Q  K  L  G  V      p.420

          .         | 13         .         .         .         .    g.73230
 TCTAAACTCAACTTTTGG | CTAATTCAAGGTAGTGCCTGGTGGTGTGGAACAATCATTTTG    c.1320
 S  K  L  N  F  W   | L  I  Q  G  S  A  W  W  C  G  T  I  I  L      p.440

          .         .         .          | 14        .         .    g.75685
 AAATTTCTGACATCTAAAATCTTAGGCGTTTCAGACCAC | ATTCGCCTGAGTGATCTTATA    c.1380
 K  F  L  T  S  K  I  L  G  V  S  D  H   | I  R  L  S  D  L  I      p.460

          .         .         .         .         .         .       g.75745
 GCAGCCAGAATCTTAAGGTATACAGATTTTGATACTTTAATATATACCTGTGCTCCCGAA       c.1440
 A  A  R  I  L  R  Y  T  D  F  D  T  L  I  Y  T  C  A  P  E         p.480

          .         .  | 15      .         .         .         .    g.77576
 TTTGACTTCATGGAAAAAGCG | ACTCCGCTGAGATACACAAAGACATTATTGCTTCCAGTT    c.1500
 F  D  F  M  E  K  A   | T  P  L  R  Y  T  K  T  L  L  L  P  V      p.500

          .         .         .    | 16    .         .         .    g.79468
 GTTATGGTGATTACATGTTTTATCTTTAAAAAG | ACTGTTCGTGATATTTCATATGTTTTA    c.1560
 V  M  V  I  T  C  F  I  F  K  K   | T  V  R  D  I  S  Y  V  L      p.520

          .         . | 17       .         .      | 18  .         . g.91064
 GCTACAAACATTTATCTAAG | AAAACAGCTCCTTGAACACAGTGAG | CTGGCTTTTCACACA c.1620
 A  T  N  I  Y  L  R  |  K  Q  L  L  E  H  S  E   | L  A  F  H  T   p.540

          .         .         .         .         .         .       g.91124
 TTGCAGTTGTTAGTGTTTACTGCCCTTGCCATTTTAATTATGAGGCTAAAGATGTTTTTG       c.1680
 L  Q  L  L  V  F  T  A  L  A  I  L  I  M  R  L  K  M  F  L         p.560

          .         .         .         .      | 19  .         .    g.92753
 ACACCGCACATGTGTGTTATGGCTTCCTTGATATGCTCTCGACAG | CTCTTTGGCTGGCTT    c.1740
 T  P  H  M  C  V  M  A  S  L  I  C  S  R  Q   | L  F  G  W  L      p.580

          .         .         .         .         .         .       g.92813
 TTTCGCAGAGTTCGTTTTGAGAAGGTTATCTTTGGCATTTTAACAGTGATGTCAATACAA       c.1800
 F  R  R  V  R  F  E  K  V  I  F  G  I  L  T  V  M  S  I  Q         p.600

          .         .         .         .         .         .       g.92873
 GGTTATGCAAACCTCCGTAATCAATGGAGCATAATAGGAGAATTTAATAATTTGCCTCAG       c.1860
 G  Y  A  N  L  R  N  Q  W  S  I  I  G  E  F  N  N  L  P  Q         p.620

          .         .         .         . | 20       .         .    g.102737
 GAAGAACTTTTACAGTGGATCAAATACAGTACCACATCAG | ATGCTGTCTTTGCAGGTGCC    c.1920
 E  E  L  L  Q  W  I  K  Y  S  T  T  S  D |   A  V  F  A  G  A      p.640

          .         .         .         .         .         .       g.102797
 ATGCCTACAATGGCAAGCATCAAGCTGTCTACACTTCATCCCATTGTGAATCATCCACAT       c.1980
 M  P  T  M  A  S  I  K  L  S  T  L  H  P  I  V  N  H  P  H         p.660

          .         . | 21       .         .         .         .    g.104265
 TACGAAGATGCAGACTTGAG | GGCTCGGACAAAAATAGTTTATTCTACATATAGTCGAAAA    c.2040
 Y  E  D  A  D  L  R  |  A  R  T  K  I  V  Y  S  T  Y  S  R  K      p.680

          .         .         .         .         .         .       g.104325
 TCTGCCAAAGAAGTAAGAGATAAATTGTTGGAGTTACATGTGAATTATTATGTTTTAGAA       c.2100
 S  A  K  E  V  R  D  K  L  L  E  L  H  V  N  Y  Y  V  L  E         p.700

          .         .       | 22 .         .         .         .    g.112946
 GAGGCATGGTGTGTTGTGAGAACTAA | GCCTGGTTGCAGTATGCTTGAAATCTGGGATGTG    c.2160
 E  A  W  C  V  V  R  T  K  |  P  G  C  S  M  L  E  I  W  D  V      p.720

          .         .         .         .         .         .       g.113006
 GAAGACCCTTCCAATGCAGCTAACCCTCCCTTATGTAGCGTCCTGCTCGAAGACGCCAGG       c.2220
 E  D  P  S  N  A  A  N  P  P  L  C  S  V  L  L  E  D  A  R         p.740

          .         .         .         .         .                 g.113063
 CCTTACTTCACCACAGTATTTCAGAATAGTGTGTACAGAGTATTAAAGGTTAACTGA          c.2277
 P  Y  F  T  T  V  F  Q  N  S  V  Y  R  V  L  K  V  N  X            p.758

          .         .         .         .         .         .       g.113123
 gaaggatactacccattttactatggcacaatgccgtgtgtcaaaaacaatcaccctttg       c.*60

          .         .         .         .         .         .       g.113183
 gcttattcacattaataaaaatcacaagctttaataacagacacttaaaaataagataaa       c.*120

          .         .         .         .         .         .       g.113243
 aatggattggaaatttttctgattactaaaaggtaaattacttttctgttcattgaatgt       c.*180

          .         .         .         .         .         .       g.113303
 cagccttattaagcttgtcatataagttattaaatcattcatgtcatactgcataaacaa       c.*240

          .         .         .         .         .         .       g.113363
 atgttcatttcagaattttaaagagaaatgtatataaaagaacaatgaattttaataaat       c.*300

          .         .         .         .         .         .       g.113423
 caggggtatgtaagtcctttttcatccaactaggtgaattgcttcagattttctctagta       c.*360

          .         .         .         .         .         .       g.113483
 ccagagggtacctcctcaaactctttgaaccacttaaggcagaagaatgcaagctctgaa       c.*420

          .         .         .         .         .         .       g.113543
 atgacatccttaaaatgctgatactggtcacagcctctttacctctgtgaggaaattgta       c.*480

          .         .         .         .         .         .       g.113603
 acagtgtgtcttttaaggtgtttttattttaccagcccttaagaaagatctctaatacct       c.*540

          .         .         .         .         .         .       g.113663
 tttaatacttttttttaataatttcaagttgaagtgtttttaaaaacactttgttttgta       c.*600

          .         .         .         .         .         .       g.113723
 atgttttgaatctcttgagatgtgtttaccccactagatacatatttgccactggttagt       c.*660

          .         .         .         .         .         .       g.113783
 tctccatctaagctcaagaggttattcatctctctttagattccagtggcttttctttta       c.*720

          .         .         .         .         .         .       g.113843
 acatccaggtaaaacagaaactgctatggtatacaaccaagttttggggttaaacataat       c.*780

          .         .         .         .         .         .       g.113903
 cagaaaagaaaatccagttaaatttatgaagtgagattttcagatcctagatcttgaata       c.*840

          .         .         .         .         .         .       g.113963
 aaggaaaggtcttttcatcttgatggccccaaagcttgttggtcatggtctttatttctg       c.*900

          .         .         .         .         .         .       g.114023
 gccactatcttcttaaataatatatttttaagccctcatttatttttggttttgggtgag       c.*960

          .         .         .         .         .         .       g.114083
 gaaagtcatgttttctaagtcctctcccctaataaaacctacccaacaatagtgctttga       c.*1020

          .         .         .         .         .         .       g.114143
 aaagtggtagttatcttgaagatactcttgccaaatgcaaagataaacattctttttgtc       c.*1080

          .         .         .         .         .         .       g.114203
 tgctttataaatatgaaatatgccagatctatagtattttaatgtgcatctactttaaat       c.*1140

          .         .         .         .         .         .       g.114263
 gagtcatcttggggtttttataattcccttatgttcttgcccctctacacttgaaataac       c.*1200

          .         .         .         .         .         .       g.114323
 aaaatgccttaattttatggattagttctcttatagtagacaggcagctatatgcagcaa       c.*1260

          .         .         .         .         .         .       g.114383
 aaccaataaagttatttttcaactttcatagttgtaaaatatcttataacagaatacaaa       c.*1320

          .         .         .         .         .         .       g.114443
 acagctaagaaaacatgccacattttattttagcattttcaaataatttgtttttggtgt       c.*1380

          .         .         .         .         .         .       g.114503
 aagcacaggataaaaaaggagagcgtcaaagaaaagagacataacacctaacattcataa       c.*1440

          .         .         .         .         .         .       g.114563
 aaattaacaaagtatattttggatgatgtttttacaggaaatattttaaataagttggta       c.*1500

          .         .         .         .         .         .       g.114623
 gaacttttaaaatggtactgtattagctaataaaatattcagtacaaatatatgtttgga       c.*1560

          .         .         .                                     g.114662
 tttatgcattaaaaaactaataaaattatttccaacttt                            c.*1599

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Dpy-19-like 2 (C. elegans) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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